Somatic hypermutations and isotype restricted exceptionally long CDR3H contribute to antibody diversification in cattle

Veterinary Immunology and Immunopathology

Volumn 127, Issue 1-2, 2009, Pages 106-113

  Kaushik, Azad K ^a   Kehrli Jr , Marcus E ^b   Kurtz, A ^a   Ng, S ^a   Koti, M ^a   Shojaei, F ^a   Saini, Surinder S ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Antibody; Bovine leukocyte adhesion deficiency; Cattle; CDR3H; Immunoglobulin; Somatic mutations; VDJ

Indexed keywords

ASPARTIC ACID; BETA2 INTEGRIN; CD18 ANTIGEN; GLYCINE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ANTIBODY STRUCTURE; ARTICLE; CATTLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; HEAVY CHAIN; INFECTION; LEUKOCYTE ADHERENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PROTEIN EXPRESSION; SOMATIC HYPERMUTATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY DIVERSITY; BASE SEQUENCE; CATTLE; CATTLE DISEASES; COMPLEMENTARITY DETERMINING REGIONS; DNA PRIMERS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; IMMUNOGLOBULIN M; LEUKOCYTE-ADHESION DEFICIENCY SYNDROME; MOLECULAR SEQUENCE DATA; POINT MUTATION; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

BOS; BOS TAURUS; BOVINAE;

EID: 57749192917     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.09.024     Document Type: Article

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