Synthesis and pharmacological exploitation of clioquinol-derived copper-binding apoptosis inducers triggering reactive oxygen species generation and MAPK pathway activation

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 20, 2009, Pages 7239-7247

  Chen, Hui Ling ^a   Chang, Chun Yi ^b   Lee, Hsun Tzu ^b   Lin, Hua Hsuan ^b   Lu, Pei Jung ^a   Yang, Chia Ning ^c   Shiau, Chung Wai ^d   Shaw, Arthur Y ^b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b TAMKANG UNIVERSITY   (Taiwan)

^c NATIONAL UNIVERSITY OF KAOHSIUNG   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Clioquinol; Mannich type reaction; MAPK pathway activation; Metal binding property; Reactive oxygen species (ROS)

Indexed keywords

5 NITRO 7 [(4 TOSYLPIPERAZIN 1 YL)METHYL]QUINOLIN 8 OL; 7 [[4 (PHENYLSULFONYL)PIPERAZIN 1 YL]METHYL]QUINOLIN 8 OL; CASPASE; CLIOQUINOL; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; TEMPOL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVATION; HELA CELL; HUMAN; HUMAN CELL; MANNICH REACTION; OXIDATIVE STRESS;

APOPTOSIS; CELL DIVISION; CLIOQUINOL; COPPER; HELA CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; REACTIVE OXYGEN SPECIES;

EID: 71749090438     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.054     Document Type: Article

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