Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 12, 2014, Pages 2753-2757

  Shah, Falgun ^a   Louise May, Shirley ^a   Greene, Nigel ^a  

^a PFIZER INC   (United States)

Author keywords

ATP depletion assay; c Log P; Chemotype sensitivity; Cytotoxicity assay; Exploratory Toxicology Studies; HepG2; THLE; TPSA

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOTOXIN;

ARTICLE; CHEMOSENSITIVITY; CYTOTOXICITY ASSAY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZATION; PHYSICAL CHEMISTRY; PREDICTION; PROBABILITY; SURFACE PROPERTY; ACIDITY; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SAFETY; EPITHELIUM CELL; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; LC50; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; TRANSFORMED CELL LINE; TRANSFORMED HUMAN LIVER EPITHELIAL CELL LINE; CHEMISTRY; DRUG SCREENING; IC50; PH; RECEIVER OPERATING CHARACTERISTIC; TOXICITY TESTING;

ADENOSINE TRIPHOSPHATE; CELL LINE; CYTOTOXINS; DRUG SCREENING ASSAYS, ANTITUMOR; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; ROC CURVE; TOXICITY TESTS;

EID: 84900789855     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.039     Document Type: Article

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