An update on in vitro test methods in human hepatic drug biotransformation research: Pros and cons

Toxicology and Applied Pharmacology

Volumn 189, Issue 3, 2003, Pages 233-246

  Brandon, Esther F A ^a   Raap, Christiaan D ^a   Meijerman, Irma ^a   Beijnen, Jos H ^a,b   Schellens, Jan H M ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Biotransformation; Cell lines; Human liver fractions; In vitro techniques; Liver slices; Microsomes; Supersomes

Indexed keywords

17 OCTADECYNOIC ACID; 3 METHYLCHOLANTHRENE; ALPHA NAPHTHOFLAVONE; BARBITURIC ACID DERIVATIVE; BUFURALOL; CAFFEINE; CHLORZOXAZONE; CODEINE; COUMARIN; DICLOFENAC; DIETHYLDITHIOCARBAMIC ACID; ETHOXYRESORUFIN DEETHYLASE; FURAFYLLINE; HALOPERIDOL; KETOCONAZOLE; LAURIC ACID; MEPHENYTOIN; MIDAZOLAM; PACLITAXEL; PENTOXYRESORUFIN DEALKYLASE; PHENACETIN O DEETHYLASE; POLYCYCLIC HYDROCARBON; QUINIDINE; RIFAMPICIN; SERTRALINE; SULFAPHENAZOLE; TESTOSTERONE; TICLOPIDINE; TOLBUTAMIDE; WARFARIN;

ACCURACY; CELL LINE; CYTOSOL; DRUG BIOAVAILABILITY; GRAPEFRUIT JUICE; HUMAN; IN VITRO STUDY; LIVER CELL; LIVER PERFUSION; LIVER SLICE; MICROSOME; NONHUMAN; REVIEW; SCREENING TEST;

EID: 0038278508     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00128-5     Document Type: Review

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