메뉴 건너뛰기




Volumn 87, Issue 8, 2007, Pages 792-806

Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes

Author keywords

Fatty liver disease; Immortalized human hepatocytes; Insulin signaling; Lipid metabolism; Microarrays; Steatosis

Indexed keywords

ACYL COENZYME A DESATURASE; ADENOSINE TRIPHOSPHATE CITRATE LYASE; ADIPOPHILIN; ALPHA INTERFERON; ANGIOPOIETIN 1; ASPARTATE AMMONIA LIGASE; CALDESMON; CASPASE 3; CHOLESTEROL; COLLAGEN TYPE 4; COLLAGEN TYPE 8; EPIDERMAL GROWTH FACTOR RECEPTOR; FATTY ACID; GLUTATHIONE PEROXIDASE 1; INSULIN; ISOPENTENYL DIPHOSPHATE DELTA ISOMERASE; KERATIN; LOW DENSITY LIPOPROTEIN RECEPTOR; METALLOTHIONEIN II; MYOSIN; OLEIC ACID; PERIPLAKIN; PEROXIREDOXIN; SELENOPROTEIN W; STEFIN A; SYNDECAN 4; THROMBOMODULIN; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 4;

EID: 34447555806     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.3700590     Document Type: Article
Times cited : (62)

References (55)
  • 3
    • 29244468261 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in children
    • Mager DR, Roberts EA. Nonalcoholic fatty liver disease in children. Clin Liver Dis 2006;10:109-131, vi-vii.
    • (2006) Clin Liver Dis , vol.10
    • Mager, D.R.1    Roberts, E.A.2
  • 4
    • 0031799747 scopus 로고    scopus 로고
    • Hepatic steatosis: Innocent bystander or guilty party?
    • Day CP, James OF. Hepatic steatosis: innocent bystander or guilty party? Hepatology 1998;27:1463-1466.
    • (1998) Hepatology , vol.27 , pp. 1463-1466
    • Day, C.P.1    James, O.F.2
  • 5
    • 0037301686 scopus 로고    scopus 로고
    • Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies
    • Castera L, Hezode C, Roudot-Thoraval F, et al. Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies. Gut 2003;52:288-292.
    • (2003) Gut , vol.52 , pp. 288-292
    • Castera, L.1    Hezode, C.2    Roudot-Thoraval, F.3
  • 6
    • 0036892355 scopus 로고    scopus 로고
    • Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients
    • Westin J, Nordlinder H, Lagging M, et al. Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients. J Hepatol 2002;37:837-842.
    • (2002) J Hepatol , vol.37 , pp. 837-842
    • Westin, J.1    Nordlinder, H.2    Lagging, M.3
  • 7
    • 0036294003 scopus 로고    scopus 로고
    • Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C
    • Hickman IJ, Clouston AD, Macdonald GA, et al. Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis C. Gut 2002;51:89-94.
    • (2002) Gut , vol.51 , pp. 89-94
    • Hickman, I.J.1    Clouston, A.D.2    Macdonald, G.A.3
  • 8
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • Adams LA, Lymp JF, St Sauver J, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 2005;129:113-121.
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St Sauver, J.3
  • 9
    • 18544365700 scopus 로고    scopus 로고
    • Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis
    • Ratziu V, Bonyhay L, Di Martino V, et al. Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis. Hepatology 2002;35:1485-1493.
    • (2002) Hepatology , vol.35 , pp. 1485-1493
    • Ratziu, V.1    Bonyhay, L.2    Di Martino, V.3
  • 10
    • 33644850802 scopus 로고    scopus 로고
    • Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: Possible role in steatosis
    • Bradbury MW. Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. Am J Physiol Gastrointest Liver Physiol 2006;290:G194-G198.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Bradbury, M.W.1
  • 11
    • 0036207720 scopus 로고    scopus 로고
    • Apolipoprotein synthesis in nonalcoholic steatohepatitis
    • Charlton M, Sreekumar R, Rasmussen D, et al. Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology 2002;35:898-904.
    • (2002) Hepatology , vol.35 , pp. 898-904
    • Charlton, M.1    Sreekumar, R.2    Rasmussen, D.3
  • 12
    • 0038643426 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein: Another mechanism for drug-induced steatosis in mice
    • Letteron P, Sutton A, Mansouri A, et al. Inhibition of microsomal triglyceride transfer protein: another mechanism for drug-induced steatosis in mice. Hepatology 2003;38:133-140.
    • (2003) Hepatology , vol.38 , pp. 133-140
    • Letteron, P.1    Sutton, A.2    Mansouri, A.3
  • 13
    • 0842300373 scopus 로고    scopus 로고
    • Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease
    • Lonardo A, Adinolfi LE, Loria P, et al. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004;126:586-597.
    • (2004) Gastroenterology , vol.126 , pp. 586-597
    • Lonardo, A.1    Adinolfi, L.E.2    Loria, P.3
  • 14
    • 0035196704 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress
    • Robertson G, Leclercq I, Farrell GC. Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. Am J Physiol Gastrointest Liver Physiol 2001;281:G1135-G1139.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281
    • Robertson, G.1    Leclercq, I.2    Farrell, G.C.3
  • 15
    • 20944451594 scopus 로고    scopus 로고
    • Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism
    • Galli A, Svegliati-Baroni G, Ceni E, et al. Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism. Hepatology 2005;41:1074-1084.
    • (2005) Hepatology , vol.41 , pp. 1074-1084
    • Galli, A.1    Svegliati-Baroni, G.2    Ceni, E.3
  • 16
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome
    • Chitturi S, Abeygunasekera S, Farrell GC, et al. NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002;35:373-379.
    • (2002) Hepatology , vol.35 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3
  • 17
    • 23044501638 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and insulin resistance: Importance of risk factors and histological spectrum
    • Guidorizzi de Siqueira AC, Cotrim HP, Rocha R, et al. Non-alcoholic fatty liver disease and insulin resistance: importance of risk factors and histological spectrum. Eur J Gastroenterol Hepatol 2005;17:837-841.
    • (2005) Eur J Gastroenterol Hepatol , vol.17 , pp. 837-841
    • Guidorizzi de Siqueira, A.C.1    Cotrim, H.P.2    Rocha, R.3
  • 18
    • 28844446679 scopus 로고    scopus 로고
    • Hepatic steatosis and insulin resistance: Does etiology make a difference?
    • Lonardo A, Lombardini S, Scaglioni F, et al. Hepatic steatosis and insulin resistance: does etiology make a difference? J Hepatol 2006;44:190-196.
    • (2006) J Hepatol , vol.44 , pp. 190-196
    • Lonardo, A.1    Lombardini, S.2    Scaglioni, F.3
  • 19
    • 33748312093 scopus 로고    scopus 로고
    • Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism
    • Matsumoto M, Han S, Kitamura T, et al. Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. J Clin Invest 2006;116:2464-2472.
    • (2006) J Clin Invest , vol.116 , pp. 2464-2472
    • Matsumoto, M.1    Han, S.2    Kitamura, T.3
  • 20
    • 0034283596 scopus 로고    scopus 로고
    • Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes
    • Azzout-Marniche D, Becard D, Guichard C, et al. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochem J 2000;350(Part 2):389-393.
    • (2000) Biochem J , vol.350 , Issue.PART 2 , pp. 389-393
    • Azzout-Marniche, D.1    Becard, D.2    Guichard, C.3
  • 21
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004;114:147-152.
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 22
    • 0036260017 scopus 로고    scopus 로고
    • Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes
    • Matsumoto M, Ogawa W, Teshigawara K, et al. Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes. Diabetes 2002;51:1672-1680.
    • (2002) Diabetes , vol.51 , pp. 1672-1680
    • Matsumoto, M.1    Ogawa, W.2    Teshigawara, K.3
  • 23
    • 14644426519 scopus 로고    scopus 로고
    • Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism
    • Taniguchi CM, Ueki K, Kahn R. Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism. J Clin Invest 2005;115:718-727.
    • (2005) J Clin Invest , vol.115 , pp. 718-727
    • Taniguchi, C.M.1    Ueki, K.2    Kahn, R.3
  • 24
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein AE, Canbay A, Angulo P, et al. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003;125:437-443.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3
  • 25
    • 2342559886 scopus 로고    scopus 로고
    • Steatosis and liver cell apoptosis in chronic hepatitis C: A mechanism for increased liver injury
    • Walsh MJ, Vanags DM, Clouston AD, et al. Steatosis and liver cell apoptosis in chronic hepatitis C: a mechanism for increased liver injury. Hepatology 2004;39:1230-1238.
    • (2004) Hepatology , vol.39 , pp. 1230-1238
    • Walsh, M.J.1    Vanags, D.M.2    Clouston, A.D.3
  • 26
    • 0042033294 scopus 로고    scopus 로고
    • Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease
    • Roskams T, Yang SQ, Koteish A, et al. Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. Am J Pathol 2003;163:1301-1311.
    • (2003) Am J Pathol , vol.163 , pp. 1301-1311
    • Roskams, T.1    Yang, S.Q.2    Koteish, A.3
  • 27
    • 30944453514 scopus 로고    scopus 로고
    • Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray
    • Chiappini F, Barrier A, Saffroy R, et al. Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray. Lab Invest 2006;86:154-165.
    • (2006) Lab Invest , vol.86 , pp. 154-165
    • Chiappini, F.1    Barrier, A.2    Saffroy, R.3
  • 28
    • 0038461088 scopus 로고    scopus 로고
    • Hepatic gene expression in histologically progressive nonalcoholic steatohepatitis
    • Sreekumar R, Rosado B, Rasmussen D, et al. Hepatic gene expression in histologically progressive nonalcoholic steatohepatitis. Hepatology 2003;38:244-251.
    • (2003) Hepatology , vol.38 , pp. 244-251
    • Sreekumar, R.1    Rosado, B.2    Rasmussen, D.3
  • 29
    • 24144503408 scopus 로고    scopus 로고
    • A genomic and proteomic study of the spectrum of nonalcoholic fatty liver disease
    • Younossi ZM, Baranova A, Ziegler K, et al. A genomic and proteomic study of the spectrum of nonalcoholic fatty liver disease. Hepatology 2005;42:665-674.
    • (2005) Hepatology , vol.42 , pp. 665-674
    • Younossi, Z.M.1    Baranova, A.2    Ziegler, K.3
  • 30
    • 27744539431 scopus 로고    scopus 로고
    • Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes
    • Nguyen TH, Mai G, Villiger P, et al. Treatment of acetaminophen-induced acute liver failure in the mouse with conditionally immortalized human hepatocytes. J Hepatol 2005;43:1031-1037.
    • (2005) J Hepatol , vol.43 , pp. 1031-1037
    • Nguyen, T.H.1    Mai, G.2    Villiger, P.3
  • 31
    • 0242317675 scopus 로고    scopus 로고
    • Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis
    • Peirson SN, Butler JN, Foster RG. Experimental validation of novel and conventional approaches to quantitative real-time PCR data analysis. Nucleic Acids Res 2003;31:e73.
    • (2003) Nucleic Acids Res , vol.31
    • Peirson, S.N.1    Butler, J.N.2    Foster, R.G.3
  • 32
    • 78651052311 scopus 로고
    • Preparation of lipide extracts from brain tissue
    • Folch J, Ascoli I, Lees M, et al. Preparation of lipide extracts from brain tissue. J Biol Chem 1951;191:833-841.
    • (1951) J Biol Chem , vol.191 , pp. 833-841
    • Folch, J.1    Ascoli, I.2    Lees, M.3
  • 33
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 34
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 35
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A, Zein NN, Yerian LM, et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006;44:27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3
  • 36
    • 0041669368 scopus 로고    scopus 로고
    • The mechanisms underlying hepatitis C virus genotype 3-mediated liver damage
    • Farinati F, Cardin R, Bortolami M, et al. The mechanisms underlying hepatitis C virus genotype 3-mediated liver damage. J Hepatol 2003;39:292-294.
    • (2003) J Hepatol , vol.39 , pp. 292-294
    • Farinati, F.1    Cardin, R.2    Bortolami, M.3
  • 37
    • 0033985856 scopus 로고    scopus 로고
    • Failure of regeneration of the steatotic rat liver: Disruption at two different levels in the regeneration pathway
    • Selzner M, Clavien PA. Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway. Hepatology 2000;31:35-42.
    • (2000) Hepatology , vol.31 , pp. 35-42
    • Selzner, M.1    Clavien, P.A.2
  • 38
    • 0034812914 scopus 로고    scopus 로고
    • Disrupted signaling and inhibited regeneration in obese mice with fatty livers: Implications for nonalcoholic fatty liver disease pathophysiology
    • Yang SQ, Lin HZ, Mandal AK, et al. Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. Hepatology 2001;34:694-706.
    • (2001) Hepatology , vol.34 , pp. 694-706
    • Yang, S.Q.1    Lin, H.Z.2    Mandal, A.K.3
  • 39
    • 7044220856 scopus 로고    scopus 로고
    • Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury
    • Bantel H, Lugering A, Heidemann J, et al. Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 2004;40:1078-1087.
    • (2004) Hepatology , vol.40 , pp. 1078-1087
    • Bantel, H.1    Lugering, A.2    Heidemann, J.3
  • 40
    • 0037203345 scopus 로고    scopus 로고
    • Lipoapoptosis: Its mechanism and its diseases
    • Unger RH, Orci L. Lipoapoptosis: its mechanism and its diseases. Biochim Biophys Acta 2002;1585:202-212.
    • (2002) Biochim Biophys Acta , vol.1585 , pp. 202-212
    • Unger, R.H.1    Orci, L.2
  • 41
    • 0037621952 scopus 로고    scopus 로고
    • Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury
    • Leclercq IA, Field J, Farrell GC. Leptin-specific mechanisms for impaired liver regeneration in ob/ob mice after toxic injury. Gastroenterology 2003;124:1451-1464.
    • (2003) Gastroenterology , vol.124 , pp. 1451-1464
    • Leclercq, I.A.1    Field, J.2    Farrell, G.C.3
  • 42
    • 22144454185 scopus 로고    scopus 로고
    • Impaired proliferation of nonparenchymal cells participates in an impairment of liver regeneration in db/db mice
    • Uetsuka K, Shirai M, Yamauchi H, et al. Impaired proliferation of nonparenchymal cells participates in an impairment of liver regeneration in db/db mice. Exp Mol Pathol 2005;79:51-58.
    • (2005) Exp Mol Pathol , vol.79 , pp. 51-58
    • Uetsuka, K.1    Shirai, M.2    Yamauchi, H.3
  • 43
    • 30844437022 scopus 로고    scopus 로고
    • Adipose differentiation-related protein is degraded through the proteasome-dependent pathway during regression of lipid-storing cells
    • Masuda Y, Itabe H, Odaki M, et al. Adipose differentiation-related protein is degraded through the proteasome-dependent pathway during regression of lipid-storing cells. J Lipid Res 2005;47:87-98.
    • (2005) J Lipid Res , vol.47 , pp. 87-98
    • Masuda, Y.1    Itabe, H.2    Odaki, M.3
  • 44
    • 0036626952 scopus 로고    scopus 로고
    • Enhanced GLUT2 gene expression in an oleic acid-induced in vitro fatty liver model
    • Okamoto Y, Tanaka S, Haga Y. Enhanced GLUT2 gene expression in an oleic acid-induced in vitro fatty liver model. Hepatol Res 2002;23:138-144.
    • (2002) Hepatol Res , vol.23 , pp. 138-144
    • Okamoto, Y.1    Tanaka, S.2    Haga, Y.3
  • 45
    • 3042824524 scopus 로고    scopus 로고
    • Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
    • Feldstein AE, Werneburg NW, Canbay A, et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 2004;40:185-194.
    • (2004) Hepatology , vol.40 , pp. 185-194
    • Feldstein, A.E.1    Werneburg, N.W.2    Canbay, A.3
  • 46
    • 24044536090 scopus 로고    scopus 로고
    • Recent concepts in non-alcoholic fatty liver disease
    • Adams LA, Angulo P. Recent concepts in non-alcoholic fatty liver disease. Diabet Med 2005;22:1129-1133.
    • (2005) Diabet Med , vol.22 , pp. 1129-1133
    • Adams, L.A.1    Angulo, P.2
  • 47
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005;42:987-1000.
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 48
    • 0033231294 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with insulin resistance
    • Marchesini G, Brizi M, Morselli-Labate AM, et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999;107:450-455.
    • (1999) Am J Med , vol.107 , pp. 450-455
    • Marchesini, G.1    Brizi, M.2    Morselli-Labate, A.M.3
  • 49
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • Samuel VT, Liu ZX, Qu X, et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 2004;279:32345-32353.
    • (2004) J Biol Chem , vol.279 , pp. 32345-32353
    • Samuel, V.T.1    Liu, Z.X.2    Qu, X.3
  • 50
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal AJ, Campbell-Sargent C, Mirshahi F, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001;120:1183-1192.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 51
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • Shimomura I, Matsuda M, Hammer RE, et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 2000;6:77-86.
    • (2000) Mol Cell , vol.6 , pp. 77-86
    • Shimomura, I.1    Matsuda, M.2    Hammer, R.E.3
  • 52
    • 0037189517 scopus 로고    scopus 로고
    • Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice
    • Sun Y, Liu S, Ferguson S, et al. Phosphoenolpyruvate carboxykinase overexpression selectively attenuates insulin signaling and hepatic insulin sensitivity in transgenic mice. J Biol Chem 2002;277:23301-23307.
    • (2002) J Biol Chem , vol.277 , pp. 23301-23307
    • Sun, Y.1    Liu, S.2    Ferguson, S.3
  • 53
    • 33644514920 scopus 로고    scopus 로고
    • Tissue-specific roles of IRS proteins in insulin signaling and glucose transport
    • Thirone AC, Huang C, Klip A. Tissue-specific roles of IRS proteins in insulin signaling and glucose transport. Trends Endocrinol Metab 2006;17:72-78.
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 72-78
    • Thirone, A.C.1    Huang, C.2    Klip, A.3
  • 54
    • 31044446941 scopus 로고    scopus 로고
    • Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
    • Dong X, Park S, Lin X, et al. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 2006;116:101-114.
    • (2006) J Clin Invest , vol.116 , pp. 101-114
    • Dong, X.1    Park, S.2    Lin, X.3
  • 55
    • 13444287857 scopus 로고    scopus 로고
    • Expression analysis of a human hepatic cell line in response to palmitate
    • Swagell CD, Henly DC, Morris CP. Expression analysis of a human hepatic cell line in response to palmitate. Biochem Biophys Res Commun 2005;328:432-441.
    • (2005) Biochem Biophys Res Commun , vol.328 , pp. 432-441
    • Swagell, C.D.1    Henly, D.C.2    Morris, C.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.