Forced activation of β-catenin signaling supports the transformation of hTERT-immortalized human fetal hepatocytes

Molecular Cancer Research

Volumn 9, Issue 9, 2011, Pages 1222-1231

  Wege, Henning ^a   Heim, Denise ^a   Lütgehetmann, Marc ^a   Dierlamm, Judith ^a   Lohse, Ansgar W ^a   Brümmendorf, Tim H ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF AACHEN MEDICAL CENTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MUTANT PROTEIN; TELOMERASE INHIBITOR; TELOMERASE REVERSE TRANSCRIPTASE;

AGAR MEDIUM; ANCHORAGE INDEPENDENT GROWTH; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CELL CLONE; CELL IMMORTALIZATION; CELL PROLIFERATION; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; COLONY FORMATION; CONTROLLED STUDY; CYTOGENETICS; FETUS CELL; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CULTURE; MONITORING; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SERUM; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BETA CATENIN; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; FETUS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION; TELOMERASE; TRANSCRIPTIONAL ACTIVATION;

MUS MUSCULUS;

EID: 80052864015     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-10-0474     Document Type: Article

References (39)

1. Hussain K, El-Serag HB. Epidemiology, screening, diagnosis and treatment of hepatocellular carcinoma. Minerva Gastroenterol Dietol 2009;55:123-38.
2. Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009;27:1485-91.
3. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33:787-91.
4. Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985;43:405-13. (Pubitemid 16213265)
5. Greider CW. Telomeres. Curr Opin Cell Biol 1991;3:444-51.
6. Shay JW,Pereira-Smith OM, Wright WE. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 1991;196:33-9. (Pubitemid 121006368)
7. Oh BK, Jo CK, Park C, Kim K, Jung LW, Han KH, et al. Telomere shortening and telomerase reactivation in dysplastic nodules of human hepatocarcinogenesis. J Hepatol 2003;39:786-92. (Pubitemid 37372189)
8. Oh BK, Kim YJ, Park C, Park YN. Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis. Am J Pathol 2005;166:73-80. (Pubitemid 40051661)
9. Takaishi H, Kitamoto M, Takahashi S, Aikata H, Kawakami Y, Nakanishi T, et al. Precancerous hepatic nodules had significant levels of telomerase activity determined by sensitive quantitation using a hybridization protection assay. Cancer 2000;88:312-7. (Pubitemid 30051814)
10. Hytiroglou P, Kotoula V, Thung SN, Tsokos M, Fiel MI, Papadimitriou CS. Telomerase activity in precancerous hepatic nodules. Cancer 1998;82:1831-8. (Pubitemid 28208637)
11. Kojima H, Yokosuka O, Imazeki F, Saisho H, Omata M. Telomerase activity and telomere length in hepatocellular carcinoma and chronic liver disease. Gastroenterology 1997;112:493-500. (Pubitemid 27078836)
12. Komine F, Shimojima M, Moriyama M, Amaki S, Uchida T, Arakawa Y. Telomerase activity of needle-biopsied liver samples: its usefulness for diagnosis and judgement of efficacy of treatment of small hepatocellular carcinoma. J Hepatol 2000;32:235-41. (Pubitemid 30093902)
13. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70. (Pubitemid 30046295)
14. Takigawa Y, Brown AM. Wnt signaling in liver cancer. Curr Drug Targets 2008;9:1013-24.
15. Tan X, Yuan Y, Zeng G, Apte U, Thompson MD, Cieply B, et al. Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology 2008;47:1667-79. (Pubitemid 351702749)
16. Thompson MD, Monga SP. WNT/beta-catenin signaling in liver health and disease. Hepatology 2007;45:1298-305. (Pubitemid 46775794)
17. Apte U, Thompson MD, Cui S, Liu B, Cieply B, Monga SP. Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology 2008;47:288-95. (Pubitemid 351171066)
18. Hu M, Kurobe M, Jeong YJ, Fuerer C, Ghole S, Nusse R, et al. Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology 2007;133:1579-91.
19. Lee HC, Kim M, Wands JR. Wnt/Frizzled signaling in hepatocellular carcinoma. Front Biosci 2006;11:1901-15. (Pubitemid 43253403)
20. Lustig B, Behrens J. The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol 2003;129:199-221. (Pubitemid 36713796)
21. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-70. (Pubitemid 26358996)
22. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997;275:1787-90. (Pubitemid 27136715)
23. Firestein R, Bass AJ, Kim SY, Dunn IF, Silver SJ, Guney I, et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 2008;455:547-51.
24. Laurent-Puig P, Zucman-Rossi J. Genetics of hepatocellular tumors. Oncogene 2006;25:3778-86. (Pubitemid 43980473)
25. Haker B, Fuchs S, Dierlamm J, Brummendorf TH, Wege H. Absence of oncogenic transformation despite acquisition of cytogenetic aberrations in long-term cultured telomerase-immortalized human fetal hepatocytes. Cancer Lett 2007;256:120-7. (Pubitemid 47333331)
26. Wege H, Le HT, Chui MS, Liu L, Wu J, Giri R, et al. Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology 2003;124:432-44. (Pubitemid 36169260)
27. Fleige S, Walf V, Huch S, Prgomet C, Sehm J, Pfaffl MW. Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR. Biotechnol Lett 2006;28:1601-13. (Pubitemid 44306128)
28. Wege H, Muller A, Muller L, Petri S, Petersen J, Hillert C. Regeneration in pig livers by compensatory hyperplasia induces high levels of telomerase activity. Comp Hepatol 2007;6:6.
29. Hoshida Y, Villanueva A, Llovet JM. Molecular profiling to predict hepatocellular carcinoma outcome. Expert Rev Gastroenterol Hepatol 2009;3:101-3.
30. Thorgeirsson SS, Lee JS, Grisham JW. Functional genomics of hepatocellular carcinoma. Hepatology 2006;43:S145-50.
31. Gotschel F, Kern C, Lang S, Sparna T, Markmann C, Schwager J, et al. Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis. Exp Cell Res 2008;314:1351-66.
32. Harada N, Miyoshi H, Murai N, Oshima H, Tamai Y, Oshima M, et al. Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin. Cancer Res 2002;62:1971-7. (Pubitemid 34408440)
33. Calvisi DF, Conner EA, Ladu S, Lemmer ER, Factor VM, Thorgeirsson SS. Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer. J Hepatol 2005;42:842-9. (Pubitemid 40693201)
34. Nejak-Bowen KN, Monga SP. Beta-catenin signaling, liver regeneration and hepatocellular cancer: sorting the good from the bad. Semin Cancer Biol 2011;21:44-58.
35. Keng VW, Tschida BR, Bell JB, Largaespada DA. Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system. Hepatology 2011;53:781-90.
36. Liu J, Wang Z, Tang J, Tang R, Shan X, Zhang W, et al. Hepatitis C virus core protein activates Wnt/beta-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line. Arch Virol 2011;156:1013-23.
37. Murakami K, Sakukawa R, Ikeda T, Matsuura T, Hasumura S, Nagamori S, et al. Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinase. Neoplasia 1999;1:424-30.
38. Salvi A, Sabelli C, Moncini S, Venturin M, Arici B, Riva P, et al. MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells. FEBS J 2009;276:2966-82.
39. Poon RT, Chung KK, Cheung ST, Lau CP, Tong SW, Leung KL, et al. Clinical significance of thrombospondin 1 expression in hepatocellular carcinoma. Clin Cancer Res 2004;10:4150-7. (Pubitemid 38812495)