메뉴 건너뛰기




Volumn 1250, Issue , 2015, Pages 53-76

Immortalized human hepatic cell lines for in vitro testing and research purposes

Author keywords

Cell line; Human; Immortalization; Liver

Indexed keywords

CORE PROTEIN; CRE RECOMBINASE; TELOMERASE REVERSE TRANSCRIPTASE; ONCOPROTEIN; TELOMERASE; TERT PROTEIN, HUMAN;

EID: 84927673763     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-2074-7_4     Document Type: Article
Times cited : (45)

References (136)
  • 1
    • 33847018050 scopus 로고    scopus 로고
    • Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
    • Hewitt NJ, Lechon MJ, Houston JB et al (2007) Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev 39:159-234
    • (2007) Drug Metab Rev , vol.39 , pp. 159-234
    • Hewitt, N.J.1    Lechon, M.J.2    Houston, J.B.3
  • 2
    • 33645972546 scopus 로고    scopus 로고
    • Stem cells, immortalized cells and primary cells in ADMET assays
    • Sinz M, Kim S (2006) Stem cells, immortalized cells and primary cells in ADMET assays. Drug Discov Today Technol 3:79-85
    • (2006) Drug Discov Today Technol , vol.3 , pp. 79-85
    • Sinz, M.1    Kim, S.2
  • 4
    • 84890820918 scopus 로고    scopus 로고
    • Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals
    • Rodrigues RM, De Kock J, Branson S et al (2014) Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals. Stem Cells Dev 23:44-55
    • (2014) Stem Cells Dev , vol.23 , pp. 44-55
    • Rodrigues, R.M.1    De Kock, J.2    Branson, S.3
  • 5
    • 0036924902 scopus 로고    scopus 로고
    • Improving the next generation of bioartifi cial liver devices
    • Allen JW, Bhatia SN (2002) Improving the next generation of bioartifi cial liver devices. Semin Cell Dev Biol 13:447-454
    • (2002) Semin Cell Dev Biol , vol.13 , pp. 447-454
    • Allen, J.W.1    Bhatia, S.N.2
  • 6
    • 29744467490 scopus 로고    scopus 로고
    • Which are the right cells to be used in a bioartifi cial liver?
    • Chamuleau RA, Deurholt T, Hoekstra R (2005) Which are the right cells to be used in a bioartifi cial liver? Metab Brain Dis 20: 327-335
    • (2005) Metab Brain Dis , vol.20 , pp. 327-335
    • Chamuleau, R.A.1    Deurholt, T.2    Hoekstra, R.3
  • 7
    • 0038278508 scopus 로고    scopus 로고
    • An update on in vitro test methods in human hepatic drug biotransformation research: Pros and cons
    • Brandon EF, Raap CD, Meijerman I et al (2003) An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicol Appl Pharmacol 189:233-246
    • (2003) Toxicol Appl Pharmacol , vol.189 , pp. 233-246
    • Brandon, E.F.1    Raap, C.D.2    Meijerman, I.3
  • 8
    • 66149122259 scopus 로고    scopus 로고
    • Corcoran P et al (2009)Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells
    • Choi S, Sainz B, Corcoran P et al (2009)Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells. Xenobiotica 39:205-217
    • Xenobiotica , vol.39 , pp. 205-217
    • Choi, S.1    Sainz, B.2
  • 9
    • 36049024618 scopus 로고    scopus 로고
    • Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04
    • Lim PL, Tan W, Latchoumycandane C et al (2007) Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04. Toxicol In Vitro 21:1390-1401
    • (2007) Toxicol in Vitro , vol.21 , pp. 1390-1401
    • Lim, P.L.1    Tan, W.2    Latchoumycandane, C.3
  • 10
    • 84875038806 scopus 로고    scopus 로고
    • Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicity
    • Szabo M, Veres Z, Baranyai Z et al (2013) Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicity. PLoS One 8:e59432
    • (2013) Plos One , vol.8
    • Szabo, M.1    Veres, Z.2    Baranyai, Z.3
  • 11
    • 29944444269 scopus 로고    scopus 로고
    • Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
    • Aninat C, Piton A, Glaise D et al (2006) Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34:75-83
    • (2006) Drug Metab Dispos , vol.34 , pp. 75-83
    • Aninat, C.1    Piton, A.2    Glaise, D.3
  • 12
    • 34247517355 scopus 로고    scopus 로고
    • The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
    • Guillouzo A, Corlu A, Aninat C et al (2007) The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 168:66-73
    • (2007) Chem Biol Interact , vol.168 , pp. 66-73
    • Guillouzo, A.1    Corlu, A.2    Aninat, C.3
  • 13
    • 70449727365 scopus 로고    scopus 로고
    • Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes
    • Deurholt T, van Til NP, Chhatta AA et al (2009) Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes. BMC Biotechnol 9:89
    • (2009) BMC Biotechnol , vol.9 , pp. 89
    • Deurholt, T.1    Van Til, N.P.2    Chhatta, A.A.3
  • 14
    • 70349321135 scopus 로고    scopus 로고
    • Establishment of a human neonatal hepatocyte cell line
    • Reid Y, Gaddipati JP, Yadav D et al (2009) Establishment of a human neonatal hepatocyte cell line. In Vitro Cell Dev Biol Anim 45:535-542
    • (2009) Vitro Cell Dev Biol Anim , vol.45 , pp. 535-542
    • Reid, Y.1    Gaddipati, J.P.2    Yadav, D.3
  • 15
    • 17044368822 scopus 로고    scopus 로고
    • Liver cell lines for the study of hepatocyte functions and immunological response
    • Clayton RF, Rinaldi A, Kandyba EE et al (2005) Liver cell lines for the study of hepatocyte functions and immunological response. Liver Int 25:389-402
    • (2005) Liver Int , vol.25 , pp. 389-402
    • Clayton, R.F.1    Rinaldi, A.2    Kandyba, E.E.3
  • 16
    • 62549128710 scopus 로고    scopus 로고
    • Establishment of immortalized human hepatocytes by introduction of HPV16 E6/ E7 and hTERT as cell sources for liver cellbased therapy
    • Tsuruga Y, Kiyono T, Matsushita M et al (2008) Establishment of immortalized human hepatocytes by introduction of HPV16 E6/ E7 and hTERT as cell sources for liver cellbased therapy. Cell Transplant 17:1083-1094
    • (2008) Cell Transplant , vol.17 , pp. 1083-1094
    • Tsuruga, Y.1    Kiyono, T.2    Matsushita, M.3
  • 17
    • 0034885777 scopus 로고    scopus 로고
    • Establishment of a human hepatocyte line (OUMS-29) having CYP 1A1 and 1A2 activities from fetal liver tissue by transfection of SV40 LT
    • Fukaya K, Asahi S, Nagamori S et al (2001) Establishment of a human hepatocyte line (OUMS-29) having CYP 1A1 and 1A2 activities from fetal liver tissue by transfection of SV40 LT. In Vitro Cell Dev Biol Anim 37:266-269
    • (2001) Vitro Cell Dev Biol Anim , vol.37 , pp. 266-269
    • Fukaya, K.1    Asahi, S.2    Nagamori, S.3
  • 18
    • 44149104931 scopus 로고    scopus 로고
    • Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction
    • Hariparsad N, Carr BA, Evers R et al (2008) Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. Drug Metab Dispos 36:1046-1055
    • (2008) Drug Metab Dispos , vol.36 , pp. 1046-1055
    • Hariparsad, N.1    Carr, B.A.2    Evers, R.3
  • 19
    • 27744539431 scopus 로고    scopus 로고
    • Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes
    • Nguyen TH, Mai G, Villiger P et al (2005) Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes. J Hepatol 43:1031-1037
    • (2005) J Hepatol , vol.43 , pp. 1031-1037
    • Nguyen, T.H.1    Mai, G.2    Villiger, P.3
  • 20
    • 0035408523 scopus 로고    scopus 로고
    • Novel strategies for immortalization of human hepatocytes
    • Cascio SM (2001) Novel strategies for immortalization of human hepatocytes. Artif Organs 25:529-538
    • (2001) Artif Organs , vol.25 , pp. 529-538
    • Cascio, S.M.1
  • 21
    • 84868479394 scopus 로고    scopus 로고
    • Establishment and characterization of immortalized human hepatocyte cell line for applications in bioartifi cial livers
    • Pan X, Li J, Du W et al (2012) Establishment and characterization of immortalized human hepatocyte cell line for applications in bioartifi cial livers. Biotechnol Lett 34:2183-2190
    • (2012) Biotechnol Lett , vol.34 , pp. 2183-2190
    • Pan, X.1    Li, J.2    Du, W.3
  • 22
    • 18744401640 scopus 로고    scopus 로고
    • Establishment of highly differentiated immortalized human hepatocyte line with simian virus 40 large tumor antigen for liver based cell therapy
    • Li J, Li LJ, Cao HC et al (2005) Establishment of highly differentiated immortalized human hepatocyte line with simian virus 40 large tumor antigen for liver based cell therapy. ASAIO J 51:262-268
    • (2005) ASAIO J , vol.51 , pp. 262-268
    • Li, J.1    Li, L.J.2    Cao, H.C.3
  • 23
    • 0030848684 scopus 로고    scopus 로고
    • Immortalized human hepatocytes as a tool for the study of hepatocytic (De-)differentiation
    • Schippers IJ, Moshage H, Roelofsen H et al (1997) Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation. Cell Biol Toxicol 13:375-386
    • (1997) Cell Biol Toxicol , vol.13 , pp. 375-386
    • Schippers, I.J.1    Moshage, H.2    Roelofsen, H.3
  • 24
    • 0027254424 scopus 로고
    • Simian virus 40 large tumor antigenimmortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens
    • Pfeifer AM, Cole KE, Smoot DT et al (1993) Simian virus 40 large tumor antigenimmortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. Proc Natl Acad Sci U S A 90:5123-5127
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5123-5127
    • Pfeifer, A.M.1    Cole, K.E.2    Smoot, D.T.3
  • 25
    • 0030093331 scopus 로고    scopus 로고
    • Cell lines from non-neoplastic liver and hepatocellular carcinoma tissue from a single patient
    • Noguchi M, Hirohashi S (1996) Cell lines from non-neoplastic liver and hepatocellular carcinoma tissue from a single patient. In Vitro Cell Dev Biol Anim 32:135-137
    • (1996) Vitro Cell Dev Biol Anim , vol.32 , pp. 135-137
    • Noguchi, M.1    Hirohashi, S.2
  • 26
    • 85037139991 scopus 로고    scopus 로고
    • Evaluation of a reversibly immortalized human hepatocyte line in bioartifi cial liver in pigs
    • Zhao L, Li J, Lv G et al (2012) Evaluation of a reversibly immortalized human hepatocyte line in bioartifi cial liver in pigs. Afr J Biotechnol 11:4116-4126
    • (2012) Afr J Biotechnol , vol.11 , pp. 4116-4126
    • Zhao, L.1    Li, J.2    Lv, G.3
  • 27
    • 77953681763 scopus 로고    scopus 로고
    • Transplantation of immortalized human fetal hepatocytes prevents acute liver failure in 90 % hepatectomized mice
    • Chen Y, Li J, Liu X et al (2010) Transplantation of immortalized human fetal hepatocytes prevents acute liver failure in 90 % hepatectomized mice. Transplant Proc 42:1907-1914
    • (2010) Transplant Proc , vol.42 , pp. 1907-1914
    • Chen, Y.1    Li, J.2    Liu, X.3
  • 28
    • 0035005221 scopus 로고    scopus 로고
    • Immortalization of human hepatocytes by temperature-sensitive SV40 large-T antigen
    • Smalley M, Leiper K, Tootle R et al (2001) Immortalization of human hepatocytes by temperature-sensitive SV40 large-T antigen. In Vitro Cell Dev Biol Anim 37:166-168
    • (2001) Vitro Cell Dev Biol Anim , vol.37 , pp. 166-168
    • Smalley, M.1    Leiper, K.2    Tootle, R.3
  • 29
    • 0034681522 scopus 로고    scopus 로고
    • Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes
    • Kobayashi N, Fujiwara T, Westerman KA et al (2000) Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. Science 287:1258-1262
    • (2000) Science , vol.287 , pp. 1258-1262
    • Kobayashi, N.1    Fujiwara, T.2    Westerman, K.A.3
  • 30
    • 84926332210 scopus 로고    scopus 로고
    • Growth control and cell cycle progression in cultured hepatocytes
    • In: Edwards A, Berry M, Kluwer Academic, The Netherlands
    • Ilyin G, Rescan C, Rialland M et al (2000) Growth control and cell cycle progression in cultured hepatocytes. In: Edwards A, Berry M (eds) The hepatocyte review. Kluwer Academic, The Netherlands, pp 263-280
    • (2000) The Hepatocyte Review , pp. 263-280
    • Ilyin, G.1    Rescan, C.2    Rialland, M.3
  • 31
    • 0032956298 scopus 로고    scopus 로고
    • Epidermal growth factor-and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes
    • Runge DM, Runge D, Dorko K et al (1999) Epidermal growth factor-and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes. J Hepatol 30:265-274
    • (1999) J Hepatol , vol.30 , pp. 265-274
    • Runge, D.M.1    Runge, D.2    Dorko, K.3
  • 32
    • 70350568297 scopus 로고    scopus 로고
    • Senescence and immortality in hepatocellular carcinoma
    • Ozturk M, Arslan-Ergul A, Bagislar S et al (2009) Senescence and immortality in hepatocellular carcinoma. Cancer Lett 286:103-113
    • (2009) Cancer Lett , vol.286 , pp. 103-113
    • Ozturk, M.1    Arslan-Ergul, A.2    Bagislar, S.3
  • 33
    • 0032197092 scopus 로고    scopus 로고
    • The cell cycle: A review
    • Schafer KA (1998) The cell cycle: a review. Vet Pathol 35:461-478
    • (1998) Vet Pathol , vol.35 , pp. 461-478
    • Schafer, K.A.1
  • 34
    • 0037308362 scopus 로고    scopus 로고
    • Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential
    • Wege H, Le HT, Chui MS et al (2003) Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology 124:432-444
    • (2003) Gastroenterology , vol.124 , pp. 432-444
    • Wege, H.1    Le, H.T.2    Chui, M.S.3
  • 35
    • 0031047426 scopus 로고    scopus 로고
    • Replicative senescence and cell immortality: The role of telomeres and telomerase
    • Chiu CP, Harley CB (1997) Replicative senescence and cell immortality: the role of telomeres and telomerase. Proc Soc Exp Biol Med 214:99-106
    • (1997) Proc Soc Exp Biol Med , vol.214 , pp. 99-106
    • Chiu, C.P.1    Harley, C.B.2
  • 36
    • 84888094038 scopus 로고    scopus 로고
    • Eternity and functionality: Rational access to physiologically relevant cell lines
    • Lipps C, May T, Hauser H et al (2013) Eternity and functionality: rational access to physiologically relevant cell lines. Biol Chem 394:1637-1648
    • (2013) Biol Chem , vol.394 , pp. 1637-1648
    • Lipps, C.1    May, T.2    Hauser, H.3
  • 37
    • 33749921761 scopus 로고    scopus 로고
    • Immortalization Strategies for Mammalian Cells
    • In: Jenkins N, Humana, Totowa
    • McLean J (1999) Immortalization Strategies for Mammalian Cells. In: Jenkins N (ed) Animal cell biotechnology: methods and protocols. Humana, Totowa, pp 61-72
    • (1999) Animal Cell Biotechnology: Methods and Protocols , pp. 61-72
    • McLean, J.1
  • 38
    • 84926318351 scopus 로고    scopus 로고
    • Controlled expansion of mammalian cell populations by reversible immortalization
    • Noguchi H, Kobayashi N (2013) Controlled expansion of mammalian cell populations by reversible immortalization. J Biotechnol Biomater 3:158
    • (2013) J Biotechnol Biomater , vol.3 , pp. 158
    • Noguchi, H.1    Kobayashi, N.2
  • 39
    • 77954627511 scopus 로고    scopus 로고
    • Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development
    • Waki K, Anno K, Ono T et al (2010) Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development. Cancer Sci 101:1678-1685
    • (2010) Cancer Sci , vol.101 , pp. 1678-1685
    • Waki, K.1    Anno, K.2    Ono, T.3
  • 40
    • 0347086157 scopus 로고    scopus 로고
    • In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging
    • Wege H, Chui MS, Le HT et al (2003) In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging. Cell Transplant 12:897-906
    • (2003) Cell Transplant , vol.12 , pp. 897-906
    • Wege, H.1    Chui, M.S.2    Le, H.T.3
  • 41
    • 0027367137 scopus 로고
    • Mitogen-independent DNA synthesis by fetal rat hepatocytes in primary culture
    • Curran TR, Bahner RI, Oh W et al (1993) Mitogen-independent DNA synthesis by fetal rat hepatocytes in primary culture. Exp Cell Res 209:53-57
    • (1993) Exp Cell Res , vol.209 , pp. 53-57
    • Curran, T.R.1    Bahner, R.I.2    Oh, W.3
  • 42
    • 9144237453 scopus 로고    scopus 로고
    • Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs
    • Okitsu T, Kobayashi N, Jun HS et al (2004) Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs. Diabetes 53:105-112
    • (2004) Diabetes , vol.53 , pp. 105-112
    • Okitsu, T.1    Kobayashi, N.2    Jun, H.S.3
  • 43
    • 34249277092 scopus 로고    scopus 로고
    • Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with tamoxifen-mediated selfrecombination
    • Totsugawa T, Yong C, Rivas-Carrillo JD et al (2007) Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with tamoxifen-mediated selfrecombination. J Hepatol 47:74-82
    • (2007) J Hepatol , vol.47 , pp. 74-82
    • Totsugawa, T.1    Yong, C.2    Rivas-Carrillo, J.D.3
  • 44
    • 17644418751 scopus 로고    scopus 로고
    • Use of exogenous hTERT to immortalize primary human cells
    • Lee KM, Choi KH, Ouellette MM (2004) Use of exogenous hTERT to immortalize primary human cells. Cytotechnology 45:33-38
    • (2004) Cytotechnology , vol.45 , pp. 33-38
    • Lee, K.M.1    Choi, K.H.2    Ouellette, M.M.3
  • 45
    • 0034713462 scopus 로고    scopus 로고
    • Hepatitis C virus core protein promotes immortalization of primary human hepatocytes
    • Ray RB, Meyer K, Ray R (2000) Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology 271: 197-204
    • (2000) Virology , vol.271 , pp. 197-204
    • Ray, R.B.1    Meyer, K.2    Ray, R.3
  • 46
    • 0036301977 scopus 로고    scopus 로고
    • Hepatitis C virus core protein is necessary for the maintenance of immortalized human hepatocytes
    • Basu A, Meyer K, Ray RB et al (2002) Hepatitis C virus core protein is necessary for the maintenance of immortalized human hepatocytes. Virology 298:53-62
    • (2002) Virology , vol.298 , pp. 53-62
    • Basu, A.1    Meyer, K.2    Ray, R.B.3
  • 47
    • 0032786609 scopus 로고    scopus 로고
    • Cultivation and characterization of a new immortalized human hepatocyte cell line, HepZ, for use in an artifi cial liver support system
    • Werner A, Duvar S, Müthing J et al (1999) Cultivation and characterization of a new immortalized human hepatocyte cell line, HepZ, for use in an artifi cial liver support system. Ann N Y Acad Sci 875:364-368
    • (1999) Ann N Y Acad Sci , vol.875 , pp. 364-368
    • Werner, A.1    Duvar, S.2    Müthing, J.3
  • 48
    • 84934437187 scopus 로고    scopus 로고
    • Ex vivo gene transfer into hepatocytes
    • Wang X, Mani P, Sarkar DP et al (2009) Ex vivo gene transfer into hepatocytes. Methods Mol Biol 481:117-140
    • (2009) Methods Mol Biol , vol.481 , pp. 117-140
    • Wang, X.1    Mani, P.2    Sarkar, D.P.3
  • 49
    • 0035084236 scopus 로고    scopus 로고
    • Role of immortalized hepatocyte transplantation in acute liver failure
    • Kobayashi N, Noguchi H, Watanabe T et al (2001) Role of immortalized hepatocyte transplantation in acute liver failure. Transplant Proc 33:645-646
    • (2001) Transplant Proc , vol.33 , pp. 645-646
    • Kobayashi, N.1    Noguchi, H.2    Watanabe, T.3
  • 50
    • 80052401275 scopus 로고    scopus 로고
    • Human artifi-cial chromosomes for gene delivery and the development of animal models
    • Kazuki Y, Oshimura M (2011) Human artifi-cial chromosomes for gene delivery and the development of animal models. Mol Ther 19:1591-1601
    • (2011) Mol Ther , vol.19 , pp. 1591-1601
    • Kazuki, Y.1    Oshimura, M.2
  • 51
    • 0034180682 scopus 로고    scopus 로고
    • The application of a lentiviral vector for gene transfer in fetal human hepatocytes
    • Zahler MH, Irani A, Malhi H et al (2000) The application of a lentiviral vector for gene transfer in fetal human hepatocytes. J Gene Med 2:186-193
    • (2000) J Gene Med , vol.2 , pp. 186-193
    • Zahler, M.H.1    Irani, A.2    Malhi, H.3
  • 52
    • 0033675060 scopus 로고    scopus 로고
    • Establishment of a highly differentiated immortalized adult human hepatocyte cell line by retroviral gene transfer
    • Kobayashi N, Noguchi H, Fujiwara T et al (2000) Establishment of a highly differentiated immortalized adult human hepatocyte cell line by retroviral gene transfer. Transplant Proc 32:2368-2369
    • (2000) Transplant Proc , vol.32 , pp. 2368-2369
    • Kobayashi, N.1    Noguchi, H.2    Fujiwara, T.3
  • 53
    • 0036664451 scopus 로고    scopus 로고
    • Highly effi cient lentiviral vectormediated transduction of nondividing, fully reimplantable primary hepatocytes
    • Nguyen TH, Oberholzer J, Birraux J et al (2002) Highly effi cient lentiviral vectormediated transduction of nondividing, fully reimplantable primary hepatocytes. Mol Ther 6:199-209
    • (2002) Mol Ther , vol.6 , pp. 199-209
    • Nguyen, T.H.1    Oberholzer, J.2    Birraux, J.3
  • 54
    • 0035169915 scopus 로고    scopus 로고
    • Hepatocyte transplantation: Clinical and experimental application
    • Ohashi K, Park F, Kay MA (2001) Hepatocyte transplantation: clinical and experimental application. J Mol Med 79:617-630
    • (2001) J Mol Med , vol.79 , pp. 617-630
    • Ohashi, K.1    Park, F.2    Kay, M.A.3
  • 55
    • 0029042918 scopus 로고
    • Effi cient retroviral-mediated gene transfer into primary culture of murine and human hepatocytes: Expression of the LDL receptor
    • Pages JC, Andreoletti M, Bennoun M et al (1995) Effi cient retroviral-mediated gene transfer into primary culture of murine and human hepatocytes: expression of the LDL receptor. Hum Gene Ther 6:21-30
    • (1995) Hum Gene Ther , vol.6 , pp. 21-30
    • Pages, J.C.1    Reoletti, M.2    Bennoun, M.3
  • 56
    • 33947431697 scopus 로고    scopus 로고
    • Growth factors improve gene expression after lentiviral transduction in human adult and fetal hepatocytes
    • Selden C, Mellor N, Rees M et al (2007) Growth factors improve gene expression after lentiviral transduction in human adult and fetal hepatocytes. J Gene Med 9:67-76
    • (2007) J Gene Med , vol.9 , pp. 67-76
    • Selden, C.1    Mellor, N.2    Rees, M.3
  • 57
    • 44349133270 scopus 로고    scopus 로고
    • Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes
    • Zamule SM, Strom SC, Omiecinski CJ (2008) Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. Chem Biol Interact 173:179-186
    • (2008) Chem Biol Interact , vol.173 , pp. 179-186
    • Zamule, S.M.1    Strom, S.C.2    Omiecinski, C.J.3
  • 58
    • 42249089529 scopus 로고    scopus 로고
    • Immortalized hepatocytes using human artifi-cial chromosome
    • Ito M, Ito R, Yoshihara D et al (2008) Immortalized hepatocytes using human artifi-cial chromosome. Cell Transplant 17: 165-171
    • (2008) Cell Transplant , vol.17 , pp. 165-171
    • Ito, M.1    Ito, R.2    Yoshihara, D.3
  • 59
    • 60649106590 scopus 로고    scopus 로고
    • Treatment of nonalbumin rats by transplantation of immortalized hepatocytes using artifi-cial human chromosome
    • Ito M, Ikeno M, Nagata H et al (2009) Treatment of nonalbumin rats by transplantation of immortalized hepatocytes using artifi-cial human chromosome. Transplant Proc 41:422-424
    • (2009) Transplant Proc , vol.41 , pp. 422-424
    • Ito, M.1    Ikeno, M.2    Nagata, H.3
  • 60
    • 41149129157 scopus 로고    scopus 로고
    • Telomerase-mediated life-span extension of human primary fi broblasts by human artifi cial chromosome (HAC) vector
    • Shitara S, Kakeda M, Nagata K et al (2008) Telomerase-mediated life-span extension of human primary fi broblasts by human artifi cial chromosome (HAC) vector. Biochem Biophys Res Commun 369:807-811
    • (2008) Biochem Biophys Res Commun , vol.369 , pp. 807-811
    • Shitara, S.1    Kakeda, M.2    Nagata, K.3
  • 61
    • 0037708562 scopus 로고    scopus 로고
    • Establishment of immortalized human hepatic stellate scavenger cells to develop bioartifi cial livers
    • Watanabe T, Shibata N, Westerman KA et al (2003) Establishment of immortalized human hepatic stellate scavenger cells to develop bioartifi cial livers. Transplantation 75:1873-1880
    • (2003) Transplantation , vol.75 , pp. 1873-1880
    • Watanabe, T.1    Shibata, N.2    Westerman, K.A.3
  • 62
    • 0035514239 scopus 로고    scopus 로고
    • Reactivation of liver-specifi c gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4alpha2 gene
    • Inoue Y, Miyazaki M, Tsuji T et al (2001) Reactivation of liver-specifi c gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4alpha2 gene. Int J Mol Med 8:481-487
    • (2001) Int J Mol Med , vol.8 , pp. 481-487
    • Inoue, Y.1    Miyazaki, M.2    Tsuji, T.3
  • 63
    • 84867682745 scopus 로고    scopus 로고
    • Characterization of THLEImmortalized cytochrome P450 (P450) cell lines: Gene expression background and relationship to P450-enzyme activity
    • Soltanpour Y, Hilgendorf C, Ahlström MM et al (2012) Characterization of THLEImmortalized cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity. Drug Metab Dispos 40:2054-2058
    • (2012) Drug Metab Dispos , vol.40 , pp. 2054-2058
    • Soltanpour, Y.1    Hilgendorf, C.2    Ahlström, M.M.3
  • 64
    • 0037321188 scopus 로고    scopus 로고
    • Active expression of p21 facilitates differentiation of immortalized human hepatocytes
    • Kobayashi N, Kunieda T, Sakaguchi M et al (2003) Active expression of p21 facilitates differentiation of immortalized human hepatocytes. Transplant Proc 35:433-434
    • (2003) Transplant Proc , vol.35 , pp. 433-434
    • Kobayashi, N.1    Kunieda, T.2    Sakaguchi, M.3
  • 65
    • 0036387078 scopus 로고    scopus 로고
    • Transduction of immortalized human hepatocytes with p21 to enhance differentiated phenotypes
    • Kunieda T, Kobayashi N, Sakaguchi M et al (2002) Transduction of immortalized human hepatocytes with p21 to enhance differentiated phenotypes. Cell Transplant 11:421-428
    • (2002) Cell Transplant , vol.11 , pp. 421-428
    • Kunieda, T.1    Kobayashi, N.2    Sakaguchi, M.3
  • 66
    • 0033669188 scopus 로고    scopus 로고
    • Conditionally immortalized mouse hepatocytes for use in liver gene therapy
    • Allen KJ, Reyes R, Demmler K et al (2000) Conditionally immortalized mouse hepatocytes for use in liver gene therapy. J Gastroenterol Hepatol 15:1325-1332
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 1325-1332
    • Allen, K.J.1    Reyes, R.2    Demmler, K.3
  • 67
    • 0028898438 scopus 로고
    • Conditional immortalization of Gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin-UDP-glucuronosyltransferase gene transfer
    • Fox IJ, Chowdhury NR, Gupta S et al (1995) Conditional immortalization of Gunn rat hepatocytes: an ex vivo model for evaluating methods for bilirubin-UDP-glucuronosyltransferase gene transfer. Hepatology 21:837-846
    • (1995) Hepatology , vol.21 , pp. 837-846
    • Fox, I.J.1    Chowdhury, N.R.2    Gupta, S.3
  • 68
    • 9144222636 scopus 로고    scopus 로고
    • Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization
    • May T, Hauser H, Wirth D (2004) Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization. Nucleic Acids Res 32: 5529-5538
    • (2004) Nucleic Acids Res , vol.32 , pp. 5529-5538
    • May, T.1    Hauser, H.2    Wirth, D.3
  • 69
    • 0029810898 scopus 로고    scopus 로고
    • Reversibleimmortalization of mammalian cells mediated by retroviral transfer and site-specifi c recombination
    • Westerman KA, Leboulch P (1996) Reversibleimmortalization of mammalian cells mediated by retroviral transfer and site-specifi c recombination. Proc Natl Acad Sci U S A 93:8971-8976
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 8971-8976
    • Westerman, K.A.1    Leboulch, P.2
  • 70
    • 0033166556 scopus 로고    scopus 로고
    • Reversible cell immortalization with the Cre-lox system
    • Paillard F (1999) Reversible cell immortalization with the Cre-lox system. Hum Gene Ther 10:1597-1598
    • (1999) Hum Gene Ther , vol.10 , pp. 1597-1598
    • Paillard, F.1
  • 71
    • 0034637386 scopus 로고    scopus 로고
    • Establishment of a reversibly immortalized human hepatocyte cell line by using Cre/loxP site-specifi c recombination
    • Kobayashi N, Noguchi H, Fujiwara T et al (2000) Establishment of a reversibly immortalized human hepatocyte cell line by using Cre/loxP site-specifi c recombination. Transplant Proc 32:1121-1122
    • (2000) Transplant Proc , vol.32 , pp. 1121-1122
    • Kobayashi, N.1    Noguchi, H.2    Fujiwara, T.3
  • 72
    • 77950828040 scopus 로고    scopus 로고
    • Precise conditional immortalization of mouse cells using tetracycline-regulated SV40 large T-antigen
    • Anastassiadis K, Rostovskaya M, Lubitz S et al (2010) Precise conditional immortalization of mouse cells using tetracycline-regulated SV40 large T-antigen. Genesis 48:220-232
    • (2010) Genesis , vol.48 , pp. 220-232
    • Anastassiadis, K.1    Rostovskaya, M.2    Lubitz, S.3
  • 73
    • 84879881234 scopus 로고    scopus 로고
    • Gene therapy on demand: Site-specifi c regulation of gene therapy
    • Jazwa A, Florczyk U, Jozkowicz A et al (2013) Gene therapy on demand: site-specifi c regulation of gene therapy. Gene 525:229-238
    • (2013) Gene , vol.525 , pp. 229-238
    • Jazwa, A.1    Florczyk, U.2    Jozkowicz, A.3
  • 74
    • 0030864521 scopus 로고    scopus 로고
    • Analysis of the cell tropism of HCV by using in vitro HCV-infected human lymphocytes and hepatocytes
    • Ikeda M, Kato N, Mizutani T et al (1997) Analysis of the cell tropism of HCV by using in vitro HCV-infected human lymphocytes and hepatocytes. J Hepatol 27:445-454
    • (1997) J Hepatol , vol.27 , pp. 445-454
    • Ikeda, M.1    Kato, N.2    Mizutani, T.3
  • 75
    • 0029788685 scopus 로고    scopus 로고
    • Replication of hepatitis C virus in cultured non-neoplastic human hepatocytes
    • Kato N, Ikeda M, Mizutani T et al (1996) Replication of hepatitis C virus in cultured non-neoplastic human hepatocytes. Jpn J Cancer Res 87:787-792
    • (1996) Jpn J Cancer Res , vol.87 , pp. 787-792
    • Kato, N.1    Ikeda, M.2    Mizutani, T.3
  • 76
    • 78349288446 scopus 로고    scopus 로고
    • Amino acid substitutions of hepatitis C virus core protein are not associated with intracellular antiviral response to interferon-α in vitro
    • Ikeda F, Dansako H, Nishimura G et al (2010) Amino acid substitutions of hepatitis C virus core protein are not associated with intracellular antiviral response to interferon-α in vitro . Liver Int 30:1324-1331
    • (2010) Liver Int , vol.30 , pp. 1324-1331
    • Ikeda, F.1    Dansako, H.2    Nishimura, G.3
  • 77
    • 77957936172 scopus 로고    scopus 로고
    • Hepatitis C virus infection impairs IRF-7 translocation and alpha interferon synthesis in immortalized human hepatocytes
    • Raychoudhuri A, Shrivastava S, Steele R et al (2010) Hepatitis C virus infection impairs IRF-7 translocation and alpha interferon synthesis in immortalized human hepatocytes. J Virol 84:10991-10998
    • (2010) J Virol , vol.84 , pp. 10991-10998
    • Raychoudhuri, A.1    Shrivastava, S.2    Steele, R.3
  • 78
    • 84862909215 scopus 로고    scopus 로고
    • ISG56 and IFITM1 proteins inhibit hepatitis C virus replication
    • Raychoudhuri A, Shrivastava S, Steele R et al (2011) ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. J Virol 85: 12881-12889
    • (2011) J Virol , vol.85 , pp. 12881-12889
    • Raychoudhuri, A.1    Shrivastava, S.2    Steele, R.3
  • 79
    • 0036721333 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus-like particles and cells: A model system for studying viral binding and entry
    • Triyatni M, Saunier B, Maruvada P et al (2002) Interaction of hepatitis C virus-like particles and cells: a model system for studying viral binding and entry. J Virol 76: 9335-9344
    • (2002) J Virol , vol.76 , pp. 9335-9344
    • Triyatni, M.1    Saunier, B.2    Maruvada, P.3
  • 80
    • 84868090808 scopus 로고    scopus 로고
    • Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production
    • Yu GY, He G, Li CY et al (2012) Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell 48:313-321
    • (2012) Mol Cell , vol.48 , pp. 313-321
    • Yu, G.Y.1    He, G.2    Li, C.Y.3
  • 81
    • 77955290279 scopus 로고    scopus 로고
    • Hepatitis B virus polymerase inhibits RIG-I-and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3
    • Yu S, Chen J, Wu M et al (2010) Hepatitis B virus polymerase inhibits RIG-I-and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3. J Gen Virol 91:2080-2090
    • (2010) J Gen Virol , vol.91 , pp. 2080-2090
    • Yu, S.1    Chen, J.2    Wu, M.3
  • 82
    • 0033960043 scopus 로고    scopus 로고
    • A long-term hepatitis B viremia model generated by transplanting non-tumorigenic immortalized human hepatocytes in Rag-2-defi cient mice
    • Brown JJ, Parashar B, Moshage H et al (2000) A long-term hepatitis B viremia model generated by transplanting non-tumorigenic immortalized human hepatocytes in Rag-2-defi cient mice. Hepatology 31:173-181
    • (2000) Hepatology , vol.31 , pp. 173-181
    • Brown, J.J.1    Parashar, B.2    Moshage, H.3
  • 83
    • 84891785762 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifi es RIPK4 as novel tumor suppressor in human hepatocarcinogenesis
    • Heim D, Cornils K, Schulze K et al (2014) Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifi es RIPK4 as novel tumor suppressor in human hepatocarcinogenesis. Oncogene. doi: 10.1038/onc.2013.551
    • (2014) Oncogene
    • Heim, D.1    Cornils, K.2    Schulze, K.3
  • 84
    • 80052864015 scopus 로고    scopus 로고
    • Forced activation of β-catenin signaling supports the transformation of hTERTimmortalized human fetal hepatocytes
    • Wege H, Heim D, Lütgehetmann M et al (2011) Forced activation of β-catenin signaling supports the transformation of hTERTimmortalized human fetal hepatocytes. Mol Cancer Res 9:1222-1231
    • (2011) Mol Cancer Res , vol.9 , pp. 1222-1231
    • Wege, H.1    Heim, D.2    Lütgehetmann, M.3
  • 85
    • 65749102155 scopus 로고    scopus 로고
    • C-Fos accelerates hepatocyte conversion to a fi broblastoid phenotype through ERKmediated upregulation of paxillin-Serine178 phosphorylation
    • Guller MC, Andre J, Legrand A et al (2009) c-Fos accelerates hepatocyte conversion to a fi broblastoid phenotype through ERKmediated upregulation of paxillin-Serine178 phosphorylation. Mol Carcinog 48:532-544
    • (2009) Mol Carcinog , vol.48 , pp. 532-544
    • Guller, M.C.1    Re, J.2    Legrand, A.3
  • 86
    • 61849085224 scopus 로고    scopus 로고
    • C-fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear cyclin D1
    • Guller M, Toualbi-Abed K, Legrand A et al (2008) c-fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear cyclin D1. World J Gastroenterol 14:6339-6346
    • (2008) World J Gastroenterol , vol.14 , pp. 6339-6346
    • Guller, M.1    Toualbi-Abed, K.2    Legrand, A.3
  • 87
    • 34447555806 scopus 로고    scopus 로고
    • Microarray analyses and molecular profi ling of steatosis induction in immortalized human hepatocytes
    • De Gottardi A, Vinciguerra M, Sgroi A et al (2007) Microarray analyses and molecular profi ling of steatosis induction in immortalized human hepatocytes. Lab Invest 87: 792-806
    • (2007) Lab Invest , vol.87 , pp. 792-806
    • De Gottardi, A.1    Vinciguerra, M.2    Sgroi, A.3
  • 88
    • 84872153859 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation
    • Martel C, Allouche M, Esposti DD et al (2013) Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation. Hepatology 57:93-102
    • (2013) Hepatology , vol.57 , pp. 93-102
    • Martel, C.1    Allouche, M.2    Esposti, D.D.3
  • 89
    • 67651006589 scopus 로고    scopus 로고
    • Capsid antigen presentation fl ags human hepatocytes for destruction after transduction by adeno-associated viral vectors
    • Pien GC, Basner-Tschakarjan E, Hui DJ et al (2009) Capsid antigen presentation fl ags human hepatocytes for destruction after transduction by adeno-associated viral vectors. J Clin Invest 119:1688-1695
    • (2009) J Clin Invest , vol.119 , pp. 1688-1695
    • Pien, G.C.1    Basner-Tschakarjan, E.2    Hui, D.J.3
  • 90
    • 74149089236 scopus 로고    scopus 로고
    • Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction
    • Finn JD, Hui D, Downey HD et al (2010) Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction. Mol Ther 18:135-142
    • (2010) Mol Ther , vol.18 , pp. 135-142
    • Finn, J.D.1    Hui, D.2    Downey, H.D.3
  • 91
    • 84877930020 scopus 로고    scopus 로고
    • Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specifi c CD8+ T cells
    • Martino AT, Basner-Tschakarjan E, Markusic DM et al (2013) Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specifi c CD8+ T cells. Blood 121:2224-2233
    • (2013) Blood , vol.121 , pp. 2224-2233
    • Martino, A.T.1    Basner-Tschakarjan, E.2    Markusic, D.M.3
  • 93
    • 84892879465 scopus 로고    scopus 로고
    • Cellular toxicity associated with exposure to perfl uorinated carboxylates (PFCAs) and their metabolic precursors
    • Rand AA, Rooney JP, Butt CM et al (2014) Cellular toxicity associated with exposure to perfl uorinated carboxylates (PFCAs) and their metabolic precursors. Chem Res Toxicol 27:42-50
    • (2014) Chem Res Toxicol , vol.27 , pp. 42-50
    • Rand, A.A.1    Rooney, J.P.2    Butt, C.M.3
  • 94
    • 84865208356 scopus 로고    scopus 로고
    • In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs
    • Thompson RA, Isin EM, Li Y et al (2012) In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs. Chem Res Toxicol 25:1616-1632
    • (2012) Chem Res Toxicol , vol.25 , pp. 1616-1632
    • Thompson, R.A.1    Isin, E.M.2    Li, Y.3
  • 95
    • 13444284018 scopus 로고    scopus 로고
    • New technologies and screening strategies for hepatotoxicity: Use of in vitro models
    • Dambach DM, Andrews BA, Moulin F (2005) New technologies and screening strategies for hepatotoxicity: use of in vitro models. Toxicol Pathol 33:17-26
    • (2005) Toxicol Pathol , vol.33 , pp. 17-26
    • Dambach, D.M.1    Rews, B.A.2    Moulin, F.3
  • 96
    • 56249086796 scopus 로고    scopus 로고
    • Use of four new human-derived livercell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay
    • Winter HK, Ehrlich VA, Grusch M et al (2008) Use of four new human-derived livercell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay. Mutat Res 657:133-139
    • (2008) Mutat Res , vol.657 , pp. 133-139
    • Winter, H.K.1    Ehrlich, V.A.2    Grusch, M.3
  • 97
    • 1642273510 scopus 로고    scopus 로고
    • Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line
    • Mills JB, Rose KA, Sadagopan N et al (2004) Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. J Pharmacol Exp Ther 309:303-309
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 303-309
    • Mills, J.B.1    Rose, K.A.2    Sadagopan, N.3
  • 98
    • 84868202092 scopus 로고    scopus 로고
    • Preparation and cellular uptake of PLGA particles loaded with lamivudine
    • Wang B, Chen G, Mao Z et al (2012) Preparation and cellular uptake of PLGA particles loaded with lamivudine. Chin Sci Bull 57:3985-3993
    • (2012) Chin Sci Bull , vol.57 , pp. 3985-3993
    • Wang, B.1    Chen, G.2    Mao, Z.3
  • 99
    • 40949145297 scopus 로고    scopus 로고
    • Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice
    • Tsuruga Y, Kiyono T, Matsushita M et al (2008) Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice. Transplant Proc 40:617-619
    • (2008) Transplant Proc , vol.40 , pp. 617-619
    • Tsuruga, Y.1    Kiyono, T.2    Matsushita, M.3
  • 100
    • 39549110054 scopus 로고    scopus 로고
    • Protection of hepatocytes from cytotoxic T cell mediated killing by interferonalpha
    • Willberg CB, Ward SM, Clayton RF et al (2007) Protection of hepatocytes from cytotoxic T cell mediated killing by interferonalpha. PLoS One 2:e791
    • (2007) Plos One , vol.2
    • Willberg, C.B.1    Ward, S.M.2    Clayton, R.F.3
  • 101
    • 84891503453 scopus 로고    scopus 로고
    • SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK
    • Ho L, Titus AS, Banerjee KK et al (2013) SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging 5:835-849
    • (2013) Aging , vol.5 , pp. 835-849
    • Ho, L.1    Titus, A.S.2    Banerjee, K.K.3
  • 102
    • 84880536518 scopus 로고    scopus 로고
    • The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity
    • Wargent ET, Zaibi MS, Silvestri C et al (2013) The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity. Nutr Diabetes 3:e68
    • (2013) Nutr Diabetes , vol.3
    • Wargent, E.T.1    Zaibi, M.S.2    Silvestri, C.3
  • 103
    • 84878972563 scopus 로고    scopus 로고
    • Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes
    • Caron S, Huaman SC, Dehondt H et al (2013) Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes. Mol Cell Biol 33:2202-2211
    • (2013) Mol Cell Biol , vol.33 , pp. 2202-2211
    • Caron, S.1    Huaman, S.C.2    Dehondt, H.3
  • 104
    • 84855970215 scopus 로고    scopus 로고
    • Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation?
    • Lauressergues E, Bert E, Duriez P et al (2012) Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation? Neuropharmacology 62:784-796
    • (2012) Neuropharmacology , vol.62 , pp. 784-796
    • Lauressergues, E.1    Bert, E.2    Duriez, P.3
  • 105
    • 37749011738 scopus 로고    scopus 로고
    • Cadmium induces mitochondriadependent apoptosis of normal human hepatocytes
    • Lasfer M, Vadrot N, Aoudjehane L et al (2008) Cadmium induces mitochondriadependent apoptosis of normal human hepatocytes. Cell Biol Toxicol 24:55-62
    • (2008) Cell Biol Toxicol , vol.24 , pp. 55-62
    • Lasfer, M.1    Vadrot, N.2    Aoudjehane, L.3
  • 106
    • 0031821747 scopus 로고    scopus 로고
    • Hepatitis C virus population dynamics in human lymphocytes and hepatocytes infected in vitro
    • Kato N, Ikeda M, Sugiyama K et al (1998) Hepatitis C virus population dynamics in human lymphocytes and hepatocytes infected in vitro . J Gen Virol 79:1859-1869
    • (1998) J Gen Virol , vol.79 , pp. 1859-1869
    • Kato, N.1    Ikeda, M.2    Sugiyama, K.3
  • 107
    • 0033956354 scopus 로고    scopus 로고
    • Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells
    • Ikeda M, Nozaki A, Sugiyama K et al (2000) Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells. Virus Res 66:51-63
    • (2000) Virus Res , vol.66 , pp. 51-63
    • Ikeda, M.1    Nozaki, A.2    Sugiyama, K.3
  • 108
    • 0038105558 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of interferon alpha inhibits hepatitis C virus replication in hepatocytes
    • Suzuki K, Aoki K, Ohnami S et al (2003) Adenovirus-mediated gene transfer of interferon alpha inhibits hepatitis C virus replication in hepatocytes. Biochem Biophys Res Commun 307:814-819
    • (2003) Biochem Biophys Res Commun , vol.307 , pp. 814-819
    • Suzuki, K.1    Aoki, K.2    Ohnami, S.3
  • 109
    • 0032143649 scopus 로고    scopus 로고
    • Human hepatocyte clonal cell lines that support persistent replication of hepatitis C virus
    • Ikeda M, Sugiyama K, Mizutani T et al (1998) Human hepatocyte clonal cell lines that support persistent replication of hepatitis C virus. Virus Res 56:157-167
    • (1998) Virus Res , vol.56 , pp. 157-167
    • Ikeda, M.1    Sugiyama, K.2    Mizutani, T.3
  • 110
    • 0030861248 scopus 로고    scopus 로고
    • Specifi c interaction of polypyrimidine tract-binding protein with the extreme 3′-terminal structure of the hepatitis C virus genome, the 3′X
    • Tsuchihara K, Tanaka T, Hijikata M et al (1997) Specifi c interaction of polypyrimidine tract-binding protein with the extreme 3′-terminal structure of the hepatitis C virus genome, the 3′X. J Virol 71:6720-6726
    • (1997) J Virol , vol.71 , pp. 6720-6726
    • Tsuchihara, K.1    Tanaka, T.2    Hijikata, M.3
  • 111
    • 84872808323 scopus 로고    scopus 로고
    • Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells
    • Cuconati A, Mills C, Goddard C et al (2013) Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells. PLoS One 8:e54595
    • (2013) Plos One , vol.8
    • Cuconati, A.1    Mills, C.2    Goddard, C.3
  • 112
    • 84920972464 scopus 로고    scopus 로고
    • MiR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cir-rhosis and hepatocellular cancer
    • Brockhausen J, Tay SS, Grzelak CA et al (2014) miR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cir-rhosis and hepatocellular cancer. Liver Int. doi: 10.1111/liv.12517
    • (2014) Liver Int
    • Brockhausen, J.1    Tay, S.S.2    Grzelak, C.A.3
  • 113
    • 80052846666 scopus 로고    scopus 로고
    • The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes
    • Wilson R, Warner N, Ryan K et al (2011) The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes. J Viral Hepat 18:e499-e507
    • (2011) J Viral Hepat , vol.18 , pp. 499-507
    • Wilson, R.1    Warner, N.2    Ryan, K.3
  • 114
    • 84900789855 scopus 로고    scopus 로고
    • Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines
    • Shah F, Louise-May S, Greene N (2014) Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines. Bioorg Med Chem Lett 24:2753-2757
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 2753-2757
    • Shah, F.1    Louise-May, S.2    Greene, N.3
  • 115
    • 84891315751 scopus 로고    scopus 로고
    • A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans
    • Gustafsson F, Foster AJ, Sarda S et al (2014) A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicol Sci 137:189-211
    • (2014) Toxicol Sci , vol.137 , pp. 189-211
    • Gustafsson, F.1    Foster, A.J.2    Sarda, S.3
  • 116
    • 84883457835 scopus 로고    scopus 로고
    • In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid
    • Rodrigues AV, Rollison HE, Martin S et al (2013) In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid. Arch Toxicol 87:1569-1579
    • (2013) Arch Toxicol , vol.87 , pp. 1569-1579
    • Rodrigues, A.V.1    Rollison, H.E.2    Martin, S.3
  • 117
    • 84872564401 scopus 로고    scopus 로고
    • Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite
    • Foster AJ, Prime LH, Gustafsson F et al (2013) Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite. Chem Res Toxicol 26:124-135
    • (2013) Chem Res Toxicol , vol.26 , pp. 124-135
    • Foster, A.J.1    Prime, L.H.2    Gustafsson, F.3
  • 118
    • 77953730403 scopus 로고    scopus 로고
    • Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity
    • Antolino-Lobo I, Meulenbelt J, Nijmeijer SM et al (2010) Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity. Drug Metab Dispos 38:1105-1112
    • (2010) Drug Metab Dispos , vol.38 , pp. 1105-1112
    • Antolino-Lobo, I.1    Meulenbelt, J.2    Nijmeijer, S.M.3
  • 119
    • 77952541012 scopus 로고    scopus 로고
    • Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes
    • Saha S, New LS, Ho HK et al (2010) Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes. Toxicol Lett 195:135-141
    • (2010) Toxicol Lett , vol.195 , pp. 135-141
    • Saha, S.1    New, L.S.2    Ho, H.K.3
  • 120
    • 73749083993 scopus 로고    scopus 로고
    • Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity
    • Saha S, New LS, Ho HK et al (2010) Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity. Toxicol Lett 192:141-149
    • (2010) Toxicol Lett , vol.192 , pp. 141-149
    • Saha, S.1    New, L.S.2    Ho, H.K.3
  • 121
    • 84890493012 scopus 로고    scopus 로고
    • Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat dietpromoted hepatic infl ammation and tumorigenesis in mice
    • Ip BC, Hu KQ, Liu C et al (2013) Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat dietpromoted hepatic infl ammation and tumorigenesis in mice. Cancer Prev Res 6:1304-1316
    • (2013) Cancer Prev Res , vol.6 , pp. 1304-1316
    • Ip, B.C.1    Hu, K.Q.2    Liu, C.3
  • 122
    • 84898017895 scopus 로고    scopus 로고
    • Hawthorn (Crataegus oxyacantha L) bark extract regulates antioxidant response element (ARE)-mediated enzyme expression via Nrf2 pathway activation in normal hepatocyte cell line
    • Krajka-Kuzniak V, Paluszczak J, Oszmianski J et al (2014) Hawthorn (Crataegus oxyacantha L) bark extract regulates antioxidant response element (ARE)-mediated enzyme expression via Nrf2 pathway activation in normal hepatocyte cell line. Phytother Res 28:593-602
    • (2014) Phytother Res , vol.28 , pp. 593-602
    • Krajka-Kuzniak, V.1    Paluszczak, J.2    Oszmianski, J.3
  • 123
    • 84867788971 scopus 로고    scopus 로고
    • Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes
    • Krajka-Kuzniak V, Paluszczak J, Celewicz L et al (2013) Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes. Food Chem Toxicol 51:202-209
    • (2013) Food Chem Toxicol , vol.51 , pp. 202-209
    • Krajka-Kuzniak, V.1    Paluszczak, J.2    Celewicz, L.3
  • 124
    • 84869486455 scopus 로고    scopus 로고
    • Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro
    • Krajka-Kuzniak V, Paluszczak J, Baer-Dubowska W (2013) Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro . Toxicol In Vitro 27:149-156
    • (2013) Toxicol in Vitro , vol.27 , pp. 149-156
    • Krajka-Kuzniak, V.1    Paluszczak, J.2    Baer-Dubowska, W.3
  • 125
    • 39749116856 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 1a growth and induction of autophagy
    • Ait-Goughoulte M, Kanda T, Meyer K et al (2008) Hepatitis C virus genotype 1a growth and induction of autophagy. J Virol 82:2241-2249
    • (2008) J Virol , vol.82 , pp. 2241-2249
    • Ait-Goughoulte, M.1    Kanda, T.2    Meyer, K.3
  • 126
    • 33646188826 scopus 로고    scopus 로고
    • Generation of infectious hepatitis C virus in immortalized human hepatocytes
    • Kanda T, Basu A, Steele R et al (2006) Generation of infectious hepatitis C virus in immortalized human hepatocytes. J Virol 80:4633-4639
    • (2006) J Virol , vol.80 , pp. 4633-4639
    • Kanda, T.1    Basu, A.2    Steele, R.3
  • 127
    • 36048975791 scopus 로고    scopus 로고
    • Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes
    • Kanda T, Steele R, Ray R et al (2007) Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes. J Virol 81:12375-12381
    • (2007) J Virol , vol.81 , pp. 12375-12381
    • Kanda, T.1    Steele, R.2    Ray, R.3
  • 128
    • 33745831633 scopus 로고    scopus 로고
    • Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes
    • Basu A, Saito K, Meyer K et al (2006) Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes. Apoptosis 11:1391-1400
    • (2006) Apoptosis , vol.11 , pp. 1391-1400
    • Basu, A.1    Saito, K.2    Meyer, K.3
  • 129
    • 84865592621 scopus 로고    scopus 로고
    • N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism
    • Mazumdar B, Meyer K, Ray R (2012) N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism. PLoS One 7:e44461
    • (2012) Plos One , vol.7 , pp. 44461
    • Mazumdar, B.1    Meyer, K.2    Ray, R.3
  • 130
    • 28844443906 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development
    • Qiu C, Hanson E, Olivier E et al (2005) Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Exp Hematol 33:1450-1458
    • (2005) Exp Hematol , vol.33 , pp. 1450-1458
    • Qiu, C.1    Hanson, E.2    Olivier, E.3
  • 131
    • 84898609403 scopus 로고    scopus 로고
    • FAT10, an ubiquitin-like protein, confers malignant properties in non-tumorigenic and tumorigenic cells
    • Gao Y, Theng SS, Zhuo J et al (2014) FAT10, an ubiquitin-like protein, confers malignant properties in non-tumorigenic and tumorigenic cells. Carcinogenesis 35: 923-934
    • (2014) Carcinogenesis , vol.35 , pp. 923-934
    • Gao, Y.1    Theng, S.S.2    Zhuo, J.3
  • 132
    • 84863191653 scopus 로고    scopus 로고
    • MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms
    • Wang Y, Toh HC, Chow P et al (2012) MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms. FASEB J 26:3032-3041
    • (2012) FASEB J , vol.26 , pp. 3032-3041
    • Wang, Y.1    Toh, H.C.2    Chow, P.3
  • 133
    • 84885180273 scopus 로고    scopus 로고
    • Loss of exon 4 in a human T-cell factor-4 isoform promotes hepatic tumourigenicity
    • Tomimaru Y, Xu CQ, Nambotin SB et al (2013) Loss of exon 4 in a human T-cell factor-4 isoform promotes hepatic tumourigenicity. Liver Int 33:1536-1548
    • (2013) Liver Int , vol.33 , pp. 1536-1548
    • Tomimaru, Y.1    Xu, C.Q.2    Nambotin, S.B.3
  • 134
    • 47649104878 scopus 로고    scopus 로고
    • Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand
    • Nonaka M, Tazuma S, Hyogo H et al (2008) Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. J Gastroenterol Hepatol 23:e198-e206
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 198-206
    • Nonaka, M.1    Tazuma, S.2    Hyogo, H.3
  • 135
    • 34250866800 scopus 로고    scopus 로고
    • Hydrogen peroxide stimulates pigment epithelium-derived factor gene and protein expression in the human hepatocyte cell line OUMS-29
    • Nakamura K, Yamagishi S, Yoshida T et al (2007) Hydrogen peroxide stimulates pigment epithelium-derived factor gene and protein expression in the human hepatocyte cell line OUMS-29. J Int Med Res 35:427-432
    • (2007) J Int Med Res , vol.35 , pp. 427-432
    • Nakamura, K.1    Yamagishi, S.2    Yoshida, T.3
  • 136
    • 0037222025 scopus 로고    scopus 로고
    • Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes
    • Shishido S, Koga H, Harada M et al (2003) Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes. Hepatology 37:136-147
    • (2003) Hepatology , vol.37 , pp. 136-147
    • Shishido, S.1    Koga, H.2    Harada, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.