DJ-1 promotes invasion and metastasis of pancreatic cancer cells by activating SRC/ERK/uPA

Carcinogenesis

Volumn 33, Issue 3, 2012, Pages 555-562

  He, Xiangyi ^a   Zheng, Zhong ^b   Li, Jianfang ^a   Ben, Qiwen ^c   Liu, Jun ^b   Zhang, Jianian ^a   Ji, Jun ^a   Yu, Beiqin ^a   Chen, Xuehua ^a   Su, Liping ^a   Zhou, Lin ^a   Liu, Bingya ^a   Yuan, Yaozong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DJ 1 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SHORT HAIRPIN RNA; UROKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER INVASION; CANCER PROGNOSIS; CANCER SURVIVAL; CARCINOMA CELL; CELL DISRUPTION; CELL MIGRATION; CONTROLLED STUDY; CYTOSKELETON; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LUNG METASTASIS; MALE; METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SURVIVAL TIME; TUMOR PROMOTION; UPREGULATION;

EID: 84863259132     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs002     Document Type: Article

References (34)

1. Lowenfels,A.B. et al. (2006) Epidemiology and risk factors for pancreatic cancer. Best Pract. Res. Clin. Gastroenterol., 20, 197-209.
2. Giroux,V. et al. (2009) A review of kinases implicated in pancreatic cancer. Pancreatology, 9, 738-754.
3. Pliarchopoulou,K. et al. (2009) Pancreatic cancer: current and future treatment strategies. Cancer Treat. Rev., 35, 431-436.
4. Nagakubo,D. et al. (1997) DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem. Biophys. Res. Commun., 231, 509-513.
5. Hod,Y. (2004) Differential control of apoptosis by DJ-1 in prostate benign and cancer cells. J. Cell. Biochem., 92, 1221-1233.
6. Le Naour,F. et al. (2001) Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. Clin. Cancer Res., 7, 3328-3335.
7. Liu,H. et al. (2008) Expression and role of DJ-1 in leukemia. Biochem. Biophys. Res. Commun., 375, 477-483.
8. Arnouk,H. et al. (2009) Characterization of molecular markers indicative of cervical cancer progression. Proteomics Clin. Appl., 3, 516-527.
9. Giusti,L. et al. (2008) Fine-needle aspiration of thyroid nodules: proteomic analysis to identify cancer biomarkers. J. Proteome Res., 7, 4079-4088.
10. Tian,M. et al. (2008) Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC Cancer, 8, 241.
11. Melle,C. et al. (2007) Protein profiling of microdissected pancreas carcinoma and identification of HSP27 as a potential serum marker. Clin. Chem., 53, 629-635.
12. Kim,R.H. et al. (2005) DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell, 7, 263-273.
13. Yuen,H.F. et al. (2008) DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma. Cancer Epidemiol. Biomarkers Prev., 17, 3593-3602.
14. Zhu,X.L. et al. (2010) DJ-1: a novel independent prognostic marker for survival in glottic squamous cell carcinoma. Cancer Sci., 101, 1320-1325.
15. Vasseur,S. et al. (2009) DJ-1/PARK7 is an important mediator of hypoxiainduced cellular responses. Proc. Natl Acad. Sci. USA, 106, 1111-1116.
16. Clements,C.M. et al. (2006) DJ-1, a cancer- and Parkinson's diseaseassociated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl Acad. Sci. USA, 103, 15091-15096.
17. Pardo,M. et al. (2006) The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker. Int. J. Cancer, 119, 1014-1022.
18. Sobin,L.H. (2003) TNM, sixth edition: new developments in general concepts and rules. Semin. Surg. Oncol., 21, 19-22.
19. Wang,Y.W. et al. (2006) In vitro and in vivo evidence of metallopanstimulin-1 in gastric cancer progression and tumorigenicity. Clin. Cancer Res., 12, 4965-4973.
20. Yuen,H.F. et al. (2007) Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma. Br. J. Cancer, 97, 1409-1415.
21. Ben,Q.W. et al. (2010) Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinoma. Ann. Surg. Oncol., 17, 2213-2221.
22. Blasi,F. et al. (2002) uPAR: a versatile signalling orchestrator. Nat. Rev. Mol. Cell. Biol., 3, 932-943.
23. He,Y. et al. (2007) Interaction between cancer cells and stromal fibroblasts is required for activation of the uPAR-uPA-MMP-2 cascade in pancreatic cancer metastasis. Clin. Cancer Res., 13, 3115-3124.
24. Aleyasin,H. et al. (2010) DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway. Proc. Natl Acad. Sci. USA, 107, 3186-3191.
25. Geiger,T.R. et al. (2009) Metastasis mechanisms. Biochim. Biophys. Acta, 1796, 293-308.
26. Aron,L. et al. (2010) Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons. PLoS Biol., 8, e1000349.
27. Hall,A. (2009) The cytoskeleton and cancer. CancerMetastasis Rev., 28, 5-14.
28. Kessenbrock,K. et al. (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell, 141, 52-67.
29. Yang,Y. et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl Acad. Sci. USA, 102, 13670-13675.
30. Asano,T. et al. (2004) The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene, 23, 8571-8580.
31. Tan,X. et al. (2005) Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway. J. Clin. Pathol., 58, 1242-1248.
32. Jiang,G. et al. (2010) PRSS3 promotes tumour growth and metastasis of human pancreatic cancer. Gut, 59, 1535-1544.
33. Krebiehl,G. et al. (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One, 5, e9367.
34. Gu,L. et al. (2009) Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stress. Biochem. Biophys. Res. Commun., 383, 469-474.