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Volumn 35, Issue 1, 2015, Pages 240-253

miR-181a mediates TGF-β-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer

Author keywords

Cirrhosis; EMT; Hepatocellular carcinoma; Hepatocyte; MicroRNA; TGF

Indexed keywords

BIM PROTEIN; MICRORNA; MICRORNA 181A; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; MIRN181 MICRORNA, HUMAN;

EID: 84920972464     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/liv.12517     Document Type: Article
Times cited : (70)

References (37)
  • 1
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112: 1776-84.
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 2
    • 48549084059 scopus 로고    scopus 로고
    • Hepatocyte-specific Smad7 expression attenuates TGF-β-mediated fibrogenesis and protects against liver damage
    • Dooley S, Hamzavi J, Ciuclan L, et al. Hepatocyte-specific Smad7 expression attenuates TGF-β-mediated fibrogenesis and protects against liver damage. Gastroenterology 2008; 135: 642-59.
    • (2008) Gastroenterology , vol.135 , pp. 642-659
    • Dooley, S.1    Hamzavi, J.2    Ciuclan, L.3
  • 3
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-β1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    • Kaimori A, Potter J, Kaimori JY, et al. Transforming growth factor-β1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 2007; 282: 22089-101.
    • (2007) J Biol Chem , vol.282 , pp. 22089-22101
    • Kaimori, A.1    Potter, J.2    Kaimori, J.Y.3
  • 4
    • 79958050044 scopus 로고    scopus 로고
    • Hepatocyte-derived snail1 propagates liver fibrosis progression
    • Rowe RG, Lin Y, Shimizu-Hirota R, et al. Hepatocyte-derived snail1 propagates liver fibrosis progression. Mol Cell Biol 2011; 31: 2392-403.
    • (2011) Mol Cell Biol , vol.31 , pp. 2392-2403
    • Rowe, R.G.1    Lin, Y.2    Shimizu-Hirota, R.3
  • 5
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg M, Yang C, Martino M, et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007; 282: 23337-47.
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3
  • 6
    • 79955123951 scopus 로고    scopus 로고
    • Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis
    • Chu AS, Diax R, Hui JJ, et al. Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis. Hepatology 2011; 53: 1685-95.
    • (2011) Hepatology , vol.53 , pp. 1685-1695
    • Chu, A.S.1    Diax, R.2    Hui, J.J.3
  • 7
    • 77950597707 scopus 로고    scopus 로고
    • Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice
    • Taura K, Miura K, Iwaisako K, et al. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology 2010; 51: 1027-36.
    • (2010) Hepatology , vol.51 , pp. 1027-1036
    • Taura, K.1    Miura, K.2    Iwaisako, K.3
  • 8
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • Yoshimoto S, Loo TM, Atarashi K, et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 2013; 499: 97-101.
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3
  • 9
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008; 22: 894-907.
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 10
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory PA, Bert A, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10: 593-601.
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.2    Paterson, E.L.3
  • 11
    • 79955954699 scopus 로고    scopus 로고
    • An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
    • Gregory PA, Bracken CP, Smith E, et al. An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol Biol Cell 2011; 22: 1686-98.
    • (2011) Mol Biol Cell , vol.22 , pp. 1686-1698
    • Gregory, P.A.1    Bracken, C.P.2    Smith, E.3
  • 12
    • 84891883182 scopus 로고    scopus 로고
    • MicroRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition
    • in press.
    • Parikh A, Lee C, Joseph P, et al. MicroRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition. Nat Commun 2014; 5; in press.
    • (2014) Nat Commun , vol.5
    • Parikh, A.1    Lee, C.2    Joseph, P.3
  • 13
    • 84884725701 scopus 로고    scopus 로고
    • Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK
    • Song MK, Park YK, Ryu JC. Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK. Toxicol Appl Pharmacol 2013; 273: 130-9.
    • (2013) Toxicol Appl Pharmacol , vol.273 , pp. 130-139
    • Song, M.K.1    Park, Y.K.2    Ryu, J.C.3
  • 15
    • 77950095763 scopus 로고    scopus 로고
    • TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3
    • Wang B, Hsu SH, Majumder S, et al. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene 2010; 29: 1787-97.
    • (2010) Oncogene , vol.29 , pp. 1787-1797
    • Wang, B.1    Hsu, S.H.2    Majumder, S.3
  • 16
    • 79953043006 scopus 로고    scopus 로고
    • Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM
    • Wang Y, Yu Y, Tsuyada A, et al. Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene 2011; 30: 1470-80.
    • (2011) Oncogene , vol.30 , pp. 1470-1480
    • Wang, Y.1    Yu, Y.2    Tsuyada, A.3
  • 17
    • 30344473289 scopus 로고    scopus 로고
    • Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells
    • Dahlke MH, Loi R, Warren A, et al. Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. J Hepatol 2006; 44: 334-41.
    • (2006) J Hepatol , vol.44 , pp. 334-341
    • Dahlke, M.H.1    Loi, R.2    Warren, A.3
  • 18
    • 84855989834 scopus 로고    scopus 로고
    • The proapoptotic Bcl-2 family member Bim plays a central role during the development of virus-induced hepatitis
    • Lauer C, Brunner T, Corazza N. The proapoptotic Bcl-2 family member Bim plays a central role during the development of virus-induced hepatitis. J Immunol 2012; 188: 916-22.
    • (2012) J Immunol , vol.188 , pp. 916-922
    • Lauer, C.1    Brunner, T.2    Corazza, N.3
  • 19
    • 53249137795 scopus 로고    scopus 로고
    • TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2
    • Ramesh S, Qi XJ, Wildey GM, et al. TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2. EMBO Rep 2008; 9: 990-7.
    • (2008) EMBO Rep , vol.9 , pp. 990-997
    • Ramesh, S.1    Qi, X.J.2    Wildey, G.M.3
  • 20
    • 84859445823 scopus 로고    scopus 로고
    • TGF-β in progression of liver disease
    • Dooley S, ten Dijke P. TGF-β in progression of liver disease. Cell Tissue Res 2012; 347: 245-56.
    • (2012) Cell Tissue Res , vol.347 , pp. 245-256
    • Dooley, S.1    ten Dijke, P.2
  • 21
    • 78650655487 scopus 로고    scopus 로고
    • Autocrine TGF-β protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim
    • Hoshino Y, Katsuno Y, Ehata S, Miyazono K. Autocrine TGF-β protects breast cancer cells from apoptosis through reduction of BH3-only protein, Bim. J Biochem 2011; 149: 55-65.
    • (2011) J Biochem , vol.149 , pp. 55-65
    • Hoshino, Y.1    Katsuno, Y.2    Ehata, S.3    Miyazono, K.4
  • 22
    • 70350004886 scopus 로고    scopus 로고
    • Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics
    • Gillings AS, Balmanno K, Wiggins CM, Johnson M, Cook SJ. Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics. FEBS J 2009; 276: 6050-62.
    • (2009) FEBS J , vol.276 , pp. 6050-6062
    • Gillings, A.S.1    Balmanno, K.2    Wiggins, C.M.3    Johnson, M.4    Cook, S.J.5
  • 23
    • 33745552897 scopus 로고    scopus 로고
    • Dysregulation of growth factor signaling in human hepatocellular carcinoma
    • Breuhahn K, Longerich T, Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 2006; 25: 3787-800.
    • (2006) Oncogene , vol.25 , pp. 3787-3800
    • Breuhahn, K.1    Longerich, T.2    Schirmacher, P.3
  • 24
    • 79952706985 scopus 로고    scopus 로고
    • Transforming growth factor-beta and the hallmarks of cancer
    • Tian M, Neil JR, Schiemann WP. Transforming growth factor-beta and the hallmarks of cancer. Cell Signal 2011; 23: 951-62.
    • (2011) Cell Signal , vol.23 , pp. 951-962
    • Tian, M.1    Neil, J.R.2    Schiemann, W.P.3
  • 25
    • 34447117003 scopus 로고    scopus 로고
    • Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    • Gramantieri L, Ferracin M, Fornari F, et al. Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma. Cancer Res 2007; 67: 6092-9.
    • (2007) Cancer Res , vol.67 , pp. 6092-6099
    • Gramantieri, L.1    Ferracin, M.2    Fornari, F.3
  • 26
    • 79954436127 scopus 로고    scopus 로고
    • MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis
    • Gao W, Shen H, Liu L, et al. MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis. J Cancer Res Clin Oncol 2011; 137: 557-66.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 557-566
    • Gao, W.1    Shen, H.2    Liu, L.3
  • 27
    • 79151484006 scopus 로고    scopus 로고
    • MiR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras
    • Shin KH, Bae SD, Hong HS, et al. MiR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras. Biochem Biophys Res Commun 2011; 404: 896-902.
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 896-902
    • Shin, K.H.1    Bae, S.D.2    Hong, H.S.3
  • 28
    • 77954315239 scopus 로고    scopus 로고
    • Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis
    • Gao W, Yu Y, Cao H, et al. Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis. Biomed Pharmacother 2010; 64: 399-408.
    • (2010) Biomed Pharmacother , vol.64 , pp. 399-408
    • Gao, W.1    Yu, Y.2    Cao, H.3
  • 29
    • 23044464236 scopus 로고    scopus 로고
    • Extensive modulation of a set of microRNAs in primary glioblastoma
    • Ciafrè SA, Galardi S, Mangiola A, et al. Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun 2005; 334: 1351-8.
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 1351-1358
    • Ciafrè, S.A.1    Galardi, S.2    Mangiola, A.3
  • 30
    • 56449092072 scopus 로고    scopus 로고
    • MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1
    • Miller TE, Ghoshal K, Ramaswamy B, et al. MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1. J Biol Chem 2008; 283: 29897-903.
    • (2008) J Biol Chem , vol.283 , pp. 29897-29903
    • Miller, T.E.1    Ghoshal, K.2    Ramaswamy, B.3
  • 31
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • Ji J, Yamashita T, Budhu A, et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009; 50: 472-80.
    • (2009) Hepatology , vol.50 , pp. 472-480
    • Ji, J.1    Yamashita, T.2    Budhu, A.3
  • 32
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • Yamashita T, Ji J, Budhu A, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 2009; 136: 1012-24.
    • (2009) Gastroenterology , vol.136 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3
  • 33
    • 84868136612 scopus 로고    scopus 로고
    • MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6
    • Zhang X, Nie Y, Du Y, et al. MicroRNA-181a promotes gastric cancer by negatively regulating tumor suppressor KLF6. Tumor Biol 2012; 33: 1589-97.
    • (2012) Tumor Biol , vol.33 , pp. 1589-1597
    • Zhang, X.1    Nie, Y.2    Du, Y.3
  • 34
    • 84877037101 scopus 로고    scopus 로고
    • Activin and TGF-β regulate expression of the microRNA-181 family to promote cell migration and invasion in breast cancer cells
    • Neel JC, Lebrun JJ. Activin and TGF-β regulate expression of the microRNA-181 family to promote cell migration and invasion in breast cancer cells. Cell Signal 2013; 25: 1556-66.
    • (2013) Cell Signal , vol.25 , pp. 1556-1566
    • Neel, J.C.1    Lebrun, J.J.2
  • 35
    • 84868108544 scopus 로고    scopus 로고
    • MicroRNA-181a is associated with poor prognosis of colorectal cancer
    • Nishimura J, Handa R, Yamamoto H, et al. MicroRNA-181a is associated with poor prognosis of colorectal cancer. Oncol Rep 2012; 28: 2221-6.
    • (2012) Oncol Rep , vol.28 , pp. 2221-2226
    • Nishimura, J.1    Handa, R.2    Yamamoto, H.3
  • 36
    • 33645992763 scopus 로고    scopus 로고
    • Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype
    • Grimm D, Pandey K, Nakai H, Storm TA, Kay MA. Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype. J Virol 2006; 80: 426-39.
    • (2006) J Virol , vol.80 , pp. 426-439
    • Grimm, D.1    Pandey, K.2    Nakai, H.3    Storm, T.A.4    Kay, M.A.5
  • 37
    • 0032143649 scopus 로고    scopus 로고
    • Human hepatocyte clonal cell lines that support persistent replication of hepatitis C virus
    • Ikeda M, Sugiyama K, Mizutani T, et al. Human hepatocyte clonal cell lines that support persistent replication of hepatitis C virus. Virus Res 1998; 56: 157-67.
    • (1998) Virus Res , vol.56 , pp. 157-167
    • Ikeda, M.1    Sugiyama, K.2    Mizutani, T.3


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