메뉴 건너뛰기




Volumn 275, Issue 3, 1998, Pages 413-418

The specific variable domain of camel heavy-chain antibodies is encoded in the germline

Author keywords

Dromedary; Generation os diversity; Heavy chain variable region; Heavy chain antibodies; Repertoire development

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; SOLVENT;

EID: 0032559379     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1477     Document Type: Article
Times cited : (81)

References (44)
  • 2
    • 0346139366 scopus 로고
    • Ovalbumine gene: Evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries
    • Breathnach R., Benoist C., O'Hare K., Ganon F., Chambon P. Ovalbumine gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc. Natl Acad. Sci. USA. 75:1978;4853-4857.
    • (1978) Proc. Natl Acad. Sci. USA , vol.75 , pp. 4853-4857
    • Breathnach, R.1    Benoist, C.2    O'Hare, K.3    Ganon, F.4    Chambon, P.5
  • 3
    • 0021129784 scopus 로고
    • The immunoglobulin heavy chain variable region (IgH-V) locus in the mouse. I. One hundred IgH-V genes comprise seven families of homologous genes
    • Brodeur P. H., Riblet R. The immunoglobulin heavy chain variable region (IgH-V) locus in the mouse. I. One hundred IgH-V genes comprise seven families of homologous genes. Eur. J. Immunol. 14:1984;922-940.
    • (1984) Eur. J. Immunol. , vol.14 , pp. 922-940
    • Brodeur, P.H.1    Riblet, R.2
  • 4
    • 0022339938 scopus 로고
    • Domain association in immunoglobulin molecules. The packing of variable domains
    • Chothia C., Novotny J., Bruccoleri R., Karplus M. Domain association in immunoglobulin molecules. The packing of variable domains. J. Mol. Biol. 186:1985;651-663.
    • (1985) J. Mol. Biol. , vol.186 , pp. 651-663
    • Chothia, C.1    Novotny, J.2    Bruccoleri, R.3    Karplus, M.4
  • 5
    • 2642648459 scopus 로고
    • The outline structure of the T-cell αβ receptor
    • Chothia C., Boswell D. R., Lesk A. M. The outline structure of the T-cell αβ receptor. EMBO J. 7:1988;3745-3755.
    • (1988) EMBO J. , vol.7 , pp. 3745-3755
    • Chothia, C.1    Boswell, D.R.2    Lesk, A.M.3
  • 7
    • 0028986982 scopus 로고
    • The human immunoglobulin VH repertoire
    • Cook G. P., Tomlinson I. M. The human immunoglobulin VH repertoire. Immunol. Today. 16:1995;237-242.
    • (1995) Immunol. Today , vol.16 , pp. 237-242
    • Cook, G.P.1    Tomlinson, I.M.2
  • 8
    • 0027953603 scopus 로고
    • Camelising human antibody fragments: NMR studies on VH domains
    • Davies J., Riechmann L. Camelising human antibody fragments: NMR studies on VH domains. FEBS Letters. 339:1994;285-290.
    • (1994) FEBS Letters , vol.339 , pp. 285-290
    • Davies, J.1    Riechmann, L.2
  • 9
    • 0018908498 scopus 로고
    • An immunoglobulin heavy-chain gene is formed by at least two recombinational events
    • Davis M. M., Calame K., Early P. W., Livant D. L., Joho R., Weissman I. L., Hood L. An immunoglobulin heavy-chain gene is formed by at least two recombinational events. Nature. 283:1980;733-739.
    • (1980) Nature , vol.283 , pp. 733-739
    • Davis, M.M.1    Calame, K.2    Early, P.W.3    Livant, D.L.4    Joho, R.5    Weissman, I.L.6    Hood, L.7
  • 11
    • 0021760092 scopus 로고
    • A comprehensive set of sequence analysis programs for the VAX
    • Devereux L., Haeberli P., Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucl. Acids Res. 12:1984;387-395.
    • (1984) Nucl. Acids Res. , vol.12 , pp. 387-395
    • Devereux, L.1    Haeberli, P.2    Smithies, O.3
  • 13
    • 0030450401 scopus 로고    scopus 로고
    • Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation
    • Goyenechea B., Milstein C. Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation. Proc. Natl Acad. Sci. USA. 93:1996;13979-13984.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 13979-13984
    • Goyenechea, B.1    Milstein, C.2
  • 15
    • 0024691453 scopus 로고
    • V(D)J recombination: A functional definition of the joining signals
    • Hesse J. E., Lieber M. R., Mizuuchi K., Gellert M. V(D)J recombination: a functional definition of the joining signals. Genes Dev. 3:1989;1053-1061.
    • (1989) Genes Dev. , vol.3 , pp. 1053-1061
    • Hesse, J.E.1    Lieber, M.R.2    Mizuuchi, K.3    Gellert, M.4
  • 17
    • 0019795095 scopus 로고
    • Chi, a promoter of generalized recombination in λ phage, is present in immunoglobulin genes
    • Kenter A. L., Birshtein B. K. Chi, a promoter of generalized recombination in λ phage, is present in immunoglobulin genes. Nature. 293:1981;402-404.
    • (1981) Nature , vol.293 , pp. 402-404
    • Kenter, A.L.1    Birshtein, B.K.2
  • 18
    • 0026592314 scopus 로고
    • Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding
    • Kirkham P. M., Mortari F., Newton J. A., Schroeder H. W. Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding. EMBO J. 11:1992;603-609.
    • (1992) EMBO J. , vol.11 , pp. 603-609
    • Kirkham, P.M.1    Mortari, F.2    Newton, J.A.3    Schroeder, H.W.4
  • 20
    • 0026611140 scopus 로고
    • Hgene usage and generation of antibody diversity in rabbit
    • Hgene usage and generation of antibody diversity in rabbit. Annu. Rev. Immunol. 10:1992;593-616.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 593-616
    • Knight, K.L.1
  • 23
    • 0001792015 scopus 로고
    • Molecular biology of rabbit immunoglobulin and T cell receptor genes
    • S. Dubiski. New York: John Wiley & Sons
    • Mage R. G. Molecular biology of rabbit immunoglobulin and T cell receptor genes. Dubiski S. The Rabbit in Contemporary Immunological Research. 1987;106-133 John Wiley & Sons, New York.
    • (1987) The Rabbit in Contemporary Immunological Research , pp. 106-133
    • Mage, R.G.1
  • 24
    • 0344212391 scopus 로고
    • Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region
    • Matthyssens G., Rabbitts T. H. Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. Proc. Natl Acad. Sci. USA. 77:1980;6561-6565.
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 6561-6565
    • Matthyssens, G.1    Rabbitts, T.H.2
  • 25
    • 0028168145 scopus 로고
    • Sequence and structure of VH domain from naturally occurring camel heavy chain immunoglobulins lacking light chains
    • Muyldermans S., Atarhouch T., Saldanha J., Barbosa J. A., Hamers R. Sequence and structure of VH domain from naturally occurring camel heavy chain immunoglobulins lacking light chains. Protein Eng. 7:1994;1129-1135.
    • (1994) Protein Eng. , vol.7 , pp. 1129-1135
    • Muyldermans, S.1    Atarhouch, T.2    Saldanha, J.3    Barbosa, J.A.4    Hamers, R.5
  • 26
    • 0008850369 scopus 로고
    • Structure of the 5′ ends of immunoglobulin genes: A novel conserved sequence
    • Parslow T. G., Blair D. L., Murphy W. J., Granner D. K. Structure of the 5′ ends of immunoglobulin genes: a novel conserved sequence. Proc. Natl Acad. Sci. USA. 81:1984;2650-2654.
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 2650-2654
    • Parslow, T.G.1    Blair, D.L.2    Murphy, W.J.3    Granner, D.K.4
  • 28
    • 0028291092 scopus 로고
    • Conservation of sequence in recombination signal sequence spacers
    • Ramsden D. A., Baetz K., Wu G. E. Conservation of sequence in recombination signal sequence spacers. Nucl. Acids Res. 22:1994;1785-1796.
    • (1994) Nucl. Acids Res. , vol.22 , pp. 1785-1796
    • Ramsden, D.A.1    Baetz, K.2    Wu, G.E.3
  • 29
    • 0022557584 scopus 로고
    • Hjoining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production
    • Hjoining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature. 322:1986;840-842.
    • (1986) Nature , vol.322 , pp. 840-842
    • Reth, M.1    Gehrmann, P.2    Petrac, E.3    Wiese, P.4
  • 30
    • 0028794835 scopus 로고
    • Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process
    • Reynaud C., Garcia C., Hein W. R., Weill J. Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process. Cell. 80:1995;115-125.
    • (1995) Cell , vol.80 , pp. 115-125
    • Reynaud, C.1    Garcia, C.2    Hein, W.R.3    Weill, J.4
  • 32
    • 0004202436 scopus 로고
    • Chicago: University of Chicago Press. p. 453-460
    • Romer A. S. Vertebrate Paleontology. 1945;University of Chicago Press, Chicago. p. 453-460.
    • (1945) Vertebrate Paleontology
    • Romer, A.S.1
  • 33
    • 0019214271 scopus 로고
    • Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
    • Sakano H., Maki R., Kurosawa Y., Roeder W., Tonegawa S. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature. 286:1980;676-683.
    • (1980) Nature , vol.286 , pp. 676-683
    • Sakano, H.1    Maki, R.2    Kurosawa, Y.3    Roeder, W.4    Tonegawa, S.5
  • 35
    • 0021770553 scopus 로고
    • Immunoglobulin gene 'remnant' DNA - Implications for antibody gene recombination
    • Selsing E. J., Voss J., Storb U. Immunoglobulin gene 'remnant' DNA - implications for antibody gene recombination. Nucl. Acids Res. 12:1984;4229-4246.
    • (1984) Nucl. Acids Res. , vol.12 , pp. 4229-4246
    • Selsing, E.J.1    Voss, J.2    Storb, U.3
  • 36
    • 0026504341 scopus 로고
    • Characterization of a murine immunoglobulin VH gene segment in subgroup III: A new member of the 7183 gene family
    • Sequeira A., Jouvin-Marcher E., Avrameas S. Characterization of a murine immunoglobulin VH gene segment in subgroup III: a new member of the 7183 gene family. Mol. Immunol. 29:1992;425-430.
    • (1992) Mol. Immunol. , vol.29 , pp. 425-430
    • Sequeira, A.1    Jouvin-Marcher, E.2    Avrameas, S.3
  • 37
    • 0028172252 scopus 로고
    • Expressed swine VH genes belong to a small VH gene family homologous ,to human VH III
    • Sun J., Kackskovics I., Brown W. R., Butler J. E. Expressed swine VH genes belong to a small VH gene family homologous ,to human VH III. J. Immunol. 159:1994;5618-5627.
    • (1994) J. Immunol. , vol.159 , pp. 5618-5627
    • Sun, J.1    Kackskovics, I.2    Brown, W.R.3    Butler, J.E.4
  • 38
    • 0028040792 scopus 로고
    • Rapid cDNA cloning by PCR screening
    • Takumi T., Lodish H. F. Rapid cDNA cloning by PCR screening. Biotechniques. 17:1994;443-444.
    • (1994) Biotechniques , vol.17 , pp. 443-444
    • Takumi, T.1    Lodish, H.F.2
  • 39
    • 0026785856 scopus 로고
    • The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops
    • Tomlinson I. M., Walter G., Marks J. D., Llewelyn M. B., Winter G. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J. Mol. Biol. 227:1992;776-798.
    • (1992) J. Mol. Biol. , vol.227 , pp. 776-798
    • Tomlinson, I.M.1    Walter, G.2    Marks, J.D.3    Llewelyn, M.B.4    Winter, G.5
  • 41
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity. Nature. 302:1983;575-581.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 42
    • 0026497568 scopus 로고
    • Patterns of interallelic divergence at the rabbit b locus of the immunoglobulin light chain constant region are in agreement with population genetic evidence for overdominant selection
    • van der Loo W., Verdoodt B. Patterns of interallelic divergence at the rabbit b locus of the immunoglobulin light chain constant region are in agreement with population genetic evidence for overdominant selection. Genetics. 132:1992;1105-1117.
    • (1992) Genetics , vol.132 , pp. 1105-1117
    • Van Der Loo, W.1    Verdoodt, B.2
  • 43
    • 0029872907 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes
    • Wagner S. D., Neuberger M. S. Somatic hypermutation of immunoglobulin genes. Annu. Rev. Immunol. 14:1996;441-457.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 441-457
    • Wagner, S.D.1    Neuberger, M.S.2
  • 44
    • 0026768775 scopus 로고
    • Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection
    • Zelenetz A. D., Chen T. T., Levy R. Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J. Exp. Med. 176:1992;1137-1148.
    • (1992) J. Exp. Med. , vol.176 , pp. 1137-1148
    • Zelenetz, A.D.1    Chen, T.T.2    Levy, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.