Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN

International Journal of Oncology

Volumn 35, Issue 6, 2009, Pages 1331-1341

  Kim, Yun Chul ^a   Kitaura, Hirotake ^a   Taira, Takahiro ^b   Iguchi Ariga, Sanae M M ^a   Ariga, Hiroyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

DJ 1; Oncogene; Oxidative stress; PTEN; Transformation

Indexed keywords

DJ 1 PROTEIN; HYDROGEN PEROXIDE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; DJ 1 PROTEIN, MOUSE; DJ-1 PROTEIN, MOUSE; ONCOPROTEIN; OXIDIZING AGENT;

ANIMAL CELL; ARTICLE; CARCINOGENICITY; CELL PROLIFERATION; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; ONCOGENE; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOPRECIPITATION; MASS SPECTROMETRY; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL TRANSFORMATION, NEOPLASTIC; FLUORESCENT ANTIBODY TECHNIQUE; HYDROGEN PEROXIDE; IMMUNOPRECIPITATION; MICE; NIH 3T3 CELLS; ONCOGENE PROTEINS; OXIDANTS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PTEN PHOSPHOHYDROLASE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 73949097658     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000451     Document Type: Article

References (47)

1. Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguchi-Ariga SMM and Ariga H: DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 231: 509-513, 1997.
2. Bonifati V, Rizzu P, van Baren MJ, et al: Mutations in the DJ-1 gene associated with autosomal recessive early-onset Parkinsonism. Science 299: 256-259, 2003.
3. Taira T, Saito Y, Niki T, Iguchi-Ariga SM, Takahashi K and Ariga H: DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep 5: 213-218, 2004.
4. Kinumi T, Kimata J, Taira T, Ariga H and Niki E: Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem Biophys Res Commun 317: 722-728, 2004.
5. Zhou W and Freed CR: DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. J Biol Chem 280: 43150-43158, 2005.
6. Clements CM, McNally RS, Conti BJ, Mak TW and Ting JP: DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci USA 103: 15091-15096, 2006.
7. Taira T, Iguchi-Ariga SM and Ariga H: Co-localization with DJ-1 is essential for the androgen receptor to exert its transcription activity that has been impaired by androgen antagonists. Biol Pharm Bull 27: 574-577, 2004.
8. Canet-Avilés RM, Wilson MA, Miller DW, et al: The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 101: 9103-9108, 2004.
9. Martinat C, Shendelman S, Jonason A, et al: Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES-derived cell model of primary Parkinsonism. PLoS Biol 2: e327, 2004.
10. Kim RH, Smith PD, Aleyasin H, et al: Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci USA 102: 5215-5220, 2005.
11. Kim RH, Peters M, Jang Y, et al: DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 7: 263-273, 2005.
12. Goldberg MS, Pisani A, Haburcak M, et al: Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45: 489-496, 2005.
13. Andres-Mateos E, Perier C, Zhang L, et al: DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc Natl Acad Sci USA 104: 14807-14812, 2007.
14. Takahashi-Niki K, Niki T, Taira T, Iguchi-Ariga SM and Ariga H: Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinson's disease patients. Biochem Biophys Res Commun 320: 389-397, 2004.
15. Zhou W, Zhu M, Wilson MA, Petsko GA and Fink AL: The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J Mol Biol 356: 1036-1048, 2006.
16. Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM and Ariga H: DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J Biol Chem 276: 37556-37563, 2001.
17. Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM and Ariga H: DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol Cancer Res 1: 247-261, 2003.
18. Tillman JE, Yuan J, Gu G, et al: DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. Cancer Res 67: 4630-4637, 2007.
19. Shinbo Y, Taira T, Niki T, Iguchi-Ariga SM and Ariga H: DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. Int J Oncol 26: 641-648, 2005.
20. Fan J, Ren H, Jia N, et al: DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J Biol Chem 283: 4022-4030, 2008.
21. Li HM, Niki T, Taira T, Iguchi-Ariga SM and Ariga H: Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. Free Radic Res 39: 1091-1109, 2005.
22. Hancock JT, Desikan R and Neill SJ: Role of reactive oxygen species in cell signalling pathways. Biochem Soc Trans 29: 345-350, 2001.
23. Suh YA, Arnold RS, Lassegue B, et al: Cell transformation by the superoxide-generating oxidase Mox1. Nature 401: 79-82, 1999.
24. Woo RA and Poon RY: Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. Genes Dev 18: 1317-1330, 2004.
25. Le Naour F, Misek DE, Krause MC, et al: Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin Cancer Res 7: 3328-3335, 2001.
26. MacKeigan JP, Clements CM, Lich JD, Pope RM, Hod Y and Ting JP: Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha. Cancer Res 63: 6928-6934, 2003.
27. Hod Y: Differential control of apoptosis by DJ-1 in prostate benign and cancer cells. J Cell Biochem 92: 1221-1233, 2004.
28. Zhang HY, Wang HQ, Liu HM, Guan Y and Du ZX: Regulation of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by DJ-1 in thyroid cancer cells. Endocr Relat Cancer 15: 535-544, 2008.
29. Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H and Mouradian MM: Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc Natl Acad Sci USA 102: 9691-9696, 2005.
30. Maehama T and Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378, 1998.
31. Myers MP and Tonks NK: PTEN: sometimes taking it off can be better than putting it on. Am J Hum Genet 61: 1234-1238, 1997.
32. Carnero A, Blanco-Aparicio C, Renner O, Link W and Leal JF: The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 8: 187-198, 2008.
33. Miyazaki S, Yanagida T, Nunome K, et al: DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson's disease model rats. J Neurochem 105: 2418-2434, 2008.
34. Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM and Ariga H: Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y. J Biol Chem 274: 24270-24279, 1999.
35. Shinbo Y, Niki T, Taira T, et al: Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell Death Differ 13: 96-108, 2006.
36. Leslie NR, Bennett D, Lindsay YE, Stewart H, Gray A and Downes CP: Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J 22: 5501-5510, 2003.
37. Lee SR, Yang KS, Kwon J, Lee C, Jeong W and Rhee SG: Reversible inactivation of the tumor suppressor PTEN by H2O2. J Biol Chem 277: 20336-20342, 2002.
38. Kovács KA, Lengyel F, Vértes Z, et al: Phosphorylation of PTEN (phosphatase and tensin homologue deleted on chromosome ten) protein is enhanced in human fibromyomatous uteri. J Steroid Biochem Mol Biol 103: 196-199, 2007.
39. Cantley LC and Neel BG: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96: 4240-4245, 1999.
40. Sansal I and Sellers WR: The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 22: 2954-2963, 2004.
41. Wang X, McCullough KD, Franke TF and Holbrook NJ: Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem 275: 14624-14631, 2000.
42. 2-induced cell death. Free Radic Res 40: 155-165, 2006.
43. Sekito A, Taira T, Niki T, Iguchi-Ariga SM and Ariga H: Stimulation of transforming activity of DJ-1 by Abstrakt, a DJ-1-binding protein. Int J Oncol 26: 685-689, 2005.
44. Vazquez F, Ramaswamy S, Nakamura N and Sellers WR: Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 20: 5010-5018, 2000.
45. 2 mediated cell signaling. FEBS Lett 560: 7-13, 2004.
46. Skeen JE, Bhaskar PT, Chen CC, et al: Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell 10: 269-280, 2006.
47. Vasudevan KM, Burikhanov R, Goswami A and Rangnekar VM: Suppression of PTEN expression is essential for antiapoptosis and cellular transformation by oncogenic Ras. Cancer Res 67: 10343-10350, 2007.