In vitro improvement of a shark IgNAR antibody by Qβ replicase mutation and ribosome display mimics in vivo affinity maturation

Immunology Letters

Volumn 107, Issue 2, 2006, Pages 163-168

  Kopsidas, George ^a   Roberts, Anthony S ^a   Coia, Gregory ^c   Streltsov, Victor A ^b,c   Nuttall, Stewart D ^b,c  

^a EvoGenix Limited   (Australia)

^b Department of Civil and Environmental Engineering   (Australia)

^c CSIRO   (Australia)

Author keywords

Affinity maturation; IgNAR; Immune evolution; In vitro evolution; Ribosome display; Shark antibody

Indexed keywords

IMMUNOGLOBULIN; Q BETA REPLICASE;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN BINDING; APICAL MEMBRANE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE MAPPING; GENE MUTATION; GENE TARGETING; GENETIC LINKAGE; GENETIC VARIABILITY; MUTAGENESIS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN INTERACTION; SHARK;

ANIMALS; ANTIBODIES; ANTIBODY AFFINITY; ANTIGENS, PROTOZOAN; BIOSENSING TECHNIQUES; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOGLOBULINS; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE LIBRARY; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; Q BETA REPLICASE; RIBOSOMES; RNA, MESSENGER; SHARKS;

EID: 33751164807     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2006.09.004     Document Type: Article

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