The mammalian copper transporters CTR1 and CTR2 and their roles in development and disease

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 5, 2013, Pages 960-963

  Wee, Natalie K Y ^a   Weinstein, Daniel C ^b,c   Fraser, Stuart T ^a,d   Assinder, Stephen J ^a,d  

^a UNIVERSITY OF SYDNEY   (Australia)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c CITY UNIVERSITY OF NEW YORK   (United States)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cancer; Chemotherapy; Copper transporter; Development; Immunity

Indexed keywords

CISPLATIN; COPPER PROTEIN; COPPER TRANSPORTER 1; COPPER TRANSPORTER 2; GAMMA INTERFERON; UNCLASSIFIED DRUG;

CANCER PROGNOSIS; CANCER SURVIVAL; CELL DIFFERENTIATION; CELL FUNCTION; CELL MEMBRANE; EMBRYO DEVELOPMENT; HUMAN; IMMUNE RESPONSE; IMMUNITY; IN VITRO STUDY; LUNG CANCER; MACROPHAGE; MITOCHONDRION; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; OVARY CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION; TUMOR IMMUNITY;

MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; CATION TRANSPORT PROTEINS; COPPER; HUMANS; MOLECULAR SEQUENCE DATA;

EID: 84874624733     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.01.018     Document Type: Short Survey

References (31)

1. P. Abada, and Howell SB Regulation of cisplatin cytotoxicity by Cu influx transporters Metal-based Drugs 2010 2010 Article ID 317581, 9 pages, http://dx.doi.org/10.1155/2010/317581
2. M.E. Achard, S.L. Stafford, N.J. Bokil, J. Chartres, P.V. Bernhardt, M.A. Schembri, M.J. Sweet, and A.G. McEwan Copper redistribution in murine macrophages in response to Salmonella infection Biochemical Journal 444 2012 51 57
3. J. Bertinato, E. Swist, L.J. Plouffe, S.P.J. Brooks, and M.R. L'Abbè Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells Biochemical Journal 409 2008 731 740
4. H.H. Chen, J.J. Yan, W.C. Chen, M.T. Kuo, Y.H. Lai, W.W. Lai, H.S. Liu, and W.C. Su Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy Lung Cancer 75 2012 228 234
5. C.D. Chun, and H.D. Madhani Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibiton in the human fungal pathogen Cryptococcus neoformans PLoS ONE 5 2010 e12503
6. R.A. Festa, and D.J. Thiele Copper an essential metal in biology Current Biology 21 2011 R877-R833
7. Y. Guo, K. Smith, J. Lee, D.J. Thiele, and M.J. Petris Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporter Journal of Biological Chemistry 279 2004 17428 17433
8. A. Gupta, and S. Lutsenko Human copper transporters: mechanism, role in human diseases and therapeutic potential Future Medicinal Chemistry 1 2009 1125 1142
9. K.L. Haas, A.B. Putterman, D.R. White, D.J. Thiele, and K.J. Franz Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1 Journal of the American Chemical Society 133 2011 4427 4437
10. B. Hardman, U. Manuelpillai, E.M. Wallace, J.F. Monty, D.R. Kramer, Y.M. Kuo, J.F. Mercer, and M.L. Ackland Expression, localisation and hormone regulation of the human copper transporter hCTR1 in placenta and choriocarcinoma Jeg-3 cells Placenta 27 2006 968 977
11. T. Haremaki, S.T. Fraser, Y.M. Kuo, M.H. Baron, and D.C. Weinstein Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation Proceedings of the National Academy of Sciences of the United States of America 104 2007 12029 12034
12. V. Hodgkinson, and M.J. Petris Copper homeostasis at the host-pathogen interface Journal of Biological Chemistry 287 2012 13549 13555
13. S. Ishida, J. Lee, D.J. Thiele, and I. Herskowitz Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals Proceedings of the National Academy of Sciences of the United States of America 99 2002 14298 14302
14. S. Ishida, F. Mccormick, K. Smith-Mccune, and D. Hanahan Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator Cancer Cell 17 2010 574 583
15. J.H. Kaplan, and S. Lutsenko Copper transport in mammalian cells: special care for a metal with special needs Journal of Biological Chemistry 284 2009 25461 25465
16. Y.M. Kuo, B. Zhou, D. Cosco, and J. Gitschier The copper transporter CTR1 provides an essential function in mammalian embryonic development Proceedings of the National Academy of Sciences of the United States of America 98 2001 6836 6841
17. Y.M. Kuo, A.A. Gybina, J.W. Pyatskowit, J. Gitschier, and J.R. Prohaska Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status Journal of Nutrition 136 2006 21 26
18. C.A. Larson, P.L. Adams, D.D. Jandial, B.G. Blair, R. Safaei, and S.B. Howell The role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatin Biochemical Pharmacology 80 2010 448 454
19. J. Lee, J.R. Prohaska, and D.J. Thiele Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development Proceedings of the National Academy of Sciences of the United States of America 98 2001 6842 6847
20. Y.Y. Lee, C.H. Choi, I.G. Do, S.Y. Song, W. Lee, H.S. Park, T.J. Song, M.K. Kim, T.J. Kim, J.W. Lee, D.S. Bae, and B.G. Kim Prognostic value of the copper transporters, CTR1 and CTR2, in patients with ovarian carcinoma receiving platinum-based chemotherapy Gynecologic Oncology 122 2011 361 365
21. Z. Li, S. Van Calcar, W.K. Qu Chunxu Cavenee, M.Q. Zhang, and B. Ren A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells Proceedings of the National Academy of Sciences of the United States of America 100 2003 8164 8169
22. Z.D. Liang, W-B. Tsai, M-Y. Lee, N. Savaraj, and M.T. Kuo Specificity protein 1 (SP1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression Molecular Pharmacology 81 2012 455 464
23. E.B. Maryon, S.A. Molloy, and J.H. Kaplan O-linked glycosylation at threonine 27 protects the copper transporter hCTR1 from proteolytic cleavage in mammalian cells Journal of Biological Chemistry 282 2007 20376 20387
24. T. Nevitt, H. Öhrvik, and D.J. Thiele Charting the travels of copper in eukaryotes from yeast to mammals Biochemistry and Biophysics Acta 1823 2012 1580 1593
25. E.M. Rees, J. Lee, and D.J. Thiele Mobilization of intracellular copper stores by the Ctr2 vacuolar copper transporter Journal of Biological Chemistry 279 2004 54221 54229
26. Y. Takahashi, K. Kako, S.-C. Kashiwabara, A. Takehera, Y. Inada, H. Arai, K. Nakada, H. Kodama, J.-I. Hayashi, B. Tadashi, and E. Munekata Mammalian copper chaperone cox17p has an essential role in activation of cytochrome C oxidase and embryonic development Molecular and Cellular Biology 22 2002 7614 7621
27. M.L. Turski, D.C. Brady, H.J. Kim, B.-E. Kim, Y. Nose, C.M. Counter, D.R. Winge, and D.J. Thiele A novel role for copper in Ras/mitogen-activated protein kinase signaling Molecular and Cellular Biology 32 2012 1284 1295
28. P.V. van der Berghe, D.E. Folmer, H.E. Malingre, E. van Beurden, A.E. Klomp, B. van de Sluis, M. Merkx, M. Berger, and L.W. Klomp Human copper transporter 2 is localised in late endosomes and lysosomes and facilitates cellular copper uptake The Biochemical Journal 407 2007 49 59
29. P.E. van den Berghe, and L.W. Klomp Posttranslational regulation of copper transporters Journal of Biological Inorganic Chemistry 15 2010 37 46
30. Z. Zheng, C. White, J. Lee, T.S. Peterson, A.I. Bush, G.Y. Sun, G.A. Weisman, and M.J. Petris Altered microglial copper homeostasis in a mouse model of Alzheimer's disease Journal of Neurochemistry 114 2010 1630 1638
31. B. Zhou, and J. Gitschier hCTR1: a human gene for copper uptake identified by complementation in yeast Proceedings of the National Academy of Sciences of the United States of America 94 1997 7481 7748