Beyond the cell surface: New mechanisms of receptor function

Biochemical and Biophysical Research Communications

Volumn 396, Issue 1, 2010, Pages 24-27

  Ibáñez, Carlos F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cell adhesion; GDNF; GFR 1; NCAM; RET

Indexed keywords

CELL SURFACE RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR FAMILY RECEPTOR ALPHA 1; GROWTH FACTOR RECEPTOR; NERVE CELL ADHESION MOLECULE; PROTEIN RET; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL INTERACTION; CELL SURFACE; MOLECULAR MECHANICS; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

CELL ADHESION; CELL MEMBRANE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HUMANS; LIGANDS; NEURAL CELL ADHESION MOLECULES; SIGNAL TRANSDUCTION;

EID: 77952305666     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.01.136     Document Type: Article

References (20)

1. Lin L.-F.H., Doherty D., Lile J., Bektesh S., and Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neruons. Science 260 (1993) 1130-1132
2. Airaksinen M.S., and Saarma M. The GDNF family: signalling, biological functions and therapeutic value. Nat. Rev. Neurosci. 3 (2002) 383-394
3. Trupp M., Arenas E., Fainzilber M., Nilsson A.-S., Sieber B.A., Grigoriou M., Kilkenny C., Salazar-Grueso E., Pachnis V., Arumäe U., Sariola H., Saarma M., and Ibáñez C.F. Functional receptor for glial cell line-derived neurotrophic factor encoded by the c-ret proto-oncogene product. Nature 381 (1996) 785-789
4. Treanor J., Goodman L., Desauvage F., Stone D.M., Poulsen K.T., Beck C.D., Gray C., Armanini M.P., Pollock R.A., Hefti F., Phillips H.S., Goddard A., Moore M.W., Buj-Bello A., Davies A.M., Asai N., Takahashi M., Vandlen R., Henderson C.E., and Rosenthal A. Characterization of a multicomponent receptor for GDNF. Nature 382 (1996) 80-83
5. Besset V., Scott R.P., and Ibáñez C.F. Signaling complexes and protein-protein interactions involved in the activation of the Ras and PI3K pathways by the c-ret receptor tyrosine kinase. J. Biol. Chem. 275 (2000) 39159-39166
6. Trupp M., Belluardo N., Funakoshi H., and Ibáñez C.F. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and gdnf receptor-alpha indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci. 17 (1997) 3554-3567
7. Trupp M., Scott R., Whittemore S.R., and Ibáñez C.F. Ret-dependent and -independent mechanisms of GDNF signalling in neuronal cells. J. Biol. Chem. 274 (1999) 20885-20894
8. Paratcha G., Ledda F., and Ibáñez C.F. The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell 113 (2003) 867-879
9. Niethammer P., Delling M., Sytnyk V., Dityatev A., Fukami K., and Schachner M. Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis. J. Cell Biol. 157 (2002) 521-532
10. Sjöstrand D., Carlsson J., Paratcha G., Persson B., and Ibáñez C.F. Disruption of the GDNF binding site in NCAM dissociates ligand binding and homophilic cell adhesion. J. Biol. Chem. 282 (2007) 12734-12740
11. Nielsen J., Gotfryd K., Li S., Kulahin N., Soroka V., Rasmussen K.K., Bock E., and Berezin V. Role of glial cell line-derived neurotrophic factor (GDNF)-neural cell adhesion molecule (NCAM) interactions in induction of neurite outgrowth and identification of a binding site for NCAM in the heel region of GDNF. J. Neurosci. 29 (2009) 11360-11376
12. Iwase T., Jung C.G., Bae H., Zhang M., and Soliven B. Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells. J. Neurochem. 94 (2005) 1488-1499
13. Ledda F., Paratcha G., Sandoval-Guzmán T., and Ibáñez C.F. GDNF and GFRa1 promote formation of neuronal synapses by ligand-induced cell adhesion. Nat. Neurosci. 10 (2007) 293-300
14. Paratcha G., Ibáñez C.F., and Ledda F. GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream. Mol. Cell. Neurosci. 31 (2006) 505-514
15. Sjöstrand D., and Ibáñez C.F. Insights into GFRalpha1 regulation of neural cell adhesion molecule (NCAM) function from structure-function analysis of the NCAM/GFRalpha1 receptor complex. J. Biol. Chem. 283 (2008) 13792-13798
16. Parkash V., Leppanen V.M., Virtanen H., Jurvansuu J.M., Bespalov M.M., Sidorova Y.A., Runeberg-Roos P., Saarma M., and Goldman A. The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding. J. Biol. Chem. 283 (2008) 35164-35172
17. Paratcha G., Ledda F., Baars L., Coulpier M., Besset V., Anders J., Scott R., and Ibáñez C.F. Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-ret to lipid rafts. Neuron 29 (2001) 171-184
18. Ledda F., Paratcha G., and Ibáñez C.F. Target-derived GFRalpha1 as an attractive guidance signal for developing sensory and sympathetic axons via activation of Cdk5. Neuron 36 (2002) 387-401
19. Crone S.A., and Lee K.F. The bound leading the bound: target-derived receptors act as guidance cues. Neuron 36 (2002) 333-335
20. Enomoto H., Hughes I., Golden J., Baloh R.H., Yonemura S., Heuckeroth R.O., Johnson Jr. E.M., and Milbrandt J. GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron 44 (2004) 623-636