Common mechanisms of onset of cancer and neurodegenerative diseases

Biological and Pharmaceutical Bulletin

Volumn 38, Issue 6, 2015, Pages 795-808

  Ariga, Hiroyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

C Myc; Cancer; DJ 1; Myc Modulator 1 (MM 1); Neurodegenerative disease; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AROMATIC LEVO AMINO ACID DECARBOXYLASE; DJ 1 PROTEIN; EXTRACELLULAR SUPEROXIDE DISMUTASE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MYC PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; TYROSINE 3 MONOOXYGENASE; DNA BINDING PROTEIN; MYCBP PROTEIN, HUMAN; ONCOPROTEIN; PARK7 PROTEIN, HUMAN; PFDN5 PROTEIN, HUMAN; REPRESSOR PROTEIN; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; APP GENE; ARTICLE; BILE DUCT CARCINOMA; BLADDER CARCINOMA; BREAST CANCER; BURKITT LYMPHOMA; CELL GROWTH; CEREBELLUM ATROPHY; CULTURE MEDIUM; CYTOPLASM; DEGENERATIVE DISEASE; DISEASE SEVERITY; DJ1 GENE; DNA REPLICATION; DOPAMINE RELEASE; ENDOMETRIUM CANCER; ESOPHAGUS CANCER; GENE; GENE AMPLIFICATION; GENE EXPRESSION; GENE FUNCTION; GENE PRODUCT; GENE TARGETING; GENE TRANSLOCATION; GLIOBLASTOMA; HUMAN; LARYNX CANCER; LARYNX CARCINOMA; LIVER CANCER; MELANOMA; METABOLIC SYNDROME X; MISSENSE MUTATION; MITOCHONDRION; MM1 GENE; MULTIPLE MYELOMA; NEOPLASM; NERVE DEGENERATION; NONHUMAN; ONCOGENE C MYC; OVARY CANCER; OXIDATIVE STRESS; PANCREAS CANCER; PAP1 GENE; PARKIN GENE; PARKINSON DISEASE; PATHOGENESIS; PINK1 GENE; PROSTATE CANCER; PROTEIN DNA BINDING; RETINITIS PIGMENTOSA; SIGNAL TRANSDUCTION; STOMACH CANCER; THYROID CANCER; UPREGULATION; UTERINE CERVIX CANCER; CEREBELLUM DISEASE; GENETICS; METABOLISM; ONCOGENE MYC;

CEREBELLAR DISEASES; DNA-BINDING PROTEINS; GENES, MYC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASMS; NEURODEGENERATIVE DISEASES; ONCOGENE PROTEINS; PARKINSON DISEASE; REPRESSOR PROTEINS; RETINITIS PIGMENTOSA; TRANSCRIPTION FACTORS;

EID: 84936887227     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b15-00125     Document Type: Article

References (198)

1. Blackwood EM, Eisenman RN. Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science, 251, 1211-1217 (1991).
2. Diolaiti D, McFerrin L, Carroll PA, Eisenman RN. Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis. Biochim. Biophys. Acta, 1849, 484-500 (2015).
3. Sabò A, Amati B. Genome recognition by MYC. Cold Spring Harb. Perspect. Med., 4, a014191 (2014).
4. Rahl PB, Young RA. MYC and transcription elongation. Cold Spring Harb. Perspect. Med., 4, a020990 (2014).
5. Kusnadi EP, Hannan KM, Hicks RJ, Hannan RD, Pearson RB, Kang J. Regulation of rDNA transcription in response to growth factors, nutrients and energy. Gene, 556, 27-34 (2015).
6. Iguchi-Ariga SMM, Itani T, Kiji Y, Ariga H. Possible function of c-myc products: promotion of cellular DNA replication. EMBO J., 6, 2365-2371 (1987).
7. Iguchi-Ariga SMM, Okazaki T, Itani T, Ogata M, Sato Y, Ariga H. An initiation site of DNA replication with transcriptional enhancer activity present upstream of c-myc gene. EMBO J., 7, 3135-3142 (1988).
8. Ariga H, Imamura Y, Iguchi-Ariga SMM. DNA replication origin and transcriptional enhancer in c-myc gene share the c-myc protein binding sequences. EMBO J., 8, 4273-4279 (1989).
9. Negishi Y, Iguchi-Ariga SMM, Ariga H. Protein complexes bearing myc-like antigenicity recognize two distinct DNA sequences. Oncogene, 7, 543-548 (1992).
10. Negishi Y, Nishita Y, Saëgusa Y, Kakizaki I, Galli I, Kihara F, Tamai K, Miyajima N, Iguchi-Ariga SMM, Ariga H. Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene. Oncogene, 9, 1133-1143 (1994).
11. Takayama M, Taira T, Tamai K, Iguchi-Ariga SMM, Ariga H. ORC1 interacts with c-Myc to inhibit E-box-dependent transcription by abrogating c-Myc-SNF5/INI1 interaction. Genes Cells, 5, 481-490 (2000).
12. Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SMM, Ariga H. Cell cycle-dependent switch of up- and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y. J. Biol. Chem., 274, 24270-24279 (1999).
13. Iguchi-Ariga SMM, Ariga H. Concerted mechanism of DNA replication and transcription. Cell Struct. Funct., 14, 649-651 (1989).
14. DePamphilis ML. Transcriptional elements as components of eukaryotic origins of DNA replication. Cell, 52, 635-638 (1988).
15. Gutierrez C, Guo ZS, Burhans W, DePamphilis ML, Farrell-Towt J, Ju G. Is c-myc protein directly involved in DNA replication? Science, 240, 1202-1203 (1988).
16. Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favcra R. Non-transcriptional control of DNA replication by c-Myc. Nature, 448, 445-451 (2007).
17. Said J, Lones M, Yea S. Burkitt lymphoma and MYC: what else is new? Adv. Anal. Pathol., 21, 160-165 (2014).
18. Hann SR, Eisenman RN. Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells. Mol. Cell. Biol., 4, 2486-2497 (1984).
19. Farrell AS, Sears RC. MYC degradation. Cold Spring Harb. Perspect. Med., 4, a014365 (2014).
20. Hirst SK, Grandori C. Differential activity of conditional MYC and its variant MYC-S in human mortal fibroblasts. Oncogene, 19, 5189-5197 (2000).
21. Tu WB, Helander S, Pilstål R, Hickman KA, Lourenco C, Jurisica I, Raught B, Wallner B, Sunnerhagen M, Penn LZ. Myc and its intcractors take shape. Biochim. Biophys. Acta, 1849, 469-483 (2015).
22. Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SMM, Ariga H. MM-1, a novel C-MYC associating protein which represses transcriptional activity of C-MYC. J. Biol. Chem., 273, 29794-29800 (1998).
23. Taira T, Maëda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi-Ariga SMM, Ariga H. AMY-1, a novel C-MYC binding protein that stimulates transcriptional activity of C-MYC. Genes Cells, 3, 549-565 (1998).
24. Cip1-binding protein that cooperatively enhances p21- dependent inhibitory activity toward CDK2 kinase. J. Biol. Chem., 275, 31145-31154 (2000).
25. Kuroda TS, Maita H, Tabata T, Taira T, Kitaura H, Ariga H, Iguchi-Ariga SMM. A novel nucleolar protein, PAPA-1, induces growth arrest as a result of cell cycle arrest at the G1 phase. Gene, 340, 83-98 (2004).
26. Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SMM, Ariga H. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem. Biophys. Res. Commun., 231, 509-513 (1997).
27. Maita H, Harada Y, Nagakubo D, Kitaura H, Ikeda M, Tamai T, Takahashi K, Ariga H, Iguchi-Ariga SMM. PAP-1, a novel target protein of phosphorylation by Pim-1 kinase. Eur. J. Biochem., 267, 5168-5178 (2000).
28. Hagio Y, Kimura Y, Taira T, Fujioka Y, Iguchi-Ariga SMM, Ariga H. Distinct localizations and repression activities of MM-1 isoforms toward c-Myc. J. Cell. Biochem., 97, 145-155 (2006).
29. Satou A, Taira T, Iguchi-Ariga SMM, Ariga H. A novel transrepression pathway of c-Myc: Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein. J. Biol. Chem., 276, 46562-46567 (2001).
30. Satou A, Hagio Y, Taira T, Iguchi-Ariga SMM, Ariga H. Repression of the c-fms gene in fibroblast cells by c-Myc-MM-1-TIF1β complex. FEBS Lett., 572, 211-215 (2004).
31. Fujioka Y, Taira T, Maeda Y, Tanaka S, Nishihara H, Iguchi-Ariga SMM, Nagashima K, Ariga H. MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer. J. Biol. Chem., 276, 45137-45144 (2001).
32. Yoshida T, Kitaura H, Hagio Y, Sato T, Iguchi-Ariga SMM, Ariga H. Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 gene. Exp. Cell Res., 314, 1217-1228 (2008).
33. Kimura Y, Nagao A, Fujioka Y, Satou A, Taira T, Iguchi-Ariga SMM, Ariga H. MM-1 facilitates degradation of c-Myc by recruiting proteasome and a novel ubiquitin E3 ligase. Int. J. Oncol., 31, 829-836 (2007).
34. Narita R, Kitaura H, Torii A, Tashiro E, Miyazawa M, Ariga H, Iguchi-Ariga SMM. Rabring7 degrades c-Myc through complex formation with MM-1. PLoS ONE, 7, e41891 (2012).
35. Geissler S, Siegers K, Schiebel E. A novel protein complex promoting formation of functional alpha- and gamma-tubulin. EMBO J., 17, 952-966 (1998).
36. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ. Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. Cell, 93, 863-873 (1998).
37. Miyazawa M, Tashiro E, Kitaura H, Maita H, Suto H, Iguchi-Ariga SMM, Ariga H. Prefoldin subunits are protected from ubiquitin-proteasome system-mediated degradation by forming complex with other constituent subunits. J. Biol. Chem., 286, 19191-19203 (2011).
38. Tashiro E, Zako T, Muto H, Itoo Y, Sörgjerd K, Terada N, Abe A, Miyazawa M, Kitamura A, Kitaura H, Kubota H, Macda M, Momoi T, Iguchi-Ariga SM, Kinjo M, Ariga H. Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation. J. Biol. Chem., 288, 19958-19972 (2013).
39. Takano M, Tashiro E, Kitamura A, Maita H, Iguchi-Ariga SMM, Kinjo M, Ariga H. Pretbldin prevents aggregation of α-synuclein. Brain Res., 1542, 186-194 (2014).
40. Sakono M, Zako T, Ueda H, Yohda M, Maeda M. Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin. FEBS J., 275, 5982-5993 (2008).
41. Sörgjerd KM, Zako T, Sakono M, Stirling PC, Leroux MR, Saito T, Nilsson P, Sekimoto M, Saido TC, Maeda M. Human prefoldin inhibits Amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates. Biochemistry, 52, 3532-3542 (2013).
42. Lee Y, Smith RS, Jordan W, King BL, Won J, Valpuesta JM, Naggert JK, Nishina PM. Prefoldin 5 is required for normal sensory and neuronal development in a murine model. J. Biol. Chem., 286, 726-736 (2011).
43. Abe A, Takahashi-Niki K, Takekoshi Y, Shimizu T, Kitaura H, Maita H, Iguchi-Ariga SMM, Ariga H. Prefoldin plays a role as a clearance factor in preventing proteasome inhibitor-induced protein aggregation. J. Biol. Chem., 288, 27764-27776 (2013).
44. Keen TJ, Hims MM, McKie AB, Moore AT, Doran RM, Mackey DA, Mansfield DC, Mueller RF, Bhattacharya SS, Bird AC, Markham AF, Inglehearn CF. Mutations in a protein target of the Pim-1 kinase associated with the RP9 form of autosomal dominant retinitis pigmentosa. Eur. J. Hum. Genet., 10, 245-249 (2002).
45. Maita H, Kitaura H, Keen TJ, Inglehearn CF, Ariga H, Iguchi-Ariga SMM. PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor. Exp. Cell Res., 300, 283-296 (2004).
46. Maita H, Kitaura H, Ariga H, Iguchi-Ariga SMM. Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex. Exp. Cell Res., 302, 61-68 (2005).
47. Kim YC, Kitaura H, Iguchi-Ariga SMM, Ariga H. DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc. FEBS Lett., 584. 3891-3895 (2010).
48. Hayashi T, Ishimori C, Takahashi-Niki K, Taira T, Kim Y-C, Maita H, Maita C, Ariga H, Iguchi-Ariga SMM. DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem. Biophys. Res. Commun., 390, 667-672 (2009).
49. Tsuboi Y, Munemoto H, Ishikawa S, Matsumoto K, Iguchi-Ariga SMM, Ariga H. DJ-1, a causative gene product of a familial form of Parkinson's disease, is secreted through microdomains. FEBS Lett., 582, 2643-2649 (2008).
50. Yanagida T, Tsushima J, Kitamura Y, Yanagisawa D, Takata K, Shibaike T, Yamamoto A, Taniguchi T, Yasui H, Taira T, Morikawa S, Inubushi T, Tooyama I, Ariga H. Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury. Oxid. Med. Cell. Longev., 2, 36-42 (2009).
51. Tsuchiya B, Iwaya K, Kohno N, Kawate T, Akahoshi T, Matsubara O, Mukai K. Clinical significance of DJ-1 as a secretory molecule: retrospective study of DJ-1 expression at mRNA and protein levels in ductal carcinoma of the breast. Histopathology, 61, 69-77 (2012).
52. Le Naour F, Misek DE, Krause MC, Deneux L, Giordano TJ, Scholl S, Hanash SM. Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin. Cancer Res., 7, 3328-3335 (2001).
53. Maita C, Tsuji S, Yabe I, Hamada S, Ogata A, Maita H, Iguchi-Ariga SMM, Sasaki H, Ariga H. Secretion of DJ-1 into the serum of patients with Parkinson's disease. Neurosci. Lett., 431, 86-89 (2008).
54. Waragai M, Wei J, Fujita M, Nakai M, Ho GJ, Masliah E, Akatsu H, Yamada T, Hashimoto M. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. Biochem. Biophys. Res. Commun., 345, 967-972 (2006).
55. Waragai M, Nakai M, Wei J, Fujita M, Mizuno H, Ho G, Masliah E, Akatsu H, Yokochi F, Hashimoto M. Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease. Neurosci. Leit., 425, 18-22 (2007).
56. Akazawa YO, Saito Y, Hamakubo T, Masuo Y, Yoshida Y, Nishio K, Shichiri M, Miyasaka T, Iwanari H, Mochizuki Y, Kodama T, Noguchi N, Niki E. Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson's disease model animals. Neurosci. Lett., 483, 201-205 (2010).
57. Bande MF, Santiago M, Blanco MJ, Mera P, Capeans C, Rodríguez-Alvarez MX, Pardo M, Piñeiro A. Serum DJ-1/PARK 7 is a potential biomarker of choroidal nevi transformation. Invest. Ophthalmol. Vis. Sci., 53, 62-67 (2012).
58. Koide-Yoshida S, Niki T, Ueda M, Himeno S, Taira T, Iguchi-Ariga SMM, Ando Y, Ariga H. DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. Int. J. Mol. Med., 19, 885-893 (2007).
59. Allard L, Burkhard PR, Lescuyer P, Burgess JA, Walter N, Hochstrasser DF, Sanchez JC. PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke. Clin. Chem., 51, 2043-2051 (2005).
60. Hirotani M, Maita C, Niino M, Iguchi-Ariga SMM, Hamada S, Ariga H, Sasaki H. Correlation between DJ-1 levels in the cerebrospinal iluid and the progression of disabilities in multiple sclerosis patients. Mult. Scler., 14, 1056-1060 (2008).
61. Devic I, Hwang H, Edgar JS, Izutsu K, Presland R, Pan C, Goodlett DR, Wang Y, Armaly J, Tumas V, Zabetian CP, Leverenz JB, Shi M, Zhang J. Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease. Brain, 134, e178-el78 (2011).
62. Kang WY, Yang Q, Jiang XF, Chen W, Zhang LY, Wang XY, Zhang LN, Quinn TJ, Liu J, Chen SD. Salivary DJ-1 could be an indicator of Parkinson's disease progression. Front. Aging Neurosci, 6, 102 (2014).
63. Oda M, Makita M, Iwaya K, Akiyama F, Kohno N, Tsuchiya B, Iwase T, Matsubara O. High levels of DJ-1 protein in nipple fluid of patients with breast cancer. Cancer Sci., 103, 1172-1176 (2012).
64. Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR. The Parkinson's disease protein DJ-1 is neuroprotective due to cystcine-sulfinic acid-driven mitochondrial localization. Prac. Natl. Acad. Sci. USA., 101, 9103-9108 (2004).
65. Hod Y. Differential control of apoptosis by DJ-1 in prostate benign and cancer cells. J. Cell. Biochem., 92, 1221-1233 (2004).
66. Osman WM, Abd El Atti RM, Abou Gabal HH. DJ-1 and androgen receptor immunohistochemical expression in prostatic carcinoma: a possible role in carcinogenesis. J. Egypt. Natl. Cano. Inst., 25, 223-230 (2013).
67. MacKeigan JP, Clements CM, Lich JD, Pope RM, Hod Y, Ting JP. Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha. Cancer Res., 63, 6928-6934 (2003).
68. Kim RH, Peters M, Jang Y, Shi W, Pintilie M, Fletcher GC, DeLuca C, Liepa J, Zhou L, Snow B, Binari RC, Manoukian AS, Bray MR, Liu FF, Tsao MS, Mak TW. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell, 7, 263-273 (2005).
69. Shu K, Xiao Z, Long S, Yan J, Yu X, Zhu Q, Mei T. Expression of DJ-1 in endometrial cancer: Close correlation with clinicopathological features and apoptosis. Int. J. Gynecol. Cancer, 23, 1029-1035 (2013).
70. Morelli M, Scumaci D, Di Cello A, Venturella R, Donato G, Faniello MC, Quaresima B, Cuda G, Zullo F, Costanzo F. DJ-1 in endometrial cancer: a possible biomarker to improve differential diagnosis between subtypes. Int. J. Gynecol. Cancer, 24, 649-658 (2014).
71. Srisomsap C, Subhasitanont P, Otto A, Mueller EC, Punyarit P, Wittmann-Liebold B, Svasti J. Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis. Proteomics, 2, 706-712 (2002).
72. Giusti L, Iacconi P, Ciregia F, Giannaccini G, Donatini GL, Basolo F, Miccoli P, Pinchera A, Lucacchini A. Fine-needle aspiration of thyroid nodules; proteomic analysis to identify cancer biomarkers. J. Proteorne Res., 7, 4079-4088 (2008).
73. Melle C, Ernst G, Escher N, Hartmann D, Schimmel B, Bleul A, Thieme H, Kaufmann R, Felix K, Friess HM, Settmacher U, Hommann M, Richter KK, Daffner W, Täubig H, Manger T, Claussen U, von Eggeling F. Protein profiling of microdissected pancreas carcinoma and identification of HSP27 as a potential serum marker. Clin. Chem., 53, 629-635 (2007).
74. Tian M, Cui YZ, Song GH, Zong MJ, Zhou XY, Chen Y, Han JX. Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer, 8, 241 (2008).
75. He XY, Liu BY, Yao WY, Zhao XJ, Zheng Z, Li JF, Yu BQ, Yuan YZ. Serum DJ-1 as a diagnostic marker and prognostic factor for pancreatic cancer. J. Dig. Dis., 12, 131-137 (2011).
76. Tsiaousidou A, Lambropoulou M, Chatzitheoklitos E, Tripsianis G, Tsompanidou C, Simopoulos C, Tsaroucha AK. B7H4, HSP27 and DJ-1 molecular markers as prognostic factors in pancreatic cancer. Poncreolology, 13, 564-569 (2013).
77. Yuen HF, Chan YP, Law S, Srivastava G, El-Tanani M, Mak TW, Chan KW. DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev., 17, 3593-3602 (2008).
78. Barua A, Edassery SL, Bitterman P, Abramowicz JS, Dirks AL, Bahr JM, Hales DB, Bradaric MJ, Luborsky JL. Prevalence of anti-tumor antibodies in laying hen model of human ovarian cancer. Int. J. Gynecol. Cancer, 19, 500-507 (2009).
79. Chow SN, Chen RJ, Chen CH, Chang TC, Chen LC, Lee WJ, Shen J, Chow LP. Analysis of protein profiles in human epithelial ovarian cancer tissues by proteomic technology. Eur. J. Gynoecol. Oncol., 31, 55-62 (2010).
80. Arnouk H, Merkley MA, Podolsky RH, Stöppler H, Santos C, Alvarez M, Mariategui J, Ferris D, Lee JR, Dynan WS. Characterization of molecular markers indicative of cervical cancer progression. Proteomics Clin., 3, 516-527 (2009).
81. Liu S, Yang Z, Wei H, Shen W, Liu J, Yin Q, Li X, Yi J. Increased DJ-1 and its prognostic significance in hepatocellular carcinoma. Hepatogastroenterology, 57, 1247-1256 (2010).
82. Shimwell NJ, Ward DG, Mohri Y, Mohri T, Pallan L, Teng M, Miki YC, Kusunoki M, Tucker O, Wei W, Morse J, Johnson PJ. Macrophage migration inhibitory factor and DJ-1 in gastric cancer: differences between high-incidence and low-incidence areas. Br. J. Cancer, 107, 1595-1601 (2012).
83. Li Y, Cui J, Zhang CH, Yang DJ, Chen JH, Zan WH, Li B, Li Z, He YL. High-expression of DJ-1 and loss of PTEN associated with tumor metastasis and correlated with poor prognosis of gastric carcinoma. Int. J. Med. Sci., 10, 1689-1697 (2013).
84. Zhu XL, Wang ZF, Lei WB, Zhuang HW, Hou WJ, Wen YH, Wen WP. Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma. J. Exp. Clin. Cancer Res., 31, 94 (2012).
85. Kawase H, Fujii K, Miyamoto M, Kubota KC, Hirano S, Kondo S, Inagaki F. Differential LC-MS-based proteomics of surgical human cholangiocarcinoma tissues. J. Proteome Res., 8, 4092-4103 (2009).
86. Hinkle DA, Mullett SJ, Gabris BE, Hamilton RL. DJ-1 expression in glioblastomas shows positive correlation with p53 expression and negative correlation with epidermal growth factor receptor amplification. Neuropathology, 31, 29-37 (2011).
87. Wang C, Fang M, Zhang M, Li W, Guan H, Sun Y, Xie S, Zhong X. The positive correlation between DJ-1 and β-catenin expression shows prognostic value for patients with glioma. Neuropathology, 33, 628-636 (2013).
88. Shen Z, Ren Y, Ye D, Guo J, Kang C, Ding H. Significance and relationship between DJ-1 gene and surviving gene expression in laryngeal carcinoma. Eur. J. Histochem., 55, e9 (2011).
89. Lee H, Choi SK, Ro JY. Overexpression of DJ-1 and HSP90α, and loss of PTEN associated with invasive urothelial carcinoma of urinary bladder: Possible prognostic markers. Oncol. Lett., 3, 507-512 (2012).
90. Pardo M, Garcia A, Thomas B, Pineiro A, Akoulitchev A, Dwek RA, Zitzmann N. The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker. Int. J. Cancer, 119, 1014-1022 (2006).
91. Zhou X, Xu N, Li R, Xiao Y, Gao G, Lu Q, Ding L, Li L, Li Y, Du Q, Liu X. A comparative proteomic study of homoharringtonine-induced apoptosis in leukemia K562 cells. Leuk. Lymphoma, 14, 1-8 (2015).
92. Liu H, Wang M, Li M, Wang D, Rao Q, Wang Y, Xu Z, Wang J. Expression and role of DJ-1 in leukemia. Biochem. Biophys. Res. Commun., 375, 477-483 (2008).
93. Bindukumar B, Schwartz S, Aalinkeel R, Mahajan S, Lieberman A, Chadha K. Proteomic profiling of the effect of prostate-specific antigen on prostate cancer cells. Prostate, 68, 1531-1545 (2008).
94. Zhu XL, Wang ZF, Lei WB, Zhuang HW, Jiang HY, Wen WP. DJ-1: a novel independent prognostic marker for survival in glottic squamous cell carcinoma. Cancer Sci., 101, 1320-1325 (2010).
95. Bai J, Guo C, Sun W, Li M, Meng X, Yu Y, Jin Y, Tong D, Geng J, Huang Q, Qi J, Fu S. DJ-1 may contribute to metastasis of non-small cell lung cancer. Mol. Biol. Rep., 39, 2697-2703 (2012).
96. He X, Zheng Z, Li J, Ben Q, Liu J, Zhang J, Ji J, Yu B, Chen X, Su L, Zhou L, Liu B, Yuan Y. DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA. Carcinogenesis, 33, 555-562 (2012).
97. Kawate T, Iwaya K, Kikuchi R, Kaise H, Oda M, Sato E, Hiroi S, Matsubara O, Kohno N. DJ-1 protein expression as a predictor of pathological complete remission after neoadjuvant chemotherapy in breast cancer patients. Breast Cancer Res. Treat., 139, 51-59 (2013).
98. Abd El Atti RM, Abou Gabal HH, Osman WM, Saad AS. Insights into the prognostic value of DJ-1 and MIB-1 in astrocytic tumors. Diagn. Pathol., 8, 126 (2013).
99. Han JY, Kim JS, Son JH. Mitochondrial homeostasis molecules: regulation by a trio of recessive Parkinson's disease genes. Exp. Neurobiol, 23, 345-351 (2014).
100. Camilleri A, Vassallo N. The centrality of mitochondria in the pathogenesis and treatment of Parkinson's disease. CNS Neurosci. Ther., 20, 591-602 (2014).
101. Segura-Aguilar J, Paris I, Muñoz P, Ferrari E, Zecca L, Zucca FA. Protective and toxic roles of dopamine in Parkinson's disease. J. Neurochern., 129, 898-915 (2014).
102. Dias V, Junn E, Mouradian MM. The role of oxidative stress in Parkinson's disease. J. Parkinson's Dis., 3, 461-491 (2013).
103. Abdel-Salam OM. The paths to neurodegeneration in genetic Parkinson's disease. CNS Neurol. Disord. Drug Targets, 13, 1485-1512 (2014).
104. Bonifati V. Genetics of Parkinson's disease-state of the art, 2013, Parkinsonism Relat. Disord., 20 (Suppl. 1), S23-S28 (2014).
105. Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science, 299, 256-259 (2003).
106. Bonifati V, Oostra BA, Heutink P. Linking DJ-1 to neurodegeneration offers novel insights for understanding the pathogenesis of Parkinson's disease. J. Mol. Med. (Berl.), 82, 163-174 (2004).
107. Nuytemans K, Theuns J, Cruts M, Van Broeckhoven C. Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum. Mutat., 31, 763-780 (2010).
108. Honbou K, Suzuki NN, Horiuchi M, Niki T, Taira T, Ariga H, Inagaki F. The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease. J. Biol. Chem., 278, 31380-31384 (2003).
109. Tao X, Tong L. Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease. J. Biol. Chem., 278, 31372-31379 (2003).
110. Lee SJ, Kim SJ, Kim IK, Ko J, Jeong CS, Kim GH, Park C, Kang SO, Suh PG, Lee HS, Cha SS. Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain. J. Biol. Chem., 278, 44552-44559 (2003).
111. Wilson MA, Collins JL, Hod Y, Ringo D, Petsko GA. The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease. Proc. Natl. Acad. Sci. USA., 100, 9256-9261 (2003).
112. Mitsumoto A, Nakagawa Y, Takeuchi A, Okawa K, Iwamatsu A, Takanezawa Y. Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat. Free Radic. Res., 35, 301-310 (2001).
113. Taira T, Saito Y, Niki T, Iguchi-Ariga SMM, Takahashi K, Ariga H. DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep., 5, 213-218 (2004).
114. Kinumi T, Kimata J, Taira T, Ariga H, Niki E. Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun., 317, 722-728 (2004).
115. Bandopadhyay R, Kingsbury AE, Cookson MR, Reid AR, Evans IM, Hope AD, Pittman AM, Lashley T, Canet-Aviles R, Miller DW, McLendon C, Strand C, Leonard AJ, Ariga H, Wood NW, de Silva R, Hardy JA, Lees AJ, Revesz T. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain, 127, 420-430 (2004).
116. Choi J, Sullards MC, Olzmann JA, Rees HD, Weintraub ST, Bostwick DE, Gearing M, Levey AI, Chin LS, Li L. Oxidative damage of DJ-1 is linked to sporadic Parkinson's and Alzheimer's diseases. J. Biol. Chem., 281, 10816-10824 (2006).
117. Sajjad MU, Green EW, Miller-Fleming L, Hands S, Herrera F, Campesan S, Khoshnan A, Outeiro TF, Giorgini F, Wyttenbach A. DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease. Hum. Mal. Genet., 23, 755-766 (2014).
118. Kahle PJ, Waak J, Gasser T. DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic. Biol. Med, 47, 1354-1361 (2009).
119. Wilson MA. The role of cysteine oxidation in DJ-1 function and dysfunction. Anzioxid. Redox Signal., 15, 111-122 (2011).
120. Ariga H, Takahashi-Niki K, Kato I, Maita H, Niki T, Iguchi-Ariga SMM. Neuroprotective function of DJ-1 in Parkinson's disease. Oxid. Med. Cell. Longev., 2013, 683920 (2013), review.
121. Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SMM, Ariga H. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem., 276, 37556-37563 (2001).
122. Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SMM, Ariga H. DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol. Cancer Res., 1, 247-261 (2003).
123. Shinbo Y, Taira T, Niki T, Iguchi-Ariga SMM, Ariga H. DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. Int. J. Oncol., 26, 641-648 (2005).
124. Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pill C, Gygi SP, Geula C, Yankner BA. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum. Mol. Genei., 14, 1231-1241 (2005).
125. Zhong N, Kim CY, Rizzu P, Geula C, Porter DR, Pothos EN, Squitieri F, Heutink P, Xu J. DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J. Biol. Chem., 281, 20940-2094S (2006).
126. Clements CM, McNally RS, Conti BJ, Mak TW, Ting JP. DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrt2. Proc. Natl. Acad. Sci. U.S.A., 103, 15091-15096 (2006).
127. Tillman JE, Yuan J, Gu G, Fazli L, Ghosh R, Flynt AS, Gleave M, Rennie PS, Kasper S. DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. Cancer Res., 67, 4630-4637 (2007).
128. Fan J, Ren H, Fei E, Jia N, Ying Z, Jiang P, Wu M, Wang G. Sumoylation is critical for DJ-1 to repress p53 transcriptional activity. FEBS Lett., 582, 1151-1156 (2008).
129. Fan J, Ren H, Jia N, Fei E, Zhou T, Jiang P, Wu M, Wang G. DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J. Biol. Chem., 283, 4022-4030 (2008).
130. Ishikawa S, Taira T, Takahashi-Niki K, Niki T, Ariga H, IguchiAriga SMM. Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene. J. Biol. Chem., 285, 39718-39731 (2010).
131. Yamaguchi S, Yamane T, Takahashi-Niki K, Kato I, Niki T, Goldberg MS, Shen J, Ishimoto K, Doi T, Iguchi-Ariga SMM, Ariga H. Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis. PLoS ONE, 7, e38144 (2012).
132. Kato I, Maita H, Takahashi-Niki K, Saito Y, Noguchi N, Iguchi-Ariga SMM, Ariga H. Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner. Mol. Cell. Biol., 33, 340-359 (2013).
133. Yamane T, Suzui S, Kitaura H, Takahashi-Niki K, Iguchi-Ariga SMM, Ariga H. Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice. PLOS ONE, 8, e78374 (2013).
134. Yamane T, Sugimoto N, Maita H, Watanabe K, Takahashi-Niki K, Maita C, Kato-Ose I, Ishikawa S, Gao J, Kitaura H, Niki T, Iguchi-Ariga SMM, Ariga H. Identification of DJ-1-associated regions on human genes from SH-SY5Y cells using chromatin immunoprecipitation sequence technique. Mol. Biol., 3, 15 (2013).
135. Kim JH, Choi DJ, Jeong HK, Kim J, Kim DW, Choi SY, Park SM, Suh YH, Jou I, Joe EH. DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1. Neurobiol. Dis., 60, 1-10 (2013).
136. Yokota T, Sugawara K, Ito K, Takahashi R, Ariga H, Mizusawa H. Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem. Biophys. Res. Commun., 312, 1342-1348 (2003).
137. Martinat C, Shendelman S, Jonason A, Leete T, Beal MF, Yang L, Floss T, Abeliovich A. Sensitivity to oxidative stress in DJ1-deficient dopamine neurons: an ES-derived cell model of primary Parkinsonism. PLoS Biol., 2, e327 (2004).
138. Li HM, Niki T, Taira T, Iguchi-Ariga SMM, Ariga H. Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. Free Radic. Res., 39, 1091-1099 (2005).
139. Zhang L, Shimoji M, Thomas B, Moore DJ, Yu SW, Marupudi NI, Torp R, Torgner IA, Ottersen OP, Dawson TM, Dawson VL. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum. Mol. Genet., 14, 2063-2073 (2005).
140. Krebiehl G, Ruckerbauer S, Burbulla LF, Kieper N, Maurer B, Waak J, Wolburg H, Gizatullina Z, Gellerich FN, Woitalla D, Riess O, Kahle PJ, Proikas-Cezanne T, Krüger R. Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS ONE, 5, e9367 (2010).
141. Thomas KJ, McCoy MK, Blackinton J, Beilina A, van der Brug M, Sandebring A, Miller D, Marie D, Cedazo-Minguez A, Cookson MR. DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Hum. Mol. Genet., 20, 40-50 (2011).
142. Wang X, Petrie TG, Liu Y, Liu J, Fujioka H, Zhu X. Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. J. Neurochem., 121, 830-839 (2012).
143. Heo JY, Park JH, Kim SJ, Seo KS, Han JS, Lee SH, Kim JM, Park JI, Park SK, Lim K, Hwang BD, Shong M, Kweon GR. DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assembly. PLOS ONE, 7, e32629 (2012).
144. Giaime E, Yamaguchi H, Gautier CA, Kitada T, Shen J. Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore opening. PLoS ONE, 7, e40501 (2012).
145. Maita C, Maita H, Iguchi-Ariga SMM, Ariga H. Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants. PLoS ONE, 8, e54087 (2013).
146. Yasuda T, Kaji Y, Agatsuma T, Niki T, Arisawa M, Shuto S, Ariga H, Iguchi-Ariga SMM. DJ-1 cooperates with PYCR1 in cell protection against oxidative stress. Biochem. Biophys. Res. Commun., 436, 289-294 (2013).
147. Kim RH, Peters M, Jang Y, Shi W, Pintilie M, Fletcher GC, DeLuca C, Liepa J, Zhou L, Snow B, Binari RC, Manoukian AS, Bray MR, Liu FF, Tsao MS, Mak TW. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell, 7, 263-273 (2005).
148. Kim YC, Kitaura H, Taira T, Iguchi-Ariga SMM, Ariga H. Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN. Int. J. Oncol., 35, 1331-1341 (2009).
149. Gao H, Yang W, Qi Z, Lu L, Duan C, Zhao C, Yang H. DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy. J. Mol. Biol., 423, 232-248 (2012).
150. Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, Mouradian MM. Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc. Natl. Acad. Sci. U.S.A., 102, 9691-9696 (2005).
151. Waak J, Weber SS, Görner K, Schall C, Ichijo H, Stehle T, Kahle PJ. Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. J. Biol. Chem., 284, 14245-14257 (2009).
152. 2-induced cell death. Free Radic. Res., 40, 155-165 (2006).
153. Olzmann JA, Brown K, Wilkinson KD, Rees HD, Huai Q, Ke H, Levey AI, Li L, Chin LS. Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J. Biol. Chem., 279, 8506-8515 (2004).
154. Chen J, Li L, Chin LS. Parkinson's disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. Hum. Mol. Genet., 19, 2395-2408 (2010).
155. Mitsugi H, Niki T, Takahashi-Niki K, Tanimura K, Yoshizawa-Kumagaye K, Tsunemi M, Iguchi-Ariga SMM, Ariga H. Identification of the recognition sequence and target proteins for DJ-1 protease. FEBS Lett., 587, 2493-2499 (2013).
156. Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A. DJ-1 is a redox-dependent molecular chaperone that inhibits alphasynuclein aggregate formation. PLoS Biol., 2, e362 (2004).
157. Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL. The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J. Mol. Biol., 356, 1036-1048 (2006).
158. Richarme G, Mihoub M, Dairou J, Bui LC, Leger T, Lamouri A. Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues. J. Biol. Chem., 290, 1885-1897 (2015).
159. Aleyasin H, Rousseaux MW, Phillips M, Kim RH, Bland RJ, Callaghan S, Slack RS, During MJ, Mak TW, Park DS. The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Proc. Natl. Acad. Sci. U.S.A., 104, 18748-18753 (2007).
160. Yanagisawa D, Kitamura Y, Inden M, Takata K, Taniguchi T, Morikawa S, Morita M, Inubushi T, Tooyama I, Taira T, Iguchi-Ariga SMM, Akaike A, Ariga H. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. J. Cereb. Blood Flow Metab., 28, 563-578 (2008).
161. Wagenfeld A, Gromoll J, Cooper TG. Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization. Biochem. Biophys. Res. Commun., 251, 545-549 (1998).
162. Okada M, Matsumoto K, Niki T, Taira T, Iguchi-Ariga SMM, Ariga H. DJ-1, a target protein for an endocrine disrupter, participates in the fertilization in mice. Biol. Pharm. Bull., 25, 853-856 (2002).
163. An CN, Jiang H, Wang Q, Yuan RP, Liu JM, Shi WL, Zhang ZY, Pu XP. Down-regulation of DJ-1 protein in the ejaculated spermatozoa from Chinese asthenozoospermia patients. Fertil. Steril., 96, 19-23.e2 (2011).
164. Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, Chen L, Zhuang X, Hogg J, Pare P, Tuder RM, Biswal S. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am. J. Respir. Crit. Care Med., 178, 592-604 (2008).
165. Jain D, Jain R, Eberhard D, Eglinger J, Bugliani M, Piemonti L, Marchetti P, Lammert E. Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes. J. Mol. Cell Biol., 4, 221-230 (2012).
166. Nishinaga H, Takahashi-Niki K, Taira T, Andreadis A, Iguchi-Ariga SMM, Ariga H. Expression profiles of genes in DJ-1-knockdown and Ll66P DJ-1 mutant cells. Neurosci. Lett., 390, 54-59 (2005).
167. Zhou W, Freed CR. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. J. Biol. Chem., 280, 43150-43158 (2005).
168. Yamashita S, Mori A, Kimura E, Mita S, Maeda Y, Hirano T, Uchino M. DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicity. J. Neurochem., 113, 860-870 (2010).
169. Wang Z, Liu J, Chen S, Wang Y, Cao L, Zhang Y, Kang W, Li H, Gui Y, Chen S, Ding J. DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erkl/2-Elk1 pathway in neuroprotection. Ann. Neurol., 70, 591-599 (2011).
170. Girotto S, Cendron L, Bisaglia M, Tessari I, Mammi S, Zanotti G, Bubacco L. DJ-1 is a copper chaperone acting on SOD1 activation. J. Biol. Chem., 289, 10887-10899 (2014).
171. Takahashi-Niki K, Niki T, Taira T, Iguchi-Ariga SMM, Ariga H. Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients. Biochem. Biophys. Res. Commun., 320, 389-397 (2004).
172. Kim RH, Smith PD, Aleyasin H, Hayley S, Mount MP, Pownall S, Wakeham A, You-Ten AJ, Kalia SK, Horne P, Westaway D, Lozano AM, Anisman H, Park DS, Mak TW. Hypersensitivity of DJ1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl. Acad. Sci. U.S.A., 102, 5215-5220 (2005).
173. Rizzu P, Hinkle DA, Zhukareva V, Bonifati V, Severijnen LA, Martinez D, Ravid R, Kamphorst W, Eberwine JH, Lee VM, Trojanowski JQ, Heutink P. DJ-1 colocalizes with tau inclusions: a link between Parkinsonism and dementia. Ann. Neurol., 55, 113-118 (2004).
174. Yanagida T, Takata K, Inden M, Kitamura Y, Taniguchi T, Yoshimoto K, Taira T, Ariga H. Distribution of DJ-1, Parkinson's disease-related protein PARK7, and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain. J. Pharmacol. Sci., 102, 243-247 (2006).
175. Mullett SJ, Hamilton RL, Hinkle DA. DJ-1 immunoreactivity in human brain astrocytes is dependent on infarct presence and infarct age. Neuropathology, 29, 125-131 (2009).
176. Mullett SJ, Hinkle DA. DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone. Neurobiol. Dis., 33, 28-36 (2009).
177. Collins AR, Lyon CJ, Xia X, Liu JZ, Tangirala RK, Yin F, Boyadjian R, Bikineyeva A, Praticò D, Harrison DG, Hsueh WA. Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ. Res., 104, e42-e54 (2009).
178. Malaud E, Merle D, Piquer D, Molina L, Salvetat N, Rubrecht L, Dupaty E, Galea P, Cobo S, Blanc A, Saussine M, Marty-Ané C, Albat B, Meilhac O, Rieunier F, Pouzet A, Molina F, Laune D, Fareh J. Local carotid atherosclerotic plaque proteins for the identification of circulating biomarkers in coronary patients. Atherosclerosis, 233, 551-558 (2014).
179. Cuevas S, Zhang Y, Yang Y, Escano C, Asico L, Jones JE, Armando I, Jose PA. Role of renal DJ-1 in the pathogenesis of hypertension associated with increased reactive oxygen species production. Hypertension, 59, 446-452 (2012).
180. Billia F, Hauck L, Grothe D, Konecny F, Rao V, Kim RH, Mak TW. Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo. Prac. Natl. Acad. Sci. USA., 110, 6085-6090 (2013).
181. Klawitter J, Klawitter J, Agardi E, Corby K, Leibfritz D, Lowes BD, Christians U, Seres T. Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. Cardiovasc. Res., 97, 66-76 (2013).
182. Liu M, Zhou B, Xia ZY, Zhao B, Lei SQ, Yang QJ, Xue R, Leng Y, Xu JJ, Xia Z. Hyperglycemia-induced inhibition of DJ-1 expression compromised the effectiveness of ischemic postconditioning cardioprotection in rats. Oxid. Med. Cell. Longev., 2013, 564902 (2013).
183. Yamane T, Murao S, Kozuka M, Shimizu M, Suzuki J, Kubo C, Yamaguchi A, Musashi M, Minegishi Y, Momose I, Matsushita M, Shirahata A, Furukawa N, Kobayashi R, Umezawa A, Sakamoto M, Moriya K, Saito M, Makita A, Ohkubo I, Ariga H. Serum DJ-1 level is positively associated with improvement of metabolic syndrome in Japanese women through lifestyle intervention. Nutr. Res., 34, 851-855 (2014).
184. Ishikawa S, Taira T, Niki T, Takahashi-Niki K, Maita C, Maita H, Ariga H, Iguchi-Ariga SMM. Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-l-phenylalanine (1-DOPA) decarboxylase with DJ-1. J. Biol. Chem., 284, 28832-28844 (2009).
185. Ishikawa S, Tanaka Y, Takahashi-Niki K, Niki T, Ariga H, Iguchi-Ariga SMM. Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells. Biochem. Biophys. Res. Commun., 421, 813-818 (2012).
186. Shinbo Y, Niki T, Taira T, Ooe H, Takahashi-Niki K, Maita C, Seino C, Iguchi-Ariga SMM, Ariga H. Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell Death Dyer., 13, 96-108 (2006).
187. Hattori K, Naguro I, Runchel C, Ichijo H. The roles of ASK family proteins in stress responses and diseases. Cell Commun. Signal., 7, 9 (2009).
188. Shiizaki S, Naguro I, Ichijo H. Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling. Adv. Biol. Regul., 53, 135-144 (2013).
189. Zhong N, Xu J. Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1alpha: regulation by SUMOylation and oxidation. Hum. Mol. Genet., 17, 3357-3367 (2008).
190. Pickrell AM, Youle RJ. The Roles of PINKI, Parkin, and mitochondrial fidelity in Parkinson's disease. Neuron, 85, 257-273 (2015).
191. Inden M, Taira T, Kitamura Y, Yanagida T, Tsuchiya D, Takata K, Yanagisawa D, Nishimura K, Taniguchi T, Kiso Y, Yoshimoto K, Agatsuma T, Koide-Yoshida S, Iguchi-Ariga SMM, Shimohama S, Ariga H. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiol. Dis., 24, 144-158 (2006).
192. Miyazaki S, Yanagida T, Nunome K, Ishikawa S, Inden M, Kitamura Y, Nakagawa S, Taira T, Hirota K, Niwa M, Iguchi-Ariga SMM, Ariga H. DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats. J. Neurochem., 105, 2418-2434 (2008).
193. Qu W, Fan L, Kim Y-C, Ishikawa S, Iguchi-Ariga SMM, Pu X-P, Ariga H. Kaempferol derivatives prevent oxidative stress-induced cell death in a DJ-1-dependent manner. J. Pharmacol. Sci., 110, 191-200 (2009).
194. Gao J-W, Yamane T, Maita H, Ishikawa S, Iguchi-Ariga SMM, Pu X-P, Ariga H. DJ-1-mediated protective effect of protocatechuic aldehyde against oxidative stress in SH-SY5Y cells. J. Pharmacol. Sci., 115, 36-44 (2011).
195. Kitamura Y, Watanabe S, Taguchi M, Takagi K, Kawata T, Takahashi-Niki K, Yasui H, Maita H, Iguchi-Ariga SMM, Ariga H. Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats. Mol. Neurodegener., 6, 48 (2011).
196. Inden M, Kitamura M, Takahashi K, Takata K, Ito N, Niwa R, Funayama R, Nishimura K, Taniguchi T, Honda T, Taira T, Ariga H. Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7. J. Pharmacol. Sci., 117, 189-203 (2011).
197. Yanagida T, Kitamura Y, Yamane K, Takahashi K, Takata K, Yanagisawa D, Yasui H, Taniguchi T, Taira T, Honda T, Ariga H. Protection against oxidative stress-induced neurodegeneration by a modulator for DJ-1, a wild-type of familial Parkinson's disease-linked PARK7. J. Pharmacol. Sci., 109, 463-468 (2009).
198. Takahashi-Niki K, Inafune A, Michitani N, Hatakeyama Y, Suzuki K, Sasaki M, Kitamura Y, Niki T, Iguchi-Ariga SMM, Ariga H. DJ-1-dependent protective activity of DJ-1-binding compound No. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease. J. Pharmacol. Sci., 127, 305-310 (2015).