Atypical antigen recognition mode of a shark Immunoglobulin New Antigen Receptor (IgNAR) variable domain characterized by humanization and structural analysis

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17408-17419

  Kovalenko, Oleg V ^a   Olland, Andrea ^a   Piché Nicholas, Nicole ^a   Godbole, Adarsh ^a   King, Daniel ^a   Svenson, Kristine ^a   Calabro, Valerie ^a   Müller, Mischa R ^b   Barelle, Caroline J ^c   Somers, William ^a   Gill, Davinder S ^a   Mosyak, Lidia ^a   Tchistiakova, Lioudmila ^a  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID RESIDUES; ANTIGEN BINDING; ANTIGEN RECEPTORS; ANTIGEN RECOGNITION; BINDING PROTEINS; COMPLEMENTARITY-DETERMINING REGIONS; HUMAN SERUM ALBUMINS; VARIABLE DOMAIN;

AMINO ACIDS; ANTIGEN-ANTIBODY REACTIONS; DYES; IMMUNIZATION; MOLECULES; PROTEINS; STRUCTURAL ANALYSIS;

ANTIGENS;

ALBUMIN; HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN NEW ANTIGEN RECEPTOR; IMMUNOGLOBULIN RECEPTOR; UNCLASSIFIED DRUG;

ALBUMIN BLOOD LEVEL; ANTIGEN BINDING; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; IMMUNIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEQUENCE ALIGNMENT; SQUALUS; STRUCTURE ANALYSIS;

ALBUMIN; ANTIBODIES; ANTIBODY ENGINEERING; ANTIGEN; CRYSTAL STRUCTURE; HUMANIZATION; IGNAR; V-NAR;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLOGRAPHY, X-RAY; FISH PROTEINS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; RATS; SEQUENCE HOMOLOGY, AMINO ACID; SERUM ALBUMIN; SHARKS; SINGLE-CHAIN ANTIBODIES;

CHONDRICHTHYES; RATTUS; SQUALIDAE;

EID: 84879040923     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.435289     Document Type: Article

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