Potent and long-lasting inhibition of human P2X2 receptors by copper

Neuropharmacology

Volumn 77, Issue , 2014, Pages 167-176

  Punthambaker, Sukanya ^a   Hume, Richard I ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Copper inhibition; P2X2 receptor; Potent; Wilson disease

Indexed keywords

ADENOSINE TRIPHOSPHATE; CADMIUM; COPPER CHLORIDE; CYSTEINE; HISTIDINE; NICKEL; PURINERGIC P2X2 RECEPTOR; ZINC CHLORIDE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DISULFIDE BOND; FEMALE; METAL BINDING; MUTANT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; WILD TYPE; XENOPUS LAEVIS;

COPPER INHIBITION; DIMETHYL SULFOXIDE; DITHIOTREITOL; DMSO; DTT; P2X2 RECEPTOR; POTENT; WILSON DISEASE;

ANIMALS; COPPER; HUMANS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RECEPTORS, PURINERGIC P2X2; SPECIES SPECIFICITY; XENOPUS LAEVIS;

EID: 84886266254     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.09.001     Document Type: Article

References (27)

1. G. Burnstock, and G.E. Knight Cellular distribution and functions of P2 receptor subtypes in different systems Int. Rev. Cytol. 240 2004 31 304 (Pubitemid 39539202)
2. J.D. Clyne, L.F. Wang, and R.I. Hume Mutational analysis of the conserved cysteines of the rat P2X2 purinoceptor J. Neurosci. 22 2002 3873 3880 (Pubitemid 37465695)
3. D.A. Cockayne, P.M. Dunn, Y. Zhong, W. Rong, S.G. Hamilton, G.E. Knight, H.Z. Ruan, B. Ma, P. Yip, P. Nunn, S.B. McMahon, G. Burnstock, and A.P. Ford P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP J. Physiol. 567 2005 621 639 (Pubitemid 41301057)
4. C. Coddou, C. Acuna-Castillo, P. Bull, and J.P. Huidobro-Toro Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition J. Biol. Chem. 282 2007 36879 36886
5. K.A. Cushman, J. Marsh-Haffner, J.P. Adelman, and E.W. McCleskey A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3 J. Gen. Physiol. 129 2007 345 350 (Pubitemid 46506984)
6. N. Doreulee, Y. Yanovsky, and H.L. Haas Suppression of long-term potentiation in hippocampal slices by copper Hippocampus 7 1997 666 669 (Pubitemid 28021651)
7. S.J. Ennion, and R.J. Evans Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface Mol. Pharmacol. 61 2002 303 311 (Pubitemid 34112804)
8. E.B. Gonzales, T. Kawate, and E. Gouaux Pore architecture and ion sites in acid-sensing ion channels and P2X receptors Nature 460 2009 599 604
9. D.J. Hare, J.K. Lee, A.D. Beavis, A. van Gramberg, J. George, P.A. Adlard, D.I. Finkelstein, and P.A. Doble Three-dimensional atlas of iron, copper, and zinc in the mouse cerebrum and brainstem Anal Chem. 84 2012 3990 3997
10. A. Hopt, S. Korte, H. Fink, U. Panne, R. Niessner, R. Jahn, H. Kretzschmar, and J. Herms Methods for studying synaptosomal copper release J. Neurosci. Methods 128 2003 159 172 (Pubitemid 37013560)
11. D. Huster Wilson disease Best Pract. Res. Clin. Gastroenterol. 24 2010 531 539
12. D. Huster, M.J. Finegold, C.T. Morgan, J.L. Burkhead, R. Nixon, S.M. Vanderwerf, C.T. Gilliam, and S. Lutsenko Consequences of copper accumulation in the livers of the Atp7b-/- (Wilson disease gene) knockout mice Am. J. Pathol. 168 2006 423 434 (Pubitemid 43271141)
13. P. Illes, and J.A. Ribeiro Neuronal P2 receptors of the central nervous system Curr. Top Med. Chem. 4 2004 831 838 (Pubitemid 38854841)
14. L.H. Jiang, F. Rassendren, A. Surprenant, and R.A. North Identification of amino acid residues contributing to the ATP-binding site of a purinergic P2X receptor J. Biol. Chem. 275 2000 34190 34196
15. T. Kawate, J.C. Michel, W.T. Birdsong, and E. Gouaux Crystal structure of the ATP-gated P2X(4) ion channel in the closed state Nature 460 2009 592 598
16. C.L. Keen, J.Y. Uriu-Hare, S.N. Hawk, M.A. Jankowski, G.P. Daston, C.L. Kwik-Uribe, and R.B. Rucker Effect of copper deficiency on prenatal development and pregnancy outcome Am. J. Clin. Nutr. 67 1998 1003S 1011S (Pubitemid 28198824)
17. M. Kozma, P. Szerdahelyi, and P. Kasa Histochemical detection of zinc and copper in various neurons of the central nervous system Acta Histochem. 69 1981 12 17 (Pubitemid 12234374)
18. C. Li, R.W. Peoples, and F.F. Weight Inhibition of ATP-activated current by zinc in dorsal root ganglion neurones of bullfrog J. Physiol. 505 Pt 3 1997 641 653 (Pubitemid 28022365)
19. M.T. Lorincz Neurologic Wilson's disease Ann. N. Y Acad. Sci. 1184 2010 173 187
20. S. Lutsenko, N.L. Barnes, M.Y. Bartee, and O.Y. Dmitriev Function and regulation of human copper-transporting ATPases Physiol. Rev. 87 2007 1011 1046 (Pubitemid 47084675)
21. S. Punthambaker, J.A. Blum, and R.I. Hume High potency zinc modulation of human P2X2 receptors and low potency zinc modulation of rat P2X2 receptors share a common molecular mechanism J. Biol. Chem. 287 2012 22099 22111
22. F. Rassendren, G. Buell, A. Newbolt, R.A. North, and A. Surprenant Identification of amino acid residues contributing to the pore of a P2X receptor EMBO J. 16 1997 3446 3454 (Pubitemid 27250040)
23. J.T. Rubino, and K.J. Franz Coordination chemistry of copper proteins: how nature handles a toxic cargo for essential function J. Inorg. Biochem. 107 2012 129 143
24. M. Sato, K. Ohtomo, T. Daimon, T. Sugiyama, and K. Iijima Localization of copper to afferent terminals in rat locus ceruleus, in contrast to mitochondrial copper in cerebellum J. Histochem. Cytochem. 42 1994 1585 1591 (Pubitemid 24375341)
25. R.K. Tittle, and R.I. Hume Opposite effects of zinc on human and rat P2X2 receptors J. Neurosci. 28 2008 11131 11140
26. 2+ on ATP-responses at rP2X1 and rP2X3 receptors Br. J. Pharmacol. 128 1999 486 492 (Pubitemid 29458611)
27. K. Xiong, R.W. Peoples, J.P. Montgomery, Y. Chiang, R.R. Stewart, F.F. Weight, and C. Li Differential modulation by copper and zinc of P2X2 and P2X4 receptor function J. Neurophysiol. 81 1999 2088 2094 (Pubitemid 29262543)