Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation

Toxicological Sciences

Volumn 102, Issue 1, 2008, Pages 138-149

  Chen, Sung Ho ^a   Lin, Jen Kun ^a   Liu, Shing Hwa ^a   Liang, Yu Chih ^a   Lin shiau, Shoei Yn ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Astrocytes; Caspase 3; Cu; JNK; Neocuproine; Oxidative stress

Indexed keywords

2,9 DIMETHYL 1,10 PHENANTHROLINE; ADENOSINE TRIPHOSPHATE; BATHOCUPROINE DISULFONIC ACID; CASPASE 3; CHELATING AGENT; COPPER; COPPER CHLORIDE; CYTOCHROME C; DISULFIRAM; DITHIOCARBAMIC ACID; GLUTATHIONE; IRON; LEAD; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL DEATH; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME RELEASE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEPLETION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; CASPASE 3; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CELLS, CULTURED; CHELATING AGENTS; COPPER; CYTOCHROMES C; DNA BREAKS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME ACTIVATION; GLUTATHIONE; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 8; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENANTHROLINES; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 39149122831     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm292     Document Type: Article

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