Establishment of immortalized human hepatocytes by introduction of HPV16 E6/E7 and hTERT as cell sources for liver cell-based therapy

Cell Transplantation

Volumn 17, Issue 9, 2008, Pages 1083-1094

  Tsuruga, Yosuke ^a   Kiyono, Tohru ^b   Matsushita, Michiaki ^a   Takahashi, Tohru ^a   Kasai, Hironori ^a   Matsumoto, Shuichiro ^a   Todo, Satoru ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Acetaminophen induced acute liver failure; Chromosomal instability; Dedifferentiation; Hepatocyte transplantation; Tumorigenicity

Indexed keywords

ALBUMIN; PARACETAMOL; PROTEIN E6; PROTEIN E7; PROTEIN P16; RETINOBLASTOMA PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL DEDIFFERENTIATION; CELL FUNCTION; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL PROTECTION; CELL THERAPY; CHROMOSOMAL INSTABILITY; CHROMOSOME NUMBER; CONTROLLED STUDY; DIPLOIDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; KARYOTYPING; LIVER CELL; LIVER FAILURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE;

ACETAMINOPHEN; ANIMALS; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; HEPATOCYTES; HUMAN PAPILLOMAVIRUS 16; HUMANS; KARYOTYPING; LIVER; LIVER FAILURE, ACUTE; MICE; MICE, SCID; ONCOGENE PROTEINS, VIRAL; REPRESSOR PROTEINS; SPLEEN; TELOMERASE; TUMOR SUPPRESSOR PROTEIN P53;

HUMAN PAPILLOMAVIRUS TYPE 16; MUS;

EID: 62549128710     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368908786991542     Document Type: Article

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