Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells

Journal of Biological Chemistry

Volumn 289, Issue 16, 2014, Pages 11007-11019

  Acevedo, Karla M ^a   Opazo, Carlos M ^b   Norrish, David ^a   Challis, Leesa M ^a   Li, Qiao Xin ^a   White, Anthony R ^a   Bush, Ashley I ^b   Camakaris, James ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GLYCOPROTEINS; PHOSPHORYLATION;

AMYLOID PRECURSOR PROTEINS; INTRACELLULAR LOCALIZATION; NEUROBLASTOMA CELLS; NEURONAL CELL; PATHOLOGICAL CONDITIONS; SH-SY5Y CELLS;

COPPER;

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; ALANINE; AMYLOID PRECURSOR PROTEIN; CHELATING AGENT; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; PURVALANOL A; PURVALANOL B; SERINE; THREONINE;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL STRAIN SH SY5Y; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENSITOMETRY; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPUS; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; MOUSE; MUTANT; NERVE FIBER; NERVE FIBER TRANSPORT; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRAFFICKING; SITE DIRECTED MUTAGENESIS; SYNAPSE;

AMYLOID PRECURSOR PROTEIN; CONFOCAL MICROSCOPY; COPPER; GLYCOGEN SYNTHASE KINASE 3; PHOSPHORYLATION; TRAFFICKING;

ADJUVANTS, IMMUNOLOGIC; AMINOPHENOLS; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AXONS; CELL LINE, TUMOR; COPPER; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; HUMANS; INDOLES; LITHIUM CHLORIDE; MALEIMIDES; MICE; MUTATION, MISSENSE; NEUROBLASTOMA; PHOSPHORYLATION; PROTEIN TRANSPORT; SYNAPSES;

EID: 84898963954     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.538710     Document Type: Article

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