Involvement of oxidative stress-induced ERK/JNK activation in the Cu 2+/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic β-cells

Toxicology Letters

Volumn 208, Issue 3, 2012, Pages 275-285

  Wu, Chin Ching ^a   Yen, Cheng Chieh ^b,c   Lee, kuan I ^d   Su, Chin Chuan ^e   Tang, Feng Cheng ^e   Chen, Kuo Liang ^f   Su, Yi Chang ^a   Chen, Ya Wen ^g  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^e CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^f CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Copper (Cu 2+); ERK1 2; JNK; Oxidative stress; Pancreatic cell; PDTC

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; COPPER; COPPER CHLORIDE; GLUTATHIONE; JANUS KINASE; LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PYRROLIDINE DITHIOCARBAMATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL POPULATION; CELL VIABILITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; COPPER; DIABETES MELLITUS; ENZYME ACTIVATION; FLOW CYTOMETRY; GLUTATHIONE; INSULIN-SECRETING CELLS; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; PYRROLIDINES; RATS; RNA, SMALL INTERFERING; THIOCARBAMATES;

EID: 83055182025     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.10.022     Document Type: Article

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