-
1
-
-
7944233158
-
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
-
Selkoe, D. J. (2004) Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases Nat. Cell Biol. 6, 1054-1061
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1054-1061
-
-
Selkoe, D.J.1
-
2
-
-
0026760261
-
Production of the Alzheimer amyloid β protein by normal proteolytic processing
-
Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X. D., McKay, D. M., Tintner, R., and Frangione, B. 1992, Production of the Alzheimer amyloid β protein by normal proteolytic processing Science 258, 126-129
-
(1992)
Science
, vol.258
, pp. 126-129
-
-
Shoji, M.1
Golde, T.E.2
Ghiso, J.3
Cheung, T.T.4
Estus, S.5
Shaffer, L.M.6
Cai, X.D.7
McKay, D.M.8
Tintner, R.9
Frangione, B.10
-
3
-
-
0032211830
-
The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease
-
Selkoe, D. J. (1998) The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease Trends Cell Biol. 8, 447-453
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 447-453
-
-
Selkoe, D.J.1
-
4
-
-
0037551741
-
Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders
-
Caughey, B. and Lansbury, P. T. (2003) Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders Annu. Rev. Neurosci. 26, 267-298
-
(2003)
Annu. Rev. Neurosci.
, vol.26
, pp. 267-298
-
-
Caughey, B.1
Lansbury, P.T.2
-
5
-
-
33746377894
-
Protein misfolding, functional amyloid, and human disease
-
Chiti, F. and Dobson, C. M. (2006) Protein misfolding, functional amyloid, and human disease Annu. Rev. Biochem. 75, 333-366
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 333-366
-
-
Chiti, F.1
Dobson, C.M.2
-
6
-
-
34248547813
-
Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases
-
Ferreira, S. T., Vieira, M. N., and De Felice, F. G. (2007) Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases IUBMB Life 59, 332-345
-
(2007)
IUBMB Life
, vol.59
, pp. 332-345
-
-
Ferreira, S.T.1
Vieira, M.N.2
De Felice, F.G.3
-
7
-
-
57649148788
-
Structural classification of toxic amyloid oligomers
-
Glabe, C. G. (2008) Structural classification of toxic amyloid oligomers J. Biol. Chem. 283, 29639-29643
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 29639-29643
-
-
Glabe, C.G.1
-
8
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide
-
Haass, C. and Selkoe, D. J. (2007) Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid β-peptide Nat. Rev. Mol. Cell Biol. 8, 101-112
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
9
-
-
34250819839
-
Intracellular amyloid-β in Alzheimer's disease
-
Laferla, F. M., Green, K. N., and Oddo, S. (2007) Intracellular amyloid-β in Alzheimer's disease Nat. Rev. Neurosci. 8, 499-509
-
(2007)
Nat. Rev. Neurosci.
, vol.8
, pp. 499-509
-
-
Laferla, F.M.1
Green, K.N.2
Oddo, S.3
-
10
-
-
63849197629
-
Amyloid β-protein assembly and Alzheimer disease
-
Roychaudhuri, R., Yang, M., Hoshi, M. M., and Teplow, D. B. (2009) Amyloid β-protein assembly and Alzheimer disease J. Biol. Chem. 284, 4749-4753
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 4749-4753
-
-
Roychaudhuri, R.1
Yang, M.2
Hoshi, M.M.3
Teplow, D.B.4
-
11
-
-
77749308402
-
Amyloid oligomers: Formation and toxicity of Aβ oligomers
-
Sakono, M. and Zako, T. (2010) Amyloid oligomers: Formation and toxicity of Aβ oligomers FEBS J. 277, 1348-1358
-
(2010)
FEBS J.
, vol.277
, pp. 1348-1358
-
-
Sakono, M.1
Zako, T.2
-
12
-
-
0033570337
-
Protofibrillar intermediates of amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
-
Hartley, D. M., Walsh, D. M., Ye, C. P., Diehl, T., Vasquez, S., Vassilev, P. M., Teplow, D. B., and Selkoe, D. J. (1999) Protofibrillar intermediates of amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons J. Neurosci. 19, 8876-8884
-
(1999)
J. Neurosci.
, vol.19
, pp. 8876-8884
-
-
Hartley, D.M.1
Walsh, D.M.2
Ye, C.P.3
Diehl, T.4
Vasquez, S.5
Vassilev, P.M.6
Teplow, D.B.7
Selkoe, D.J.8
-
13
-
-
0242424155
-
Self-assembly of Aβ(1-42) into globular neurotoxins
-
Chromy, B. A., Nowak, R. J., Lambert, M. P., Viola, K. L., Chang, L., Velasco, P. T., Jones, B. W., Fernandez, S. J., Lacor, P. N., Horowitz, P., Finch, C. E., Krafft, G. A., and Klein, W. L. (2003) Self-assembly of Aβ(1-42) into globular neurotoxins Biochemistry 42, 12749-12760
-
(2003)
Biochemistry
, vol.42
, pp. 12749-12760
-
-
Chromy, B.A.1
Nowak, R.J.2
Lambert, M.P.3
Viola, K.L.4
Chang, L.5
Velasco, P.T.6
Jones, B.W.7
Fernandez, S.J.8
Lacor, P.N.9
Horowitz, P.10
Finch, C.E.11
Krafft, G.A.12
Klein, W.L.13
-
14
-
-
34047249085
-
A ganglioside-induced toxic soluble Aβ assembly. Its enhanced formation from Aβ bearing the Arctic mutation
-
Yamamoto, N., Matsubara, E., Maeda, S., Minagawa, H., Takashima, A., Maruyama, W., Michikawa, M., and Yanagisawa, K. (2007) A ganglioside-induced toxic soluble Aβ assembly. Its enhanced formation from Aβ bearing the Arctic mutation J. Biol. Chem. 282, 2646-2655
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 2646-2655
-
-
Yamamoto, N.1
Matsubara, E.2
Maeda, S.3
Minagawa, H.4
Takashima, A.5
Maruyama, W.6
Michikawa, M.7
Yanagisawa, K.8
-
15
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
-
Lambert, M. P., Barlow, A. K., Chromy, B. A., Edwards, C., Freed, R., Liosatos, M., Morgan, T. E., Rozovsky, I., Trommer, B., Viola, K. L., Wals, P., Zhang, C., Finch, C. E., Krafft, G. A., and Klein, W. L. (1998) Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins Proc. Natl. Acad. Sci. U.S.A. 95, 6448-6453
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
16
-
-
0035993237
-
Aβ toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets
-
Klein, W. L. (2002) Aβ toxicity in Alzheimer's disease: Globular oligomers (ADDLs) as new vaccine and drug targets Neurochem. Int. 41, 345-352
-
(2002)
Neurochem. Int.
, vol.41
, pp. 345-352
-
-
Klein, W.L.1
-
17
-
-
0037975676
-
Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β
-
Hoshi, M., Sato, M., Matsumoto, S., Noguchi, A., Yasutake, K., Yoshida, N., and Sato, K. (2003) Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β Proc. Natl. Acad. Sci. U.S.A. 100, 6370-6375
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 6370-6375
-
-
Hoshi, M.1
Sato, M.2
Matsumoto, S.3
Noguchi, A.4
Yasutake, K.5
Yoshida, N.6
Sato, K.7
-
18
-
-
79952196722
-
Extracellular and intraneuronal HMW-AβOs represent a molecular basis of memory loss in Alzheimer's disease model mouse
-
Takamura, A., Okamoto, Y., Kawarabayashi, T., Yokoseki, T., Shibata, M., Mouri, A., Nabeshima, T., Sun, H., Abe, K., Urisu, T., Yamamoto, N., Shoji, M., Yanagisawa, K., Michikawa, M., and Matsubara, E. (2011) Extracellular and intraneuronal HMW-AβOs represent a molecular basis of memory loss in Alzheimer's disease model mouse Mol. Neurodegener. 6, 20
-
(2011)
Mol. Neurodegener.
, vol.6
, pp. 20
-
-
Takamura, A.1
Okamoto, Y.2
Kawarabayashi, T.3
Yokoseki, T.4
Shibata, M.5
Mouri, A.6
Nabeshima, T.7
Sun, H.8
Abe, K.9
Urisu, T.10
Yamamoto, N.11
Shoji, M.12
Yanagisawa, K.13
Michikawa, M.14
Matsubara, E.15
-
19
-
-
78049326855
-
Amyloid β-Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils
-
O'Nullain, B. 2010, Amyloid β-Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils J. Neurosci. 14411-14419
-
(2010)
J. Neurosci.
, pp. 14411-14419
-
-
O'Nullain, B.1
-
20
-
-
77954358960
-
Mysterious oligomerization of the amyloidogenic proteins
-
Uversky, V. N. (2010) Mysterious oligomerization of the amyloidogenic proteins FEBS J. 277, 2940-2953
-
(2010)
FEBS J.
, vol.277
, pp. 2940-2953
-
-
Uversky, V.N.1
-
21
-
-
33646127577
-
Molecular chaperones and protein quality control
-
Bukau, B., Weissman, J., and Horwich, A. (2006) Molecular chaperones and protein quality control Cell 125, 443-451
-
(2006)
Cell
, vol.125
, pp. 443-451
-
-
Bukau, B.1
Weissman, J.2
Horwich, A.3
-
22
-
-
0037040541
-
Molecular chaperones in the cytosol: From nascent chain to folded protein
-
Hartl, F. U. and Hayer-Hartl, M. (2002) Molecular chaperones in the cytosol: From nascent chain to folded protein Science 295, 1852-1858
-
(2002)
Science
, vol.295
, pp. 1852-1858
-
-
Hartl, F.U.1
Hayer-Hartl, M.2
-
23
-
-
33749538453
-
Convergent evolution of clamp-like binding sites in diverse chaperones
-
Stirling, P. C., Bakhoum, S. F., Feigl, A. B., and Leroux, M. R. (2006) Convergent evolution of clamp-like binding sites in diverse chaperones Nat. Struct. Mol. Biol. 13, 865-870
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 865-870
-
-
Stirling, P.C.1
Bakhoum, S.F.2
Feigl, A.B.3
Leroux, M.R.4
-
24
-
-
0037007283
-
Molecular chaperones: Cellular machines for protein folding
-
Walter, S. and Buchner, J. (2002) Molecular chaperones: Cellular machines for protein folding Angew. Chem., Int. Ed. 41, 1098-1113
-
(2002)
Angew. Chem., Int. Ed.
, vol.41
, pp. 1098-1113
-
-
Walter, S.1
Buchner, J.2
-
25
-
-
78149422466
-
Dealing with misfolded proteins: Examining the neuroprotective role of molecular chaperones in neurodegeneration
-
Ali, Y. O., Kitay, B. M., and Zhai, R. G. (2011) Dealing with misfolded proteins: Examining the neuroprotective role of molecular chaperones in neurodegeneration Molecules 15, 6859-6887
-
(2011)
Molecules
, vol.15
, pp. 6859-6887
-
-
Ali, Y.O.1
Kitay, B.M.2
Zhai, R.G.3
-
26
-
-
11144243412
-
Modulation of neurodegeneration by molecular chaperones
-
Muchowski, P. J. and Wacker, J. L. (2005) Modulation of neurodegeneration by molecular chaperones Nat. Rev. Neurosci. 6, 11-22
-
(2005)
Nat. Rev. Neurosci.
, vol.6
, pp. 11-22
-
-
Muchowski, P.J.1
Wacker, J.L.2
-
27
-
-
78149466716
-
αb-Crystallin inhibits the cell toxicity associated with amyloid fibril formation by κ-casein and the amyloid-β peptide
-
Dehle, F. C., Ecroyd, H., Musgrave, I. F., and Carver, J. A. (2010) αB-Crystallin inhibits the cell toxicity associated with amyloid fibril formation by κ-casein and the amyloid-β peptide Cell Stress Chaperones 15, 1013-1026
-
(2010)
Cell Stress Chaperones
, vol.15
, pp. 1013-1026
-
-
Dehle, F.C.1
Ecroyd, H.2
Musgrave, I.F.3
Carver, J.A.4
-
28
-
-
70449461063
-
The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of β-amyloid peptide
-
King, M., Nafar, F., Clarke, J., and Mearow, K. (2009) The small heat shock protein Hsp27 protects cortical neurons against the toxic effects of β-amyloid peptide J. Neurosci. Res. 87, 3161-3175
-
(2009)
J. Neurosci. Res.
, vol.87
, pp. 3161-3175
-
-
King, M.1
Nafar, F.2
Clarke, J.3
Mearow, K.4
-
29
-
-
79960298697
-
Sequestration of Toxic Oligomers by HspB1 as a Cytoprotective Mechanism
-
Ojha, J., Masilamoni, G., Dunlap, D., Udoff, R. A., and Cashikar, A. G. (2011) Sequestration of Toxic Oligomers by HspB1 as a Cytoprotective Mechanism Mol. Cell. Biol. 31, 3146-3157
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 3146-3157
-
-
Ojha, J.1
Masilamoni, G.2
Dunlap, D.3
Udoff, R.A.4
Cashikar, A.G.5
-
30
-
-
0032577573
-
Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin
-
Vainberg, I. E., Lewis, S. A., Rommelaere, H., Ampe, C., Vandekerckhove, J., Klein, H. L., and Cowan, N. J. (1998) Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin Cell 93, 863-873
-
(1998)
Cell
, vol.93
, pp. 863-873
-
-
Vainberg, I.E.1
Lewis, S.A.2
Rommelaere, H.3
Ampe, C.4
Vandekerckhove, J.5
Klein, H.L.6
Cowan, N.J.7
-
31
-
-
0033521523
-
Compartmentation of protein folding in vivo: Sequestration of non-native polypeptide by the chaperonin-GimC system
-
Siegers, K., Waldmann, T., Leroux, M. R., Grein, K., Shevchenko, A., Schiebel, E., and Hartl, F. U. (1999) Compartmentation of protein folding in vivo: Sequestration of non-native polypeptide by the chaperonin-GimC system EMBO J. 18, 75-84
-
(1999)
EMBO J.
, vol.18
, pp. 75-84
-
-
Siegers, K.1
Waldmann, T.2
Leroux, M.R.3
Grein, K.4
Shevchenko, A.5
Schiebel, E.6
Hartl, F.U.7
-
32
-
-
0345201713
-
MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin
-
Leroux, M. R., Fandrich, M., Klunker, D., Siegers, K., Lupas, A. N., Brown, J. R., Schiebel, E., Dobson, C. M., and Hartl, F. U. (1999) MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin EMBO J. 18, 6730-6743
-
(1999)
EMBO J.
, vol.18
, pp. 6730-6743
-
-
Leroux, M.R.1
Fandrich, M.2
Klunker, D.3
Siegers, K.4
Lupas, A.N.5
Brown, J.R.6
Schiebel, E.7
Dobson, C.M.8
Hartl, F.U.9
-
33
-
-
0037010171
-
Structure and function of a protein folding machine: The eukaryotic cytosolic chaperonin CCT
-
Valpuesta, J. M., Martin-Benito, J., Gomez-Puertas, P., Carrascosa, J. L., and Willison, K. R. (2002) Structure and function of a protein folding machine: The eukaryotic cytosolic chaperonin CCT FEBS Lett. 529, 11-16
-
(2002)
FEBS Lett.
, vol.529
, pp. 11-16
-
-
Valpuesta, J.M.1
Martin-Benito, J.2
Gomez-Puertas, P.3
Carrascosa, J.L.4
Willison, K.R.5
-
34
-
-
33846238951
-
Divergent substrate-binding mechanisms reveal an evolutionary specialization of eukaryotic prefoldin compared to its archaeal counterpart
-
Martin-Benito, J., Gomez-Reino, J., Stirling, P. C., Lundin, V. F., Gomez-Puertas, P., Boskovic, J., Chacon, P., Fernandez, J. J., Berenguer, J., Leroux, M. R., and Valpuesta, J. M. (2007) Divergent substrate-binding mechanisms reveal an evolutionary specialization of eukaryotic prefoldin compared to its archaeal counterpart Structure 15, 101-110
-
(2007)
Structure
, vol.15
, pp. 101-110
-
-
Martin-Benito, J.1
Gomez-Reino, J.2
Stirling, P.C.3
Lundin, V.F.4
Gomez-Puertas, P.5
Boskovic, J.6
Chacon, P.7
Fernandez, J.J.8
Berenguer, J.9
Leroux, M.R.10
Valpuesta, J.M.11
-
35
-
-
1842585903
-
Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin
-
Lundin, V. F., Stirling, P. C., Gomez-Reino, J., Mwenifumbo, J. C., Obst, J. M., Valpuesta, J. M., and Leroux, M. R. (2004) Molecular clamp mechanism of substrate binding by hydrophobic coiled-coil residues of the archaeal chaperone prefoldin Proc. Natl. Acad. Sci. U.S.A. 101, 4367-4372
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 4367-4372
-
-
Lundin, V.F.1
Stirling, P.C.2
Gomez-Reino, J.3
Mwenifumbo, J.C.4
Obst, J.M.5
Valpuesta, J.M.6
Leroux, M.R.7
-
36
-
-
3843093899
-
Kinetics and binding sites for interaction of the prefoldin with a group II chaperonin: Contiguous non-native substrate and chaperonin binding sites in the archaeal prefoldin
-
Okochi, M., Nomura, T., Zako, T., Arakawa, T., Iizuka, R., Ueda, H., Funatsu, T., Leroux, M., and Yohda, M. (2004) Kinetics and binding sites for interaction of the prefoldin with a group II chaperonin: Contiguous non-native substrate and chaperonin binding sites in the archaeal prefoldin J. Biol. Chem. 279, 31788-31795
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31788-31795
-
-
Okochi, M.1
Nomura, T.2
Zako, T.3
Arakawa, T.4
Iizuka, R.5
Ueda, H.6
Funatsu, T.7
Leroux, M.8
Yohda, M.9
-
37
-
-
55949096479
-
Formation of highly toxic soluble amyloid β oligomers by the molecular chaperone prefoldin
-
Sakono, M., Zako, T., Ueda, H., Yohda, M., and Maeda, M. (2008) Formation of highly toxic soluble amyloid β oligomers by the molecular chaperone prefoldin FEBS J. 275, 5982-5993
-
(2008)
FEBS J.
, vol.275
, pp. 5982-5993
-
-
Sakono, M.1
Zako, T.2
Ueda, H.3
Yohda, M.4
Maeda, M.5
-
38
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K. H., Mistl, C., Rothacher, S., Ledermann, B., Burki, K., Frey, P., Paganetti, P. A., Waridel, C., Calhoun, M. E., Jucker, M., Probst, A., Staufenbiel, M., and Sommer, B. (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology Proc. Natl. Acad. Sci. U.S.A. 94, 13287-13292
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.H.4
Mistl, C.5
Rothacher, S.6
Ledermann, B.7
Burki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
39
-
-
1042278172
-
Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding
-
Simons, C. T., Staes, A., Rommelaere, H., Ampe, C., Lewis, S. A., and Cowan, N. J. (2004) Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding J. Biol. Chem. 279, 4196-4203
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 4196-4203
-
-
Simons, C.T.1
Staes, A.2
Rommelaere, H.3
Ampe, C.4
Lewis, S.A.5
Cowan, N.J.6
-
40
-
-
0035659917
-
Clearance of extracellular and cell-associated amyloid β peptide through viral expression of neprilysin in primary neurons
-
Hama, E., Shirotani, K., Masumoto, H., Sekine-Aizawa, Y., Aizawa, H., and Saido, T. C. (2001) Clearance of extracellular and cell-associated amyloid β peptide through viral expression of neprilysin in primary neurons J. Biochem. 130, 721-726
-
(2001)
J. Biochem.
, vol.130
, pp. 721-726
-
-
Hama, E.1
Shirotani, K.2
Masumoto, H.3
Sekine-Aizawa, Y.4
Aizawa, H.5
Saido, T.C.6
-
41
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., and Glabe, C. G. (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis Science 300, 486-489
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
42
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., and Selkoe, D. J. (2002) Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo Nature 416, 535-539
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
Cullen, W.K.4
Anwyl, R.5
Wolfe, M.S.6
Rowan, M.J.7
Selkoe, D.J.8
-
43
-
-
33846633336
-
Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
-
Lacor, P. N., Buniel, M. C., Furlow, P. W., Clemente, A. S., Velasco, P. T., Wood, M., Viola, K. L., and Klein, W. L. (2007) Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease J. Neurosci. 27, 796-807
-
(2007)
J. Neurosci.
, vol.27
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
Clemente, A.S.4
Velasco, P.T.5
Wood, M.6
Viola, K.L.7
Klein, W.L.8
-
44
-
-
25844494542
-
Sick chaperones, cellular stress, and disease
-
Macario, A. J. and Conway de Macario, E. (2005) Sick chaperones, cellular stress, and disease N. Engl. J. Med. 353, 1489-1501
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 1489-1501
-
-
Macario, A.J.1
Conway De Macario, E.2
-
45
-
-
36248968668
-
Heat shock proteins and amateur chaperones in amyloid-β accumulation and clearance in Alzheimer's disease
-
Wilhelmus, M. M., de Waal, R. M., and Verbeek, M. M. (2007) Heat shock proteins and amateur chaperones in amyloid-β accumulation and clearance in Alzheimer's disease Mol. Neurobiol. 35, 203-216
-
(2007)
Mol. Neurobiol.
, vol.35
, pp. 203-216
-
-
Wilhelmus, M.M.1
De Waal, R.M.2
Verbeek, M.M.3
-
46
-
-
80053601511
-
BRICHOS domain associated with lung fibrosis, dementia and cancer: A chaperone that prevents amyloid fibril formation?
-
Willander, H., Hermansson, E., Johansson, J., and Presto, J. (2011) BRICHOS domain associated with lung fibrosis, dementia and cancer: A chaperone that prevents amyloid fibril formation? FEBS J. 278, 3893-3904
-
(2011)
FEBS J.
, vol.278
, pp. 3893-3904
-
-
Willander, H.1
Hermansson, E.2
Johansson, J.3
Presto, J.4
-
47
-
-
1242274389
-
Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed β-amyloid in neurons
-
Magrane, J., Smith, R. C., Walsh, K., and Querfurth, H. W. (2004) Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed β-amyloid in neurons J. Neurosci. 24, 1700-1706
-
(2004)
J. Neurosci.
, vol.24
, pp. 1700-1706
-
-
Magrane, J.1
Smith, R.C.2
Walsh, K.3
Querfurth, H.W.4
-
48
-
-
33748561495
-
Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers
-
Behrends, C., Langer, C. A., Boteva, R., Bottcher, U. M., Stemp, M. J., Schaffar, G., Rao, B. V., Giese, A., Kretzschmar, H., Siegers, K., and Hartl, F. U. (2006) Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers Mol. Cell 23, 887-897
-
(2006)
Mol. Cell
, vol.23
, pp. 887-897
-
-
Behrends, C.1
Langer, C.A.2
Boteva, R.3
Bottcher, U.M.4
Stemp, M.J.5
Schaffar, G.6
Rao, B.V.7
Giese, A.8
Kretzschmar, H.9
Siegers, K.10
Hartl, F.U.11
-
49
-
-
33749176269
-
Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state
-
Kitamura, A., Kubota, H., Pack, C. G., Matsumoto, G., Hirayama, S., Takahashi, Y., Kimura, H., Kinjo, M., Morimoto, R. I., and Nagata, K. (2006) Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state Nat. Cell Biol. 8, 1163-1170
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1163-1170
-
-
Kitamura, A.1
Kubota, H.2
Pack, C.G.3
Matsumoto, G.4
Hirayama, S.5
Takahashi, Y.6
Kimura, H.7
Kinjo, M.8
Morimoto, R.I.9
Nagata, K.10
-
50
-
-
33749177252
-
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions
-
Tam, S., Geller, R., Spiess, C., and Frydman, J. (2006) The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions Nat. Cell Biol. 8, 1155-1162
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1155-1162
-
-
Tam, S.1
Geller, R.2
Spiess, C.3
Frydman, J.4
-
51
-
-
30744471638
-
Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis
-
Sorgjerd, K., Ghafouri, B., Jonsson, B. H., Kelly, J. W., Blond, S. Y., and Hammarstrom, P. (2006) Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis J. Mol. Biol. 356, 469-482
-
(2006)
J. Mol. Biol.
, vol.356
, pp. 469-482
-
-
Sorgjerd, K.1
Ghafouri, B.2
Jonsson, B.H.3
Kelly, J.W.4
Blond, S.Y.5
Hammarstrom, P.6
-
52
-
-
0028828044
-
Clusterin (apoJ) alters the aggregation of amyloid β-peptide (Aβ1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress
-
Oda, T., Wals, P., Osterburg, H. H., Johnson, S. A., Pasinetti, G. M., Morgan, T. E., Rozovsky, I., Stine, W. B., Snyder, S. W., Holzman, T. F., Krafft, G. A., and Finch, C. E. (1995) Clusterin (apoJ) alters the aggregation of amyloid β-peptide (Aβ1-42) and forms slowly sedimenting Aβ complexes that cause oxidative stress Exp. Neurol. 136, 22-31
-
(1995)
Exp. Neurol.
, vol.136
, pp. 22-31
-
-
Oda, T.1
Wals, P.2
Osterburg, H.H.3
Johnson, S.A.4
Pasinetti, G.M.5
Morgan, T.E.6
Rozovsky, I.7
Stine, W.B.8
Snyder, S.W.9
Holzman, T.F.10
Krafft, G.A.11
Finch, C.E.12
-
53
-
-
0033584258
-
The molecular chaperone αb-crystallin enhances amyloid β neurotoxicity
-
Stege, G. J., Renkawek, K., Overkamp, P. S., Verschuure, P., van Rijk, A. F., Reijnen-Aalbers, A., Boelens, W. C., Bosman, G. J., and de Jong, W. W. (1999) The molecular chaperone αB-crystallin enhances amyloid β neurotoxicity Biochem. Biophys. Res. Commun. 262, 152-156
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.262
, pp. 152-156
-
-
Stege, G.J.1
Renkawek, K.2
Overkamp, P.S.3
Verschuure, P.4
Van Rijk, A.F.5
Reijnen-Aalbers, A.6
Boelens, W.C.7
Bosman, G.J.8
De Jong, W.W.9
-
54
-
-
21244434862
-
Facilitated release of substrate protein from prefoldin by chaperonin
-
Zako, T., Iizuka, R., Okochi, M., Nomura, T., Ueno, T., Tadakuma, H., Yohda, M., and Funatsu, T. (2005) Facilitated release of substrate protein from prefoldin by chaperonin FEBS Lett. 579, 3718-3724
-
(2005)
FEBS Lett.
, vol.579
, pp. 3718-3724
-
-
Zako, T.1
Iizuka, R.2
Okochi, M.3
Nomura, T.4
Ueno, T.5
Tadakuma, H.6
Yohda, M.7
Funatsu, T.8
-
55
-
-
80055020556
-
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins
-
Sinha, S., Lopes, D. H., Du, Z., Pang, E. S., Shanmugam, A., Lomakin, A., Talbiersky, P., Tennstaedt, A., McDaniel, K., Bakshi, R., Kuo, P. Y., Ehrmann, M., Benedek, G. B., Loo, J. A., Klarner, F. G., Schrader, T., Wang, C., and Bitan, G. (2011) Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins J. Am. Chem. Soc. 133, 16958-16969
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 16958-16969
-
-
Sinha, S.1
Lopes, D.H.2
Du, Z.3
Pang, E.S.4
Shanmugam, A.5
Lomakin, A.6
Talbiersky, P.7
Tennstaedt, A.8
McDaniel, K.9
Bakshi, R.10
Kuo, P.Y.11
Ehrmann, M.12
Benedek, G.B.13
Loo, J.A.14
Klarner, F.G.15
Schrader, T.16
Wang, C.17
Bitan, G.18
-
56
-
-
84863229747
-
Atomic view of a toxic amyloid small oligomer
-
Laganowsky, A., Liu, C., Sawaya, M. R., Whitelegge, J. P., Park, J., Zhao, M., Pensalfini, A., Soriaga, A. B., Landau, M., Teng, P. K., Cascio, D., Glabe, C., and Eisenberg, D. (2012) Atomic view of a toxic amyloid small oligomer Science 335, 1228-1231
-
(2012)
Science
, vol.335
, pp. 1228-1231
-
-
Laganowsky, A.1
Liu, C.2
Sawaya, M.R.3
Whitelegge, J.P.4
Park, J.5
Zhao, M.6
Pensalfini, A.7
Soriaga, A.B.8
Landau, M.9
Teng, P.K.10
Cascio, D.11
Glabe, C.12
Eisenberg, D.13
-
57
-
-
84863799510
-
Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity
-
Ladiwala, A. R., Litt, J., Kane, R. S., Aucoin, D. S., Smith, S. O., Ranjan, S., Davis, J., Van Nostrand, W. E., and Tessier, P. M. (2012) Conformational Differences between Two Amyloid β Oligomers of Similar Size and Dissimilar Toxicity J. Biol. Chem. 287, 24765-24773
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 24765-24773
-
-
Ladiwala, A.R.1
Litt, J.2
Kane, R.S.3
Aucoin, D.S.4
Smith, S.O.5
Ranjan, S.6
Davis, J.7
Van Nostrand, W.E.8
Tessier, P.M.9
-
58
-
-
70450257636
-
Isolation and characterization of patient-derived, toxic, high mass amyloid β-protein (Aβ) assembly from Alzheimer disease brains
-
Noguchi, A., Matsumura, S., Dezawa, M., Tada, M., Yanazawa, M., Ito, A., Akioka, M., Kikuchi, S., Sato, M., Ideno, S., Noda, M., Fukunari, A., Muramatsu, S., Itokazu, Y., Sato, K., Takahashi, H., Teplow, D. B., Nabeshima, Y., Kakita, A., Imahori, K., and Hoshi, M. (2009) Isolation and characterization of patient-derived, toxic, high mass amyloid β-protein (Aβ) assembly from Alzheimer disease brains J. Biol. Chem. 284, 32895-32905
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 32895-32905
-
-
Noguchi, A.1
Matsumura, S.2
Dezawa, M.3
Tada, M.4
Yanazawa, M.5
Ito, A.6
Akioka, M.7
Kikuchi, S.8
Sato, M.9
Ideno, S.10
Noda, M.11
Fukunari, A.12
Muramatsu, S.13
Itokazu, Y.14
Sato, K.15
Takahashi, H.16
Teplow, D.B.17
Nabeshima, Y.18
Kakita, A.19
Imahori, K.20
Hoshi, M.21
more..
-
59
-
-
85027929889
-
Aβ oligomer-induced synapse degeneration in Alzheimer's disease
-
Wilcox, K. C., Lacor, P. N., Pitt, J., and Klein, W. L. (2011) Aβ oligomer-induced synapse degeneration in Alzheimer's disease Cell. Mol. Neurobiol. 31, 939-948
-
(2011)
Cell. Mol. Neurobiol.
, vol.31
, pp. 939-948
-
-
Wilcox, K.C.1
Lacor, P.N.2
Pitt, J.3
Klein, W.L.4
-
60
-
-
80053589341
-
Membrane and surface interactions of Alzheimer's Aβ peptide: Insights into the mechanism of cytotoxicity
-
Williams, T. L. and Serpell, L. C. (2011) Membrane and surface interactions of Alzheimer's Aβ peptide: Insights into the mechanism of cytotoxicity FEBS J. 278, 3905-3917
-
(2011)
FEBS J.
, vol.278
, pp. 3905-3917
-
-
Williams, T.L.1
Serpell, L.C.2
-
61
-
-
79953844411
-
Comparative studies of nontoxic and toxic amyloids interacting with membrane models at the air-water interface
-
Ta, H. P., Berthelot, K., Coulary-Salin, B., Desbat, B., Gean, J., Servant, L., Cullin, C., and Lecomte, S. (2011) Comparative studies of nontoxic and toxic amyloids interacting with membrane models at the air-water interface Langmuir 27, 4797-4807
-
(2011)
Langmuir
, vol.27
, pp. 4797-4807
-
-
Ta, H.P.1
Berthelot, K.2
Coulary-Salin, B.3
Desbat, B.4
Gean, J.5
Servant, L.6
Cullin, C.7
Lecomte, S.8
-
62
-
-
77952320068
-
Molecular mechanism of Thioflavin-T binding to amyloid fibrils
-
Biancalana, M. and Koide, S. (2010) Molecular mechanism of Thioflavin-T binding to amyloid fibrils Biochim. Biophys. Acta 1804, 1405-1412
-
(2010)
Biochim. Biophys. Acta
, vol.1804
, pp. 1405-1412
-
-
Biancalana, M.1
Koide, S.2
-
63
-
-
84861206757
-
Toxic fibrillar oligomers of amyloid-β have cross-β structure
-
Stroud, J. C., Liu, C., Teng, P. K., and Eisenberg, D. (2012) Toxic fibrillar oligomers of amyloid-β have cross-β structure Proc. Natl. Acad. Sci. U.S.A. 109, 7717-7722
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 7717-7722
-
-
Stroud, J.C.1
Liu, C.2
Teng, P.K.3
Eisenberg, D.4
-
64
-
-
27644583266
-
Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers
-
Iqbal, K., Flory, M., Khatoon, S., Soininen, H., Pirttila, T., Lehtovirta, M., Alafuzoff, I., Blennow, K., Andreasen, N., Vanmechelen, E., and Grundke-Iqbal, I. (2005) Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers Ann. Neurol. 58, 748-757
-
(2005)
Ann. Neurol.
, vol.58
, pp. 748-757
-
-
Iqbal, K.1
Flory, M.2
Khatoon, S.3
Soininen, H.4
Pirttila, T.5
Lehtovirta, M.6
Alafuzoff, I.7
Blennow, K.8
Andreasen, N.9
Vanmechelen, E.10
Grundke-Iqbal, I.11
-
65
-
-
0030599039
-
Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein e allele ε4 during 14 months follow-up
-
Blomberg, M., Jensen, M., Basun, H., Lannfelt, L., and Wahlund, L. O. (1996) Increasing cerebrospinal fluid tau levels in a subgroup of Alzheimer patients with apolipoprotein E allele ε4 during 14 months follow-up Neurosci. Lett. 214, 163-166
-
(1996)
Neurosci. Lett.
, vol.214
, pp. 163-166
-
-
Blomberg, M.1
Jensen, M.2
Basun, H.3
Lannfelt, L.4
Wahlund, L.O.5
-
66
-
-
0027374233
-
Detection of tau proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay
-
Vandermeeren, M., Mercken, M., Vanmechelen, E., Six, J., van de Voorde, A., Martin, J. J., and Cras, P. (1993) Detection of tau proteins in normal and Alzheimer's disease cerebrospinal fluid with a sensitive sandwich enzyme-linked immunosorbent assay J. Neurochem. 61, 1828-1834
-
(1993)
J. Neurochem.
, vol.61
, pp. 1828-1834
-
-
Vandermeeren, M.1
Mercken, M.2
Vanmechelen, E.3
Six, J.4
Van De Voorde, A.5
Martin, J.J.6
Cras, P.7
-
67
-
-
33646461282
-
β-Amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
-
Almeida, C. G., Takahashi, R. H., and Gouras, G. K. (2006) β-Amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system J. Neurosci. 26, 4277-4288
-
(2006)
J. Neurosci.
, vol.26
, pp. 4277-4288
-
-
Almeida, C.G.1
Takahashi, R.H.2
Gouras, G.K.3
-
68
-
-
27644522515
-
Amyloid peptide attenuates the proteasome activity in neuronal cells
-
Oh, S., Hong, H. S., Hwang, E., Sim, H. J., Lee, W., Shin, S. J., and Mook-Jung, I. (2005) Amyloid peptide attenuates the proteasome activity in neuronal cells Mech. Ageing Dev. 126, 1292-1299
-
(2005)
Mech. Ageing Dev.
, vol.126
, pp. 1292-1299
-
-
Oh, S.1
Hong, H.S.2
Hwang, E.3
Sim, H.J.4
Lee, W.5
Shin, S.J.6
Mook-Jung, I.7
-
69
-
-
51449096696
-
Aβ inhibits the proteasome and enhances amyloid and tau accumulation
-
Tseng, B. P., Green, K. N., Chan, J. L., Blurton-Jones, M., and LaFerla, F. M. (2008) Aβ inhibits the proteasome and enhances amyloid and tau accumulation Neurobiol. Aging 29, 1607-1618
-
(2008)
Neurobiol. Aging
, vol.29
, pp. 1607-1618
-
-
Tseng, B.P.1
Green, K.N.2
Chan, J.L.3
Blurton-Jones, M.4
Laferla, F.M.5
-
70
-
-
0035692472
-
A gene expression profile of Alzheimer's disease
-
Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J., and Somogyi, R. (2001) A gene expression profile of Alzheimer's disease DNA Cell Biol. 20, 683-695
-
(2001)
DNA Cell Biol.
, vol.20
, pp. 683-695
-
-
Loring, J.F.1
Wen, X.2
Lee, J.M.3
Seilhamer, J.4
Somogyi, R.5
-
71
-
-
79959654460
-
Association of HSP70 and its co-chaperones with Alzheimer's disease
-
Broer, L., Ikram, M. A., Schuur, M., DeStefano, A. L., Bis, J. C., Liu, F., Rivadeneira, F., Uitterlinden, A. G., Beiser, A. S., Longstreth, W. T., Hofman, A., Aulchenko, Y., Seshadri, S., Fitzpatrick, A. L., Oostra, B. A., Breteler, M. M., and van Duijn, C. M. (2011) Association of HSP70 and its co-chaperones with Alzheimer's disease J. Alzheimer's Dis. 25, 93-102
-
(2011)
J. Alzheimer's Dis.
, vol.25
, pp. 93-102
-
-
Broer, L.1
Ikram, M.A.2
Schuur, M.3
Destefano, A.L.4
Bis, J.C.5
Liu, F.6
Rivadeneira, F.7
Uitterlinden, A.G.8
Beiser, A.S.9
Longstreth, W.T.10
Hofman, A.11
Aulchenko, Y.12
Seshadri, S.13
Fitzpatrick, A.L.14
Oostra, B.A.15
Breteler, M.M.16
Van Duijn, C.M.17
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