The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription

Experimental Cell Research

Volumn 322, Issue 1, 2014, Pages 39-50

  Song, Min Ok ^a   Mattie, Michael D ^b,d   Lee, Chang Ho ^a   Freedman, Jonathan H ^c  

^a Gangneung Wonju National University   (South Korea)

^b DUKE UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d Agensys Inc   (United States)

Author keywords

ARE; Copper; Metallothionein 1; Nrf1; Nrf2; Transcription

Indexed keywords

COPPER; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTOME;

ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MT 1 GENE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TOXICOGENETICS; TRANSCRIPTION REGULATION;

ARE; COPPER; METALLOTHIONEIN-1; NRF1; NRF2; TRANSCRIPTION;

ANIMALS; CELLS, CULTURED; COPPER; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HEP G2 CELLS; HUMANS; METALLOTHIONEIN; MICE; MICE, KNOCKOUT; NF-E2-RELATED FACTOR 2; NUCLEAR RESPIRATORY FACTOR 1; TRANSCRIPTION, GENETIC;

EID: 84893737590     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2014.01.013     Document Type: Article

References (37)

1. Abdelhamid G., Anwar-Mohamed A., Elmazar M.M., El-Kadi A.O. Modulation of NAD(P)H:quinone oxidoreductase by vanadium in human hepatoma HepG2 cells. Toxicol. in vitro: Int. J. Pub. Assoc. BIBRA 2010, 24:1554-1561.
2. Chan J.Y., Kwong M. Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein. Biochim. Biophys. Acta 2000, 1517:19-26.
3. Chan J.Y., Kwong M., Lu R., Chang J., Wang B., Yen T.S., Kan Y.W. Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf1, results in anemia and embryonic lethality in mice. EMBO J. 1998, 17:1779-1787.
4. Chan K., Kan Y.W. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc. Natl. Acad. Sci. USA 1999, 96:12731-12736.
5. Chanas S.A., Jiang Q., McMahon M., McWalter G.K., McLellan L.I., Elcombe C.R., Henderson C.J., Wolf C.R., Moffat G.J., Itoh K., Yamamoto M., Hayes J.D. Loss of Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. Biochem. J. 2002, 365:405-416.
6. Chorley B.N., Campbell M.R., Wang X., Karaca M., Sambandan D., Bangura F., Xue P., Pi J., Kleeberger S.R., Bell D.A. Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucl. Acids Res. 2012, 40:7416-7429.
7. Copple I.M., Goldring C.E., Kitteringham N.R., Park B.K. The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity. Toxicology 2008, 246:24-33.
8. Dalton T., Palmiter R.D., Andrews G.K. Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements. Nucl. Acids Res. 1994, 22:5016-5023.
9. Favreau L.V., Pickett C.B. The rat quinone reductase antioxidant response element. Identification of the nucleotide sequence required for basal and inducible activity and detection of antioxidant response element-binding proteins in hepatoma and non-hepatoma cell lines. J. Biol. Chem. 1995, 270:24468-24474.
10. Gong P., Cederbaum A.I. Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology 2006, 43:144-153.
11. Jaiswal A.K. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic. Biol. Med. 2004, 36:1199-1207.
12. Jennings P., Limonciel A., Felice L., Leonard M.O. An overview of transcriptional regulation in response to toxicological insult. Arch. Toxicol. 2013, 87:49-72.
13. Kensler T.W., Wakabayashi N., Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 2007, 47:89-116.
14. 2+-induced oxidative stress through chelating activity and regulation of nuclear factor-erythroid-2-related factor 2 signaling. Food Sci. Biotechnol. 2012, 21:1469-1475.
15. Kobayashi A., Tsukide T., Miyasaka T., Morita T., Mizoroki T., Saito Y., Ihara Y., Takashima A., Noguchi N., Fukamizu A., Hirotsu Y., Ohtsuji M., Katsuoka F., Yamamoto M. Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes Cells 2011, 16:692-703.
16. Kwong M., Kan Y.W., Chan J.Y. The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 inα -GCSl and gss expression in mouse fibroblasts. J. Biol. Chem. 1999, 274:37491-37498.
17. Letelier M.E., Lepe A.M., Faundez M., Salazar J., Marin R., Aracena P., Speisky H. Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity. Chem. Biol. Interact. 2005, 151:71-82.
18. Ma Q. Role of nrf2 in oxidative stress and toxicity. Annu. Rev. Pharmacol. Toxicol. 2013, 53:401-426.
19. Maher J., Yamamoto M. The rise of antioxidant signaling-the evolution and hormetic actions of Nrf2. Toxicol. Appl. Pharmacol. 2010, 244:4-15.
20. Mattie M.D., Freedman J.H. Copper-inducible transcription: regulation by metal- and oxidative stressresponsive pathways. Am. J. Physiol. Cell Physiol. 2004, 286:C293-C301.
21. McMahon M., Itoh K., Yamamoto M., Chanas S.A., Henderson C.J., McLellan L.I., Wolf C.R., Cavin C., Hayes J.D. The Cap[U+05F3]n[U+05F3]Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res. 2001, 61:3299-3307.
22. Nguyen T., Huang H.C., Pickett C.B. Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK. J. Biol. Chem. 2000, 275:15466-15473.
23. Nguyen T., Nioi P., Pickett C.B. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 2009, 284:13291-13295.
24. Niture S.K., Kaspar J.W., Shen J., Jaiswal A.K. Nrf2 signaling and cell survival. Toxicol. Appl. Pharmacol. 2010, 244:37-42.
25. Ohtsuji M., Katsuoka F., Kobayashi A., Aburatani H., Hayes J.D., Yamamoto M. Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J. Biol. Chem. 2008, 283:33554-33562.
26. Osburn W.O., Kensler T.W. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mut. Res. 2008, 659:31-39.
27. Radtke F., Heuchel R., Georgiev O., Hergersberg M., Gariglio M., Dembic Z., Schaffner W. Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter. EMBO J. 1993, 12:1355-1362.
28. Scandalios J.G. Oxidative Stress and the Molecular Biology of Antioxidant Defenses 1997, Cold Spring Harbor Laboratory Press, Plainview, N.Y.
29. Shokri F., Heidari M., Gharagozloo S., Ghazi-Khansari M. In vitro inhibitory effects of antioxidants on cytotoxicity of T-2 toxin. Toxicology 2000, 146:171-176.
30. Song M.O., Li J., Freedman J.H. Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol. Genom. 2009, 38:386-401.
31. Thimmulappa R.K., Mai K.H., Srisuma S., Kensler T.W., Yamamoto M., Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 2002, 62:5196-5203.
32. Vadigepalli R., Chakravarthula P., Zak D.E., Schwaber J.S., Gonye G.E. PAINT: a promoter analysis and interaction network generation tool for gene regulatory network identification. Omics: J. Integr. Biol. 2003, 7:235-252.
33. Valko M., Morris H., Cronin M.T. Metals, toxicity and oxidative stress. Curr. Med. Chem. 2005, 12:1161-1208.
34. Venugopal R., Jaiswal A.K. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc. Natl. Acad. Sci. USA 1996, 93:14960-14965.
35. Xie T., Belinsky M., Xu Y., Jaiswal A.K. ARE- and TRE-mediated regulation of gene expression. Response to xenobiotics and antioxidants. J. Biol. Chem. 1995, 270:6894-6900.
36. Xu Z., Chen L., Leung L., Yen T.S., Lee C., Chan J.Y. Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc. Natl. Acad. Sci. U.S.A 2005, 102:4120-4125.
37. Zheng Q., Wang X.J. GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis. Nucl. Acids Res. 2008, 36:W358-W363.