The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis

Carcinogenesis

Volumn 30, Issue 7, 2009, Pages 1115-1124

  Filomeni, Giuseppe ^a   Piccirillo, Sara ^b   Graziani, Ilaria ^a   Cardaci, Simone ^a   Da Costa Ferreira, Ana M ^c   Rotilio, Giuseppe ^a,b   Ciriolo, Maria R ^a,b  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b IRCCS SAN RAFFAELE PISANA   (Italy)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE KINASE; ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; BIS[(2 OXINDOL 3 YLIMINO) 2 (AMINOETHYL)PYRIDINE N,N'] COPPER; COPPER COMPLEX; CYTOTOXIC AGENT; GLUCOSE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIVITY; ELECTRON TRANSPORT; GLYCOLYSIS; HELA CELL; HUMAN; HUMAN CELL; LIPOPHILICITY; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CARCINOMA; UTERINE CERVIX CARCINOMA;

ADENOSINE TRIPHOSPHATE; AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CATIONS; CELL LINE, TUMOR; GLUCOSE; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; ORGANOMETALLIC COMPOUNDS; OXIDATIVE STRESS; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; SCHIFF BASES; SIGNAL TRANSDUCTION;

EID: 67650141679     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp105     Document Type: Article

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