High levels of DJ-1 protein in nipple fluid of patients with breast cancer

Cancer Science

Volumn 103, Issue 6, 2012, Pages 1172-1176

  Oda, Miki ^a,b   Makita, Masujiro ^c   Iwaya, Keiichi ^a,b   Akiyama, Futoshi ^d   Kohno, Norio ^b   Tsuchiya, Benio ^e   Iwase, Takuji ^c   Matsubara, Osamu ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c CANCER INSTITUTE HOSPITAL   (Japan)

^d CANCER INSTITUTE   (Japan)

^e KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; DJ 1 PROTEIN; MESSENGER RNA;

ADULT; ARTICLE; BREAST CARCINOMA; BREAST DISCHARGE; CANCER DIAGNOSIS; CONCENTRATION (PARAMETERS); CYTOLOGY; DILUTION; DUCTOSCOPIC CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; NIPPLE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SENSITIVITY AND SPECIFICITY;

BREAST NEOPLASMS; CARCINOEMBRYONIC ANTIGEN; CARCINOMA, DUCTAL, BREAST; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MIDDLE AGED; NIPPLE ASPIRATE FLUID; NIPPLES; ONCOGENE PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 84861675793     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2012.02267.x     Document Type: Article

References (34)

1. Devitt JE. Management of nipple discharge by clinical findings. Am J Surg 1985; 149: 789-92.
2. Vargas HI, Romero L, Chlebowski RT. Management of bloody nipple discharge. Curr Treat Options Oncol 2002; 3: 157-61.
3. Hamed H, Fentiman IS. Benign breast disease. Int J Clin Pract 2001; 55: 461-4.
4. Louie LD, Crowe JP, Dawson AE et al. Identification of breast cancer in patients with pathologic nipple discharge: does ductoscopy predict malignancy? Am J Surg 2006; 192: 530-3.
5. Montroni I, Santini D, Zucchini G et al. Nipple discharge: is its significance as a risk factor for breast cancer fully understood? Observation study including 915 consecutive patients who underwent selective duct excision. Breast Cancer Res Treat 2010; 123: 895-900.
6. Gülay H, Bora S, Klliçturgay S, Hamaloǧlu E, Göksel HA. Management of nipple discharge. J Am Coll Surg 1994; 178: 471-4.
7. Simmons R, Adamovich T, Brennan M et al. Nonsurgical evaluation of pathologic nipple discharge. Ann Surg Oncol 2003; 10: 113-6.
8. Krishnamurthy S, Sneige N, Thompson PA et al. Nipple aspirate fluid cytology in breast carcinoma. Cancer 2003; 99: 97-104.
9. Takeda T, Matsui A, Sato Y et al. Nipple discharge cytology in mass screening for breast cancer. Acta Cytol 1990; 34: 161-4.
10. Khan SA, Mangat A, Rivers A, Revesz E, Susnik B, Hansen N. Office ductoscopy for surgical selection in woman with pathologic nipple discharge. Ann Surg Oncol 2011; 18: 3785-90.
11. Yamamoto D, Shoji T, Kawanishi H, Nakagawa H, Haijima H, Gondo H. A utility of duoctoscopy and fiber optic ductoscopy for patients with nipple discharge. Breast Cancer Res Treat 2001; 70: 103-8.
12. Sauter ER, Klein-Szanto A, Macgibbon B, Ehya H. Nipple aspirate fluid and ductoscopy to detect breast cancer. Diagn Cytopathol 2010; 38: 244-51.
13. Mori T, Inaji H, Koyama H et al. Evaluation of an improved dot-immunobinding assay for carcinoembryonic antigen determination in nipple discharge in early breast cancer: results of multicenter study. Jpn J Clin Oncol 1992; 22: 371-6.
14. Zhao Y, Verselis SJ, Klar N et al. Nipple fluid carcinoembryonic antigen and prostate-specific antigen in cancer-bearing and tumor-free breasts. J Clin Oncol 2001; 19: 1462-7.
15. Motomura K, Koyama H, Noguchi S, Inaji H, Azyma C. Detection of c-erbB-2 gene amplification in nipple discharge by means of polymerase chain reaction. Breast Cancer Res Treat 1995; 33: 89-92.
16. Tsuchiya B, Iwaya K, Kohno N et al. Clinical significance of DJ-1 as a secretion molecule: retrospective study of expression of both DJ-1 mRNA and protein in ductal carcinoma of the breast. Histopathology 2011; doi: 10.11111/j.1365-2559.2012.0402.x [Epub ahead of print].
17. Nagakubo D, Taira T, Kitaura H et al. DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 1997; 231: 509-13.
18. Kim RH, Peters M, Jang YJ, Shi W, Pintilie M, Fletcher GC. DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 2005; 7: 263-73.
19. Le Naour F, Misek DE, Krause MC et al. Proteomic-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin Cancer Res 2001; 7: 3328-35.
20. Tsuboi Y, Munemoto H, Ishikawa S, Matsumoto K, Iguchi-Ariga SM, Ariga H. DJ-1, a causative gene product of a familial form of Parkinson's disease, is secreted through microdomains. FEBS Lett 2008; 582: 2643-9.
21. Canet-Aviles RM, Wilson MA, Cookson MR et al. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 2004; 101: 9103-8.
22. Li HM, Niki T, Taira T, Iguchi-Ariga SMM, Ariga H. Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp 70 by oxidative stress. Free Radiac Res 2005; 39: 1091-9.
23. Makita M, Akiyama F, Gomi N, Iwase T, Kasumi F, Sakamoto G. Endoscopic and histologic findings of intraductal lesions presenting with nipple discharge. Breast J 2006; 12(5 Suppl 2): S210-7.
24. Kuerer HM, Goldknopf IL, Fritsche H, Krishnamurthy S, Sheta EA, Hunt KK. Identification of distinct protein expression patterns in bilateral matched pair breast ductal fluid specimens from women with unilateral invasive breast carcinoma. High-throughput biomarker discovery. Cancer 2002; 95: 2276-82.
25. Maita C, Tsuji S, Yabe I et al. Secretion of DJ-1 into the serum of patients with Parkinson's disease. Neurosci Lett 2008; 431: 86-9.
26. Hong Z, Shi M, Chung KA et al. DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain 2010; 133: 713-26.
27. Tian M, Cui YZ, Song GH et al. Proteomic analysis identifies MMP-9, DJ-1 and AIBG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer 2008; 8: 241-52.
28. He XY, Liu BY, Yao WY et al. Serum DJ-1 as a diagnostic marker and prognostic factor for pancreatic cancer. J Dig Dis 2011; 12: 131-7.
29. Foretova L, Garber JE, Sadowsky NL et al. Carcinoembryonic antigen in breast nipple aspirate fluid. Cancer Epidemiol Biomakers Prev 1998; 7: 195-8.
30. Sauter ER, Shan S, Hewett JE et al. Proteomic analysis of nipple fluid using SELDI-TOF-MS. Int J Cancer 2005; 114: 791-6.
31. Alexander H, Stegner AL, Wagner-Mann C, Bois GCD, Alexander S, Sauter ER. Proteomic analysis to identify breast cancer biomarkers in nipple aspirate fluid. Clin Cancer Res 2004; 10: 7500-10.
32. Sartippour MR, Zhang L, Lu M, Wang HJ, Brooks MN. Nipple fluid basic fibroblast growth factor in patients with breast cancer. Cancer Epidemiol Biomarkers Prev 2005; 14: 2995-8.
33. Kuerer HM, Thompson PA, Krishnamurthy S et al. High and differential expression of HER-2/neu extracellular domain in bilateral ductal fluids from women with unilateral invasive breast cancer. Clin Cancer Res 2003; 9: 601-5.
34. Knobbe CB, Revett TJ, Bai Y et al. Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with HSP90. J Proteome Res 2011; 10: 4388-404.