Telomerase-mediated life-span extension of human primary fibroblasts by human artificial chromosome (HAC) vector

Biochemical and Biophysical Research Communications

Volumn 369, Issue 3, 2008, Pages 807-811

  Shitara, Shingo ^a   Kakeda, Minoru ^b   Nagata, Keiko ^b   Hiratsuka, Masaharu ^a   Sano, Akiko ^b   Osawa, Kanako ^b   Okazaki, Akiyo ^b   Katoh, Motonobu ^a   Kazuki, Yasuhiro ^a   Oshimura, Mitsuo ^a   Tomizuka, Kazuma ^a,b  

^a TOTTORI UNIVERSITY   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Cellular proliferation; hTERT; Human artificial chromosome (HAC); Life span extension; Non integrating vector; Primary cultured cells; Telomerase

Indexed keywords

BETA GALACTOSIDASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; ARTIFICIAL CHROMOSOME; CELL PROLIFERATION; CELL THERAPY; CLONE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REPRESSION; EPISOME; FIBROBLAST; GENE ACTIVATION; GENE CASSETTE; GENE DELIVERY SYSTEM; GENE INSERTION; HUMAN; HUMAN CELL; LIFESPAN; MOLECULAR CLONING; MUTAGENESIS; ONCOGENE; PRIORITY JOURNAL; RETROVIRUS;

ANIMALS; CELL AGING; CELL DIVISION; CELL PROLIFERATION; CHO CELLS; CHROMOSOMES, ARTIFICIAL, HUMAN; CRICETINAE; CRICETULUS; FIBROBLASTS; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; TELOMERASE;

EID: 41149129157     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.119     Document Type: Article

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