Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function

Journal of Biological Chemistry

Volumn 279, Issue 9, 2004, Pages 8506-8515

  Olzmann, James A ^a   Brown, Keith ^a   Wilkinson, Keith D ^a   Rees, Howard D ^a   Huai, Qing ^b   Ke, Hengming ^b   Levey, Allan I ^a   Li, Lian ^a   Chin, Lih Shen ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMERS; DISEASE CONTROL; MOLECULAR STRUCTURE; MUTAGENESIS;

CHAPERONE; HETERODIMERS; INTRINSIC FOLDING;

PROTEINS;

ALANINE; CYSTEINE; DJ 1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; CATALYSIS; FAMILIAL DISEASE; GENE DISRUPTION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOTOR DYSFUNCTION; NERVE DEGENERATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; RECEPTOR GENE; UBIQUITINATION;

AMINO ACID SEQUENCE; ANTIBODIES; BRAIN CHEMISTRY; CATALYSIS; CYSTEINE ENDOPEPTIDASES; DIMERIZATION; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUMINESCENT PROTEINS; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUTATION; ONCOGENE PROTEINS; PARKINSONIAN DISORDERS; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; UBIQUITIN;

EID: 1542349213     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311017200     Document Type: Article

References (54)

1. Lang, A. E., and Lozano, A. M. (1998) N. Engl. J. Med. 339, 1044-1053
2. Lang, A. E., and Lozano, A. M. (1998) N. Engl. J. Med. 339, 1130-1143
3. Gwinn-Hardy, K. (2002) Mov. Disord. 17, 645-656
4. Dawson, T. M., and Dawson, V. L. (2003) J. Clin. Investig. 111, 145-151
5. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840
6. Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., and Shimizu, N. (1998) Nature 392, 605-608
7. Leroy, E., Boyer, R., Auburger, G., Leube, B., Ulm, G., Mezey, E., Harta, G., Brownstein, M. J., Jonnalagada, S., Chernova, T., Dehejia, A., Lavedan, C., Gasser, T., Steinbach, P. J., Wilkinson, K. D., and Polymeropoulos, M. H. (1998) Nature 395, 451-452
8. McNaught, K. S., and Olanow, C. W. (2003) Ann. Neurol. 53, S73-S86
9. Giasson, B. I., Lee, V. M., Ravina, B., Gwinn-Hardy, K., Crawley, A., St. George-Hyslop, P. H., Lang, A. E., Heutink, P., Bonifati, V., Hardy, J., Singleton, A., Wilson, M. A., Collins, J. L., Hod, Y., Ringe, D., and Petsko, G. A. (2003) Cell 114, 1-8
10. Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C., Squitieri, F., Ibanez, P., Joosse, M., van Dongen, J. W., Vanacore, N., van Swieten, J. C., Brice, A., Meco, G., van Duijn, C. M., Oostra, B. A., and Heutink, P. (2003) Science 299, 256-259
11. Hague, S., Rogaeva, E., Hernandez, D., Gulick, C., Singleton, A., Hanson, M., Johnson, J., Weiser, R., Gallardo, M., Ravina, B., Gwinn-Hardy, K., Crawley, A., St. George-Hyslop, P. H., Lang, A. E., Heutink, P., Bonifati, V., Hardy, J., Wilson, M. A., Collins, J. L., Hod, Y., Ringe, D., and Petsko, G. A. (2003) Ann. Neurol. 54, 271-274
12. Nagakubo, D., Taira, T., Kitaura, H., Ikeda, M., Tamai, K, Iguchi-Ariga, S. M., and Ariga, H. (1997) Biochem. Biophys. Res. Commun. 231, 509-513
13. Le Naour, F., Misek, D. E., Krause, M. C., Deneux, L., Giordano, T. J., Scholl, S., and Hanash, S. M. (2001) Clin. Cancer Res. 7, 3328-3335
14. Hod, Y., Pentyala, S. N., Whyard, T. C., and El-Maghrabi, M. R. (1999) J. Cell Biochem. 72, 435-444
15. Wagenfeld, A., Gromoll, J., and Cooper, T. G. (1998) Biochem. Biophys. Res. Commun. 251, 545-549
16. Welch, J. E., Barbee, R. R., Roberts, N. L., Suarez, J. D., and Klinefelter, G. R. (1998) J. Androl. 19, 385-393
17. Klinefelter, G. R., Laskey, J. W., Ferrell, J., Suarez, J. D., and Roberts, N. L. (1997) J. Androl. 18, 139-150
18. Klinefelter, G. R., Welch, J. E., Perreault, S. D., Moore, H. D., Zucker, R. M., Suarez, J. D., Roberts, N. L., Bobseine, K., and Jeffay, S. (2002) J. Androl. 23, 48-63
19. Takahashi, K., Taira, T., Niki, T., Seino, C., Iguchi-Ariga, S. M., and Ariga, H. (2001) J. Biol. Chem. 276, 37556-37563
20. Niki, T., Takahashi-Niki, K., Taira, T., Iguchi-Ariga, S. M., and Ariga, H. (2003) Mol. Cancer Res. 1, 247-261
21. Mitsumoto, A., Nakagawa, Y., Takeuchi, A., Okawa, K., Iwamatsu, A., and Takanezawa, Y. (2001) Free Radic. Res. 35, 301-310
22. Mitsumoto, A., and Nakagawa, Y. (2001) Free Radic. Res. 35, 885-893
23. Halio, S. B., Blumentals, I. I., Short, S. A., Merrill, B. M., and Kelly, R. M. (1996) J. Bacteriol. 178, 2605-2612
24. Mizote, T., Tsuda, M., Smith, D. D., Nakayama, H., and Nakazawa, T. (1999) Microbiology 145, 495-501
25. Huai, Q., Sun, Y., Wang, H., Chin, L. S., Li, L., Robinson, H., and Ke, H. (2003) FEBS Lett. 549, 171-175
26. Tao, X., and Tong, L. (2003) J. Biol. Chem. 278, 31372-31379
27. Wilson, M. A., Collins, J. L., Hod, Y., Ringe, D., and Petsko, G. A. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 9256-9261
28. Honbou, K., Suzuki, N. N., Horiuchi, M., Niki, T., Taira, T., Ariga, H., and Inagaki, F. (2003) J. Biol. Chem. 278, 31380-31384
29. Lee, S. J., Kim, S. J., Kim, I. K., Ko, J., Jeong, C. S., Kim, G. H., Park, C., Kang, S. O., Suh, P. G., Lee, H. S., and Cha, S. S. (2003) J. Biol. Chem. 278, 44552-44559
30. Li, L., Schuchard, M., Palma, A., Pradier, L., and McNamee, M. G. (1990) Biochemistry (Mosc.) 29, 5428-5436
31. Chin, L. S., Nugent, R. D., Raynor, M. C., Vavalle, J. P., and Li, L. (2000) J. Biol. Chem. 275, 1191-1200
32. Li, Y., Chin, L. S., Weigel, C., and Li, L. (2001) J. Biol. Chem. 276, 40824-40833
33. Buchner, J., Grallert, H., and Jakob, U. (1998) Methods Enzymol. 290, 323-338
34. Blumentals, I. I., Robinson, A. S., and Kelly, R. M. (1990) Appl. Environ. Microbiol. 56, 1992-1998
35. Du, X., Choi, I. G., Kim, R., Wang, W., Jancarik, J., Yokota, H., and Kim, S. H. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 14079-14084
36. Jones, L. J., Upson, R. H., Haugland, R. P., Panchuk-Voloshina, N., Zhou, M., and Haugland, R. P. (1997) Anal. Biochem. 251, 144-152
37. Batra, R., Khayat, R., and Tong, L. (2001) Nat. Struct. Biol. 8, 810-817
38. Chin, L.-S., Raynor, M. C., Wei, X., Chen, H., and Li, L. (2001) J. Biol. Chem. 276, 7069-7078
39. Wheeler, T. C., Chin, L. S., Li, Y., Roudabush, F. L., and Li, L. (2002) J. Biol. Chem. 277, 10273-10282
40. Chin, L.-S., Vavalle, J. P., and Li, L. (2002) J. Biol. Chem. 277, 35071-35079
41. Sastry, M. S., Korotkov, K., Brodsky, Y., and Baneyx, F. (2002) J. Biol. Chem. 277, 46026-46034
42. Wilkinson, K. D. (2000) Semin. Cell Dev. Biol. 11, 141-148
43. Glickman, M. H., and Ciechanover, A. (2002) Physiol. Rev. 82, 373-428
44. Miller, D. W., Ahmad, R., Hague, S., Baptista, M. J., Canet-Aviles, R., McLendon, C., Carter, D. M., Zhu, P. P., Stadler, J., Chandran, J., Klinefelter, G. R., Blackstone, C., and Cookson, M. R. (2003) J. Biol. Chem. 278, 36588-36595
45. Ellison, M. J., and Hochstrasser, M. (1991) J. Biol. Chem. 266, 21150-21157
46. Wilson, K. P., Black, J. A., Thomson, J. A., Kim, E. E., Griffith, J. P., Navia, M. A., Murcko, M. A., Chambers, S. P., Aldape, R. A., Raybuck, S. A., and Livingston, D. J. (1994) Nature 370, 270-275
47. Walker, N. P., Talanian, R. V., Brady, K. D., Dang, L. C., Bump, N. J., Ferenz, C. R., Franklin, S., Ghayur, T., Hackett, M. C., and Hammill, L. D. (1994) Cell 78, 343-352
48. Darke, P. L., Chen, E., Hall, D. L., Sardana, M. K., Veloski, C. A., LaFemina, R. L., Shafer, J. A., and Kuo, L. C. (1994) J. Biol. Chem. 269, 18708-18711
49. McGrath, W. J., Baniecki, M. L., Li, C., McWhirter, S. M., Brown, M. T., Toledo, D. L., and Mangel, W. F. (2001) Biochemistry (Mosc.) 40, 13237-13245
50. Macedo, M. G., Anar, B., Bronner, I. F., Cannella, M., Squitieri, F., Bonifati, V., Hoogeveen, A., Heutink, P., and Rizzu, P. (2003) Hum. Mol. Genet. 12, 2807-2816
51. McClellan, A. J., and Frydman, J. (2001) Nat. Cell Biol. 3, E51-E53
52. Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuno, Y., and Takahashi, R. (2001) Cell 105, 891-902
53. Imai, Y., Soda, M., Hatakeyama, S., Akagi, T., Hashikawa, T., Nakayama, K. I., and Takahashi, R. (2002) Mol. Cell 10, 55-67
54. Tsai, Y. C., Fishman, P. S., Thakor, N. V., and Oyler, G. A. (2003) J. Biol. Chem. 278, 22044-22055