Enhancement of hypermutation frequency in the chicken B cell line DT40 for efficient diversification of the antibody repertoire

Biochemical and Biophysical Research Communications

Volumn 396, Issue 2, 2010, Pages 353-358

  Magari, Masaki ^a   Kanehiro, Yuichi ^a   Todo, Kagefumi ^a   Ikeda, Mika ^a   Kanayama, Naoki ^a   Ohmori, Hitoshi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

AID; Chicken B cell line DT40; Gene conversion; Hypermutation; Monoclonal antibody

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; IMMUNOGLOBULIN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY LIBRARY; ANTIBODY PRODUCTION; ANTIBODY SCREENING; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CONTROLLED STUDY; GENE CONVERSION; GENE EXPRESSION; GENETIC ENGINEERING; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; IMMUNOGLOBULIN VARIABLE REGION; IN VITRO STUDY; MUTATION RATE; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SOMATIC HYPERMUTATION; WILD TYPE;

ANIMALS; ANTIBODIES, MONOCLONAL; B-LYMPHOCYTES; CELL LINE; CHICKENS; CYTIDINE DEAMINASE; IMMUNOGLOBULIN VARIABLE REGION; PEPTIDE LIBRARY; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 77952741054     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.04.096     Document Type: Article

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