-
1
-
-
33847018050
-
Primary hepatocytes: Current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies
-
Hewitt NJ, Lechon MJ, Houston JB et al (2007) Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab Rev 39:159-234
-
(2007)
Drug Metab Rev
, vol.39
, pp. 159-234
-
-
Hewitt, N.J.1
Lechon, M.J.2
Houston, J.B.3
-
2
-
-
33645972546
-
Stem cells, immortalized cells and primary cells in ADMET assays
-
Sinz M, Kim S (2006) Stem cells, immortalized cells and primary cells in ADMET assays. Drug Discov Today Technol 3:79-85
-
(2006)
Drug Discov Today Technol
, vol.3
, pp. 79-85
-
-
Sinz, M.1
Kim, S.2
-
4
-
-
84890820918
-
Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals
-
Rodrigues RM, De Kock J, Branson S et al (2014) Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals. Stem Cells Dev 23:44-55
-
(2014)
Stem Cells Dev
, vol.23
, pp. 44-55
-
-
Rodrigues, R.M.1
De Kock, J.2
Branson, S.3
-
5
-
-
0036924902
-
Improving the next generation of bioartifi cial liver devices
-
Allen JW, Bhatia SN (2002) Improving the next generation of bioartifi cial liver devices. Semin Cell Dev Biol 13:447-454
-
(2002)
Semin Cell Dev Biol
, vol.13
, pp. 447-454
-
-
Allen, J.W.1
Bhatia, S.N.2
-
6
-
-
29744467490
-
Which are the right cells to be used in a bioartifi cial liver?
-
Chamuleau RA, Deurholt T, Hoekstra R (2005) Which are the right cells to be used in a bioartifi cial liver? Metab Brain Dis 20: 327-335
-
(2005)
Metab Brain Dis
, vol.20
, pp. 327-335
-
-
Chamuleau, R.A.1
Deurholt, T.2
Hoekstra, R.3
-
7
-
-
0038278508
-
An update on in vitro test methods in human hepatic drug biotransformation research: Pros and cons
-
Brandon EF, Raap CD, Meijerman I et al (2003) An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicol Appl Pharmacol 189:233-246
-
(2003)
Toxicol Appl Pharmacol
, vol.189
, pp. 233-246
-
-
Brandon, E.F.1
Raap, C.D.2
Meijerman, I.3
-
8
-
-
66149122259
-
Corcoran P et al (2009)Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells
-
Choi S, Sainz B, Corcoran P et al (2009)Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells. Xenobiotica 39:205-217
-
Xenobiotica
, vol.39
, pp. 205-217
-
-
Choi, S.1
Sainz, B.2
-
9
-
-
36049024618
-
Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04
-
Lim PL, Tan W, Latchoumycandane C et al (2007) Molecular and functional characterization of drug-metabolizing enzymes and transporter expression in the novel spontaneously immortalized human hepatocyte line HC-04. Toxicol In Vitro 21:1390-1401
-
(2007)
Toxicol in Vitro
, vol.21
, pp. 1390-1401
-
-
Lim, P.L.1
Tan, W.2
Latchoumycandane, C.3
-
10
-
-
84875038806
-
Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicity
-
Szabo M, Veres Z, Baranyai Z et al (2013) Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicity. PLoS One 8:e59432
-
(2013)
Plos One
, vol.8
-
-
Szabo, M.1
Veres, Z.2
Baranyai, Z.3
-
11
-
-
29944444269
-
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells
-
Aninat C, Piton A, Glaise D et al (2006) Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab Dispos 34:75-83
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 75-83
-
-
Aninat, C.1
Piton, A.2
Glaise, D.3
-
12
-
-
34247517355
-
The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
-
Guillouzo A, Corlu A, Aninat C et al (2007) The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. Chem Biol Interact 168:66-73
-
(2007)
Chem Biol Interact
, vol.168
, pp. 66-73
-
-
Guillouzo, A.1
Corlu, A.2
Aninat, C.3
-
13
-
-
70449727365
-
Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes
-
Deurholt T, van Til NP, Chhatta AA et al (2009) Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes. BMC Biotechnol 9:89
-
(2009)
BMC Biotechnol
, vol.9
, pp. 89
-
-
Deurholt, T.1
Van Til, N.P.2
Chhatta, A.A.3
-
14
-
-
70349321135
-
Establishment of a human neonatal hepatocyte cell line
-
Reid Y, Gaddipati JP, Yadav D et al (2009) Establishment of a human neonatal hepatocyte cell line. In Vitro Cell Dev Biol Anim 45:535-542
-
(2009)
Vitro Cell Dev Biol Anim
, vol.45
, pp. 535-542
-
-
Reid, Y.1
Gaddipati, J.P.2
Yadav, D.3
-
15
-
-
17044368822
-
Liver cell lines for the study of hepatocyte functions and immunological response
-
Clayton RF, Rinaldi A, Kandyba EE et al (2005) Liver cell lines for the study of hepatocyte functions and immunological response. Liver Int 25:389-402
-
(2005)
Liver Int
, vol.25
, pp. 389-402
-
-
Clayton, R.F.1
Rinaldi, A.2
Kandyba, E.E.3
-
16
-
-
62549128710
-
Establishment of immortalized human hepatocytes by introduction of HPV16 E6/ E7 and hTERT as cell sources for liver cellbased therapy
-
Tsuruga Y, Kiyono T, Matsushita M et al (2008) Establishment of immortalized human hepatocytes by introduction of HPV16 E6/ E7 and hTERT as cell sources for liver cellbased therapy. Cell Transplant 17:1083-1094
-
(2008)
Cell Transplant
, vol.17
, pp. 1083-1094
-
-
Tsuruga, Y.1
Kiyono, T.2
Matsushita, M.3
-
17
-
-
0034885777
-
Establishment of a human hepatocyte line (OUMS-29) having CYP 1A1 and 1A2 activities from fetal liver tissue by transfection of SV40 LT
-
Fukaya K, Asahi S, Nagamori S et al (2001) Establishment of a human hepatocyte line (OUMS-29) having CYP 1A1 and 1A2 activities from fetal liver tissue by transfection of SV40 LT. In Vitro Cell Dev Biol Anim 37:266-269
-
(2001)
Vitro Cell Dev Biol Anim
, vol.37
, pp. 266-269
-
-
Fukaya, K.1
Asahi, S.2
Nagamori, S.3
-
18
-
-
44149104931
-
Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction
-
Hariparsad N, Carr BA, Evers R et al (2008) Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. Drug Metab Dispos 36:1046-1055
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 1046-1055
-
-
Hariparsad, N.1
Carr, B.A.2
Evers, R.3
-
19
-
-
27744539431
-
Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes
-
Nguyen TH, Mai G, Villiger P et al (2005) Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes. J Hepatol 43:1031-1037
-
(2005)
J Hepatol
, vol.43
, pp. 1031-1037
-
-
Nguyen, T.H.1
Mai, G.2
Villiger, P.3
-
20
-
-
0035408523
-
Novel strategies for immortalization of human hepatocytes
-
Cascio SM (2001) Novel strategies for immortalization of human hepatocytes. Artif Organs 25:529-538
-
(2001)
Artif Organs
, vol.25
, pp. 529-538
-
-
Cascio, S.M.1
-
21
-
-
84868479394
-
Establishment and characterization of immortalized human hepatocyte cell line for applications in bioartifi cial livers
-
Pan X, Li J, Du W et al (2012) Establishment and characterization of immortalized human hepatocyte cell line for applications in bioartifi cial livers. Biotechnol Lett 34:2183-2190
-
(2012)
Biotechnol Lett
, vol.34
, pp. 2183-2190
-
-
Pan, X.1
Li, J.2
Du, W.3
-
22
-
-
18744401640
-
Establishment of highly differentiated immortalized human hepatocyte line with simian virus 40 large tumor antigen for liver based cell therapy
-
Li J, Li LJ, Cao HC et al (2005) Establishment of highly differentiated immortalized human hepatocyte line with simian virus 40 large tumor antigen for liver based cell therapy. ASAIO J 51:262-268
-
(2005)
ASAIO J
, vol.51
, pp. 262-268
-
-
Li, J.1
Li, L.J.2
Cao, H.C.3
-
23
-
-
0030848684
-
Immortalized human hepatocytes as a tool for the study of hepatocytic (De-)differentiation
-
Schippers IJ, Moshage H, Roelofsen H et al (1997) Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation. Cell Biol Toxicol 13:375-386
-
(1997)
Cell Biol Toxicol
, vol.13
, pp. 375-386
-
-
Schippers, I.J.1
Moshage, H.2
Roelofsen, H.3
-
24
-
-
0027254424
-
Simian virus 40 large tumor antigenimmortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens
-
Pfeifer AM, Cole KE, Smoot DT et al (1993) Simian virus 40 large tumor antigenimmortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. Proc Natl Acad Sci U S A 90:5123-5127
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 5123-5127
-
-
Pfeifer, A.M.1
Cole, K.E.2
Smoot, D.T.3
-
25
-
-
0030093331
-
Cell lines from non-neoplastic liver and hepatocellular carcinoma tissue from a single patient
-
Noguchi M, Hirohashi S (1996) Cell lines from non-neoplastic liver and hepatocellular carcinoma tissue from a single patient. In Vitro Cell Dev Biol Anim 32:135-137
-
(1996)
Vitro Cell Dev Biol Anim
, vol.32
, pp. 135-137
-
-
Noguchi, M.1
Hirohashi, S.2
-
26
-
-
85037139991
-
Evaluation of a reversibly immortalized human hepatocyte line in bioartifi cial liver in pigs
-
Zhao L, Li J, Lv G et al (2012) Evaluation of a reversibly immortalized human hepatocyte line in bioartifi cial liver in pigs. Afr J Biotechnol 11:4116-4126
-
(2012)
Afr J Biotechnol
, vol.11
, pp. 4116-4126
-
-
Zhao, L.1
Li, J.2
Lv, G.3
-
27
-
-
77953681763
-
Transplantation of immortalized human fetal hepatocytes prevents acute liver failure in 90 % hepatectomized mice
-
Chen Y, Li J, Liu X et al (2010) Transplantation of immortalized human fetal hepatocytes prevents acute liver failure in 90 % hepatectomized mice. Transplant Proc 42:1907-1914
-
(2010)
Transplant Proc
, vol.42
, pp. 1907-1914
-
-
Chen, Y.1
Li, J.2
Liu, X.3
-
28
-
-
0035005221
-
Immortalization of human hepatocytes by temperature-sensitive SV40 large-T antigen
-
Smalley M, Leiper K, Tootle R et al (2001) Immortalization of human hepatocytes by temperature-sensitive SV40 large-T antigen. In Vitro Cell Dev Biol Anim 37:166-168
-
(2001)
Vitro Cell Dev Biol Anim
, vol.37
, pp. 166-168
-
-
Smalley, M.1
Leiper, K.2
Tootle, R.3
-
29
-
-
0034681522
-
Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes
-
Kobayashi N, Fujiwara T, Westerman KA et al (2000) Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes. Science 287:1258-1262
-
(2000)
Science
, vol.287
, pp. 1258-1262
-
-
Kobayashi, N.1
Fujiwara, T.2
Westerman, K.A.3
-
30
-
-
84926332210
-
Growth control and cell cycle progression in cultured hepatocytes
-
In: Edwards A, Berry M, Kluwer Academic, The Netherlands
-
Ilyin G, Rescan C, Rialland M et al (2000) Growth control and cell cycle progression in cultured hepatocytes. In: Edwards A, Berry M (eds) The hepatocyte review. Kluwer Academic, The Netherlands, pp 263-280
-
(2000)
The Hepatocyte Review
, pp. 263-280
-
-
Ilyin, G.1
Rescan, C.2
Rialland, M.3
-
31
-
-
0032956298
-
Epidermal growth factor-and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes
-
Runge DM, Runge D, Dorko K et al (1999) Epidermal growth factor-and hepatocyte growth factor-receptor activity in serum-free cultures of human hepatocytes. J Hepatol 30:265-274
-
(1999)
J Hepatol
, vol.30
, pp. 265-274
-
-
Runge, D.M.1
Runge, D.2
Dorko, K.3
-
32
-
-
70350568297
-
Senescence and immortality in hepatocellular carcinoma
-
Ozturk M, Arslan-Ergul A, Bagislar S et al (2009) Senescence and immortality in hepatocellular carcinoma. Cancer Lett 286:103-113
-
(2009)
Cancer Lett
, vol.286
, pp. 103-113
-
-
Ozturk, M.1
Arslan-Ergul, A.2
Bagislar, S.3
-
33
-
-
0032197092
-
The cell cycle: A review
-
Schafer KA (1998) The cell cycle: a review. Vet Pathol 35:461-478
-
(1998)
Vet Pathol
, vol.35
, pp. 461-478
-
-
Schafer, K.A.1
-
34
-
-
0037308362
-
Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential
-
Wege H, Le HT, Chui MS et al (2003) Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology 124:432-444
-
(2003)
Gastroenterology
, vol.124
, pp. 432-444
-
-
Wege, H.1
Le, H.T.2
Chui, M.S.3
-
35
-
-
0031047426
-
Replicative senescence and cell immortality: The role of telomeres and telomerase
-
Chiu CP, Harley CB (1997) Replicative senescence and cell immortality: the role of telomeres and telomerase. Proc Soc Exp Biol Med 214:99-106
-
(1997)
Proc Soc Exp Biol Med
, vol.214
, pp. 99-106
-
-
Chiu, C.P.1
Harley, C.B.2
-
36
-
-
84888094038
-
Eternity and functionality: Rational access to physiologically relevant cell lines
-
Lipps C, May T, Hauser H et al (2013) Eternity and functionality: rational access to physiologically relevant cell lines. Biol Chem 394:1637-1648
-
(2013)
Biol Chem
, vol.394
, pp. 1637-1648
-
-
Lipps, C.1
May, T.2
Hauser, H.3
-
37
-
-
33749921761
-
Immortalization Strategies for Mammalian Cells
-
In: Jenkins N, Humana, Totowa
-
McLean J (1999) Immortalization Strategies for Mammalian Cells. In: Jenkins N (ed) Animal cell biotechnology: methods and protocols. Humana, Totowa, pp 61-72
-
(1999)
Animal Cell Biotechnology: Methods and Protocols
, pp. 61-72
-
-
McLean, J.1
-
38
-
-
84926318351
-
Controlled expansion of mammalian cell populations by reversible immortalization
-
Noguchi H, Kobayashi N (2013) Controlled expansion of mammalian cell populations by reversible immortalization. J Biotechnol Biomater 3:158
-
(2013)
J Biotechnol Biomater
, vol.3
, pp. 158
-
-
Noguchi, H.1
Kobayashi, N.2
-
39
-
-
77954627511
-
Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development
-
Waki K, Anno K, Ono T et al (2010) Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development. Cancer Sci 101:1678-1685
-
(2010)
Cancer Sci
, vol.101
, pp. 1678-1685
-
-
Waki, K.1
Anno, K.2
Ono, T.3
-
40
-
-
0347086157
-
In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging
-
Wege H, Chui MS, Le HT et al (2003) In vitro expansion of human hepatocytes is restricted by telomere-dependent replicative aging. Cell Transplant 12:897-906
-
(2003)
Cell Transplant
, vol.12
, pp. 897-906
-
-
Wege, H.1
Chui, M.S.2
Le, H.T.3
-
41
-
-
0027367137
-
Mitogen-independent DNA synthesis by fetal rat hepatocytes in primary culture
-
Curran TR, Bahner RI, Oh W et al (1993) Mitogen-independent DNA synthesis by fetal rat hepatocytes in primary culture. Exp Cell Res 209:53-57
-
(1993)
Exp Cell Res
, vol.209
, pp. 53-57
-
-
Curran, T.R.1
Bahner, R.I.2
Oh, W.3
-
42
-
-
9144237453
-
Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs
-
Okitsu T, Kobayashi N, Jun HS et al (2004) Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs. Diabetes 53:105-112
-
(2004)
Diabetes
, vol.53
, pp. 105-112
-
-
Okitsu, T.1
Kobayashi, N.2
Jun, H.S.3
-
43
-
-
34249277092
-
Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with tamoxifen-mediated selfrecombination
-
Totsugawa T, Yong C, Rivas-Carrillo JD et al (2007) Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with tamoxifen-mediated selfrecombination. J Hepatol 47:74-82
-
(2007)
J Hepatol
, vol.47
, pp. 74-82
-
-
Totsugawa, T.1
Yong, C.2
Rivas-Carrillo, J.D.3
-
44
-
-
17644418751
-
Use of exogenous hTERT to immortalize primary human cells
-
Lee KM, Choi KH, Ouellette MM (2004) Use of exogenous hTERT to immortalize primary human cells. Cytotechnology 45:33-38
-
(2004)
Cytotechnology
, vol.45
, pp. 33-38
-
-
Lee, K.M.1
Choi, K.H.2
Ouellette, M.M.3
-
45
-
-
0034713462
-
Hepatitis C virus core protein promotes immortalization of primary human hepatocytes
-
Ray RB, Meyer K, Ray R (2000) Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology 271: 197-204
-
(2000)
Virology
, vol.271
, pp. 197-204
-
-
Ray, R.B.1
Meyer, K.2
Ray, R.3
-
46
-
-
0036301977
-
Hepatitis C virus core protein is necessary for the maintenance of immortalized human hepatocytes
-
Basu A, Meyer K, Ray RB et al (2002) Hepatitis C virus core protein is necessary for the maintenance of immortalized human hepatocytes. Virology 298:53-62
-
(2002)
Virology
, vol.298
, pp. 53-62
-
-
Basu, A.1
Meyer, K.2
Ray, R.B.3
-
47
-
-
0032786609
-
Cultivation and characterization of a new immortalized human hepatocyte cell line, HepZ, for use in an artifi cial liver support system
-
Werner A, Duvar S, Müthing J et al (1999) Cultivation and characterization of a new immortalized human hepatocyte cell line, HepZ, for use in an artifi cial liver support system. Ann N Y Acad Sci 875:364-368
-
(1999)
Ann N Y Acad Sci
, vol.875
, pp. 364-368
-
-
Werner, A.1
Duvar, S.2
Müthing, J.3
-
48
-
-
84934437187
-
Ex vivo gene transfer into hepatocytes
-
Wang X, Mani P, Sarkar DP et al (2009) Ex vivo gene transfer into hepatocytes. Methods Mol Biol 481:117-140
-
(2009)
Methods Mol Biol
, vol.481
, pp. 117-140
-
-
Wang, X.1
Mani, P.2
Sarkar, D.P.3
-
49
-
-
0035084236
-
Role of immortalized hepatocyte transplantation in acute liver failure
-
Kobayashi N, Noguchi H, Watanabe T et al (2001) Role of immortalized hepatocyte transplantation in acute liver failure. Transplant Proc 33:645-646
-
(2001)
Transplant Proc
, vol.33
, pp. 645-646
-
-
Kobayashi, N.1
Noguchi, H.2
Watanabe, T.3
-
50
-
-
80052401275
-
Human artifi-cial chromosomes for gene delivery and the development of animal models
-
Kazuki Y, Oshimura M (2011) Human artifi-cial chromosomes for gene delivery and the development of animal models. Mol Ther 19:1591-1601
-
(2011)
Mol Ther
, vol.19
, pp. 1591-1601
-
-
Kazuki, Y.1
Oshimura, M.2
-
51
-
-
0034180682
-
The application of a lentiviral vector for gene transfer in fetal human hepatocytes
-
Zahler MH, Irani A, Malhi H et al (2000) The application of a lentiviral vector for gene transfer in fetal human hepatocytes. J Gene Med 2:186-193
-
(2000)
J Gene Med
, vol.2
, pp. 186-193
-
-
Zahler, M.H.1
Irani, A.2
Malhi, H.3
-
52
-
-
0033675060
-
Establishment of a highly differentiated immortalized adult human hepatocyte cell line by retroviral gene transfer
-
Kobayashi N, Noguchi H, Fujiwara T et al (2000) Establishment of a highly differentiated immortalized adult human hepatocyte cell line by retroviral gene transfer. Transplant Proc 32:2368-2369
-
(2000)
Transplant Proc
, vol.32
, pp. 2368-2369
-
-
Kobayashi, N.1
Noguchi, H.2
Fujiwara, T.3
-
53
-
-
0036664451
-
Highly effi cient lentiviral vectormediated transduction of nondividing, fully reimplantable primary hepatocytes
-
Nguyen TH, Oberholzer J, Birraux J et al (2002) Highly effi cient lentiviral vectormediated transduction of nondividing, fully reimplantable primary hepatocytes. Mol Ther 6:199-209
-
(2002)
Mol Ther
, vol.6
, pp. 199-209
-
-
Nguyen, T.H.1
Oberholzer, J.2
Birraux, J.3
-
54
-
-
0035169915
-
Hepatocyte transplantation: Clinical and experimental application
-
Ohashi K, Park F, Kay MA (2001) Hepatocyte transplantation: clinical and experimental application. J Mol Med 79:617-630
-
(2001)
J Mol Med
, vol.79
, pp. 617-630
-
-
Ohashi, K.1
Park, F.2
Kay, M.A.3
-
55
-
-
0029042918
-
Effi cient retroviral-mediated gene transfer into primary culture of murine and human hepatocytes: Expression of the LDL receptor
-
Pages JC, Andreoletti M, Bennoun M et al (1995) Effi cient retroviral-mediated gene transfer into primary culture of murine and human hepatocytes: expression of the LDL receptor. Hum Gene Ther 6:21-30
-
(1995)
Hum Gene Ther
, vol.6
, pp. 21-30
-
-
Pages, J.C.1
Reoletti, M.2
Bennoun, M.3
-
56
-
-
33947431697
-
Growth factors improve gene expression after lentiviral transduction in human adult and fetal hepatocytes
-
Selden C, Mellor N, Rees M et al (2007) Growth factors improve gene expression after lentiviral transduction in human adult and fetal hepatocytes. J Gene Med 9:67-76
-
(2007)
J Gene Med
, vol.9
, pp. 67-76
-
-
Selden, C.1
Mellor, N.2
Rees, M.3
-
57
-
-
44349133270
-
Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes
-
Zamule SM, Strom SC, Omiecinski CJ (2008) Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. Chem Biol Interact 173:179-186
-
(2008)
Chem Biol Interact
, vol.173
, pp. 179-186
-
-
Zamule, S.M.1
Strom, S.C.2
Omiecinski, C.J.3
-
58
-
-
42249089529
-
Immortalized hepatocytes using human artifi-cial chromosome
-
Ito M, Ito R, Yoshihara D et al (2008) Immortalized hepatocytes using human artifi-cial chromosome. Cell Transplant 17: 165-171
-
(2008)
Cell Transplant
, vol.17
, pp. 165-171
-
-
Ito, M.1
Ito, R.2
Yoshihara, D.3
-
59
-
-
60649106590
-
Treatment of nonalbumin rats by transplantation of immortalized hepatocytes using artifi-cial human chromosome
-
Ito M, Ikeno M, Nagata H et al (2009) Treatment of nonalbumin rats by transplantation of immortalized hepatocytes using artifi-cial human chromosome. Transplant Proc 41:422-424
-
(2009)
Transplant Proc
, vol.41
, pp. 422-424
-
-
Ito, M.1
Ikeno, M.2
Nagata, H.3
-
60
-
-
41149129157
-
Telomerase-mediated life-span extension of human primary fi broblasts by human artifi cial chromosome (HAC) vector
-
Shitara S, Kakeda M, Nagata K et al (2008) Telomerase-mediated life-span extension of human primary fi broblasts by human artifi cial chromosome (HAC) vector. Biochem Biophys Res Commun 369:807-811
-
(2008)
Biochem Biophys Res Commun
, vol.369
, pp. 807-811
-
-
Shitara, S.1
Kakeda, M.2
Nagata, K.3
-
61
-
-
0037708562
-
Establishment of immortalized human hepatic stellate scavenger cells to develop bioartifi cial livers
-
Watanabe T, Shibata N, Westerman KA et al (2003) Establishment of immortalized human hepatic stellate scavenger cells to develop bioartifi cial livers. Transplantation 75:1873-1880
-
(2003)
Transplantation
, vol.75
, pp. 1873-1880
-
-
Watanabe, T.1
Shibata, N.2
Westerman, K.A.3
-
62
-
-
0035514239
-
Reactivation of liver-specifi c gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4alpha2 gene
-
Inoue Y, Miyazaki M, Tsuji T et al (2001) Reactivation of liver-specifi c gene expression in an immortalized human hepatocyte cell line by introduction of the human HNF4alpha2 gene. Int J Mol Med 8:481-487
-
(2001)
Int J Mol Med
, vol.8
, pp. 481-487
-
-
Inoue, Y.1
Miyazaki, M.2
Tsuji, T.3
-
63
-
-
84867682745
-
Characterization of THLEImmortalized cytochrome P450 (P450) cell lines: Gene expression background and relationship to P450-enzyme activity
-
Soltanpour Y, Hilgendorf C, Ahlström MM et al (2012) Characterization of THLEImmortalized cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity. Drug Metab Dispos 40:2054-2058
-
(2012)
Drug Metab Dispos
, vol.40
, pp. 2054-2058
-
-
Soltanpour, Y.1
Hilgendorf, C.2
Ahlström, M.M.3
-
64
-
-
0037321188
-
Active expression of p21 facilitates differentiation of immortalized human hepatocytes
-
Kobayashi N, Kunieda T, Sakaguchi M et al (2003) Active expression of p21 facilitates differentiation of immortalized human hepatocytes. Transplant Proc 35:433-434
-
(2003)
Transplant Proc
, vol.35
, pp. 433-434
-
-
Kobayashi, N.1
Kunieda, T.2
Sakaguchi, M.3
-
65
-
-
0036387078
-
Transduction of immortalized human hepatocytes with p21 to enhance differentiated phenotypes
-
Kunieda T, Kobayashi N, Sakaguchi M et al (2002) Transduction of immortalized human hepatocytes with p21 to enhance differentiated phenotypes. Cell Transplant 11:421-428
-
(2002)
Cell Transplant
, vol.11
, pp. 421-428
-
-
Kunieda, T.1
Kobayashi, N.2
Sakaguchi, M.3
-
66
-
-
0033669188
-
Conditionally immortalized mouse hepatocytes for use in liver gene therapy
-
Allen KJ, Reyes R, Demmler K et al (2000) Conditionally immortalized mouse hepatocytes for use in liver gene therapy. J Gastroenterol Hepatol 15:1325-1332
-
(2000)
J Gastroenterol Hepatol
, vol.15
, pp. 1325-1332
-
-
Allen, K.J.1
Reyes, R.2
Demmler, K.3
-
67
-
-
0028898438
-
Conditional immortalization of Gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin-UDP-glucuronosyltransferase gene transfer
-
Fox IJ, Chowdhury NR, Gupta S et al (1995) Conditional immortalization of Gunn rat hepatocytes: an ex vivo model for evaluating methods for bilirubin-UDP-glucuronosyltransferase gene transfer. Hepatology 21:837-846
-
(1995)
Hepatology
, vol.21
, pp. 837-846
-
-
Fox, I.J.1
Chowdhury, N.R.2
Gupta, S.3
-
68
-
-
9144222636
-
Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization
-
May T, Hauser H, Wirth D (2004) Transcriptional control of SV40 T-antigen expression allows a complete reversion of immortalization. Nucleic Acids Res 32: 5529-5538
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 5529-5538
-
-
May, T.1
Hauser, H.2
Wirth, D.3
-
69
-
-
0029810898
-
Reversibleimmortalization of mammalian cells mediated by retroviral transfer and site-specifi c recombination
-
Westerman KA, Leboulch P (1996) Reversibleimmortalization of mammalian cells mediated by retroviral transfer and site-specifi c recombination. Proc Natl Acad Sci U S A 93:8971-8976
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 8971-8976
-
-
Westerman, K.A.1
Leboulch, P.2
-
70
-
-
0033166556
-
Reversible cell immortalization with the Cre-lox system
-
Paillard F (1999) Reversible cell immortalization with the Cre-lox system. Hum Gene Ther 10:1597-1598
-
(1999)
Hum Gene Ther
, vol.10
, pp. 1597-1598
-
-
Paillard, F.1
-
71
-
-
0034637386
-
Establishment of a reversibly immortalized human hepatocyte cell line by using Cre/loxP site-specifi c recombination
-
Kobayashi N, Noguchi H, Fujiwara T et al (2000) Establishment of a reversibly immortalized human hepatocyte cell line by using Cre/loxP site-specifi c recombination. Transplant Proc 32:1121-1122
-
(2000)
Transplant Proc
, vol.32
, pp. 1121-1122
-
-
Kobayashi, N.1
Noguchi, H.2
Fujiwara, T.3
-
72
-
-
77950828040
-
Precise conditional immortalization of mouse cells using tetracycline-regulated SV40 large T-antigen
-
Anastassiadis K, Rostovskaya M, Lubitz S et al (2010) Precise conditional immortalization of mouse cells using tetracycline-regulated SV40 large T-antigen. Genesis 48:220-232
-
(2010)
Genesis
, vol.48
, pp. 220-232
-
-
Anastassiadis, K.1
Rostovskaya, M.2
Lubitz, S.3
-
73
-
-
84879881234
-
Gene therapy on demand: Site-specifi c regulation of gene therapy
-
Jazwa A, Florczyk U, Jozkowicz A et al (2013) Gene therapy on demand: site-specifi c regulation of gene therapy. Gene 525:229-238
-
(2013)
Gene
, vol.525
, pp. 229-238
-
-
Jazwa, A.1
Florczyk, U.2
Jozkowicz, A.3
-
74
-
-
0030864521
-
Analysis of the cell tropism of HCV by using in vitro HCV-infected human lymphocytes and hepatocytes
-
Ikeda M, Kato N, Mizutani T et al (1997) Analysis of the cell tropism of HCV by using in vitro HCV-infected human lymphocytes and hepatocytes. J Hepatol 27:445-454
-
(1997)
J Hepatol
, vol.27
, pp. 445-454
-
-
Ikeda, M.1
Kato, N.2
Mizutani, T.3
-
75
-
-
0029788685
-
Replication of hepatitis C virus in cultured non-neoplastic human hepatocytes
-
Kato N, Ikeda M, Mizutani T et al (1996) Replication of hepatitis C virus in cultured non-neoplastic human hepatocytes. Jpn J Cancer Res 87:787-792
-
(1996)
Jpn J Cancer Res
, vol.87
, pp. 787-792
-
-
Kato, N.1
Ikeda, M.2
Mizutani, T.3
-
76
-
-
78349288446
-
Amino acid substitutions of hepatitis C virus core protein are not associated with intracellular antiviral response to interferon-α in vitro
-
Ikeda F, Dansako H, Nishimura G et al (2010) Amino acid substitutions of hepatitis C virus core protein are not associated with intracellular antiviral response to interferon-α in vitro . Liver Int 30:1324-1331
-
(2010)
Liver Int
, vol.30
, pp. 1324-1331
-
-
Ikeda, F.1
Dansako, H.2
Nishimura, G.3
-
77
-
-
77957936172
-
Hepatitis C virus infection impairs IRF-7 translocation and alpha interferon synthesis in immortalized human hepatocytes
-
Raychoudhuri A, Shrivastava S, Steele R et al (2010) Hepatitis C virus infection impairs IRF-7 translocation and alpha interferon synthesis in immortalized human hepatocytes. J Virol 84:10991-10998
-
(2010)
J Virol
, vol.84
, pp. 10991-10998
-
-
Raychoudhuri, A.1
Shrivastava, S.2
Steele, R.3
-
78
-
-
84862909215
-
ISG56 and IFITM1 proteins inhibit hepatitis C virus replication
-
Raychoudhuri A, Shrivastava S, Steele R et al (2011) ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. J Virol 85: 12881-12889
-
(2011)
J Virol
, vol.85
, pp. 12881-12889
-
-
Raychoudhuri, A.1
Shrivastava, S.2
Steele, R.3
-
79
-
-
0036721333
-
Interaction of hepatitis C virus-like particles and cells: A model system for studying viral binding and entry
-
Triyatni M, Saunier B, Maruvada P et al (2002) Interaction of hepatitis C virus-like particles and cells: a model system for studying viral binding and entry. J Virol 76: 9335-9344
-
(2002)
J Virol
, vol.76
, pp. 9335-9344
-
-
Triyatni, M.1
Saunier, B.2
Maruvada, P.3
-
80
-
-
84868090808
-
Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production
-
Yu GY, He G, Li CY et al (2012) Hepatic expression of HCV RNA-dependent RNA polymerase triggers innate immune signaling and cytokine production. Mol Cell 48:313-321
-
(2012)
Mol Cell
, vol.48
, pp. 313-321
-
-
Yu, G.Y.1
He, G.2
Li, C.Y.3
-
81
-
-
77955290279
-
Hepatitis B virus polymerase inhibits RIG-I-and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3
-
Yu S, Chen J, Wu M et al (2010) Hepatitis B virus polymerase inhibits RIG-I-and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3. J Gen Virol 91:2080-2090
-
(2010)
J Gen Virol
, vol.91
, pp. 2080-2090
-
-
Yu, S.1
Chen, J.2
Wu, M.3
-
82
-
-
0033960043
-
A long-term hepatitis B viremia model generated by transplanting non-tumorigenic immortalized human hepatocytes in Rag-2-defi cient mice
-
Brown JJ, Parashar B, Moshage H et al (2000) A long-term hepatitis B viremia model generated by transplanting non-tumorigenic immortalized human hepatocytes in Rag-2-defi cient mice. Hepatology 31:173-181
-
(2000)
Hepatology
, vol.31
, pp. 173-181
-
-
Brown, J.J.1
Parashar, B.2
Moshage, H.3
-
83
-
-
84891785762
-
Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifi es RIPK4 as novel tumor suppressor in human hepatocarcinogenesis
-
Heim D, Cornils K, Schulze K et al (2014) Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifi es RIPK4 as novel tumor suppressor in human hepatocarcinogenesis. Oncogene. doi: 10.1038/onc.2013.551
-
(2014)
Oncogene
-
-
Heim, D.1
Cornils, K.2
Schulze, K.3
-
84
-
-
80052864015
-
Forced activation of β-catenin signaling supports the transformation of hTERTimmortalized human fetal hepatocytes
-
Wege H, Heim D, Lütgehetmann M et al (2011) Forced activation of β-catenin signaling supports the transformation of hTERTimmortalized human fetal hepatocytes. Mol Cancer Res 9:1222-1231
-
(2011)
Mol Cancer Res
, vol.9
, pp. 1222-1231
-
-
Wege, H.1
Heim, D.2
Lütgehetmann, M.3
-
85
-
-
65749102155
-
C-Fos accelerates hepatocyte conversion to a fi broblastoid phenotype through ERKmediated upregulation of paxillin-Serine178 phosphorylation
-
Guller MC, Andre J, Legrand A et al (2009) c-Fos accelerates hepatocyte conversion to a fi broblastoid phenotype through ERKmediated upregulation of paxillin-Serine178 phosphorylation. Mol Carcinog 48:532-544
-
(2009)
Mol Carcinog
, vol.48
, pp. 532-544
-
-
Guller, M.C.1
Re, J.2
Legrand, A.3
-
86
-
-
61849085224
-
C-fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear cyclin D1
-
Guller M, Toualbi-Abed K, Legrand A et al (2008) c-fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear cyclin D1. World J Gastroenterol 14:6339-6346
-
(2008)
World J Gastroenterol
, vol.14
, pp. 6339-6346
-
-
Guller, M.1
Toualbi-Abed, K.2
Legrand, A.3
-
87
-
-
34447555806
-
Microarray analyses and molecular profi ling of steatosis induction in immortalized human hepatocytes
-
De Gottardi A, Vinciguerra M, Sgroi A et al (2007) Microarray analyses and molecular profi ling of steatosis induction in immortalized human hepatocytes. Lab Invest 87: 792-806
-
(2007)
Lab Invest
, vol.87
, pp. 792-806
-
-
De Gottardi, A.1
Vinciguerra, M.2
Sgroi, A.3
-
88
-
-
84872153859
-
Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation
-
Martel C, Allouche M, Esposti DD et al (2013) Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation. Hepatology 57:93-102
-
(2013)
Hepatology
, vol.57
, pp. 93-102
-
-
Martel, C.1
Allouche, M.2
Esposti, D.D.3
-
89
-
-
67651006589
-
Capsid antigen presentation fl ags human hepatocytes for destruction after transduction by adeno-associated viral vectors
-
Pien GC, Basner-Tschakarjan E, Hui DJ et al (2009) Capsid antigen presentation fl ags human hepatocytes for destruction after transduction by adeno-associated viral vectors. J Clin Invest 119:1688-1695
-
(2009)
J Clin Invest
, vol.119
, pp. 1688-1695
-
-
Pien, G.C.1
Basner-Tschakarjan, E.2
Hui, D.J.3
-
90
-
-
74149089236
-
Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction
-
Finn JD, Hui D, Downey HD et al (2010) Proteasome inhibitors decrease AAV2 capsid derived peptide epitope presentation on MHC class I following transduction. Mol Ther 18:135-142
-
(2010)
Mol Ther
, vol.18
, pp. 135-142
-
-
Finn, J.D.1
Hui, D.2
Downey, H.D.3
-
91
-
-
84877930020
-
Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specifi c CD8+ T cells
-
Martino AT, Basner-Tschakarjan E, Markusic DM et al (2013) Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specifi c CD8+ T cells. Blood 121:2224-2233
-
(2013)
Blood
, vol.121
, pp. 2224-2233
-
-
Martino, A.T.1
Basner-Tschakarjan, E.2
Markusic, D.M.3
-
92
-
-
84884466578
-
Cytochrome P450 Induction
-
In: Lu C, Li A, Wiley, Hoboken
-
LeCluyse E, Sinz M, Hewitt N et al (2010) Cytochrome P450 Induction. In: Lu C, Li A (eds) Enzyme inhibition in drug discovery and development: the good and the bad. Wiley, Hoboken, pp 265-314
-
(2010)
Enzyme Inhibition in Drug Discovery and Development: The Good and The Bad
, pp. 265-314
-
-
Lecluyse, E.1
Sinz, M.2
Hewitt, N.3
-
93
-
-
84892879465
-
Cellular toxicity associated with exposure to perfl uorinated carboxylates (PFCAs) and their metabolic precursors
-
Rand AA, Rooney JP, Butt CM et al (2014) Cellular toxicity associated with exposure to perfl uorinated carboxylates (PFCAs) and their metabolic precursors. Chem Res Toxicol 27:42-50
-
(2014)
Chem Res Toxicol
, vol.27
, pp. 42-50
-
-
Rand, A.A.1
Rooney, J.P.2
Butt, C.M.3
-
94
-
-
84865208356
-
In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs
-
Thompson RA, Isin EM, Li Y et al (2012) In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs. Chem Res Toxicol 25:1616-1632
-
(2012)
Chem Res Toxicol
, vol.25
, pp. 1616-1632
-
-
Thompson, R.A.1
Isin, E.M.2
Li, Y.3
-
95
-
-
13444284018
-
New technologies and screening strategies for hepatotoxicity: Use of in vitro models
-
Dambach DM, Andrews BA, Moulin F (2005) New technologies and screening strategies for hepatotoxicity: use of in vitro models. Toxicol Pathol 33:17-26
-
(2005)
Toxicol Pathol
, vol.33
, pp. 17-26
-
-
Dambach, D.M.1
Rews, B.A.2
Moulin, F.3
-
96
-
-
56249086796
-
Use of four new human-derived livercell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay
-
Winter HK, Ehrlich VA, Grusch M et al (2008) Use of four new human-derived livercell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay. Mutat Res 657:133-139
-
(2008)
Mutat Res
, vol.657
, pp. 133-139
-
-
Winter, H.K.1
Ehrlich, V.A.2
Grusch, M.3
-
97
-
-
1642273510
-
Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line
-
Mills JB, Rose KA, Sadagopan N et al (2004) Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line. J Pharmacol Exp Ther 309:303-309
-
(2004)
J Pharmacol Exp Ther
, vol.309
, pp. 303-309
-
-
Mills, J.B.1
Rose, K.A.2
Sadagopan, N.3
-
98
-
-
84868202092
-
Preparation and cellular uptake of PLGA particles loaded with lamivudine
-
Wang B, Chen G, Mao Z et al (2012) Preparation and cellular uptake of PLGA particles loaded with lamivudine. Chin Sci Bull 57:3985-3993
-
(2012)
Chin Sci Bull
, vol.57
, pp. 3985-3993
-
-
Wang, B.1
Chen, G.2
Mao, Z.3
-
99
-
-
40949145297
-
Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice
-
Tsuruga Y, Kiyono T, Matsushita M et al (2008) Effect of intrasplenic transplantation of immortalized human hepatocytes in the treatment of acetaminophen-induced acute liver failure SCID mice. Transplant Proc 40:617-619
-
(2008)
Transplant Proc
, vol.40
, pp. 617-619
-
-
Tsuruga, Y.1
Kiyono, T.2
Matsushita, M.3
-
100
-
-
39549110054
-
Protection of hepatocytes from cytotoxic T cell mediated killing by interferonalpha
-
Willberg CB, Ward SM, Clayton RF et al (2007) Protection of hepatocytes from cytotoxic T cell mediated killing by interferonalpha. PLoS One 2:e791
-
(2007)
Plos One
, vol.2
-
-
Willberg, C.B.1
Ward, S.M.2
Clayton, R.F.3
-
101
-
-
84891503453
-
SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK
-
Ho L, Titus AS, Banerjee KK et al (2013) SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging 5:835-849
-
(2013)
Aging
, vol.5
, pp. 835-849
-
-
Ho, L.1
Titus, A.S.2
Banerjee, K.K.3
-
102
-
-
84880536518
-
The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity
-
Wargent ET, Zaibi MS, Silvestri C et al (2013) The cannabinoid Δ(9)-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity. Nutr Diabetes 3:e68
-
(2013)
Nutr Diabetes
, vol.3
-
-
Wargent, E.T.1
Zaibi, M.S.2
Silvestri, C.3
-
103
-
-
84878972563
-
Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes
-
Caron S, Huaman SC, Dehondt H et al (2013) Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes. Mol Cell Biol 33:2202-2211
-
(2013)
Mol Cell Biol
, vol.33
, pp. 2202-2211
-
-
Caron, S.1
Huaman, S.C.2
Dehondt, H.3
-
104
-
-
84855970215
-
Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation?
-
Lauressergues E, Bert E, Duriez P et al (2012) Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation? Neuropharmacology 62:784-796
-
(2012)
Neuropharmacology
, vol.62
, pp. 784-796
-
-
Lauressergues, E.1
Bert, E.2
Duriez, P.3
-
105
-
-
37749011738
-
Cadmium induces mitochondriadependent apoptosis of normal human hepatocytes
-
Lasfer M, Vadrot N, Aoudjehane L et al (2008) Cadmium induces mitochondriadependent apoptosis of normal human hepatocytes. Cell Biol Toxicol 24:55-62
-
(2008)
Cell Biol Toxicol
, vol.24
, pp. 55-62
-
-
Lasfer, M.1
Vadrot, N.2
Aoudjehane, L.3
-
106
-
-
0031821747
-
Hepatitis C virus population dynamics in human lymphocytes and hepatocytes infected in vitro
-
Kato N, Ikeda M, Sugiyama K et al (1998) Hepatitis C virus population dynamics in human lymphocytes and hepatocytes infected in vitro . J Gen Virol 79:1859-1869
-
(1998)
J Gen Virol
, vol.79
, pp. 1859-1869
-
-
Kato, N.1
Ikeda, M.2
Sugiyama, K.3
-
107
-
-
0033956354
-
Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells
-
Ikeda M, Nozaki A, Sugiyama K et al (2000) Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells. Virus Res 66:51-63
-
(2000)
Virus Res
, vol.66
, pp. 51-63
-
-
Ikeda, M.1
Nozaki, A.2
Sugiyama, K.3
-
108
-
-
0038105558
-
Adenovirus-mediated gene transfer of interferon alpha inhibits hepatitis C virus replication in hepatocytes
-
Suzuki K, Aoki K, Ohnami S et al (2003) Adenovirus-mediated gene transfer of interferon alpha inhibits hepatitis C virus replication in hepatocytes. Biochem Biophys Res Commun 307:814-819
-
(2003)
Biochem Biophys Res Commun
, vol.307
, pp. 814-819
-
-
Suzuki, K.1
Aoki, K.2
Ohnami, S.3
-
109
-
-
0032143649
-
Human hepatocyte clonal cell lines that support persistent replication of hepatitis C virus
-
Ikeda M, Sugiyama K, Mizutani T et al (1998) Human hepatocyte clonal cell lines that support persistent replication of hepatitis C virus. Virus Res 56:157-167
-
(1998)
Virus Res
, vol.56
, pp. 157-167
-
-
Ikeda, M.1
Sugiyama, K.2
Mizutani, T.3
-
110
-
-
0030861248
-
Specifi c interaction of polypyrimidine tract-binding protein with the extreme 3′-terminal structure of the hepatitis C virus genome, the 3′X
-
Tsuchihara K, Tanaka T, Hijikata M et al (1997) Specifi c interaction of polypyrimidine tract-binding protein with the extreme 3′-terminal structure of the hepatitis C virus genome, the 3′X. J Virol 71:6720-6726
-
(1997)
J Virol
, vol.71
, pp. 6720-6726
-
-
Tsuchihara, K.1
Tanaka, T.2
Hijikata, M.3
-
111
-
-
84872808323
-
Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells
-
Cuconati A, Mills C, Goddard C et al (2013) Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells. PLoS One 8:e54595
-
(2013)
Plos One
, vol.8
-
-
Cuconati, A.1
Mills, C.2
Goddard, C.3
-
112
-
-
84920972464
-
MiR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cir-rhosis and hepatocellular cancer
-
Brockhausen J, Tay SS, Grzelak CA et al (2014) miR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cir-rhosis and hepatocellular cancer. Liver Int. doi: 10.1111/liv.12517
-
(2014)
Liver Int
-
-
Brockhausen, J.1
Tay, S.S.2
Grzelak, C.A.3
-
113
-
-
80052846666
-
The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes
-
Wilson R, Warner N, Ryan K et al (2011) The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes. J Viral Hepat 18:e499-e507
-
(2011)
J Viral Hepat
, vol.18
, pp. 499-507
-
-
Wilson, R.1
Warner, N.2
Ryan, K.3
-
114
-
-
84900789855
-
Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines
-
Shah F, Louise-May S, Greene N (2014) Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines. Bioorg Med Chem Lett 24:2753-2757
-
(2014)
Bioorg Med Chem Lett
, vol.24
, pp. 2753-2757
-
-
Shah, F.1
Louise-May, S.2
Greene, N.3
-
115
-
-
84891315751
-
A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans
-
Gustafsson F, Foster AJ, Sarda S et al (2014) A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicol Sci 137:189-211
-
(2014)
Toxicol Sci
, vol.137
, pp. 189-211
-
-
Gustafsson, F.1
Foster, A.J.2
Sarda, S.3
-
116
-
-
84883457835
-
In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid
-
Rodrigues AV, Rollison HE, Martin S et al (2013) In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid. Arch Toxicol 87:1569-1579
-
(2013)
Arch Toxicol
, vol.87
, pp. 1569-1579
-
-
Rodrigues, A.V.1
Rollison, H.E.2
Martin, S.3
-
117
-
-
84872564401
-
Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite
-
Foster AJ, Prime LH, Gustafsson F et al (2013) Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite. Chem Res Toxicol 26:124-135
-
(2013)
Chem Res Toxicol
, vol.26
, pp. 124-135
-
-
Foster, A.J.1
Prime, L.H.2
Gustafsson, F.3
-
118
-
-
77953730403
-
Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity
-
Antolino-Lobo I, Meulenbelt J, Nijmeijer SM et al (2010) Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity. Drug Metab Dispos 38:1105-1112
-
(2010)
Drug Metab Dispos
, vol.38
, pp. 1105-1112
-
-
Antolino-Lobo, I.1
Meulenbelt, J.2
Nijmeijer, S.M.3
-
119
-
-
77952541012
-
Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes
-
Saha S, New LS, Ho HK et al (2010) Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes. Toxicol Lett 195:135-141
-
(2010)
Toxicol Lett
, vol.195
, pp. 135-141
-
-
Saha, S.1
New, L.S.2
Ho, H.K.3
-
120
-
-
73749083993
-
Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity
-
Saha S, New LS, Ho HK et al (2010) Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity. Toxicol Lett 192:141-149
-
(2010)
Toxicol Lett
, vol.192
, pp. 141-149
-
-
Saha, S.1
New, L.S.2
Ho, H.K.3
-
121
-
-
84890493012
-
Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat dietpromoted hepatic infl ammation and tumorigenesis in mice
-
Ip BC, Hu KQ, Liu C et al (2013) Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat dietpromoted hepatic infl ammation and tumorigenesis in mice. Cancer Prev Res 6:1304-1316
-
(2013)
Cancer Prev Res
, vol.6
, pp. 1304-1316
-
-
Ip, B.C.1
Hu, K.Q.2
Liu, C.3
-
122
-
-
84898017895
-
Hawthorn (Crataegus oxyacantha L) bark extract regulates antioxidant response element (ARE)-mediated enzyme expression via Nrf2 pathway activation in normal hepatocyte cell line
-
Krajka-Kuzniak V, Paluszczak J, Oszmianski J et al (2014) Hawthorn (Crataegus oxyacantha L) bark extract regulates antioxidant response element (ARE)-mediated enzyme expression via Nrf2 pathway activation in normal hepatocyte cell line. Phytother Res 28:593-602
-
(2014)
Phytother Res
, vol.28
, pp. 593-602
-
-
Krajka-Kuzniak, V.1
Paluszczak, J.2
Oszmianski, J.3
-
123
-
-
84867788971
-
Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes
-
Krajka-Kuzniak V, Paluszczak J, Celewicz L et al (2013) Phloretamide, an apple phenolic compound, activates the Nrf2/ARE pathway in human hepatocytes. Food Chem Toxicol 51:202-209
-
(2013)
Food Chem Toxicol
, vol.51
, pp. 202-209
-
-
Krajka-Kuzniak, V.1
Paluszczak, J.2
Celewicz, L.3
-
124
-
-
84869486455
-
Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro
-
Krajka-Kuzniak V, Paluszczak J, Baer-Dubowska W (2013) Xanthohumol induces phase II enzymes via Nrf2 in human hepatocytes in vitro . Toxicol In Vitro 27:149-156
-
(2013)
Toxicol in Vitro
, vol.27
, pp. 149-156
-
-
Krajka-Kuzniak, V.1
Paluszczak, J.2
Baer-Dubowska, W.3
-
125
-
-
39749116856
-
Hepatitis C virus genotype 1a growth and induction of autophagy
-
Ait-Goughoulte M, Kanda T, Meyer K et al (2008) Hepatitis C virus genotype 1a growth and induction of autophagy. J Virol 82:2241-2249
-
(2008)
J Virol
, vol.82
, pp. 2241-2249
-
-
Ait-Goughoulte, M.1
Kanda, T.2
Meyer, K.3
-
126
-
-
33646188826
-
Generation of infectious hepatitis C virus in immortalized human hepatocytes
-
Kanda T, Basu A, Steele R et al (2006) Generation of infectious hepatitis C virus in immortalized human hepatocytes. J Virol 80:4633-4639
-
(2006)
J Virol
, vol.80
, pp. 4633-4639
-
-
Kanda, T.1
Basu, A.2
Steele, R.3
-
127
-
-
36048975791
-
Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes
-
Kanda T, Steele R, Ray R et al (2007) Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes. J Virol 81:12375-12381
-
(2007)
J Virol
, vol.81
, pp. 12375-12381
-
-
Kanda, T.1
Steele, R.2
Ray, R.3
-
128
-
-
33745831633
-
Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes
-
Basu A, Saito K, Meyer K et al (2006) Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes. Apoptosis 11:1391-1400
-
(2006)
Apoptosis
, vol.11
, pp. 1391-1400
-
-
Basu, A.1
Saito, K.2
Meyer, K.3
-
129
-
-
84865592621
-
N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism
-
Mazumdar B, Meyer K, Ray R (2012) N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism. PLoS One 7:e44461
-
(2012)
Plos One
, vol.7
, pp. 44461
-
-
Mazumdar, B.1
Meyer, K.2
Ray, R.3
-
130
-
-
28844443906
-
Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development
-
Qiu C, Hanson E, Olivier E et al (2005) Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development. Exp Hematol 33:1450-1458
-
(2005)
Exp Hematol
, vol.33
, pp. 1450-1458
-
-
Qiu, C.1
Hanson, E.2
Olivier, E.3
-
131
-
-
84898609403
-
FAT10, an ubiquitin-like protein, confers malignant properties in non-tumorigenic and tumorigenic cells
-
Gao Y, Theng SS, Zhuo J et al (2014) FAT10, an ubiquitin-like protein, confers malignant properties in non-tumorigenic and tumorigenic cells. Carcinogenesis 35: 923-934
-
(2014)
Carcinogenesis
, vol.35
, pp. 923-934
-
-
Gao, Y.1
Theng, S.S.2
Zhuo, J.3
-
132
-
-
84863191653
-
MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms
-
Wang Y, Toh HC, Chow P et al (2012) MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms. FASEB J 26:3032-3041
-
(2012)
FASEB J
, vol.26
, pp. 3032-3041
-
-
Wang, Y.1
Toh, H.C.2
Chow, P.3
-
133
-
-
84885180273
-
Loss of exon 4 in a human T-cell factor-4 isoform promotes hepatic tumourigenicity
-
Tomimaru Y, Xu CQ, Nambotin SB et al (2013) Loss of exon 4 in a human T-cell factor-4 isoform promotes hepatic tumourigenicity. Liver Int 33:1536-1548
-
(2013)
Liver Int
, vol.33
, pp. 1536-1548
-
-
Tomimaru, Y.1
Xu, C.Q.2
Nambotin, S.B.3
-
134
-
-
47649104878
-
Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand
-
Nonaka M, Tazuma S, Hyogo H et al (2008) Cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand. J Gastroenterol Hepatol 23:e198-e206
-
(2008)
J Gastroenterol Hepatol
, vol.23
, pp. 198-206
-
-
Nonaka, M.1
Tazuma, S.2
Hyogo, H.3
-
135
-
-
34250866800
-
Hydrogen peroxide stimulates pigment epithelium-derived factor gene and protein expression in the human hepatocyte cell line OUMS-29
-
Nakamura K, Yamagishi S, Yoshida T et al (2007) Hydrogen peroxide stimulates pigment epithelium-derived factor gene and protein expression in the human hepatocyte cell line OUMS-29. J Int Med Res 35:427-432
-
(2007)
J Int Med Res
, vol.35
, pp. 427-432
-
-
Nakamura, K.1
Yamagishi, S.2
Yoshida, T.3
-
136
-
-
0037222025
-
Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes
-
Shishido S, Koga H, Harada M et al (2003) Hydrogen peroxide overproduction in megamitochondria of troglitazone-treated human hepatocytes. Hepatology 37:136-147
-
(2003)
Hepatology
, vol.37
, pp. 136-147
-
-
Shishido, S.1
Koga, H.2
Harada, M.3
|