Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: An ES- derived cell model of primary Parkinsonism

PLoS Biology

Volumn 2, Issue 11, 2004, Pages

  Martinat, Cecile ^a   Shendelman, Shoshana ^a   Jonason, Alan ^a   Leete, Thomas ^a   Beal, M Flint ^b   Yang, Lichuan ^b   Floss, Thomas ^c   Abeliovich, Asa ^a  

^a Columbia University ^*  (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DJ 1 PROTEIN; PROTEASOME; PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; DJ 1 PROTEIN, MOUSE; DJ-1 PROTEIN, MOUSE; DOPAMINE; HYDROGEN PEROXIDE; ONCOPROTEIN;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; DOPAMINERGIC NERVE CELL; EMBRYONIC STEM CELL; GENE MUTATION; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PARKINSONISM; SURVIVAL; ANIMAL; BIOLOGICAL MODEL; CELL SURVIVAL; CYTOLOGY; DEGENERATIVE DISEASE; DISEASE MODEL; EMBRYO; FLUORESCENCE MICROSCOPY; GENE DELETION; GENE VECTOR; GENETICS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MOLECULAR GENETICS; MOUSE; MOUSE MUTANT; MUTATION; NERVE CELL; PARKINSON DISEASE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STEM CELL; SUBSTANTIA NIGRA;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; DOPAMINE; EMBRYO; GENE DELETION; GENETIC VECTORS; HETEROZYGOTE; HOMOZYGOTE; HUMANS; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTATION; NEURODEGENERATIVE DISEASES; NEURONS; ONCOGENE PROTEINS; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEASOME ENDOPEPTIDASE COMPLEX; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STEM CELLS; SUBSTANTIA NIGRA;

EID: 13944279784     PISSN: 15449173     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pbio.0020327     Document Type: Article

References (42)

1. Abeliovich A, Schmitz Y, Farinas I, Choi-Lundberg D, Ho WH, et al. (2000) Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25: 239-252.
2. Barberi T, Klivenyi P, Calingasan NY, Lee H, Kawamata H, et al. (2003) Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol 21: 1200-1207.
3. Bian K, Gao Z, Weisbrodt N, Murad F (2003) The nature of heme/iron-induced protein tyrosine nitration. Proc Natl Acad Sci U S A 100: 5712-5717.
4. Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, et al. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299: 256-259.
5. Dauer W, Przedborski S (2003) Parkinson's disease: Mechanisms and models. Neuron 39: 889-909.
6. Demasi M, Davies KJ (2003) Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism. FEBS Lett 542: 89-94.
7. de Nobel H, Lawrie L, Brul S, Klis F, Davis M, et al. (2001) Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae. Yeast 18: 1413-1428.
8. Farrer M, Wavrant-De Vrieze F, Crook R, Boles L, Perez-Tur J, et al. (1998) Low frequency of α-synuclein mutations in familial Parkinson's disease. Ann Neurol 43: 394-397.
9. Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, et al. (2000) A de novo designed helixturn-helix peptide forms nontoxic amyloid fibrils. Nat Struct Biol 7: 1095-1099.
10. Floss T, Wurst W (2002) Functional genomics by gene-trapping in embryonic stem cells. Methods Mol Biol 185: 347-379.
11. Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, et al. (2002) Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein. Neuron 34: 521-533.
12. Gobeil S, Boucher CC, Nadeau D, Poirier GG (2001) Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): Implication of lysosomal proteases. Cell Death Differ 8: 588-594.
13. Goldberg MS, Lansbury PT (2000) Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson's disease? Nat Cell Biol 2: E115-119.
14. Goldberg MS, Fleming SM, Palacino JJ, Cepeda C, Lam HA, et al. (2003) Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem 278: 43628-43635.
15. Hague S, Rogaeva E, Hernandez D, Gulick C, Singleton A, et al. (2003) Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation. Ann Neurol 54: 271-274.
16. Han BS, Hong HS, Choi WS, Markelonis GJ, Oh TH, et al. (2003) Caspase-dependent and - independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment. J Neurosci 23: 5069-5078.
17. Hattori N, Shimura H, Kubo S, Kitada T, Wang M, et al. (2000) Autosomal recessive juvenile parkinsonism: A key to understanding nigral degeneration in sporadic Parkinson's disease. Neuropathology 20: (Suppl) 85-90.
18. Itier JM, Ibanez P, Mena MA, Abbas N, Cohen-Salmon C, et al. (2003) Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Hum Mol Genet 12: 2277-2291.
19. Jenner P (2003) Oxidative stress in Parkinson's disease. Ann Neurol 53: (Suppl 3) 26-38.
20. Jenner P, Olanow CW (1998) Understanding cell death in Parkinson's disease. Ann Neurol 44: (Suppl 1) 72-84.
21. Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, et al. (2000) Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28: 31-40.
22. Lee MK, Stirling W, Xu Y, Xu X, Qui D, et al. (2002) Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A 99: 8968-8973.
23. Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, et al. (2000) Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders. Science 287: 1265-1269.
24. McCormack AL, Thiruchelvam M, Manning-Bog AB, Thiffault C, Langston JW, et al. (2002) Environmental risk factors and Parkinson's disease: Selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol Dis 10: 119-127.
25. Mitsumoto A, Nakagawa Y (2001) DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin. Free Radic Res 35: 885-893.
26. Mitsumoto A, Nakagawa Y, Takeuchi A, Okawa K, Iwamatsu A, et al. (2001) Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat. Free Radic Res 35: 301-310.
27. Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, et al. (2001) Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 152: 657-668.
28. Morizane A, Takahashi J, Takagi Y, Sasai Y, Hashimoto N (2002) Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell-derived inducing activity. J Neurosci Res 69: 934-939.
29. Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, et al. (1997) DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 231: 509-513.
30. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, et al. (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276: 2045-2047.
31. Pothos E, Desmond M, Sulzer D (1996) L-3,4-dihydroxyphenylalanine increases the quantal size of exocytotic dopamine release in vitro. J Neurochem 66: 629-636.
32. Rideout HJ, Larsen KE, Sulzer D, Stefanis L (2001) Proteasomal inhibition leads to formation of ubiquitin/α-synuclein-immunoreactive inclusions in PC12 cells. J Neurochem 78: 899-908.
33. Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, et al. (2003) A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 33: 401-406.
34. Shendelman S, Jonason A, Martinat C, Leete T, Abeliovich A (2004) DJ-1 is a redox-dependent molecular chaperone that inhibits α-synuclein aggregation formation. PLoS Biol 2: (11) e362.
35. Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, et al. (2002) An in vitro model of Parkinson's disease: Linking mitochondrial impairment to altered α-synuclein metabolism and oxidative damage. J Neurosci 22: 7006-7015.
36. Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, et al. (1998) Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett 251: 205-208.
37. Staropoli JF, McDermott C, Martinat C, Schulman B, Demireva E, et al. (2003) Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity. Neuron 37: 735-749.
38. Taira T, Saito Y, Niki T, Iguchi-Ariga SM, Takahashi K, et al. (2004) DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep 5: 213-218.
39. Trojanowski JQ, Lee VM (1998) Aggregation of neurofilament and α-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia. Arch Neurol 55: 151-152.
40. Walrand S, Valeix S, Rodriguez C, Ligot P, Chassagne J, et al. (2003) Flow cytometry study of polymorphonuclear neutrophil oxidative burst: A comparison of three fluorescent probes. Clin Chim Acta 331: 103-110.
41. Yang L, Matthews RT, Schulz JB, Klockgether T, Liao AW, et al. (1998) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. J Neurosci 18: 8145-8152.
42. Yokota T, Sugawara K, Ito K, Takahashi R, Ariga H, et al. (2003) Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem Biophys Res Commun 312: 1342-1348.