Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 34, 2012, Pages 13733-13738

  Siggs, Owen M ^a   Cruite, Justin T ^a   Du, Xin ^a   Rutschmann, Sophie ^a,c   Masliah, Eliezer ^b   Beutler, Bruce ^a,d   Oldstone, Michael B A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

ATPase; Menkes disease; N ethyl N nitrosourea (ENU) mutagenesis; Neurodegeneration; Pigmentation

Indexed keywords

COPPER; MENKES PROTEIN; PRION PROTEIN; WILSON DISEASE PROTEIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; HEMIZYGOTE; HOMEOSTASIS; HYPOPIGMENTATION; MISSENSE MUTATION; MOUSE; NONHUMAN; PHENOTYPE; PRION DISEASE; PRIORITY JOURNAL; SCRAPIE;

ADENOSINE TRIPHOSPHATASES; ALLELES; ANIMALS; CATION TRANSPORT PROTEINS; COPPER; ETHYLNITROSOUREA; HOMEOSTASIS; MALE; MENKES KINKY HAIR SYNDROME; MICE; MICE, INBRED C57BL; MUTAGENESIS; MUTATION; PHENOTYPE; PIGMENTATION; PRIONS; SCRAPIE;

EID: 84865287014     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211499109     Document Type: Article

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