Pyrrolidine dithiocarbamate (PDTC)/Cu complex induces lung epithelial cell apoptosis through mitochondria and ER-stress pathways

Toxicology Letters

Volumn 199, Issue 3, 2010, Pages 333-340

  Chen, Ya Wen ^a   Chen, Kuo Liang ^b   Chen, Chun Hung ^b   Wu, Hsi Chin ^b   Su, Chin Chuan ^c   Wu, Chin Ching ^d   Way, Tzong Der ^d   Hung, Dong Zong ^b,d   Yen, Cheng Chien ^e,f   Yang, Yuan Ting ^d   Lu, Tien Hui ^d  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^f CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Cu; ER stress; Lung epithelial cells; Mitochondria; PDTC

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 12; CASPASE 3; CASPASE 7; CASPASE 9; COPPER CHLORIDE; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; PYRROLIDINE DITHIOCARBAMATE; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE; CELL SURVIVAL; COPPER; ENDOPLASMIC RETICULUM; EPITHELIAL CELLS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG; MITOCHONDRIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLIDINES; RATS; SIGNAL TRANSDUCTION; THIOCARBAMATES;

EID: 78650510594     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.09.016     Document Type: Article

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