Copper as a key regulator of cell signalling pathways

Expert Reviews in Molecular Medicine

Volumn 16, Issue , 2014, Pages

  Grubman, Alexandra ^a   White, Anthony R ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; COPPER; PROTEIN KINASE;

ANIMAL; CELL NUCLEUS; DEGENERATIVE DISEASE; HUMAN; METABOLISM; NEOPLASM; PHOSPHORYLATION; PHYSIOLOGY; PRION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL NUCLEUS; COPPER; HUMANS; NEOPLASMS; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION; PRIONS; PROTEIN KINASES; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

EID: 84934769324     PISSN: 14623994     EISSN: None     Source Type: Journal    
DOI: 10.1017/erm.2014.11     Document Type: Article

References (182)

1. Maret, W. (2013) Zinc biochemistry: from a single zinc enzyme to a key element of life. Advances in Nutrition 4, 82-91
2. Ciuffreda, L. et al. (2013) Signaling intermediates (MAPKand PI3 K) as therapeutic targets in NSCLC. Current Pharmceutical Design PMID: 24138714
3. Chen, G. and Goeddel, D.V. (2002) TNF-R1 signaling: a beautiful pathway. Science 296, 1634-1635
4. Ibanez, C.F. (2010) Beyond the cell surface: new mechanisms of receptor function. Biochemical and Biophysical Research Communications 396, 24-27
5. Latek, D. et al. (2012) G protein-coupled receptors-recent advances. Acta Biochimica Polonica 59, 515-529
6. Madhani, H.D. (2006) Functional analysis of protein kinase networks in living cells: beyond "knock-outs" and "knock-downs". Methods 40, 251-254
7. Yan-Na, L., Ren-Zhong, W. and Zhao-Peng, L. (2013) Recent developments of small molecule PI3 K/mTOR dual inhibitors. Mini Reviews in Medicinal Chemistry 13, 2047-2059
8. Kazi, J.U., Kabir, N.N. and Ronnstrand, L. (2013) Protein kinase C (PKC) as a drug target in chronic lymphocytic leukemia. Medical Oncology 30, 757
9. Neuzillet, C. et al. (2013) MEK in cancer and cancer therapy. Pharmacology Therapy 141, 160-171
10. Bubici, C. and Papa, S. (2013) JNK signaling in cancer: in need of new, smarter therapeutic targets. British Journal of Pharmacology 171, 24-37
11. Niederst, M.J. and Engelman, J.A. (2013) Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer. Science Signaling 6, re6
12. Chan, C.B. and Ye,K. (2013) Serine-arginine protein kinases: new players in neurodegenerative diseases? Reviews in Neuroscience 24, 401-413
13. Shukla, V., Skuntz, S. and Pant, H.C. (2012) Deregulated Cdk5 activity is involved in inducing Alzheimer's disease. Archives of Medical Research 43, 655-662
14. Kanaan, N.M. et al. (2013) Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system. Experimental Neurology 246, 44-53
15. Wang, J.Z. et al. (2013) Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. Journal of Alzheimer's Disease 33(Suppl 1), S123-S139
16. Wilhelmus, M.M. et al. (2012) Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders. Free Radical Biology and Medicine 53, 983-992
17. Bocharov, E.V. et al. (2013) Structure of FGFR3 transmembrane domain dimer: implications for signaling and human pathologies. Structure 21, 2087-2093
18. Shi, J. and Wei, L. (2013) Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil. Journal of Cardiovascular Pharmacology 62, 341-354
19. Provenzano, A., Kurian, S. and Abraham, J. (2013) Overcoming endocrine resistance in breast cancer: role of the PI3 K and the mTOR pathways. Expert Reviews in Anticancer Therapeutics 13, 143-147
20. Banci, L. et al. (2010) Cellular copper distribution: a mechanistic systems biology approach. Cellular and Molecular Life Sciences 67, 2563-2589
21. Telianidis, J. et al. (2013) Role of the P-typeATPases, ATP7A and ATP7B in brain copper homeostasis. Frontiers in Aging Neuroscience 5, 44
22. Nevitt, T., Ohrvik, H. and Thiele, D.J. (2012) Charting the travels of copper in eukaryotes from yeast to mammals. Biochimica Biophysica Acta 1823, 1580-1593
23. McMillin, G.A., Travis, J.J. and Hunt, J.W. (2009) Direct measurement of free copper in serum or plasma ultrafiltrate. American Journal of Clinical Pathology 131, 160-165
24. Kodama, H. et al. (1988) Does CSF copper level in Wilson disease reflect copper accumulation in the brain? Pediatric Neurology 4, 35-37
25. Gaier, E.D., Eipper, B.A. and Mains, R.E. (2013) Copper signaling in the mammalian nervous system: synaptic effects. Journal of Neuroscience Research 91, 2-19
26. Kim, H., Wu, X. and Lee, J. (2013) SLC31 (CTR) family of copper transporters in health and disease. Molecular Aspects of Medicine 34, 561-570
27. Hasan, N.M. and Lutsenko, S. (2012) Regulation of copper transporters in human cells. Current Topics in Membranes 69, 137-161
28. Wee, N.K. et al. (2013) The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease. International Journal of Biochemistry and Cell Biology 45, 960-963
29. Squitti, R. and Polimanti, R. (2013) Copper phenotype in Alzheimer's disease: dissecting the pathway. American Journal of Neurodegenerative Disease 2, 46-56
30. Greenough, M.A., Camakaris, J. and Bush, A.I. (2013) Metal dyshomeostasis and oxidative stress in Alzheimer's disease. Neurochemistry International 62, 540-555
31. Tisato, F. et al. (2010) Copper in diseases and treatments, and copper-based anticancer strategies. Medical Research Reviews 30, 708-749
32. Bourassa, M.W. and Miller, L.M. (2012) Metal imaging in neurodegenerative diseases. Metallomics 4, 721-738
33. New, E.J. (2012) Tools to study distinct metal pools in biology. Dalton Transactions 42, 3210-329
34. Miller, E.W. et al. (2006) Preparation and use of Coppersensor-1, a synthetic fluorophore for livecell copper imaging. Nature Protocols 1, 824-827
35. Domaille, D.W., Que, E.L. and Chang, C.J. (2008) Synthetic fluorescent sensors for studying the cell biology of metals. Nature Chemical Biology 4, 168-175
36. Dodani, S.C. et al. (2011) A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis. Journal of the American Chemical Society 133, 8606-8616
37. Price, K.A. et al. (2012) The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells. Chemical Science 3, 2748-2759
38. Travaglia, A. et al. (2012) Copper, BDNF and its Nterminal domain: inorganic features and biological perspectives. Chemistry 18, 15618-15631
39. Travaglia, A. et al. (2011) The inorganic perspective of nerve growth factor: interactions of Cu2+ and Zn2+ with the N-terminus fragment of nerve growth factor encompassing the recognition domain of the TrkA receptor. Chemistry 17, 3726-3738
40. Ross, G.M. et al. (2001) The binding of zinc and copper ions to nerve growth factor is differentially affected by pH: implications for cerebral acidosis. Journal of Neurochemistry 78, 515-523
41. Wang,W. et al. (1999) Zinc and copper inhibit nerve growth factor-mediated protection from oxidative stress-induced apoptosis. Neuroscience Letters 259, 115-118
42. Birkaya, B. and Aletta, J.M. (2005) NGF promotes copper accumulation required for optimum neurite outgrowth and protein methylation. Journal of Neurobiology 63, 49-61
43. Di Serio, C. et al. (2008) The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway. Cancer Letters 267, 67-74
44. Soldi, R. et al. (2007) Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Experimental Cell Research 313, 3308-3318
45. Samet, J.M. et al. (1998) Activation of MAPKs in human bronchial epithelial cells exposed to metals. American Journal of Physiology 275, L551-L558
46. Samet, J.M. et al. (1999) Tyrosine phosphatases as targets in metal-induced signaling in human airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology 21, 357-364
47. Wu, W. et al. (1999) Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals. American Journal of Physiology 277, L924-L931
48. Price, K.A. et al. (2009) Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity. Journal of Medicinal Chemistry 52, 6606-6620
49. Crouch, P.J. et al. (2009) Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 106, 381-386
50. Hehlgans, S., Haase, M. and Cordes, N. (2007) Signalling via integrins: implications for cell survival and anticancer strategies. Biochimica Biophysica Acta 1775, 163-180
51. Fan, C. et al. (2010) A novel copper complex of salicylaldehyde pyrazole hydrazone induces apoptosis through up-regulating integrin beta4 in H322 lung carcinoma cells. European Journal of Medicinal Chemistry 45, 1438-1446
52. Fan, C. et al. (2009) Novel complex of copper and a salicylaldehyde pyrazole hydrazone derivative induces apoptosis through up-regulating integrin beta 4 in vascular endothelial cells. Chemical Research and Toxicology 22, 1517-1525
53. Tenaud, I. et al. (1999) In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese. British Journal of Dermatology 140, 26-34
54. Tenaud, I. et al. (2000) Zinc, copper and manganese enhanced keratinocyte migration through a functional modulation of keratinocyte integrins. Experimental Dermatology 9, 407-416
55. Kang, Y.A. et al. (2009) Copper-GHK increases integrin expression and p63 positivity by keratinocytes. Archives of Dermatological Research 301, 301-306
56. Weaver, M.S., Workman, G. and Sage, E.H. (2008) The copper binding domain of SPARCmediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase. Journal of Biological Chemistry 283, 22826-22837
57. Zhou, Y., Bourcy, K. and Kang, Y.J. (2009) Copperinduced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway. Cardiovascular Research 84, 54-63
58. Mizuno, S. et al. (2012) Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation. PLoS One 7, e30678
59. Price, K.A. et al. (2008) Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide. International Journal of Biochemistry and Cell Biology 40, 1901-1917
60. Hornshaw, M.P. et al. (1995) Copper binding to the N-terminal tandem repeat region of mammalian and avian prion protein: structural studies using synthetic peptides. Biochemical and Biophysical Research Communications 214, 993-999
61. Brown, D.R. et al. (1997) The cellular prion protein binds copper in vivo. Nature 390, 684-687
62. Stevens, D.J. et al. (2009) Early onset prion disease from octarepeat expansion correlates with copper binding properties. PLoS Pathogens 5, e1000390
63. Sigurdsson, E.M. et al. (2003) Copper chelation delays the onset of prion disease. Journal of Biological Chemistry 278, 46199-46202
64. Siggs, O.M. et al. (2012) Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proceedings of the National Academy of Sciences of the United States of America 109, 13733-13738
65. Mitteregger, G. et al. (2009) Role of copper and manganese in prion disease progression. Brain Research 1292, 155-164
66. Varela-Nallar, L., Gonzalez, A. and Inestrosa, N.C. (2006) Role of copper in prion diseases: deleterious or beneficial? Current Pharmaceutical Design 12, 2587-2595
67. Armendariz, A.D. et al. (2004) Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App. Physiological Genomics 20, 45-54
68. Bellingham, S.A. et al. (2009) Regulation of prion gene expression by transcription factors SP1 and metal transcription factor-1. Journal of Biological Chemistry 284, 1291-1301
69. Varela-Nallar, L. et al. (2006) Induction of cellular prion protein gene expression by copper in neurons. American Journal of Physiology, Cell Physiology 290, C271-C281
70. Marchetti, C., Baranowska-Bosiacka, I. and Gavazzo, P. (2013) Multiple effects of copper on NMDA receptor currents. Brain Research 1542, 20-31
71. Schlief, M.L. et al. (2006) Role of the Menkes coppertransporting ATPase in NMDA receptor-mediated neuronal toxicity. Proceedings of the National Academy of Sciences of the United States of America 103, 14919-14924
72. Acuna-Castillo, C. et al. (2007) Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor. Journal of Neurochemistry 101, 17-26
73. Huidobro-Toro, J.P., Lorca, R.A. and Coddou, C. (2008) Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors. European Biophysics Journal 37, 301-314
74. Punthambaker, S. and Hume, R.I. (2013) Potent and long-lasting inhibition of human P2X2 receptors by copper. Neuropharmacology 77C, 167-176
75. Tamano, H. and Takeda, A. (2011) Dynamic action of neurometals at the synapse. Metallomics 3, 656-661
76. Ostrakhovitch, E.A. et al. (2002) Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species. Archives of Biochemistry and Biophysics 397, 232-239
77. Eckers, A., Reimann, K. and Klotz, L.O. (2009) Nickel and copper ion-induced stress signaling in human hepatoma cells: analysis of phosphoinositide 3′-kinase/Akt signaling. Biometals 22, 307-316
78. Ostrakhovitch, E.A. and Cherian, M.G. (2004) Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc. Archives of Biochemistry and Biophysics 423, 351-361
79. Barthel, A. et al. (2007) Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions: mechanisms and consequences. Archives of Biochemistry and Biophysics 463, 175-182
80. Tsai, C.Y. et al. (2012) Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling. Biochemical Pharmacology 84, 1007-1013
81. Turski, M.L. et al. (2012) A novel role for copper in Ras/mitogen-activated protein kinase signaling. Molecular and Cellular Biology 32, 1284-1295
82. Nawaz, M. et al. (2006) Copper-induced stimulation of extracellular signal-regulated kinase in trout hepatocytes: the role of reactive oxygen species, Ca2 +, and cell energetics and the impact of extracellular signal-regulated kinase signaling on apoptosis and necrosis. Toxicological Sciences 92, 464-475
83. Piret, J.P. et al. (2012)Copper(II) oxide nanoparticles penetrate into HepG2 cells, exert cytotoxicity via oxidative stress and induce pro-inflammatory response. Nanoscale 4, 7168-7184
84. Chen, S.H. et al. (2008) Involvement of activating transcription factors JNK, NF-kappaB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex. European Journal of Pharmacology 594, 9-17
85. Wu, C.C. et al. (2012) Involvement of oxidative stress-induced ERK/JNK activation in the Cu(2+)/pyrrolidine dithiocarbamate complextriggered mitochondria-regulated apoptosis in pancreatic beta-cells. Toxicology Letters 208, 275-285
86. Chen,Y.W. et al. (2010) Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways. Toxicology Letters 199, 333-340
87. Liu, P. et al. (2012) Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells. British Journal of Cancer 107, 1488-1497
88. Xu, B. et al. (2011) Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells. Blood Cells, Molecules and Diseases 47, 264-269
89. Chen, S.H. et al. (2008) Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation. Toxicological Science 102, 138-149
90. Mattie, M.D., McElwee, M.K. and Freedman, J.H. (2008) Mechanism of copper-activated transcription: activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. Journal of Molecular Biology 383, 1008-1018
91. Moon, S.K. et al. (2004) PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinase. Journal of Cellular Physiology 198, 310-323
92. Chen, X. et al. (2009) p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons. Biochemical and Biophysical Research Communications 379, 944-948
93. Kadowaki, S. et al. (2009) Trientine, a copperchelating agent, induced apoptosis in murine fibrosarcoma cells by activation of the p38 MAPK pathway. Journal of Veterinary Medical Science 71, 1541-1544
94. Wang, Q. et al. (2010) Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems. Chemical Communications (Cambridge) 46, 3547-3549
95. Yuan, C. et al. (2012) Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex. Chemical Communications (Cambridge) 48, 1153-1155
96. Bica, L. et al. (2014) Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation. PLoS One 9, e90070
97. Urquiza, N.M. et al. (2010) Copper(II) complexes of methimazole, an anti Grave's disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor. Biometals 23, 255-264
98. Hanahisa, Y. and Yamaguchi, M. (1998) Inhibitory effect of zinc and copper on phosphatase activity in the brain cytosol of rats: involvement of SH groups. Biological and Pharmaceutical Bulletin 21, 1222-1225
99. Zhang, D. and Glass, C. (2013) Towards an understanding of cell-specific functions of signaldependent transcription factors. Journal of Molecular Endocrinology 51, T37-50
100. Rutherford, J.C. and Bird, A.J. (2004) Metalresponsive transcription factors that regulate iron, zinc, and copper homeostasis in eukaryotic cells. Eukaryotic Cell 3, 1-13
101. Radtke, F. et al. (1995) Functional domains of the heavy metal-responsive transcription regulator MTF-1. Nucleic Acids Research 23, 2277-2286
102. Song, M.O. et al. (2014) The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription. Experimental Cell Research 322, 39-50
103. Wang, X.J. et al. (2010) Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para-and ortho-hydroquinones. Chemical Biology 17, 75-85
104. Song, I.S. et al. (2008) Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells. Molecular Pharmacology 74, 705-713
105. Cherian, M.G. and Apostolova, M.D. (2000) Nuclear localization of metallothionein during cell proliferation and differentiation. Cellular and Molecular Biology (Noisy-le-grand) 46, 347-356
106. Itoh, S. et al. (2008) Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation. Journal of Biological Chemistry 283, 9157-9167
107. Muller, P.A. and Klomp, L.W. (2009) ATOX1: a novel copper-responsive transcription factor in mammals? International Journal of Biochemistry and Cell Biology 41, 1233-1236
108. McElwee, M.K., Song, M.O. and Freedman, J.H. (2009) Copper activation of NF-kappaB signaling in HepG2 cells. Journal of Molecular Biology 393, 1013-1021
109. Song, M.O., Li, J. and Freedman, J.H. (2009) Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiological Genomics 38, 386-401
110. Satake,H. et al. (1995) Cupric ion blocksNF kappa B activation through inhibiting the signal-induced phosphorylation of I kappa B alpha. Biochemical and Biophysical Research Communications 216, 568-573
111. Walter, P.L. et al. (2006) Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions. Archives of Biochemistry and Biophysics 454, 107-113
112. Hoti, N. et al. (2004) p53-dependent apoptotic mechanism of a new designer bimetallic compound tri-phenyl tin benzimidazolethiol copper chloride (TPT-CuCl2): in vivo studies inWistar rats aswell as in vitro studies in human cervical cancer cells. Journal of Pharmacology and Experimental Therapeutics 311, 22-33
113. Bartuzi, P., Hofker, M.H. and van de Sluis, B. (2013) Tuning NF-kappaB activity: a touch of COMMD proteins. Biochimica et Biophysica Acta 1832, 2315-2321
114. Sarkar, B. and Roberts, E.A. (2011) The puzzle posed by COMMD1, a newly discovered protein binding Cu(II). Metallomics 3, 20-27
115. Trempe, J.F. and Fon, E.A. (2013) Structure and function of Parkin, PINK1, and DJ-1, the three musketeers of neuroprotection. Frontiers in Neurology 4, 38
116. Clayton, E.L., Minogue, S. andWaugh, M.G. (2013) Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases. Molecular Neurobiology 47, 361-372
117. Um, J.W. and Strittmatter, S.M. (2013) Amyloidbeta induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease. Prion 7, 37-41
118. Russo, E. et al. (2012) ThemTORsignaling pathway in the brain: focus on epilepsy and epileptogenesis. Molecular Neurobiology 46, 662-681
119. Jellinger, K.A. (2013) The relevance of metals in the pathophysiology of neurodegeneration, pathological considerations. International Reviews of Neurobiology 110C, 1-47
120. Malm, T.M. et al. (2007) Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting betaamyloid burden. Journal of Neuroscience 27, 3712-3721
121. Kitazawa, M., Cheng, D. and Laferla, F.M. (2009) Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. Journal of Neurochemistry 108, 1550-1560
122. Persichini, T. et al. (2006) Copper activates the NFkappaB pathway in vivo. Antioxidants and Redox Signaling 8, 1897-1904
123. Davis, C.D. and Johnson, W.T. (2001) Dietary copper and dimethylhydrazine affect protein kinase C isozyme protein and mRNA expression and the formation of aberrant crypts in colon of rats. Biofactors 15, 11-26
124. Leung, M.H., Harada, T. and Kee, T.W. (2013) Delivery of curcumin and medicinal effects of the copper(II)-curcumin complexes. Current Pharmaceutical Design 19, 2070-2083
125. Pan, J. et al. (2012) Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease through suppressing mitochondria dysfunction. Translational Neurodegeneration 1, 16
126. Jiang, H. et al. (2011) Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicity. Biological and Pharmaceutical Bulletin 34, 1194-1197
127. Liu, Z. et al. (2011) Curcumin protects against A53 T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism. Pharmacology Research 63, 439-444
128. Wang, M.S. et al. (2010) Curcumin reduces alphasynuclein induced cytotoxicity in Parkinson's disease cell model. BMC Neuroscience 11, 57
129. Grubman, A., White, A.R. and Liddell, J.R. (2013) Mitochondrial metals as a potential therapeutic target in neurodegeneration. British Journal of Pharmacology 171, 2159-2173
130. Iwunze, M.O. and McEwan, D. (2004) Peroxynitrite interaction with curcumin solubilized in ethanolic solution. Cellular and Molecular Biology (Noisy-legrand) 50, 749-752
131. Dairam, A. et al. (2008) Antioxidant and ironbinding properties of curcumin, capsaicin, and S-allylcysteine reduce oxidative stress in rat brain homogenate. Journal of Agriculture and Food Chemistry 56, 3350-3356
132. Garcia, C.R. et al. (2012) Prevention of iron-and copper-mediated DNA damage by catecholamine and amino acid neurotransmitters, L-DOPA, and curcumin: metal binding as a general antioxidant mechanism. Dalton Transactions 41, 6458-6467
133. Ferrari, E. et al. (2013) Metal binding ability of curcumin derivatives: a theoretical vs. experimental approach. Dalton Transactions 42, 5304-5313
134. Lou, J.R. et al. (2010) Transient metals enhance cytotoxicity of curcumin: potential involvement of the NF-kappaB and mTOR signaling pathways. Anticancer Research 30, 3249-3255
135. Kunwar, A. et al. (2007) Delayed activation of PKCdelta and NFkappaB and higher radioprotection in splenic lymphocytes by copper (II)-Curcumin (1:1) complex as compared to curcumin. Journal of Cellular Biochemistry 102, 1214-1224
136. John, V.D., Kuttan, G. and Krishnankutty, K. (2002) Anti-tumour studies of metal chelates of synthetic curcuminoids. Journal of Experimental and Clinical Cancer Research 21, 219-224
137. Pan, Q., Bao, L.W. and Merajver, S.D. (2003) Tetrathiomolybdate inhibits angiogenesis and metastasis through suppression of the NFkappaB signaling cascade. Molecular Cancer Research 1, 701-706
138. White, A.R. et al. (2006) Degradation of the Alzheimer disease amyloid beta-peptide by metaldependent up-regulation of metalloprotease activity. Journal of Biological Chemistry 281, 17670-17680
139. Daniel, K.G. et al. (2005) Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells. Breast Cancer Research 7, R897-R908
140. Ding, W.Q. et al. (2005) Anticancer activity of the antibiotic clioquinol. Cancer Research 65, 3389-3395
141. Daniel, K.G. et al. (2007) Copper-binding compounds as proteasome inhibitors and apoptosis inducers in human cancer. Frontiers in Bioscience 12, 135-144
142. Chen, H.L. et al. (2009) Synthesis and pharmacological exploitation of clioquinol-derived copper-binding apoptosis inducers triggering reactive oxygen species generation and MAPK pathway activation. Bioorganic and Medicinal Chemistry 17, 7239-7247
143. Laine, A.L. and Passirani, C. (2012) Novel metalbased anticancer drugs: a new challenge in drug delivery. Current Opinions in Pharmacology 12, 420-426
144. Duncan, C. and White, A.R. (2012) Copper complexes as therapeutic agents. Metallomics 4, 127-138
145. Colotti, G. et al. (2012) Metals and metal derivatives in medicine. Mini Reviews in Medicinal Chemistry PMID: 22512556
146. Filomeni, G. et al. (2009) The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis. Carcinogenesis 30, 1115-1124
147. Shrivastav, A. et al. (2006) Copper(II) and manganese(III) complexes of N'-[(2-hydroxy phenyl) carbonothioyl] pyridine-2-carbohydrazide: novel therapeutic agents for cancer. Biochimie 88, 1209-1216
148. Trejo-Solis, C. et al. (2012) Copper compound induces autophagyand apoptosis of glioma cells by reactive oxygen species and JNK activation. BMC Cancer 12, 156
149. Lutsenko, S. (2010) Human copper homeostasis: a network of interconnected pathways. Current Opinions in Chemical Biology 14, 211-217
150. Choo, X.Y. et al. (2013) Neuroinflammation and copper in Alzheimer's disease. International Journal of Alzheimer's Disease 2013, 145345
151. Gupte, A. and Mumper, R.J. (2009) Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treatment Reviews 35, 32-46
152. Rupesh, K.R. et al. (2010) 2,2′-Bipyridyl based copper complexes down regulate expression of proinflammatory cytokines and suppress MAPKs in mitogen induced peripheral blood mononuclear cells. European Journal of Medicinal Chemistry 45, 2141-2146
153. Rushworth, G.F. and Megson, I.L. (2014) Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacology and Therapeutics 141, 150-159
154. Aruoma, O.I. et al. (1989) The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radical Biology and Medicine 6, 593-597
155. Zheng, J. et al. (2010) N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death. Cancer Letters 298, 186-194
156. Offen, D. et al. (2004) A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis. Journal of Neurochemistry 89, 1241-1251
157. Taba, P. (2013) Metals and movement disorders. Current Opinions in Neurology 26, 435-441
158. Parker, S.J. et al. (2013) Biometals in rare neurodegenerative disorders of childhood. Frontiers in Aging Neuroscience 5, 14
159. Ayton, S., Lei, P. and Bush, A.I. (2013) Metallostasis in Alzheimer's disease. Free Radical Biology and Medicine 62, 76-89
160. Ward, R.J., Dexter, D.T. and Crichton, R.R. (2012) Chelating agents for neurodegenerative diseases. Current Medicinal Chemistry 19, 2760-2772
161. Schrag, M. et al. (2011) Iron, zinc and copper in the Alzheimer's disease brain: a quantitative metaanalysis. Some insight on the influence of citation bias on scientific opinion. Progress in Neurobiology 94, 296-306
162. Bica, L. et al. (2009) Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease. Molecular Biosystems 5, 134-142
163. Barnham, K.J. et al. (2004) Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid. FASEB Journal 18, 1427-1429
164. Adlard, P.A. et al. (2010) Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease? Journal of Neuroscience 30, 1631-1636
165. Atwood, C.S. et al. (1998) Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis. Journal of Biological Chemistry 273, 12817-12826
166. Curtain, C.C. et al. (2001) Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. Journal of Biological Chemistry 276, 20466-20473
167. Huang, X. et al. (2004) Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. Journal of Biological Inorganic Chemistry 9, 954-960
168. Multhaup, G. et al. (1996) The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I). Science 271, 1406-1409
169. White, A.R. et al. (1999) The Alzheimer's disease amyloid precursor protein modulates copperinduced toxicity and oxidative stress in primary neuronal cultures. Journal of Neuroscience 19, 9170-9179
170. Acevedo, K.M. et al. (2014) Phosphorylation of amyloid precursor protein at Threonine-668 is essential for its copper-responsive trafficking in SHSY5Y neuroblastoma cells. Journal of Biological Chemistry 289, 11007-11019
171. Cherny, R.A. et al. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30, 665-676
172. Ritchie, C.W. et al. (2003) Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Archives of Neurology 60, 1685-1691
173. Filiz, G. et al. (2008) Clioquinol inhibits peroxidemediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity. International Journal of Biochemistry and Cell Biology 40, 1030-1042
174. Caragounis, A. et al. (2007) Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands. Biochemical Journal 407, 435-450
175. Crouch, P.J. et al. (2011) The Alzheimer's therapeutic PBT2 promotes amyloid-beta degradation and GSK3 phosphorylation via a metal chaperone activity. Journal of Neurochemistry 119, 220-230
176. Parker, S.J. et al. (2012) Inhibition of TDP-43 Accumulation by Bis(thiosemicarbazonato)-Copper Complexes. PLoS One 7, e42277
177. Soon, C.P. et al. (2011) Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitriteinduced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model. Journal of Biological Chemistry 286, 44035-44044
178. Hung, L.W. et al. (2012) The hypoxia imaging agent Cu-II(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease. Journal of Experimental Medicine 209, 837-854
179. Akatsu, H. et al. (2012) Transition metal abnormalities in progressive dementias. Biometals 25, 337-350
180. Crouch, P.J. and Barnham, K.J. (2012) Therapeutic redistribution of metal ions to treat Alzheimer's disease. Accounts of Chemical Research 45, 1604-1611
181. Donnelly, P.S. et al. (2008) Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide. Journal of Biological Chemistry 283, 4568-4577
182. McAllum, E.J. et al. (2013) Therapeutic effects of Cu(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14, 586-590