Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Yamaguchi, Shiori ^a   Yamane, Takuya ^a   Takahashi Niki, Kazuko ^a   Kato, Izumi ^a   Niki, Takeshi ^a   Goldberg, Matthew S ^b   Shen, Jie ^b   Ishimoto, Kenji ^c   Doi, Takefumi ^c   Iguchi Ariga, Sanae M M ^a   Ariga, Hiroyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CHOLESTEROL; DJ 1 PROTEIN; ESTROGEN; LIVER X RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; DJ 1 PROTEIN, MOUSE; DJ-1 PROTEIN, MOUSE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHOLESTEROL BLOOD LEVEL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DJ 1 GENE; DNA MICROARRAY; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; FEMALE; GENE EXPRESSION; LOW DENSITY LIPOPROTEIN RECEPTOR GENE; MALE; MITOCHONDRION; MOUSE; NONHUMAN; ONCOGENE; OXIDATIVE STRESS; PARKINSON DISEASE; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; ANIMAL; BLOOD; CELL STRAIN 3T3; GENE SILENCING; GENETICS; HOMEOSTASIS; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE;

MUS;

ANIMALS; BASE SEQUENCE; CHOLESTEROL; CHOLESTEROL, LDL; FEMALE; GENE KNOCKDOWN TECHNIQUES; HOMEOSTASIS; HUMANS; MALE; MICE; NIH 3T3 CELLS; ONCOGENE PROTEINS; PROMOTER REGIONS, GENETIC; RECEPTORS, LDL; STEROL REGULATORY ELEMENT BINDING PROTEINS; TRANSCRIPTIONAL ACTIVATION;

EID: 84861635170     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038144     Document Type: Article

References (66)

1. Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, et al. (1997) DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commum 231: 509-513.
2. Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, et al. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism. Science 299: 256-259.
3. Canet-Aviles RM, Wilson MA, Miller DW, Ahmad R, McLendon C, et al. (2004) The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 101: 9103-9108.
4. Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A, (2004) DJ-1 is a redox-dependent molecular chaperone that inhibits a-synuclein aggregate formation. PLoS Biol 2: e362.
5. Zhang L, Shimoji M, Thomas B, Moore DJ, Yu S, et al. (2005) Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum Mol Genet 14: 2063-2073.
6. Shinbo Y, Niki T, Taira T, Ooe H, Takahashi-Niki K, et al. (2006) Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell Death Diff 13: 96-108.
7. Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SMM, et al. (2001) DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx to the receptor. J Biol Chem 276: 37556-37563.
8. Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SMM, Ariga H, (2003) DJBP: A novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol Cancer Res 1: 247-261.
9. Shinbo Y, Taira T, Niki T, Iguchi-Ariga SMM, Ariga H, (2005) DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. Int J Oncol 26: 641-648.
10. Zhong N, Kim CY, Rizzu P, Geula C, Porter DR, et al. (2006) DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J Biol Chem 281: 20940-20948.
11. Clements CM, McNally RS, Conti BJ, Mak TW, Ting JP, (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci USA 103: 15091-15096.
12. Tillman JE, Yuan J, Gu G, Fazli L, Ghosh R, et al. (2007) DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. Cancer Res 67: 4630-4637.
13. Ishikawa S, Taira T, Niki T, Takahashi-Niki K, Maita C, et al. (2009) Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. J Biol Chem 284: 28832-28844.
14. Fan J, Ren H, Ji N, Fei E, Zhou T, et al. (2008) DJ-1 decreases bax expression through repressing p53 transcriptional activity. J Biol Chem 283: 4022-4030.
15. Xu J, Zhong N, Wang H, Elias JE, Kim CY, et al. (2005) The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet 14: 1231-1241.
16. Taira T, Saito Y, Niki T, Iguchi-Ariga SMM, Takahashi K, et al. (2004) DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep 5: 213-218.
17. Kinumi T, Kimata J, Taira T, Ariga H, Niki E, (2004) Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem Biophys Res Commun 317: 722-728.
18. Martinat C, Shendelman S, Jonason A, Leete T, Beal MF, et al. (2004) Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: An ES derived cell model of primary Parkinsonism. PLoS Biol 2: e327.
19. Inden M, Taira T, Kitamura Y, Yanagida T, Tsuchiya D, et al. (2006) PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model. Neurobiol Dis 24: 144-158.
20. Yanagida T, Tsushima J, Kitamura Y, Yanagisawa D, Takata K, et al. (2009) Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury. Oxid Med Cell Longev 2: 36-42.
21. Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL, (2006) The oxidation state of DJ-1 regulates its chaperone activity toward α-synuclein. J Mol Biol 356: 1036-1048.
22. Olzmann JA, Brown K, Wilkinson KD, Rees HD, Huai Q, et al. (2004) Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J Biol Chem 279: 8506-8515.
23. Koide-Yoshida S, Niki T, Ueda M, Himeno S, Taira T, et al. (2007) DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. Int J Mol Med 19: 885-893.
24. Chen J, Li L, Chin LS, (2010) Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage. Hum Mol Genet 19: 2395-408.
25. Ooe H, Taira T, Iguchi-Ariga SMM, Ariga H, (2005) Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1. Toxicol Sci 88: 114-126.
26. Li HM, Niki T, Taira T, Iguchi-Ariga SMM, Ariga H, (2005) Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. Free Radic Res 39: 1091-1099.
27. Junn E, Jang WE, Zhao X, Jeong B, Mouradian MM, (2009) Mitochondrial localization of DJ-1 leads to enhanced neuroprotection. J Neurosci Res 87: 123-129.
28. Hayashi T, Ishimori C, Takahashi-Niki K, Taira T, Kim YC, et al. (2009) DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem Biophys Res Commun 390: 667-672.
29. Kim RH, Peters M, Jang Y, Shi W, Pintilie M, et al. (2005) DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 7: 263-273.
30. Kim YC, Kitaura H, Taira T, Iguchi-Ariga SMM, Ariga H, (2009) Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN. Int J Oncol 35: 1331-1341.
31. Waak J, Weber SS, Görner K, Schall C, Ichijo H, et al. (2009) Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1. J Biol Chem 284: 14245-14257.
32. Mo JS, Jung J, Yoon JH, Hong JA, Kim MY, et al. (2010) DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. J Cell Biochem 110: 229-237.
33. Sekito A, Koide-Yoshida S, Niki T, Taira T, Iguchi-Ariga SMM, et al. (2006) DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. Free Radic Res 40: 155-165.
34. Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, et al. (2005) Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc Natl Acad Sci USA 102: 9691-9696.
35. Nishinaga H, Takahashi-Niki K, Taira T, Andreadis A, Iguchi-Ariga SMM, et al. (2005) Expression profiles of genes in DJ-1-knockdown and L166P DJ-1 mutant cells. Neurosci Lett 390: 54-59.
36. Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, et al. (1993) SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci USA 90: 11603-11607.
37. Sato R, Yang J, Wang X, Evans MJ, Ho YK, et al. (1994) Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J Biol Chem 269: 17267-17273.
38. Yieh L, Sanchez HB, Osborne T, (1995) Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter. Proc Natl Acad Sci USA 92: 6102-6106.
39. Bennett MK, Ngo TT, Athanikar JN, Rosenfeld JM, Osborne TF, (1999) Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein. J Biol Chem 274: 13025-13032.
40. Bruning JC, Lingohr P, Gillette J, Hanstein B, Avci H, et al. (2003) Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoprotein-receptor. Steroid Biochem Mol Biol 86: 113-121.
41. Ishimoto K, Tachibana K, Sumitomo M, Omote S, Hanano I, et al. (2006) Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha. FEBS Lett 580: 4929-4933.
42. Rishi V, Gal J, Krylov D, Fridriksson J, Boysen MS, et al. (2004) SREBP-1 dimerization specificity maps to both the helix-loop-helix and leucine zipper domains: use of a dominant negative. J Biol Chem 279: 11863-11874.
43. Ishibashi S, Brown M, Goldstein J, Gerard R, Hammer R, et al. (1993) Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92: 883-893.
44. Osborne TF, Espenshade PJ, (2009) Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been Genes Dev 23: 2578-2591.
45. Mills GL, Taylaur CE, (1971) The distribution and composition of serum lipoproteins in eighteen animals. Comp Bwchem Physwl 40: 489-501.
46. Hst KH, Ghanta VK, Hiramoto RN, (1981) Immunosuppressive effect of mouse serum lipoproteins. I. In vitro studies. J Immunol 126: 1909-1913.
47. Camus MC, Chapman MJ, Forgez P, Laplaud PM, (1983) Distribution and characterization of the serum lipoproteins and apoproteins in the mouse, Mus musculus. J Lipid Res 24: 1210-1228.
48. Lee AH, Scapa EF, Cohen DE, Glimcher LH, (2008) Regulation of hepatic lipogenesis by the transcription factor XBP1 Science 320: 1492-1496.
49. Yokota T, Sugawara K, Ito K, Takahashi R, Ariga H, et al. (2003) Down regulation of DJ-1 enhances the cell death by oxidative stress, ER-stress and proteasome inhibition. Biochem Biophys Res Commun 312: 1342-1348.
50. Hirata F, Fujita K, Ishikura Y, Hosoda K, Ishikawa T, et al. (1996) Hypocholesterolemic effect of sesame lignan in humans. Atherosclerosis 122: 135-136.
51. Anthony MS, Clarkson TB, Williams JK, (1998) Effects of soy isoflavones on atherosclerosis: potential mechanisms. Am J Clin Nutr 68: 1390S-1393S.
52. Berthold HK, Sudhop T, Von Bergmann K, (1998) Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism: a randomized controlled trial. J Am Med Assoc 279: 1900-1902.
53. Khor HT, Ng TT, (2000) Effects of administration of alpha-tocopherol and tocotrienols on serum lipids and liver HMG CoA reductase activity. Int J Food Sci Nutr 51: S3-S11.
54. Walsh BW, Schiff I, Rosner B, Greenberg L, Ravnikar V, et al. (1991) Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 325: 1196-1204.
55. Valk-de Roo GW, Stehouwer CDA, Meijer P, Mijatovic V, Kluft C, et al. (1999) Both raloxifene and estrogen reduce major cardiovascular risk factors in healthy postmenopausal women: A 2-year, placebo-controlled study. Arterioscler Throm Vasc Biol 19: 2993-3000.
56. Abbey M, Owen A, Suzakawa M, Roach P, Nestel PJ, (1999) Effects of menopause and hormone replacement therapy on plasma lipids, lipoproteins and LDL-receptor activity. Maturitas 33: 259-269.
57. Rustembegovic A, Sofic E, Wichart I, (2006) Serum prolactin, leptin, lipids and lipoproteins levels during antipsychotics treatment in Parkinson's disease and related psychosis. Med Arh 60: 211-212.
58. Huang X, Chen H, Miller WC, Mailman RB, Woodard JL, et al. (2007) Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease. Mov Disord 22: 377-381.
59. Huang X, Abbott RD, Petrovitch H, Mailman RB, Ross GW, (2008) Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging Study. Mov Disord 23: 1013-1018.
60. Goldberg MS, Pisani A, Haburcak M, Haburcak M, Vortherms TA, et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45: 489-496.
61. Wolozin B, Wang SW, Li NC, Lee A, Lee TA, et al. (2007) Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med 5: 20.
62. Takahashi-Niki K, Niki T, Taira T, Iguchi-Ariga SMM, Ariga H, (2004) Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients. Biochem Biophys Res Commun 320: 389-397.
63. Ariga H, Sugano S, (1983) Initiation of simian virus 40 DNA replication in vitro. J Virol 48: 481-491.
64. Yoshida T, Kitaura H, Hagio Y, Sato T, Iguchi-Ariga SMM, et al. (2008) Negative regulation of the Wnt signal by MM-1 through inhibiting expression of the wnt4 gene. Exp Cell Res 314: 1217-1228.
65. Graham FL, van der Eb AJ, (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52: 456-467.
66. Ariga H, Imamura Y, Iguchi-Ariga SMM, (1989) DNA replication origin with transcriptional enhancer activity shares the c-myc protein binding sequences. EMBO J 8: 4273-4279.