Disulfiram/copper complex activated JNK/c-jun pathway and sensitized cytotoxicity of doxorubicin in doxorubicin resistant leukemia HL60 cells

Blood Cells, Molecules, and Diseases

Volumn 47, Issue 4, 2011, Pages 264-269

  Xu, Bing ^a   Shi, Pengcheng ^a   Fombon, Ivo S ^b   Zhang, Yanyan ^a   Huang, Fen ^a   Wang, Weiguang ^b   Zhou, Shuyun ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

Author keywords

Copper; Disulfiram; HL60 Dox; JNK

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; COPPER COMPLEX; DISULFIRAM; DOXORUBICIN; JANUS KINASE; PROTEIN BCL 2; PROTEIN C JUN;

APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL STRAIN HL 60; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL LINE, TUMOR; COPPER; DISULFIRAM; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; HL-60 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEUKEMIA, MYELOID, ACUTE; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN;

EID: 82955234022     PISSN: 10799796     EISSN: 10960961     Source Type: Journal    
DOI: 10.1016/j.bcmd.2011.08.004     Document Type: Article

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