Involvement of activating transcription factors JNK, NF-κB, and AP-1 in apoptosis induced by pyrrolidine dithiocarbamate/Cu complex

European Journal of Pharmacology

Volumn 594, Issue 1-3, 2008, Pages 9-17

  Chen, Sung Ho ^a   Lin, Jen Kun ^a   Liang, Yu Chih ^a   Pan, Min Hsiung ^a   Liu, Shing Hwa ^a   Lin Shiau, Shoei Yn ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

AP 1; Apoptosis; BCPS; Caspase; Copper; JNK; NF B; Oxidative stress; PDTC

Indexed keywords

ASCORBIC ACID; BATHOCUPROINE DISULFONATE; CHELATING AGENT; COPPER; COPPER CHLORIDE; CYTOCHROME C; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL LEVEL; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TIME;

APOPTOSIS; CASPASE 3; CELL SURVIVAL; COPPER; CYTOCHROMES C; DNA FRAGMENTATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLOW CYTOMETRY; FREE RADICALS; HL-60 CELLS; HUMANS; I-KAPPA B KINASE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIALS; MITOCHONDRIAL MEMBRANES; NF-KAPPA B; POLY(ADP-RIBOSE) POLYMERASES; PYRROLIDINES; SPECTROPHOTOMETRY, ATOMIC; SULFHYDRYL COMPOUNDS; THIOCARBAMATES; TRANSCRIPTION FACTOR AP-1;

EID: 50549096389     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.07.024     Document Type: Article

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