Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity

Journal of Medicinal Chemistry

Volumn 52, Issue 21, 2009, Pages 6606-6620

  Price, Katherine Ann ^a,b   Caragounis, Aphrodite ^a,b   Paterson, Brett M ^a,c   Filiz, Gulay ^a   Volitakis, Irene ^b   Masters, Colin L ^b   Barnham, Kevin J ^a,b,c   Donnelly, Paul S ^a,c   Crouch, Peter J ^a,b   White, Anthony R ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIS(THIOSEMICARBAZONATO); CYTOKINE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOGEN SYNTHASE KINASE 3; GLYOXALBIS[N(4) METHYLTHIOSEMICARBAZONATO]COPPER; GROWTH FACTOR; METAL COMPLEX; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE; TYROSINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; GLIA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; NEUROPROTECTION; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION;

CELL LINE; CELL LINE, TUMOR; COORDINATION COMPLEXES; COPPER; CYTOKINES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEUROGLIA; NEUROPROTECTIVE AGENTS; ORGANOMETALLIC COMPOUNDS; PHOSPHORYLATION; PROTEIN ARRAY ANALYSIS; PROTEIN TYROSINE PHOSPHATASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; THIOSEMICARBAZONES;

EID: 71049118151     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9007938     Document Type: Article

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