DJ-1-dependent protective activity of DJ-1-binding compound no. 23 against neuronal cell death in MPTP-treated mouse model of Parkinson's disease

Journal of Pharmacological Sciences

Volumn 127, Issue 3, 2015, Pages 305-310

  Takahashi Niki, Kazuko ^a   Inafune, Ayako ^b   Michitani, Naruyuki ^b   Hatakeyama, Yoshitaka ^b   Suzuki, Kotaro ^b   Sasaki, Mai ^b   Kitamura, Yoshihisa ^c   Niki, Takeshi ^a   Iguchi Ariga, Sanae M M ^a   Ariga, Hiroyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b New Drug Development Research Center Inc   (Japan)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Compound; DJ 1; MPTP; Neuroprotection; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ANTIPARKINSON AGENT; DJ 1 PROTEIN; N [4 [8 METHYL (4 HYDROIMIDAZO[1,2 A]PYRIDIN 2 YL)]PHENYL] (3,4,5 TRIMETHOXYPHENYL)CARBOXAMIDE; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; DJ-1 PROTEIN, MOUSE; DOPAMINE; N-(4-(8-METHYL(4-HYDROIMIDAZO(1,2-A)PYRIDIN-2-YL))PHENYL)(3,4,5-TRIMETHOXYPHENYL)CARBOXAMIDE; NEUROPROTECTIVE AGENT; NEUROTOXIN; ONCOPROTEIN; PEROXIREDOXIN; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; GENE INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LOCOMOTION; MALE; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OUTCOME ASSESSMENT; PARKINSON DISEASE; ROTAROD TEST; SUBSTANTIA NIGRA; WILD TYPE MOUSE; ANIMAL; BRAIN; C57BL MOUSE; CELL DEATH; CYTOLOGY; DISEASE MODEL; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PHYSIOLOGY;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; BENZAMIDES; BRAIN; CELL DEATH; DISEASE MODELS, ANIMAL; DOPAMINE; DOPAMINERGIC NEURONS; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPROTECTIVE AGENTS; NEUROTOXINS; ONCOGENE PROTEINS; OXIDATIVE STRESS; PARKINSON DISEASE; PEROXIREDOXINS; PYRIDINES; SUBSTANTIA NIGRA;

EID: 84936878975     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1016/j.jphs.2015.01.010     Document Type: Article

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