메뉴 건너뛰기




Volumn 129, Issue 6, 2014, Pages 898-915

Protective and toxic roles of dopamine in Parkinson's disease

Author keywords

5 6 indolequinone; aminochrome; dopa mine o quinone; dopamine; neurodegeneration; neuromelanin; Parkinson s disease

Indexed keywords

5,6 INDOLEQUINONE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE 13A1; ALPHA SYNUCLEIN; AMINE OXIDASE (FLAVIN CONTAINING); AMINOCHROME; CATECHOL ORTHO METHYLTRANSFERASE; DIHYDROLIPOAMIDE DEHYDROGENASE; DJ 1 PROTEIN; DOPAMINE; DOPAMINE O QUINONE; LEUCINE RICH REPEAT KINASE 2; METHYLTRANSFERASE; NEUROMELANIN; PROTEASOME; PROTEIN PINK 1; PROTEIN SERINE THREONINE KINASE; QUINONE DERIVATIVE; UBIQUITIN PROTEIN LIGASE E3; UBIQUITIN THIOLESTERASE; UBIQUITIN THIOLESTERASE L1; UNCLASSIFIED DRUG;

EID: 84902326763     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12686     Document Type: Review
Times cited : (361)

References (176)
  • 1
    • 0345490853 scopus 로고    scopus 로고
    • A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease
    • Abbas N., Lücking C. B., Ricard S., et al,. (1999) A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease. Hum. Mol. Genet. 8, 567-574.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 567-574
    • Abbas, N.1    Lücking, C.B.2    Ricard, S.3
  • 2
    • 2942536124 scopus 로고    scopus 로고
    • On the neurotoxicity of leukoaminochrome o-semiquinone radical derived of dopamine oxidation: Mitochondria damage, necrosis and hydroxyl radical formation
    • Arriagada A., Paris I., Sanchez de las Matas M. J., et al,. (2004) On the neurotoxicity of leukoaminochrome o-semiquinone radical derived of dopamine oxidation: mitochondria damage, necrosis and hydroxyl radical formation. Neurobiol. Dis. 16, 468-477.
    • (2004) Neurobiol. Dis. , vol.16 , pp. 468-477
    • Arriagada, A.1    Paris, I.2    Sanchez De Las Matas, M.J.3
  • 4
    • 0028965835 scopus 로고
    • Superoxide dismutase and catalase enhance autoxidation during one-electron reduction of aminochrome by NADPH-cytochrome P-450 reductase
    • Baez S., Linderson Y., and, Segura-Aguilar J., (1995) Superoxide dismutase and catalase enhance autoxidation during one-electron reduction of aminochrome by NADPH-cytochrome P-450 reductase. Biochem. Mol. Med. 54, 12-18.
    • (1995) Biochem. Mol. Med. , vol.54 , pp. 12-18
    • Baez, S.1    Linderson, Y.2    Segura-Aguilar, J.3
  • 5
    • 0030967073 scopus 로고    scopus 로고
    • Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes
    • Baez S., Segura-Aguilar J., Widersten M., Johansson A. S., and, Mannervik B., (1997) Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Biochem. J. 324, 25-28.
    • (1997) Biochem. J. , vol.324 , pp. 25-28
    • Baez, S.1    Segura-Aguilar, J.2    Widersten, M.3    Johansson, A.S.4    Mannervik, B.5
  • 6
    • 0031930771 scopus 로고    scopus 로고
    • Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease
    • Banati R. B., Daniel S. E., and, Blunt S. B., (1998) Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease. Mov. Disord. 13, 221-227.
    • (1998) Mov. Disord. , vol.13 , pp. 221-227
    • Banati, R.B.1    Daniel, S.E.2    Blunt, S.B.3
  • 7
    • 84884250340 scopus 로고    scopus 로고
    • The function of α-synuclein
    • Bendor J. T., Logan T. P., and, Edwards R. H., (2013) The function of α-synuclein. Neuron 79, 1044-1066.
    • (2013) Neuron , vol.79 , pp. 1044-1066
    • Bendor, J.T.1    Logan, T.P.2    Edwards, R.H.3
  • 8
    • 34447500591 scopus 로고    scopus 로고
    • Kinetic and structural analysis of the early oxidation products of dopamine: Analysis of the interactions with alpha-synuclein
    • Bisaglia M., Mammi S., and, Bubacco L., (2007) Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein. J. Biol. Chem. 282, 15597-15605.
    • (2007) J. Biol. Chem. , vol.282 , pp. 15597-15605
    • Bisaglia, M.1    Mammi, S.2    Bubacco, L.3
  • 9
    • 77954959651 scopus 로고    scopus 로고
    • Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: Implications for mitochondrial dysfunction in Parkinson disease
    • Bisaglia M., Soriano M. E., Arduini I., Mammi S., and, Bubacco L., (2010) Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: implications for mitochondrial dysfunction in Parkinson disease. Biochim. Biophys. Acta. 1802, 699-706.
    • (2010) Biochim. Biophys. Acta. , vol.1802 , pp. 699-706
    • Bisaglia, M.1    Soriano, M.E.2    Arduini, I.3    Mammi, S.4    Bubacco, L.5
  • 10
  • 11
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block M. L., Zecca L., and, Hong J., (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.3
  • 12
    • 58149127699 scopus 로고    scopus 로고
    • Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X-ray microspectroscopy
    • Bohic S., Murphy K., Paulus W., Cloetens P., Salomé M., Susini J., and, Double K., (2008) Intracellular chemical imaging of the developmental phases of human neuromelanin using synchrotron X-ray microspectroscopy. Anal. Chem. 80, 9557-9566.
    • (2008) Anal. Chem. , vol.80 , pp. 9557-9566
    • Bohic, S.1    Murphy, K.2    Paulus, W.3    Cloetens, P.4    Salomé, M.5    Susini, J.6    Double, K.7
  • 13
    • 0037428241 scopus 로고    scopus 로고
    • Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    • Bonifati V., Rizzu P., van Baren M. J., et al,. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299, 256-259.
    • (2003) Science , vol.299 , pp. 256-259
    • Bonifati, V.1    Rizzu, P.2    Van Baren, M.J.3
  • 15
    • 33749520640 scopus 로고    scopus 로고
    • The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface
    • Bush W. D., Garguilo J., Zucca F. A., Albertini A., Zecca L., Edwards G. S., Nemanich R. J., and, Simon J. D., (2006) The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface. Proc. Natl Acad. Sci. USA 103, 14785-14789.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 14785-14789
    • Bush, W.D.1    Garguilo, J.2    Zucca, F.A.3    Albertini, A.4    Zecca, L.5    Edwards, G.S.6    Nemanich, R.J.7    Simon, J.D.8
  • 18
    • 76249088643 scopus 로고    scopus 로고
    • A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles
    • Cartier E. A., Parra L. A., Baust T. B., Quiroz M., Salazar G., Faundez V., Egaña L., and, Torres G. E., (2010) A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles. J. Biol. Chem. 151, 957-966.
    • (2010) J. Biol. Chem. , vol.151 , pp. 957-966
    • Cartier, E.A.1    Parra, L.A.2    Baust, T.B.3    Quiroz, M.4    Salazar, G.5    Faundez, V.6    Egaña, L.7    Torres, G.E.8
  • 19
    • 0029066498 scopus 로고
    • Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA
    • Cases O., Seif I., Grimsby J., et al,. (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268, 1763-1766.
    • (1995) Science , vol.268 , pp. 1763-1766
    • Cases, O.1    Seif, I.2    Grimsby, J.3
  • 20
    • 80053421300 scopus 로고    scopus 로고
    • Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: Implications for drug development
    • Chen J., Song J., Yuan P., Tian Q., Ji Y., Ren-Patterson R., Liu G., Sei Y., and, Weinberger D. R., (2011) Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development. J. Biol. Chem. 286, 34752-34760.
    • (2011) J. Biol. Chem. , vol.286 , pp. 34752-34760
    • Chen, J.1    Song, J.2    Yuan, P.3    Tian, Q.4    Ji, Y.5    Ren-Patterson, R.6    Liu, G.7    Sei, Y.8    Weinberger, D.R.9
  • 21
    • 0029878379 scopus 로고    scopus 로고
    • Elevated 5-S-cysteinyldopamine/homovanillic acid ratio and reduced homovanillic acid in cerebrospinal fluid: Possible markers for and potential insights into the pathoetiology of Parkinson's disease
    • Cheng F. C., Kuo J. S., Chia L. G., and, Dryhurst G., (1996) Elevated 5-S-cysteinyldopamine/homovanillic acid ratio and reduced homovanillic acid in cerebrospinal fluid: possible markers for and potential insights into the pathoetiology of Parkinson's disease. J. Neural Transm. 103, 433-446.
    • (1996) J. Neural Transm. , vol.103 , pp. 433-446
    • Cheng, F.C.1    Kuo, J.S.2    Chia, L.G.3    Dryhurst, G.4
  • 22
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the a-synuclein protofibril by a dopamine- α-synuclein adduct
    • Conway K. A., Rochet J. C., Bieganski R. M., and, Lansbury P. T., Jr, (2001) Kinetic stabilization of the a-synuclein protofibril by a dopamine- α-synuclein adduct. Science 294, 1346-1349.
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.A.1    Rochet, J.C.2    Bieganski, R.M.3    Lansbury, Jr.P.T.4
  • 24
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo A. M., Stefanis L., Fredenburg R., Lansbury P. T., and, Sulzer D., (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305, 1292-1295.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 26
    • 0022539310 scopus 로고
    • Selectivity of the parkinsonian neurotoxin MPTP: Toxic metabolite MPP+ binds to neuromelanin
    • D'Amato R. J., Lipman Z. P., and, Snyder S. H., (1986) Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin. Science 231, 987-989.
    • (1986) Science , vol.231 , pp. 987-989
    • D'Amato, R.J.1    Lipman, Z.P.2    Snyder, S.H.3
  • 28
    • 0024356620 scopus 로고
    • Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
    • Dexter D. T., Wells F. R., Lees A. J., Agid F., Agid Y., Jenner P., and, Marsden C. D., (1989) Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 52, 1830-1836.
    • (1989) J. Neurochem. , vol.52 , pp. 1830-1836
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3    Agid, F.4    Agid, Y.5    Jenner, P.6    Marsden, C.D.7
  • 31
    • 2442597991 scopus 로고    scopus 로고
    • Inhibition of DT-diaphorase potentiates the in vivo neurotoxic effect of intranigral injection of salsolinol in rats
    • Díaz-Véliz G., Mora S., Lungenstrass H., and, Segura-Aguilar J., (2004b) Inhibition of DT-diaphorase potentiates the in vivo neurotoxic effect of intranigral injection of salsolinol in rats. Neurotox. Res. 5, 629-633.
    • (2004) Neurotox. Res. , vol.5 , pp. 629-633
    • Díaz-Véliz, G.1    Mora, S.2    Lungenstrass, H.3    Segura-Aguilar, J.4
  • 32
    • 47049090944 scopus 로고    scopus 로고
    • Copper neurotoxicity in rat substantia nigra and striatum is dependent on DT-diaphorase inhibition
    • Díaz-Véliz G., Paris I., Mora S., Raisman-Vozari R., and, Segura-Aguilar J., (2008) Copper neurotoxicity in rat substantia nigra and striatum is dependent on DT-diaphorase inhibition. Chem. Res. Toxicol. 21, 1180-1185.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 1180-1185
    • Díaz-Véliz, G.1    Paris, I.2    Mora, S.3    Raisman-Vozari, R.4    Segura-Aguilar, J.5
  • 33
    • 84884825977 scopus 로고    scopus 로고
    • A molecular dynamics simulation-based interpretation of nuclear magnetic resonance multidimensional heteronuclear spectra of α-synuclein dopamine adducts
    • Dibenedetto D., Rossetti G., Caliandro R., and, Carloni P., (2013) A molecular dynamics simulation-based interpretation of nuclear magnetic resonance multidimensional heteronuclear spectra of α-synuclein dopamine adducts. Biochemistry 52, 6672-6683.
    • (2013) Biochemistry , vol.52 , pp. 6672-6683
    • Dibenedetto, D.1    Rossetti, G.2    Caliandro, R.3    Carloni, P.4
  • 36
    • 0014240538 scopus 로고
    • Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed brain tissue
    • Earle K. M., (1968) Studies on Parkinson's disease including x-ray fluorescent spectroscopy of formalin fixed brain tissue. J. Neuropathol. Exp. Neurol. 27, 1-14.
    • (1968) J. Neuropathol. Exp. Neurol. , vol.27 , pp. 1-14
    • Earle, K.M.1
  • 37
    • 84865860748 scopus 로고    scopus 로고
    • Protein degradation pathways in Parkinson's disease: Curse or blessing
    • Ebrahimi-Fakhari D., Wahlster L., and, McLean P. J., (2012) Protein degradation pathways in Parkinson's disease: curse or blessing. Acta Neuropathol. 124, 153-172.
    • (2012) Acta Neuropathol. , vol.124 , pp. 153-172
    • Ebrahimi-Fakhari, D.1    Wahlster, L.2    McLean, P.J.3
  • 38
    • 84868374313 scopus 로고    scopus 로고
    • Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure
    • Engelen M., Vanna R., Bellei C., Zucca F. A., Wakamatsu K., Monzani E., Ito S., Casella L., and, Zecca L., (2012) Neuromelanins of human brain have soluble and insoluble components with dolichols attached to the melanic structure. PLoS ONE 7, e48490.
    • (2012) PLoS ONE , vol.7
    • Engelen, M.1    Vanna, R.2    Bellei, C.3    Zucca, F.A.4    Wakamatsu, K.5    Monzani, E.6    Ito, S.7    Casella, L.8    Zecca, L.9
  • 39
    • 77749295404 scopus 로고    scopus 로고
    • Regulation of dopamine transporter function by protein-protein interactions: New discoveries and methodological challenges
    • Eriksen J., Jørgensen T. N., and, Gether U., (2010) Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges. J. Neurochem. 113, 27-41.
    • (2010) J. Neurochem. , vol.113 , pp. 27-41
    • Eriksen, J.1    Jørgensen, T.N.2    Gether, U.3
  • 40
    • 84864150600 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Parkinson's disease: Molecular mechanisms and pathophysiological consequences
    • Exner N., Lutz A. K., Haass C., and, Winklhofer K. F., (2012) Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J. 31, 3038-3062.
    • (2012) EMBO J. , vol.31 , pp. 3038-3062
    • Exner, N.1    Lutz, A.K.2    Haass, C.3    Winklhofer, K.F.4
  • 41
    • 33645102892 scopus 로고    scopus 로고
    • Modifications of the iron-neuromelanin system in Parkinson's disease
    • Fasano M., Bergamasco B., and, Lopiano L., (2006) Modifications of the iron-neuromelanin system in Parkinson's disease. J. Neurochem. 96, 909-916.
    • (2006) J. Neurochem. , vol.96 , pp. 909-916
    • Fasano, M.1    Bergamasco, B.2    Lopiano, L.3
  • 42
    • 0042433192 scopus 로고    scopus 로고
    • Neuromelanin associated redox-Active iron is increased in the substantia nigra of patients with Parkinson's disease
    • Faucheux B. A., Martin M. E., Beaumont C., Hauw J. J., Agid Y., and, Hirsch E. C., (2003) Neuromelanin associated redox-Active iron is increased in the substantia nigra of patients with Parkinson's disease. J. Neurochem. 86, 1142-1148.
    • (2003) J. Neurochem. , vol.86 , pp. 1142-1148
    • Faucheux, B.A.1    Martin, M.E.2    Beaumont, C.3    Hauw, J.J.4    Agid, Y.5    Hirsch, E.C.6
  • 44
  • 45
    • 0001393031 scopus 로고
    • On the nature of pigment granules in the cells of the locus coeruleus and substantia nigra
    • Foley J. M., and, Baxter D., (1958) On the nature of pigment granules in the cells of the locus coeruleus and substantia nigra. J. Neuropathol. Exp. Neurol. 17, 586-598.
    • (1958) J. Neuropathol. Exp. Neurol. , vol.17 , pp. 586-598
    • Foley, J.M.1    Baxter, D.2
  • 47
    • 0022573434 scopus 로고
    • Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine, dopa and dopac in the brains of eight mammalian species
    • Fornstedt B., Rosengren E., and, Carlsson A., (1986) Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine, dopa and dopac in the brains of eight mammalian species. Neuropharmacology 25, 451-454.
    • (1986) Neuropharmacology , vol.25 , pp. 451-454
    • Fornstedt, B.1    Rosengren, E.2    Carlsson, A.3
  • 48
    • 34250702138 scopus 로고    scopus 로고
    • Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line-An experimental cell model for dopamine toxicity studies
    • Fuentes P., Paris I., Nassif M., Caviedes P., and, Segura-Aguilar J., (2007) Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line-An experimental cell model for dopamine toxicity studies. Chem. Res. Toxicol. 20, 776-783.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 776-783
    • Fuentes, P.1    Paris, I.2    Nassif, M.3    Caviedes, P.4    Segura-Aguilar, J.5
  • 49
    • 0033848307 scopus 로고    scopus 로고
    • Enzymatic dopamine peroxidation in substantia nigra of human brain
    • Galzigna L., De Iuliis A., and, Zanatta L., (2000) Enzymatic dopamine peroxidation in substantia nigra of human brain. Clin. Chim. Acta 300, 131-138.
    • (2000) Clin. Chim. Acta , vol.300 , pp. 131-138
    • Galzigna, L.1    De Iuliis, A.2    Zanatta, L.3
  • 50
    • 79956088518 scopus 로고    scopus 로고
    • Characterization of reduced and oxidized dopamine and 3,4-dihydrophenylacetic acid, on brain mitochondrial electron transport chain activities
    • Gautam A. H., and, Zeevalk G. D., (2011) Characterization of reduced and oxidized dopamine and 3,4-dihydrophenylacetic acid, on brain mitochondrial electron transport chain activities. Biochim. Biophys. Acta 1807, 819-828.
    • (2011) Biochim. Biophys. Acta , vol.1807 , pp. 819-828
    • Gautam, A.H.1    Zeevalk, G.D.2
  • 51
    • 0037053312 scopus 로고    scopus 로고
    • Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling
    • Geha R. M., Chen K., Wouters J., Ooms F., and, Shih J. C., (2002) Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling. J. Biol. Chem. 277, 17209-17216.
    • (2002) J. Biol. Chem. , vol.277 , pp. 17209-17216
    • Geha, R.M.1    Chen, K.2    Wouters, J.3    Ooms, F.4    Shih, J.C.5
  • 52
    • 0025763177 scopus 로고
    • Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease
    • Gibb W. R., and, Lees A. J., (1991) Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 54, 388-396.
    • (1991) J. Neurol. Neurosurg. Psychiatry , vol.54 , pp. 388-396
    • Gibb, W.R.1    Lees, A.J.2
  • 53
    • 66149143952 scopus 로고    scopus 로고
    • Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons
    • Guillot T. S., and, Miller G. W., (2009) Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons. Mol. Neurobiol. 39, 149-170.
    • (2009) Mol. Neurobiol. , vol.39 , pp. 149-170
    • Guillot, T.S.1    Miller, G.W.2
  • 54
    • 0030071106 scopus 로고    scopus 로고
    • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    • Giros B., Jaber M., Jones S. R., Wightman R. M., and, Caron M. G., (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379, 606-612.
    • (1996) Nature , vol.379 , pp. 606-612
    • Giros, B.1    Jaber, M.2    Jones, S.R.3    Wightman, R.M.4    Caron, M.G.5
  • 56
    • 0026746512 scopus 로고
    • Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: A LAMMA study
    • Good P. F., Olanow C. W., and, Perl D. P., (1992) Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study. Brain Res. 593, 343-346.
    • (1992) Brain Res. , vol.593 , pp. 343-346
    • Good, P.F.1    Olanow, C.W.2    Perl, D.P.3
  • 58
    • 0018148688 scopus 로고
    • Autoxidation versus covalent binding of Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro
    • Graham D. G., Tiffany S. M., Bell W. R. Jr, and, Gutknecht W. F., (1978) Autoxidation versus covalent binding of Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Mol. Pharmacol. 14, 644-653.
    • (1978) Mol. Pharmacol. , vol.14 , pp. 644-653
    • Graham, D.G.1    Tiffany, S.M.2    Bell, Jr.W.R.3    Gutknecht, W.F.4
  • 59
    • 20144388975 scopus 로고    scopus 로고
    • Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease
    • Greggio E., Bergantino E., Carter D., et al,. (2005) Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease. J. Neurochem. 93, 246-256.
    • (2005) J. Neurochem. , vol.93 , pp. 246-256
    • Greggio, E.1    Bergantino, E.2    Carter, D.3
  • 60
    • 0030886278 scopus 로고    scopus 로고
    • L-DOPA is a substrate for tyrosine hydroxylase
    • Haavik J., (1997) L-DOPA is a substrate for tyrosine hydroxylase. J. Neurochem. 69, 1720-1728.
    • (1997) J. Neurochem. , vol.69 , pp. 1720-1728
    • Haavik, J.1
  • 61
    • 0028812293 scopus 로고
    • Enzymatic oxidation of dopamine: The role of prostaglandin H synthase
    • Hastings T. G., (1995) Enzymatic oxidation of dopamine: the role of prostaglandin H synthase. J. Neurochem. 64, 919-924.
    • (1995) J. Neurochem. , vol.64 , pp. 919-924
    • Hastings, T.G.1
  • 62
    • 0014333601 scopus 로고
    • Catecholamine oxidation and ionization properties indicated from the H+ release, tritium exchange, and spectral changes which occur during ferricyanide oxidation
    • Harrison W. H., Whisler W. W., and, Hill B. J., (1968) Catecholamine oxidation and ionization properties indicated from the H+ release, tritium exchange, and spectral changes which occur during ferricyanide oxidation. Biochemistry 7, 3089-3094.
    • (1968) Biochemistry , vol.7 , pp. 3089-3094
    • Harrison, W.H.1    Whisler, W.W.2    Hill, B.J.3
  • 63
    • 0032575607 scopus 로고    scopus 로고
    • Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene
    • Hattori N., Matsumine H., Asakawa S., et al,. (1998) Point mutations (Thr240Arg and Gln311Stop) [correction of Thr240Arg and Ala311Stop] in the Parkin gene. Biochem. Biophys. Res. Commun. 249, 754-758.
    • (1998) Biochem. Biophys. Res. Commun. , vol.249 , pp. 754-758
    • Hattori, N.1    Matsumine, H.2    Asakawa, S.3
  • 64
    • 84872687901 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism
    • Hauser D. N., and, Hastings T. G., (2013) Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism. Neurobiol. Dis. 51, 35-42.
    • (2013) Neurobiol. Dis. , vol.51 , pp. 35-42
    • Hauser, D.N.1    Hastings, T.G.2
  • 65
    • 84881522331 scopus 로고    scopus 로고
    • Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4
    • Hauser D. N., Dukes A. A., Mortimer A. D., and, Hastings T. G., (2013) Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4. Free Radic Biol Med. 65, 419-427.
    • (2013) Free Radic Biol Med. , vol.65 , pp. 419-427
    • Hauser, D.N.1    Dukes, A.A.2    Mortimer, A.D.3    Hastings, T.G.4
  • 67
    • 0014209801 scopus 로고
    • Electrochemical studies of the oxidation pathways of catecholamines
    • Hawley M. D., Tatawawadi S. V., Piekarski S., and, Adams R. N., (1967) Electrochemical studies of the oxidation pathways of catecholamines. J. Am. Chem. Soc. 89, 447-450.
    • (1967) J. Am. Chem. Soc. , vol.89 , pp. 447-450
    • Hawley, M.D.1    Tatawawadi, S.V.2    Piekarski, S.3    Adams, R.N.4
  • 68
    • 5444235520 scopus 로고    scopus 로고
    • Genetic causes of Parkinson's disease: UCHL-1
    • Healy D. G., Abou-Sleiman P. M., and, Wood N. W., (2004) Genetic causes of Parkinson's disease: UCHL-1. Cell Tissue Res. 318, 189-194.
    • (2004) Cell Tissue Res. , vol.318 , pp. 189-194
    • Healy, D.G.1    Abou-Sleiman, P.M.2    Wood, N.W.3
  • 69
    • 0023740954 scopus 로고
    • Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
    • Hirsch E., Graybiel A. M., and, Agid Y. A., (1988) Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 334, 345-348.
    • (1988) Nature , vol.334 , pp. 345-348
    • Hirsch, E.1    Graybiel, A.M.2    Agid, Y.A.3
  • 70
    • 84898638399 scopus 로고    scopus 로고
    • Glutathione transferase M2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction
    • Huenchuguala S., Muñoz P., Zavala P., et al,. (2014) Glutathione transferase M2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction. Autophagy 10, 52-64.
    • (2014) Autophagy , vol.10 , pp. 52-64
    • Huenchuguala, S.1    Muñoz, P.2    Zavala, P.3
  • 71
    • 0032480361 scopus 로고    scopus 로고
    • Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?
    • Ikemoto K., Nagatsu I., Ito S., King R. A., Nishimura A., and, Nagatsu T., (1998) Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra? Neurosci. Lett. 253, 198-200.
    • (1998) Neurosci. Lett. , vol.253 , pp. 198-200
    • Ikemoto, K.1    Nagatsu, I.2    Ito, S.3    King, R.A.4    Nishimura, A.5    Nagatsu, T.6
  • 72
    • 77956522541 scopus 로고    scopus 로고
    • Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
    • Irrcher I., Aleyasin H., Seifert E. L., et al,. (2010) Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum. Mol. Genet. 19, 3734-3746.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 3734-3746
    • Irrcher, I.1    Aleyasin, H.2    Seifert, E.L.3
  • 73
    • 0023640283 scopus 로고
    • Sulphydryl compounds in melanogenesis. Part I. Reaction of cysteine and glutathione with 5,6-dihydroxyindoles
    • d'Ischia A., Napolitano A., and, Prota G., (1987) Sulphydryl compounds in melanogenesis. Part I. Reaction of cysteine and glutathione with 5,6-dihydroxyindoles. Tetrahedron 43, 5351-5356.
    • (1987) Tetrahedron , vol.43 , pp. 5351-5356
    • D'Ischia, A.1    Napolitano, A.2    Prota, G.3
  • 74
    • 33749519378 scopus 로고    scopus 로고
    • Encapsulation of a reactive core in neuromelanin
    • Ito S., (2006) Encapsulation of a reactive core in neuromelanin. Proc. Natl Acad. Sci. USA 103, 14647-14648.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 14647-14648
    • Ito, S.1
  • 75
    • 42549092546 scopus 로고    scopus 로고
    • Chemistry of mixed melanogenesis - Pivotal roles of dopaquinone
    • Ito S., and, Wakamatsu K., (2008) Chemistry of mixed melanogenesis- pivotal roles of dopaquinone. Photochem. Photobiol. 84, 582-592.
    • (2008) Photochem. Photobiol. , vol.84 , pp. 582-592
    • Ito, S.1    Wakamatsu, K.2
  • 79
    • 20144387207 scopus 로고    scopus 로고
    • Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: Evidence of a common founder across European populations
    • Kachergus J., Mata I. F., Hulihan M., et al,. (2005) Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. Am. J. Hum. Genet. 76, 672-680.
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 672-680
    • Kachergus, J.1    Mata, I.F.2    Hulihan, M.3
  • 80
    • 84875415994 scopus 로고    scopus 로고
    • α-Synuclein oligomers and clinical implications for Parkinson disease
    • Kalia L. V., Kalia S. K., McLean P. J., Lozano A. M., and, Lang A. E., (2013) α-Synuclein oligomers and clinical implications for Parkinson disease. Ann. Neurol. 73, 155-169.
    • (2013) Ann. Neurol. , vol.73 , pp. 155-169
    • Kalia, L.V.1    Kalia, S.K.2    McLean, P.J.3    Lozano, A.M.4    Lang, A.E.5
  • 81
    • 84890548633 scopus 로고    scopus 로고
    • Melanin affinity and its possible role in neurodegeneration
    • Karlsson O., and, Lindquist N. G., (2013) Melanin affinity and its possible role in neurodegeneration. J. Neural. Transm. 120, 1623-1630.
    • (2013) J. Neural. Transm. , vol.120 , pp. 1623-1630
    • Karlsson, O.1    Lindquist, N.G.2
  • 82
    • 0026662141 scopus 로고
    • Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?
    • Kastner A., Hirsch E. C., Lejeune O., Javoy-Agid F., Rascol O., and, Agid Y., (1992) Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? J. Neurochem. 59, 1080-1109.
    • (1992) J. Neurochem. , vol.59 , pp. 1080-1109
    • Kastner, A.1    Hirsch, E.C.2    Lejeune, O.3    Javoy-Agid, F.4    Rascol, O.5    Agid, Y.6
  • 84
    • 0032531095 scopus 로고    scopus 로고
    • Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: Possible endogenous toxin to serotonin neurons
    • Kuhn D. M., and, Arthur R., Jr, (1998) Dopamine inactivates tryptophan hydroxylase and forms a redox-cycling quinoprotein: possible endogenous toxin to serotonin neurons. J. Neurosci. 18, 7111-7117.
    • (1998) J. Neurosci. , vol.18 , pp. 7111-7117
    • Kuhn, D.M.1    Arthur, Jr.R.2
  • 85
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston J. W., Forno L. S., Tetrud J., Reeves A. G., Kaplan J. A., and, Karluk D., (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 46, 598-605.
    • (1999) Ann. Neurol. , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 86
    • 0027619954 scopus 로고
    • Interaction between chemicals and melanin
    • Larsson B. S., (1993) Interaction between chemicals and melanin. Pigment Cell Res. 6, 127-133.
    • (1993) Pigment Cell Res. , vol.6 , pp. 127-133
    • Larsson, B.S.1
  • 88
    • 0030886119 scopus 로고    scopus 로고
    • Irreversible inhibition of mitochondrial complex i by 7-(2-Aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxyli c acid (DHBT-1): A putative nigral endotoxin of relevance to Parkinson's disease
    • Li H., and, Dryhurst G., (1997) Irreversible inhibition of mitochondrial complex I by 7-(2-Aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3- carboxyli c acid (DHBT-1): a putative nigral endotoxin of relevance to Parkinson's disease. J. Neurochem. 69, 1530-1541.
    • (1997) J. Neurochem. , vol.69 , pp. 1530-1541
    • Li, H.1    Dryhurst, G.2
  • 89
    • 0034694152 scopus 로고    scopus 로고
    • Role of microtubules and actin filaments in the movement of mitochondria in the axons and dendrites of cultured hippocampal neurons
    • Ligon L. A., and, Steward O., (2000) Role of microtubules and actin filaments in the movement of mitochondria in the axons and dendrites of cultured hippocampal neurons. J. Comp. Neurol. 427, 351-361.
    • (2000) J. Comp. Neurol. , vol.427 , pp. 351-361
    • Ligon, L.A.1    Steward, O.2
  • 90
    • 0023558226 scopus 로고
    • Neuromelanin and its possible protective and destructive properties
    • Lindquist N. G., Larsson B. S., and, Lydén-Sokolowski A., (1987) Neuromelanin and its possible protective and destructive properties. Pigment Cell Res. 1, 133-136.
    • (1987) Pigment Cell Res. , vol.1 , pp. 133-136
    • Lindquist, N.G.1    Larsson, B.S.2    Lydén-Sokolowski, A.3
  • 91
    • 0023823245 scopus 로고
    • Autoradiography of [14C]paraquat or [14C]diquat in frogs and mice: Accumulation in neuromelanin
    • Lindquist N. G., Larsson B. S., and, Lyden-Sokolowski A., (1988) Autoradiography of [14C]paraquat or [14C]diquat in frogs and mice: accumulation in neuromelanin. Neurosci. Lett. 93, 1-6.
    • (1988) Neurosci. Lett. , vol.93 , pp. 1-6
    • Lindquist, N.G.1    Larsson, B.S.2    Lyden-Sokolowski, A.3
  • 92
    • 0030598917 scopus 로고    scopus 로고
    • Dopamine, 6-hydroxydopamine, iron, and dioxygen-their mutual interactions and possible implication in the development of Parkinson's disease
    • Linert W., Herlinger E., Jameson R. F., Kienzl E., Jellinger K., and, Youdim M. B., (1996) Dopamine, 6-hydroxydopamine, iron, and dioxygen-their mutual interactions and possible implication in the development of Parkinson's disease. Biochim. Biophys. Acta 1316, 160-168.
    • (1996) Biochim. Biophys. Acta , vol.1316 , pp. 160-168
    • Linert, W.1    Herlinger, E.2    Jameson, R.F.3    Kienzl, E.4    Jellinger, K.5    Youdim, M.B.6
  • 93
    • 77956914561 scopus 로고    scopus 로고
    • Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity
    • Lozano J., Muñoz P., Nore B. F., Ledoux S., and, Segura-Aguilar J., (2010) Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity. Chem. Res. Toxicol. 23, 1492-1496.
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 1492-1496
    • Lozano, J.1    Muñoz, P.2    Nore, B.F.3    Ledoux, S.4    Segura-Aguilar, J.5
  • 94
    • 28244484729 scopus 로고    scopus 로고
    • Structures for amyloid fibrils
    • Makin O. S., and, Serpell L. C., (2005) Structures for amyloid fibrils. FEBS J. 272, 5950-5961.
    • (2005) FEBS J. , vol.272 , pp. 5950-5961
    • Makin, O.S.1    Serpell, L.C.2
  • 95
    • 78649344814 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of L-dopa treatment
    • Marin C., and, Obeso J. A., (2010) Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of L-dopa treatment. Int. Rev. Neurobiol. 95, 191-205.
    • (2010) Int. Rev. Neurobiol. , vol.95 , pp. 191-205
    • Marin, C.1    Obeso, J.A.2
  • 96
    • 0020996094 scopus 로고
    • Neuromelanin and Parkinson's disease
    • Marsden C. D., (1983) Neuromelanin and Parkinson's disease. J. Neural Transm. Suppl. 19, 121-141.
    • (1983) J. Neural Transm. Suppl. , vol.19 , pp. 121-141
    • Marsden, C.D.1
  • 97
    • 84881376026 scopus 로고    scopus 로고
    • Alpha-synuclein and protein degradation pathways in Parkinson's disease: A pathological feed-back loop
    • Martinez-Vicente M., and, Vila M., (2013) Alpha-synuclein and protein degradation pathways in Parkinson's disease: a pathological feed-back loop. Exp. Neurol. 247, 308-313.
    • (2013) Exp. Neurol. , vol.247 , pp. 308-313
    • Martinez-Vicente, M.1    Vila, M.2
  • 98
    • 0028969650 scopus 로고
    • Prostaglandin H synthetase-mediated metabolism of dopamine: Implication for Parkinson's disease
    • Mattammal M. B., Strong R., Lakshmi V. M., Chung H. D., and, Stephenson A. H., (1995) Prostaglandin H synthetase-mediated metabolism of dopamine: implication for Parkinson's disease. J. Neurochem. 64, 1645-1654.
    • (1995) J. Neurochem. , vol.64 , pp. 1645-1654
    • Mattammal, M.B.1    Strong, R.2    Lakshmi, V.M.3    Chung, H.D.4    Stephenson, A.H.5
  • 99
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer P. L., Itagaki S., Boyes B. E., and, McGeer E. G., (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38, 1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 100
    • 0032169935 scopus 로고    scopus 로고
    • Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: Relevance to Parkinson's disease
    • Merad-Boudia M., Nicole A., Santiard-Baron D., Saillé C., and, Ceballos-Picot I., (1998) Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease. Biochem. Pharmacol. 56, 645-655.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 645-655
    • Merad-Boudia, M.1    Nicole, A.2    Santiard-Baron, D.3    Saillé, C.4    Ceballos-Picot, I.5
  • 101
    • 0033030440 scopus 로고    scopus 로고
    • Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease
    • Miller G. W., Erickson J. D., Perez J. T., Penland S. N., Mash D. C., Rye D. B., and, Levey A. I., (1999) Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease. Exp. Neurol. 156, 138-148.
    • (1999) Exp. Neurol. , vol.156 , pp. 138-148
    • Miller, G.W.1    Erickson, J.D.2    Perez, J.T.3    Penland, S.N.4    Mash, D.C.5    Rye, D.B.6    Levey, A.I.7
  • 102
    • 84894291922 scopus 로고    scopus 로고
    • α-Synuclein and mitochondrial dysfunction in Parkinson's disease
    • Mullin S., and, Schapira A., (2013) α-Synuclein and mitochondrial dysfunction in Parkinson's disease. Mol. Neurobiol. 47, 587-597.
    • (2013) Mol. Neurobiol. , vol.47 , pp. 587-597
    • Mullin, S.1    Schapira, A.2
  • 103
    • 84860341994 scopus 로고    scopus 로고
    • Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity
    • Muñoz P., Paris I., Sanders L. H., Greenamyre J. T., and, Segura-Aguilar J., (2012) Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. Biochim. Biophys. Acta 1822, 1125-1136.
    • (2012) Biochim. Biophys. Acta , vol.1822 , pp. 1125-1136
    • Muñoz, P.1    Paris, I.2    Sanders, L.H.3    Greenamyre, J.T.4    Segura-Aguilar, J.5
  • 104
    • 77953104962 scopus 로고    scopus 로고
    • Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice
    • Myöhänen T. T., Schendzielorz N., and, Männistö P. T., (2010) Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice. J. Neurochem. 113, 1632-1643.
    • (2010) J. Neurochem. , vol.113 , pp. 1632-1643
    • Myöhänen, T.T.1    Schendzielorz, N.2    Männistö, P.T.3
  • 105
    • 79955679714 scopus 로고    scopus 로고
    • Oxidation chemistry of catecholamines and neuronal degeneration: An update
    • Napolitano A., Manini P., and, d'Ischia M., (2011) Oxidation chemistry of catecholamines and neuronal degeneration: an update. Curr. Med. Chem. 18, 1832-1845.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 1832-1845
    • Napolitano, A.1    Manini, P.2    D'Ischia, M.3
  • 106
    • 53849095181 scopus 로고    scopus 로고
    • Myoglobin modification by enzyme-generated dopamine reactive species
    • Nicolis S., Zucchelli M., Monzani E., and, Casella L., (2008) Myoglobin modification by enzyme-generated dopamine reactive species. Chem. Eur. J. 14, 8661-8673.
    • (2008) Chem. Eur. J. , vol.14 , pp. 8661-8673
    • Nicolis, S.1    Zucchelli, M.2    Monzani, E.3    Casella, L.4
  • 107
    • 20444401187 scopus 로고    scopus 로고
    • Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome - Mediated conformational alterations
    • Norris E. H., Giasson B. I., Hodara R., Xu S., Trojanowski J. Q., Ischiropoulos H., and, Lee V. M., (2005) Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J. Biol. Chem. 280, 21212-21219.
    • (2005) J. Biol. Chem. , vol.280 , pp. 21212-21219
    • Norris, E.H.1    Giasson, B.I.2    Hodara, R.3    Xu, S.4    Trojanowski, J.Q.5    Ischiropoulos, H.6    Lee, V.M.7
  • 108
    • 0035052491 scopus 로고    scopus 로고
    • Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line
    • Paris I., Dagnino-Subiabre A., Marcelain K., Bennett L. B., Caviedes P., Caviedes R., Olea-Azar C., and, Segura-Aguilar J., (2001) Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line. J. Neurochem. 77, 519-529.
    • (2001) J. Neurochem. , vol.77 , pp. 519-529
    • Paris, I.1    Dagnino-Subiabre, A.2    Marcelain, K.3    Bennett, L.B.4    Caviedes, P.5    Caviedes, R.6    Olea-Azar, C.7    Segura-Aguilar, J.8
  • 111
    • 67649413595 scopus 로고    scopus 로고
    • Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death
    • Paris I., Perez-Pastene C., Couve E., Caviedes P., Ledoux S., and, Segura-Aguilar J., (2009) Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death. J. Biol. Chem. 284, 13306-13315.
    • (2009) J. Biol. Chem. , vol.284 , pp. 13306-13315
    • Paris, I.1    Perez-Pastene, C.2    Couve, E.3    Caviedes, P.4    Ledoux, S.5    Segura-Aguilar, J.6
  • 115
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M. H., Lavedan C., Leroy E., et al,. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3
  • 116
    • 33749133430 scopus 로고    scopus 로고
    • Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
    • Ramirez A., Heimbach A., Gründemann J., et al,. (2006) Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat. Genet. 38, 1184-1191.
    • (2006) Nat. Genet. , vol.38 , pp. 1184-1191
    • Ramirez, A.1    Heimbach, A.2    Gründemann, J.3
  • 117
    • 84860484992 scopus 로고    scopus 로고
    • Targeting alpha-synuclein for the treatment of Parkinson's disease
    • Rohn T. T., (2012) Targeting alpha-synuclein for the treatment of Parkinson's disease. CNS Neurol. Disord. Drug Targets. 11, 174-179.
    • (2012) CNS Neurol. Disord. Drug Targets. , vol.11 , pp. 174-179
    • Rohn, T.T.1
  • 119
    • 0018190446 scopus 로고
    • Binding of dopaminergic drugs by the neuromelanin of the substantia nigra, synthetic melanins and melanin granules
    • Salazar M., Sokoloski T. D., and, Patil P. N., (1978) Binding of dopaminergic drugs by the neuromelanin of the substantia nigra, synthetic melanins and melanin granules. Fed. Proc. 37, 2403-2407.
    • (1978) Fed. Proc. , vol.37 , pp. 2403-2407
    • Salazar, M.1    Sokoloski, T.D.2    Patil, P.N.3
  • 120
    • 0028145566 scopus 로고
    • Increased monoamine oxidase B activity in plaque-Associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography
    • Saura J., Luque J. M., Cesura A. M., Da Prada M., Chan-Palay V., Huber G., Loffler J., and, Richards J. G., (1994) Increased monoamine oxidase B activity in plaque-Associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience 62, 15-30.
    • (1994) Neuroscience , vol.62 , pp. 15-30
    • Saura, J.1    Luque, J.M.2    Cesura, A.M.3    Da Prada, M.4    Chan-Palay, V.5    Huber, G.6    Loffler, J.7    Richards, J.G.8
  • 121
    • 0024259752 scopus 로고
    • Distribution of DT diaphorase in the rat brain: Biochemical and immunohistochemical studies
    • Schultzberg M., Segura-Aguilar J., and, Lind C., (1988) Distribution of DT diaphorase in the rat brain: biochemical and immunohistochemical studies. Neuroscience 27, 763-776.
    • (1988) Neuroscience , vol.27 , pp. 763-776
    • Schultzberg, M.1    Segura-Aguilar, J.2    Lind, C.3
  • 122
    • 0030175944 scopus 로고    scopus 로고
    • Peroxidase activity of liver microsomal vitamin D 25-hydroxylase and cytochrome P450 1A2 catalyzes 25-hydroxylation of vitamin D3 and oxidation of dopamine to aminochrome
    • Segura-Aguilar J., (1996) Peroxidase activity of liver microsomal vitamin D 25-hydroxylase and cytochrome P450 1A2 catalyzes 25-hydroxylation of vitamin D3 and oxidation of dopamine to aminochrome. Biochem. Mol. Med. 58, 122-129.
    • (1996) Biochem. Mol. Med. , vol.58 , pp. 122-129
    • Segura-Aguilar, J.1
  • 123
    • 0024854643 scopus 로고
    • 3+ induced neurotoxicity of dopamine: Prevention of quinone derived oxygen toxicity by DT-diaphorase and superoxide dismutase
    • 3+ induced neurotoxicity of dopamine: prevention of quinone derived oxygen toxicity by DT-diaphorase and superoxide dismutase. Chem. Biol. Interact. 72, 309-324.
    • (1989) Chem. Biol. Interact. , vol.72 , pp. 309-324
    • Segura-Aguilar, J.1    Lind, C.2
  • 124
    • 0031041078 scopus 로고    scopus 로고
    • Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome
    • Segura-Aguilar J., Baez S., Widersten M., Welch C. J., and, Mannervik B., (1997) Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome. J. Biol. Chem. 272, 5727-5731.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5727-5731
    • Segura-Aguilar, J.1    Baez, S.2    Widersten, M.3    Welch, C.J.4    Mannervik, B.5
  • 125
    • 0032486311 scopus 로고    scopus 로고
    • Metabolic activation of dopamine o-quinones to o-semiquinones by NADPH cytochrome P450 reductase may play an important role in oxidative stress and apoptotic effects
    • Segura-Aguilar J., Metodiewa D., and, Welch C., (1998) Metabolic activation of dopamine o-quinones to o-semiquinones by NADPH cytochrome P450 reductase may play an important role in oxidative stress and apoptotic effects. Biochim. Biophys. Acta 1381, 1-6.
    • (1998) Biochim. Biophys. Acta , vol.1381 , pp. 1-6
    • Segura-Aguilar, J.1    Metodiewa, D.2    Welch, C.3
  • 126
    • 0036203058 scopus 로고    scopus 로고
    • Inhibition of DT-diaphorase is a requirement for Mn (III) to produce a 6-OH-dopamine like rotational behaviour
    • Segura-Aguilar J., Diaz-Veliz G., Mora S., and, Herrera-Marschitz M., (2002) Inhibition of DT-diaphorase is a requirement for Mn (III) to produce a 6-OH-dopamine like rotational behaviour. Neurotox. Res. 4, 127-131.
    • (2002) Neurotox. Res. , vol.4 , pp. 127-131
    • Segura-Aguilar, J.1    Diaz-Veliz, G.2    Mora, S.3    Herrera-Marschitz, M.4
  • 128
    • 33646378453 scopus 로고    scopus 로고
    • Neuromelanin induces oxidative stress in mitochondria through release of iron: Mechanism behind the inhibition of 26S proteasome
    • Shamoto-Nagai M., Maruyama W., Yi H., Akao Y., Tribl F., Gerlach M., Osawa T., Riederer P., and, Naoi M., (2006) Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome. J. Neural. Transm. 113, 633-644.
    • (2006) J. Neural. Transm. , vol.113 , pp. 633-644
    • Shamoto-Nagai, M.1    Maruyama, W.2    Yi, H.3    Akao, Y.4    Tribl, F.5    Gerlach, M.6    Osawa, T.7    Riederer, P.8    Naoi, M.9
  • 129
    • 0029967920 scopus 로고    scopus 로고
    • Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-Acetylcysteinyl conjugates of dopamine: Possible metabolites of relevance to Parkinson's disease
    • Shen X. M., Xia B., Wrona M. Z., and, Dryhurst G., (1996) Synthesis, redox properties, in vivo formation, and neurobehavioral effects of N-Acetylcysteinyl conjugates of dopamine: possible metabolites of relevance to Parkinson's disease. Chem. Res. Toxicol. 9, 1117-1126.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 1117-1126
    • Shen, X.M.1    Xia, B.2    Wrona, M.Z.3    Dryhurst, G.4
  • 130
    • 0026073176 scopus 로고
    • Molecular basis of human MAO A and B
    • Shih J. C., (1991) Molecular basis of human MAO A and B. Neuropsychopharmacology 4, 1-7.
    • (1991) Neuropsychopharmacology , vol.4 , pp. 1-7
    • Shih, J.C.1
  • 131
    • 0007590705 scopus 로고    scopus 로고
    • Molecular biology of monoamine oxidase A and B: Their role in the degradation of serotonin
    • in (Baumgarten H. G. and Gothert M. eds), 129, Springer-Verlag, Berlin
    • Shih J. C., Grimsby J., and, Chen K., (1997) Molecular biology of monoamine oxidase A and B: their role in the degradation of serotonin, in Handbook of Experimental Pharmacology. Serotoninergic Neurons and 5-HT Receptors in the CNS (, Baumgarten H. G., and, Gothert M., eds), Vol. 129, pp. 655-670. Springer-Verlag, Berlin.
    • (1997) Handbook of Experimental Pharmacology. Serotoninergic Neurons and 5-HT Receptors in the CNS , pp. 655-670
    • Shih, J.C.1    Grimsby, J.2    Chen, K.3
  • 132
    • 17044461766 scopus 로고    scopus 로고
    • Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: An electron paramagnetic resonance spectroscopy study
    • Shima T., Sarna T., Swartz H. M., Stroppolo A., Gerbasi R., and, Zecca L., (1997) Binding of iron to neuromelanin of human substantia nigra and synthetic melanin: an electron paramagnetic resonance spectroscopy study. Free Radic. Biol. Med. 23, 110-119.
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 110-119
    • Shima, T.1    Sarna, T.2    Swartz, H.M.3    Stroppolo, A.4    Gerbasi, R.5    Zecca, L.6
  • 134
    • 0033559008 scopus 로고    scopus 로고
    • Cytotoxic and genotoxic potential of dopamine
    • Stokes A. H., Hastings T. G., and, Vrana K. E., (1999) Cytotoxic and genotoxic potential of dopamine. J. Neurosci. Res. 55, 659-665.
    • (1999) J. Neurosci. Res. , vol.55 , pp. 659-665
    • Stokes, A.H.1    Hastings, T.G.2    Vrana, K.E.3
  • 135
    • 0026987995 scopus 로고
    • Developmental aspects of the monoamine-degrading enzyme monoamine oxidase
    • Strolin-Benedetti M., Dostert P., and, Tipton K. F., (1992) Developmental aspects of the monoamine-degrading enzyme monoamine oxidase. Dev. Pharmacol. Ther. 18, 191-200.
    • (1992) Dev. Pharmacol. Ther. , vol.18 , pp. 191-200
    • Strolin-Benedetti, M.1    Dostert, P.2    Tipton, K.F.3
  • 136
    • 84881027032 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in Parkinson's disease
    • Subramaniam S. R., and, Chesselet M. F., (2013) Mitochondrial dysfunction and oxidative stress in Parkinson's disease. Prog. Neurobiol. 107, 17-32.
    • (2013) Prog. Neurobiol. , vol.107 , pp. 17-32
    • Subramaniam, S.R.1    Chesselet, M.F.2
  • 137
    • 0001672745 scopus 로고    scopus 로고
    • Intraneuronal dopamine-quinone synthesis: A review
    • Sulzer D., and, Zecca L., (2000) Intraneuronal dopamine-quinone synthesis: a review. Neurotox. Res. 1, 181-195.
    • (2000) Neurotox. Res. , vol.1 , pp. 181-195
    • Sulzer, D.1    Zecca, L.2
  • 138
    • 12944305793 scopus 로고    scopus 로고
    • Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles
    • Sulzer D., Bogulavsky J., Larsen K. E., et al,. (2000) Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proc. Natl Acad. Sci. USA 97, 11869-11874.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 11869-11874
    • Sulzer, D.1    Bogulavsky, J.2    Larsen, K.E.3
  • 139
    • 45449093259 scopus 로고    scopus 로고
    • Neuronal pigmented autophagic vacuoles: Lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
    • Sulzer D., Mosharov E., Talloczy Z., Zucca F. A., Simon J. D., and, Zecca L., (2008) Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease. J. Neurochem. 106, 24-36.
    • (2008) J. Neurochem. , vol.106 , pp. 24-36
    • Sulzer, D.1    Mosharov, E.2    Talloczy, Z.3    Zucca, F.A.4    Simon, J.D.5    Zecca, L.6
  • 140
    • 84875703698 scopus 로고    scopus 로고
    • Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson's disease
    • Taylor J. M., Main B. S., and, Crack P. J., (2013) Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson's disease. Neurochem. Int. 62, 803-819.
    • (2013) Neurochem. Int. , vol.62 , pp. 803-819
    • Taylor, J.M.1    Main, B.S.2    Crack, P.J.3
  • 141
    • 0033846716 scopus 로고    scopus 로고
    • Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid
    • Thompson M., Capdevila J. H., and, Strobel H. W., (2000) Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid. J. Pharmacol. Exp. Ther. 294, 1120-1130.
    • (2000) J. Pharmacol. Exp. Ther. , vol.294 , pp. 1120-1130
    • Thompson, M.1    Capdevila, J.H.2    Strobel, H.W.3
  • 142
    • 84878775802 scopus 로고    scopus 로고
    • Structure and function of parkin, PINK1, and DJ-1, the three musketeers of neuroprotection
    • Trempe J. F., and, Fon E. A., (2013) Structure and function of parkin, PINK1, and DJ-1, the three musketeers of neuroprotection. Front Neurol. 4, 38.
    • (2013) Front Neurol. , vol.4 , pp. 38
    • Trempe, J.F.1    Fon, E.A.2
  • 144
    • 38449122692 scopus 로고    scopus 로고
    • Tyrosinase is not detected in human catecholaminergic neurons by immunohistochemistry and Western blot analysis
    • Tribl F., Arzberger T., Riederer P., and, Gerlach M., (2007) Tyrosinase is not detected in human catecholaminergic neurons by immunohistochemistry and Western blot analysis. J. Neural Transm. Suppl. 72, 51-55.
    • (2007) J. Neural Transm. Suppl. , vol.72 , pp. 51-55
    • Tribl, F.1    Arzberger, T.2    Riederer, P.3    Gerlach, M.4
  • 145
    • 84881376726 scopus 로고    scopus 로고
    • Advances in the genetics of Parkinson disease
    • Trinh J., and, Farrer M., (2013) Advances in the genetics of Parkinson disease. Nat Rev. Neurol. 9, 445-454.
    • (2013) Nat Rev. Neurol. , vol.9 , pp. 445-454
    • Trinh, J.1    Farrer, M.2
  • 146
    • 0016907344 scopus 로고
    • Potential oxidative pathways of brain catecholamines
    • Tse D. C., McCreery R. L., and, Adams R. N., (1976) Potential oxidative pathways of brain catecholamines. J. Med. Chem. 19, 37-40.
    • (1976) J. Med. Chem. , vol.19 , pp. 37-40
    • Tse, D.C.1    McCreery, R.L.2    Adams, R.N.3
  • 147
    • 2442668926 scopus 로고    scopus 로고
    • Hereditary early-onset Parkinson's disease caused by mutations in PINK1
    • Valente E. M., Abou-Sleiman P. M., Caputo V., et al,. (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304, 1158-1160.
    • (2004) Science , vol.304 , pp. 1158-1160
    • Valente, E.M.1    Abou-Sleiman, P.M.2    Caputo, V.3
  • 148
    • 39249083911 scopus 로고    scopus 로고
    • Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: Implications for Parkinson disease
    • Van Laar V. S., Dukes A. A., Cascio M., and, Hastings T. G., (2008) Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: implications for Parkinson disease. Neurobiol. Dis. 29, 477-489.
    • (2008) Neurobiol. Dis. , vol.29 , pp. 477-489
    • Van Laar, V.S.1    Dukes, A.A.2    Cascio, M.3    Hastings, T.G.4
  • 149
    • 67349280174 scopus 로고    scopus 로고
    • Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells
    • Van Laar V. S., Mishizen A. J., Cascio M., and, Hastings T. G., (2009) Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells. Neurobiol. Dis. 34, 487-500.
    • (2009) Neurobiol. Dis. , vol.34 , pp. 487-500
    • Van Laar, V.S.1    Mishizen, A.J.2    Cascio, M.3    Hastings, T.G.4
  • 150
    • 0042731682 scopus 로고    scopus 로고
    • The structure of neuromelanin as studied by chemical degradative methods
    • Wakamatsu K., Fujikawa K., Zucca F. A., Zecca L., and, Ito S., (2003) The structure of neuromelanin as studied by chemical degradative methods. J. Neurochem. 86, 1015-1023.
    • (2003) J. Neurochem. , vol.86 , pp. 1015-1023
    • Wakamatsu, K.1    Fujikawa, K.2    Zucca, F.A.3    Zecca, L.4    Ito, S.5
  • 152
    • 80055014261 scopus 로고    scopus 로고
    • Quinoprotein adducts accumulate in the substantia nigra of aged rats and correlate with dopamine-induced toxicity in SH-SY5Y cells
    • Wang N., Wang Y., Yu G., Yuan C., and, Ma J., (2011) Quinoprotein adducts
    • (2011) Neurochem. Res. , vol.36 , pp. 2169-2175
    • Wang, N.1    Wang, Y.2    Yu, G.3    Yuan, C.4    Ma, J.5
  • 153
    • 34548154319 scopus 로고    scopus 로고
    • Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain
    • Ward W. C., Guan Z., Zucca F. A., Fariello R. G., Kordestani R., Zecca L., Raetz C. R., and, Simon J. D., (2007) Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain. J. Lipid Res. 48, 1457-1462.
    • (2007) J. Lipid Res. , vol.48 , pp. 1457-1462
    • Ward, W.C.1    Guan, Z.2    Zucca, F.A.3    Fariello, R.G.4    Kordestani, R.5    Zecca, L.6    Raetz, C.R.7    Simon, J.D.8
  • 154
    • 84864094542 scopus 로고    scopus 로고
    • Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease
    • Weinreb O., Amit T., Riederer P., Youdim M. B., and, Mandel S. A., (2011) Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease. Int. Rev. Neurobiol. 100, 127-149.
    • (2011) Int. Rev. Neurobiol. , vol.100 , pp. 127-149
    • Weinreb, O.1    Amit, T.2    Riederer, P.3    Youdim, M.B.4    Mandel, S.A.5
  • 155
    • 0023942459 scopus 로고
    • Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem
    • Westlund K. N., Denney R. M., Rose R. M., and, Abell C. W., (1988) Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem. Neuroscience 25, 439-456.
    • (1988) Neuroscience , vol.25 , pp. 439-456
    • Westlund, K.N.1    Denney, R.M.2    Rose, R.M.3    Abell, C.W.4
  • 156
    • 0025074333 scopus 로고
    • Biochemistry and genetics of monoamine oxidase
    • Weyler W., Hsu Y. P., and, Breakefield X. O., (1990) Biochemistry and genetics of monoamine oxidase. Pharmacol. Ther. 47, 391-417.
    • (1990) Pharmacol. Ther. , vol.47 , pp. 391-417
    • Weyler, W.1    Hsu, Y.P.2    Breakefield, X.O.3
  • 157
    • 0035112815 scopus 로고    scopus 로고
    • Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter
    • Whitehead R. E., Ferrer J. V., Javitch J. A., and, Justice J. B., (2001) Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter. J. Neurochem. 76, 1242-1251.
    • (2001) J. Neurochem. , vol.76 , pp. 1242-1251
    • Whitehead, R.E.1    Ferrer, J.V.2    Javitch, J.A.3    Justice, J.B.4
  • 158
    • 0037366093 scopus 로고    scopus 로고
    • Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-Activated protein kinase: Implications for Parkinson's disease
    • Wilms H., Rosenstiel P., Sievers J., Deuschl G., Zecca L., and, Lucius R., (2003) Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-Activated protein kinase: implications for Parkinson's disease. Faseb J. 17, 500-502.
    • (2003) Faseb J. , vol.17 , pp. 500-502
    • Wilms, H.1    Rosenstiel, P.2    Sievers, J.3    Deuschl, G.4    Zecca, L.5    Lucius, R.6
  • 159
    • 33750351505 scopus 로고    scopus 로고
    • Parkinson's disease: Premotor clinico-pathological correlations
    • Wolters E. Ch., and, Braak H., (2006) Parkinson's disease: premotor clinico-pathological correlations. J. Neural Transm. Suppl. 70, 309-319.
    • (2006) J. Neural Transm. Suppl. , vol.70 , pp. 309-319
    • Wolters, E.Ch.1    Braak, H.2
  • 161
    • 0032403510 scopus 로고    scopus 로고
    • Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase
    • Xu Y., Stokes A. H., Roskoski R., Jr, and, Vrana K. E., (1998) Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase. J. Neurosci. Res. 54, 691-697.
    • (1998) J. Neurosci. Res. , vol.54 , pp. 691-697
    • Xu, Y.1    Stokes, A.H.2    Roskoski, Jr.R.3    Vrana, K.E.4
  • 162
    • 33747624165 scopus 로고    scopus 로고
    • A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition
    • Zafar K. S., Siegel D., and, Ross D., (2006) A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition. Mol. Pharmacol. 70, 1079-1086.
    • (2006) Mol. Pharmacol. , vol.70 , pp. 1079-1086
    • Zafar, K.S.1    Siegel, D.2    Ross, D.3
  • 163
    • 0028999659 scopus 로고
    • The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systems
    • Zareba M., Bober A., Korytowski W., Zecca L., and, Sarna T., (1995) The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systems. Biochim. Biophys. Acta 1271, 343-348.
    • (1995) Biochim. Biophys. Acta , vol.1271 , pp. 343-348
    • Zareba, M.1    Bober, A.2    Korytowski, W.3    Zecca, L.4    Sarna, T.5
  • 164
    • 0028006428 scopus 로고
    • Iron and other metals in neuromelanin, substantia nigra, and putamen of human brain
    • Zecca L., Pietra R., Goj C., Mecacci C., Radice D., and, Sabbioni E., (1994) Iron and other metals in neuromelanin, substantia nigra, and putamen of human brain. J. Neurochem. 62, 1097-1101.
    • (1994) J. Neurochem. , vol.62 , pp. 1097-1101
    • Zecca, L.1    Pietra, R.2    Goj, C.3    Mecacci, C.4    Radice, D.5    Sabbioni, E.6
  • 165
    • 0034024975 scopus 로고    scopus 로고
    • Interaction of human substantia nigra neuromelanin with lipids and peptides
    • Zecca L., Costi P., Mecacci C., Ito S., Terreni M., and, Sonnino S., (2000) Interaction of human substantia nigra neuromelanin with lipids and peptides. J. Neurochem. 74, 1758-1765.
    • (2000) J. Neurochem. , vol.74 , pp. 1758-1765
    • Zecca, L.1    Costi, P.2    Mecacci, C.3    Ito, S.4    Terreni, M.5    Sonnino, S.6
  • 166
    • 0034880274 scopus 로고    scopus 로고
    • Combined biochemical separation and INAA for the determination of iron and other metals in Neuromelanin of human brain Substantia Nigra
    • Zecca L., Tampellini D., Costi P., Rizzio E., Giaveri G., and, Gallorini M., (2001a) Combined biochemical separation and INAA for the determination of iron and other metals in Neuromelanin of human brain Substantia Nigra. J. Radioanal. Nucl. Chem. 249, 449-454.
    • (2001) J. Radioanal. Nucl. Chem. , vol.249 , pp. 449-454
    • Zecca, L.1    Tampellini, D.2    Costi, P.3    Rizzio, E.4    Giaveri, G.5    Gallorini, M.6
  • 167
    • 0035103932 scopus 로고    scopus 로고
    • Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: Consequences for iron storage and neurodegenerative processes
    • Zecca L., Gallorini M., Schünemann V., Trautwein A. X., Gerlach M., Riederer P., Vezzoni P., and, Tampellini D., (2001b) Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes. J. Neurochem. 76, 1766-1773.
    • (2001) J. Neurochem. , vol.76 , pp. 1766-1773
    • Zecca, L.1    Gallorini, M.2    Schünemann, V.3    Trautwein, A.X.4    Gerlach, M.5    Riederer, P.6    Vezzoni, P.7    Tampellini, D.8
  • 168
    • 0037116582 scopus 로고    scopus 로고
    • The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease
    • Zecca L., Fariello R., Riederer P., Sulzer D., Gatti A., and, Tampellini D., (2002) The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease. FEBS Lett. 510, 216-220.
    • (2002) FEBS Lett. , vol.510 , pp. 216-220
    • Zecca, L.1    Fariello, R.2    Riederer, P.3    Sulzer, D.4    Gatti, A.5    Tampellini, D.6
  • 170
    • 56249140814 scopus 로고    scopus 로고
    • New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals
    • Zecca L., Bellei C., Costi P., et al,. (2008a) New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals. Proc. Natl Acad. Sci. USA 105, 17567-17572.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 17567-17572
    • Zecca, L.1    Bellei, C.2    Costi, P.3
  • 171
    • 48749123360 scopus 로고    scopus 로고
    • Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease
    • Zecca L., Casella L., Albertini A., Bellei C., Zucca F. A., Engelen M., Zadlo A., Szewczyk G., Zareba M., and, Sarna T., (2008b) Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease. J. Neurochem. 106, 1866-1875.
    • (2008) J. Neurochem. , vol.106 , pp. 1866-1875
    • Zecca, L.1    Casella, L.2    Albertini, A.3    Bellei, C.4    Zucca, F.A.5    Engelen, M.6    Zadlo, A.7    Szewczyk, G.8    Zareba, M.9    Sarna, T.10
  • 172
    • 47749110631 scopus 로고    scopus 로고
    • Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: Implications for Parkinson's disease
    • Zecca L., Wilms H., Geick S., et al,. (2008c) Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta Neuropathol. 116, 47-55.
    • (2008) Acta Neuropathol. , vol.116 , pp. 47-55
    • Zecca, L.1    Wilms, H.2    Geick, S.3
  • 173
    • 78650527643 scopus 로고    scopus 로고
    • Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: Implications for progression of Parkinson's disease
    • Zhang W., Phillips K., Wielgus A. R., et al,. (2011) Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotox. Res. 19, 63-72.
    • (2011) Neurotox. Res. , vol.19 , pp. 63-72
    • Zhang, W.1    Phillips, K.2    Wielgus, A.R.3
  • 175
    • 67650153168 scopus 로고    scopus 로고
    • Dopamine (DA) induced irreversible proteasome inhibition via da derived quinones
    • Zhou Z. D., and, Lim T. M., (2009) Dopamine (DA) induced irreversible proteasome inhibition via DA derived quinones. Free Radic. Res. 43, 417-430.
    • (2009) Free Radic. Res. , vol.43 , pp. 417-430
    • Zhou, Z.D.1    Lim, T.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.