The application of a lentiviral vector for gene transfer in fetal human hepatocytes

Journal of Gene Medicine

Volumn 2, Issue 3, 2000, Pages 186-193

  Zahler, Marisa H ^a   Irani, Adil ^a   Malhi, Harmeet ^a   Reutens, Anne T ^a   Albanese, Chris ^a   Bouzahzah, Boumediene ^a   Joyce, David ^b   Gupta, Sanjeev ^a   Pestell, Richard G ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Gene transfer; Green fluorescent protein (GFP) hepatic transplantation; Lentivirus

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS;

GREEN FLUORESCENT PROTEIN; PHOTOPROTEIN;

ADULT; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CELL TRANSPLANTATION; COMPARATIVE STUDY; CYTOLOGY; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; LENTIVIRINAE; LIVER; METABOLISM; MOUSE; MOUSE MUTANT; PRENATAL DEVELOPMENT;

ADULT; ANIMALS; CELL TRANSPLANTATION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LENTIVIRUS; LIVER; LUMINESCENT PROTEINS; MICE; MICE, INBRED BALB C; MICE, SCID;

EID: 0034180682     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-2254(200005/06)2:3<186::aid-jgm100>3.0.co;2-6     Document Type: Article

References (39)

1. Miyake K, Tohyama T, Shimada T. Stable integration of human immunodeficiency virus-based retroviral vectors into the chromosomes of nondividing cells. Hum Gen Ther 1996; 7: 2281-2286.
2. Ott M, Stockert RJ, Ma Q, Gagandeep S, Gupta S. Simultaneous up-regulation of viral receptor expression and DNA synthesis is required for increasing efficiency of retroviral hepatic gene transfer. J Bio Chem 1998; 273: 11954-11961.
3. Roe T, Reynolds TC, Yu G, Brown PO. Integration of murine leukemia virus depends on mitosis. EMBO J 1993; 12: 2099-2108.
4. Bosch A, McCray PBJ, Chang SM, Ulich TR, Simonet WS, Jolly DJ, Davidson BL. Proliferation induced by keratinocyte growth factor enhances in vivo retroviral-mediated gene transfer to mouse hepatocytes. J Clin Invest 1996; 98: 2683-2687.
5. Lieber A, Vrancken Peeters MJ, Meuse L, Fausto N, Perkins J, Kay MA. Adenovirus mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo. Proc Natl Acad Sci U S A 1995; 92: 6210-6214.
6. Lewis PF, Emerman M. Passage through mitosis is required for oncoretroviruses but not for the human immundeficiency virus. J Virol 1994; 68: 510-516.
7. Gallay P, Hope T, Chin D, Trono D. HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. Proc Natl Acad Sci U S A 1997; 94: 9825-9830.
8. Kafri T, Blomer U, Peterson DA, Gage FH, Verma IM. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet 1997; 17: 314-317.
9. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-266.
10. Naldini L, Blomer U, Gage FH, Trono D, Verma IM. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A 1996; 93: 11382-11388.
11. Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol 1997; 15: 871-875.
12. Blomer U, Naldini L, Kafri T, Trono D, Verma IM, Gage FH. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol 1997; 71: 6641-6649.
13. Miyoshi H, Takahashi M, Gage FH, Verma IM. Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A 1997; 94: 10319-10323.
14. Sutton RE, Wu HTM, Rigg R, Bohnlein E, Brown PO. Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells. J Virol 1998; 72: 5781-5788.
15. Abe A, Miyanohara A, Friedmann T. Polybrene increases the efficiency of gene transfer by lipofection. Gene Ther 1998; 5: 708-711.
16. Andreadis S, Palsson BO. Coupled effects of polybrene and calf serum on the efficiency of retroviral transduction and the stability of retroviral vectors. Hum Gene Ther 1997; 8: 285-291.
17. Hainline BE, Padilla LM, Chong SK, Heifetz SA, Palmer C, Zhou FC. Fetal tissue derived from spontaneous pregnancy losses is insufficient for human transplantation. Obstet Gynecol 1995; 85: 619-624.
18. Croizat H, Nagel RL. Inhomogeneity of the circulating BFU-E regulation in sickle cell anaemia: accessory cells properties and BFU-E growth factor response pattern. Br J Haematol 1993; 84: 481-491.
19. Mahli H, Ma Q, Slehria S, Ubashevsky EL, Logdberg L, Badve S, Gupta S. Spontaneous origin of an oncogenic cell line designated HFL from the human fetal liver. Hepatology 1999; 30: 258A.
20. Gupta S, Rajvanshi P, Sokhi RP, Slehria S, Yam A, Kerr A, Novikoff PM. Entry and integration of transplanted hepatocytes in liver plates occur by disruption of hepatic sinusoidal endothelium. Hepatology 1999; 29: 509-519.
21. Ott M, Rajvanshi P, Sokhi R, Alpini G, Aragona E, Dabeva M, Shafritz DA, Gupta S. Differentiation-specific regulation of transgene expression in a diploid epithelial cell line derived from the normal F344 rat liver. J Pathol 1999; 187: 365-373.
22. Lybarger L, Dempsey D, Franek KJ, Chervenak R. Rapid generation and flow cytometric analysis of stable GFP-expressing cells. Cytometry 1996; 25: 211-220.
23. Gupta S, Vemuru RP, Lee ChyphenD, Yerneni P, Aragona E, Burk RD. Hepatocytes exhibit superior transgene expression after transplantation into liver and spleen compared with peritoneal cavity or dorsal fat pad: implications for hepatic gene therapy. Hum Gene Ther 1994; 5: 959-967.
24. Park F, Ohashi K, Chiu W, Naldini L, Kay MA. Efficient lentiviral transduction of liver requires cell cycling in vivo. Nat genet 2000; 24: 49-52.
25. Yang Y, Wilson JM. Clearance of adenovirus-infected hepatocytes by MHC class 1-restricted CD4+ CTLs in vivo. J Immunol 1995; 155: 2564-2570.
26. Yang Y, Jooss KU, Su Q, Ertl HC, Wilson JM. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocyte in vivo. Gene Ther 1996; 3: 137-144.
27. DeMatteo RP, Chu G, Ahn M, Chang E, Burke C, Raper C, Barker CF, Markmann JF. Immunologic barriers to hepatic adenoviral gene therapy for transplantation. Transplantation 1997; 63: 315-319.
28. Gagandeep S, Ott M, Sokhi RP, Gupta S. Rapid clearance of syngeneic transplanted hepatocytes following transduction with E-1-deleted adenovirus indicates early host immune responses and offers novel ways for studying viral vector, target cell and host interactions. Gene Ther 1999; 6: 729-736.
29. Flotte TR, Carter BJ. Adeno-associated virus vectors for gene therapy. Gene Ther 1995; 357-362.
30. Linden RM, Ward P, Giraud C, Winocour E, Berns KI. Site-specific integration by adeno-associated virus. Proc Natl Acad Sci U S A 1996; 93: 11288-11294.
31. Zlokovic BV, Apuzzo MLJ. Cellular and molecular neurosurgery: pathways from concept to reality - Part II: Vector systems and delivery methodologies for gene therapy of the central nervous system. Neurosurgery 1997; 40: 805-811.
32. Blomer U, Naldini L, Verma IM, Trono D, Gage FH. Applications of gene therapy to the CNS. Hum Nat Genet 1996; 5: 1397-1404.
33. Marconi P, Krisky D, Oligino T, Poliani PL, Ramakrishnan R, Goins WF, Fink DJ, Glorioso JC. Replication-defective herpes simplex virus vectors for gene transfer in vivo. Proc Natl Acad Sci U S A 1996; 93: 11319-11320.
34. Roizman B. The function of herpes simplex virus genes: a primer for genetic engineering of novel vectors. Proc Natl Acad Sci U S A 1996; 93: 11307-11312.
35. Lu B, Gupta S, Federoff H. Ex vivo gene transfer using a defective herpes simplex viral vector. Hepatology 1995; 21: 752-759.
36. Gupta S, Gorla GR, Irani AN. Hepatocyte transplantation: emerging insights into mechanisms of liver repopulation and their relevance to potential therapies. J Hepatol 1999; 30: 162-170.
37. Holland EC, Varmus HE. Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proc Natl Acad Sci U S A 1998; 95: 1218-1223.
38. Farina KL, Wyckoff JB, Lee H, Segall JE, Condeelis JS, Jones JG. Cell motility of tumor cells visualised in living intact primary tumors using green fluorescent protein. Cancer Res 1998; 58: 2528-2532.
39. Kalejta RF, Shenk T, Beavis AJ. Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry. Cytometry 1997; 29: 286-291.