Serum DJ-1 as a diagnostic marker and prognostic factor for pancreatic cancer

Journal of Digestive Diseases

Volumn 12, Issue 2, 2011, Pages 131-137

  He, Xiang Yi ^a   Liu, Bing Ya ^a   Yao, Wei Yan ^a   Zhao, Xiao Jiao ^a   Zheng, Zhong ^b   Li, Jian Fang ^a   Yu, Bei Qin ^a   Yuan, Yao Zong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

Biomarker; DJ 1; Pancreatic cancer

Indexed keywords

CA 19-9 ANTIGEN; DJ 1 PROTEIN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CANCER DIAGNOSIS; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHRONIC PANCREATITIS; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; ONCOGENE PROTEINS; PANCREATIC NEOPLASMS; PANCREATITIS, CHRONIC; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 79952691516     PISSN: 17512972     EISSN: 17512980     Source Type: Journal    
DOI: 10.1111/j.1751-2980.2011.00488.x     Document Type: Article

References (31)

1. Lowenfels AB, Maisonneuve P. Epidemiology and risk factors for pancreatic cancer. Best Pract Res Clin Gastroenterol 2006; 20: 197-209.
2. Giroux V, Dagorn JC, Iovanna JL. A review of kinases implicated in pancreatic cancer. Pancreatology 2009; 9: 738-54.
3. Goggins M. Molecular markers of early pancreatic cancer. J Clin Oncol 2005; 23: 4524-31.
4. Nagakubo D, Taira T, Kitaura H etal. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 1997; 231: 509-13.
5. Hod Y. Differential control of apoptosis by DJ-1 in prostate benign and cancer cells. J Cell Biochem 2004; 92: 1221-33.
6. Le Naour F, Misek DE, Krause MC etal. Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin Cancer Res 2001; 7: 3328-35.
7. Liu H, Wang M, Li M etal. Expression and role of DJ-1 in leukemia. Biochem Biophys Res Commun 2008; 375: 477-83.
8. Arnouk H, Merkley MA, Podolsky RH etal. Characterization of molecular markers indicative of cervical cancer progression. Proteomics Clin Appl 2009; 3: 516-27.
9. Giusti L, Iacconi P, Ciregia F etal. Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers. J Proteome Res 2008; 7: 4079-88.
10. Tian M, Cui YZ, Song GH etal. Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer 2008; 8: 241-51.
11. Melle C, Ernst G, Escher N etal. Protein profiling of microdissected pancreas carcinoma and identification of HSP27 as a potential serum marker. Clin Chem 2007; 53: 629-35.
12. Pardo M, Garcia A, Thomas B etal. The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker. Int J Cancer 2006; 119: 1014-22.
13. Kim RH, Peters M, Jang Y etal. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 2005; 7: 263-73.
14. Yuen HF, Chan YP, Law S etal. DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 2008; 17: 3593-602.
15. Zhu XL, Wang ZF, Lei WB, Zhuang HW, Jiang HY, Wen WP. DJ-1: a novel independent prognostic marker for survival in glottic squamous cell carcinoma. Cancer Sci 2010; 101: 1320-5.
16. Maita C, Tsuji S, Yabe I etal. Secretion of DJ-1 into the serum of patients with Parkinson's disease. Neurosci Lett 2008; 431: 86-9.
17. Hirotani M, Maita C, Niino M etal. Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients. Mult Scler 2008; 14: 1056-60.
18. Tsuboi Y, Munemoto H, Ishikawa S, Matsumoto K, Iguchi-Ariga SM, Ariga H. DJ-1, a causative gene product of a familial form of Parkinson's disease, is secreted through microdomains. FEBS Lett 2008; 582: 2643-9.
19. Koide-Yoshida S, Niki T, Ueda M etal. DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy. Int J Mol Med 2007; 19: 885-93.
20. Sobin LH. TNM, sixth edition: new developments in general concepts and rules. Semin Surg Oncol 2003; 21: 19-22.
21. Pancreas Study Group, Chinese Society of Gastroenterology. Guidelines for the diagnosis and treatment of chronic pancreatitis (Nanjing, 2005). Chin J Dig Dis 2005; 6: 198-201.
22. Tillman JE, Yuan J, Gu G etal. DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. Cancer Res 2007; 67: 4630-7.
23. Fan J, Ren H, Fei E etal. Sumoylation is critical for DJ-1 to repress p53 transcriptional activity. FEBS Lett 2008; 582: 1151-6.
24. Fan J, Ren H, Jia N etal. DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J Biol Chem 2008; 283: 4022-30.
25. Clements CM, McNally RS, Conti BJ, Mak TW, Ting JP. DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci USA 2006; 103: 15091-6.
26. Vasseur S, Afzal S, Tardivel-Lacombe J, Park DS, Iovanna JL, Mak TW. DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. Proc Natl Acad Sci USA 2009; 106: 1111-16.
27. Blackinton J, Lakshminarasimhan M, Thomas KJ etal. Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1. J Biol Chem 2009; 284: 6476-85.
28. Krebiehl G, Ruckerbauer S, Burbulla LF etal. Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS ONE 2010; 5: e9367.
29. Hao LY, Giasson BI, Bonini NM. DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function. Proc Natl Acad Sci USA 2010; 107: 9747-52.
30. Kim YC, Kitaura H, Iguchi-Ariga SM, Ariga H. DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-Myc. FEBS Lett 2010; 584: 3891-5.
31. Allard L, Burkhard PR, Lescuyer P etal. PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke. Clin Chem 2005; 51: 2043-51.