Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation?

Neuropharmacology

Volumn 62, Issue 2, 2012, Pages 784-796

  Lauressergues, Emilie ^a   Bert, Elodie ^a   Duriez, Patrick ^b,c   Hum, Dean ^d   Majd, Zouher ^d   Staels, Bart ^b,e,f   Cussac, Didier ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

^b UNIV LILLE   (France)

^c Faculty of Medicine   (France)

^d Genfit SA   (France)

^e INSERM UMR 1011 ^*  (France)

^f INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Antipsychotic drugs; ER stress; IHH; Lipid and cholesterol synthesis; PERK pathway; SREBP

Indexed keywords

CALCIUM ION; CLOZAPINE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; HALOPERIDOL; NEUROLEPTIC AGENT; OLANZAPINE; PROTEIN KINASE R; QUETIAPINE; RISPERIDONE; THAPSIGARGIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; FATTY ACID SYNTHESIS; FETUS; GENE; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENE TARGETING; HUMAN; HUMAN CELL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE GENE; IN VIVO STUDY; LIPID STORAGE; LIVER CELL CULTURE; LIVER METABOLISM; MALE; METABOLIC DISORDER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1 GENE; STEROL REGULATORY ELEMENT BINDING PROTEIN 2 GENE; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; CALCIUM; CELL LINE; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; FATTY ACID SYNTHETASE COMPLEX; HEPATOCYTES; HUMANS; LIPOGENESIS; MALE; ORPHAN NUCLEAR RECEPTORS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STEAROYL-COA DESATURASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNFOLDED PROTEIN RESPONSE;

EID: 84855970215     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.08.048     Document Type: Article

References (76)

1. D.B. Allison, J.L. Mentore, M. Heo, L.P. Chandler, J.C. Cappelleri, M.C. Infante, and P.J. Weiden Antipsychotic-induced weight gain: a comprehensive research synthesis Am. J. Psychiatry 156 1999 1686 1696
2. T.D. Ardizzone, R.J. Bradley, A.M. Freeman III, and D.S. Dwyer Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine Brain Res. 923 2001 82 90
3. M. Baranowski Biological role of liver X receptors J.Physiol Pharmacol. 59 Suppl. 7 2008 31 55
4. P. Baumann, C. Hiemke, S. Ulrich, G. Eckermann, I. Gaertner, M. Gerlach, H.J. Kuss, G. Laux, B. Muller-Oerlinghausen, M.L. Rao, P. Riederer, and G. Zernig The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry Pharmacopsychiatry 37 2004 243 265
5. S.P. Baymiller, P. Ball, R.P. McMahon, and R.W. Buchanan Serum glucose and lipid changes during the course of clozapine treatment: the effect of concurrent beta-adrenergic antagonist treatment Schizophr. Res. 59 2003 49 57
6. A. Bilyk, G.J. Piazza, R.G. Bistline, and M.J. Haas Separation of cholesterol, and fatty acylglycerols, acids and amides by thin-layer chromatography Lipids 26 1991 405 406
7. H.N. Boyda, L. Tse, R.M. Procyshyn, W.G. Honer, and A.M. Barr Preclinical models of antipsychotic drug-induced metabolic side effects Trends Pharmacol. Sci. 31 2010 484 497
8. M. Carlberg, A. Dricu, H. Blegen, G.E. Kass, S. Orrenius, and O. Larsson Short exposures to tunicamycin induce apoptosis in SV40-transformed but not in normal human fibroblasts Carcinogenesis 17 1996 2589 2596
9. S.M. Colgan, D. Tang, G.H. Werstuck, and R.C. Austin Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2 Int. J. Biochem. Cell Biol. 39 2007 1843 1851
10. C.W. Colton, and R.W. Manderscheid Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states Prev. Chronic. Dis. 3 2006 A42
11. C.G. Connor, P. Vassalluzzo, J.B. Sheffield, and B.L. Brownstein Alterations of the cytoplasmic organization of WIRL cells induced by trifluoperazine Tissue Cell. 15 1983 983 992
12. A. De Gottardi, L. Spahr, F. Ravier-Dall'Antonia, and A. Hadengue Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes Liver Int. 30 2010 1482 1489
13. A. De Gottardi, M. Vinciguerra, A. Sgroi, M. Moukil, F. Ravier-Dall'Antonia, V. Pazienza, P. Pugnale, M. Foti, and A. Hadengue Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes Lab. Invest. 87 2007 792 806
14. R.A. Debose-Boyd, M.S. Brown, W.P. Li, A. Nohturfft, J.L. Goldstein, and P.J. Espenshade Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi Cell 99 1999 703 712
15. K. Du, S. Herzig, R.N. Kulkarni, and M. Montminy TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver Science 300 2003 1574 1577
16. D.S. Dwyer, H.B. Pinkofsky, Y. Liu, and R.J. Bradley Antipsychotic drugs affect glucose uptake and the expression of glucose transporters in PC12 cells Prog. Neuropsychopharmacol. Biol. Psychiatry 23 1999 69 80
17. J. Engl, M. Laimer, A. Niederwanger, M. Kranebitter, M. Starzinger, M.T. Pedrini, W.W. Fleischhacker, J.R. Patsch, and C.F. Ebenbichler Olanzapine impairs glycogen synthesis and insulin signaling in L6 skeletal muscle cells Mol. Psychiatry 10 2005 1089 1096
18. J. Ferno, M.B. Raeder, A.O. Vik-Mo, S. Skrede, M. Glambek, K.J. Tronstad, H. Breilid, R. Lovlie, R.K. Berge, C. Stansberg, and V.M. Steen Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? Pharmacogenomics. J. 5 2005 298 304
19. J. Ferno, S. Skrede, A.O. Vik-Mo, B. Havik, and V.M. Steen Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs BMC Neurosci. 7 2006 69
20. J. Ferno, A.O. Vik-Mo, G. Jassim, B. Havik, K. Berge, S. Skrede, O.A. Gudbrandsen, J. Waage, N. Lunder, S. Mork, R.K. Berge, H.A. Jorgensen, and V.M. Steen Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver Psychopharmacology (Berl) 2008
21. C. Fievet, and B. Staels Liver X receptor modulators: effects on lipid metabolism and potential use in the treatment of atherosclerosis Biochem. Pharmacol. 77 2009 1316 1327
22. W.J. Gilmore, and G.M. Kirby Endoplasmic reticulum stress due to altered cellular redox status positively regulates murine hepatic CYP2A5 expression J. Pharmacol. Exp. Ther. 308 2004 600 608
23. D.C. Goff, L.M. Sullivan, J.P. McEvoy, J.M. Meyer, H.A. Nasrallah, G.L. Daumit, S. Lamberti, R.B. D'Agostino, T.S. Stroup, S. Davis, and J.A. Lieberman A comparison of ten-year cardiac risk estimates in schizophrenia patients from the CATIE study and matched controls Schizophr. Res. 80 2005 45 53
24. H.P. Harding, I. Novoa, Y. Zhang, H. Zeng, R. Wek, M. Schapira, and D. Ron Regulated translation initiation controls stress-induced gene expression in mammalian cells Mol. Cell 6 2000 1099 1108
25. H.P. Harding, Y. Zhang, H. Zeng, I. Novoa, P.D. Lu, M. Calfon, N. Sadri, C. Yun, B. Popko, R. Paules, D.F. Stojdl, J.C. Bell, T. Hettmann, J.M. Leiden, and D. Ron An integrated stress response regulates amino acid metabolism and resistance to oxidative stress Mol. Cell 11 2003 619 633
26. 2C receptor agonist, in Zucker rats Brain Res. 1011 2004 221 227
27. J.D. Horton, Y. Bashmakov, I. Shimomura, and H. Shimano Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice Proc. Natl. Acad. Sci. U.S.A. 95 1998 5987 5992
28. K.L. Houseknecht, A.S. Robertson, W. Zavadoski, E.M. Gibbs, D.E. Johnson, and H. Rollema Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effects Neuropsychopharmacology 32 2007 289 297
29. K. Isodono, T. Takahashi, H. Imoto, N. Nakanishi, T. Ogata, S. Asada, A. Adachi, T. Ueyama, H. Oh, and H. Matsubara PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes PLoS One 5 2010 e9746
30. C. Ji, C. Chan, and N. Kaplowitz Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model J. Hepatol. 45 2006 717 724
31. D.E. Johnson, H. Yamazaki, K.M. Ward, A.W. Schmidt, W.S. Lebel, J.L. Treadway, E.M. Gibbs, W.S. Zawalich, and H. Rollema Inhibitory effects of antipsychotics on carbachol-enhanced insulin secretion from perifused rat islets: role of muscarinic antagonism in antipsychotic-induced diabetes and hyperglycemia Diabetes 54 2005 1552 1558
32. H.L. Kammoun, H. Chabanon, I. Hainault, S. Luquet, C. Magnan, T. Koike, P. Ferre, and F. Foufelle GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J. Clin. Invest. 119 2009 1201 1215
33. H.L. Kammoun, I. Hainault, P. Ferre, and F. Foufelle Nutritional related liver disease: targeting the endoplasmic reticulum stress Curr. Opin. Clin. Nutr. Metab. Care 12 2009 575 582
34. 1 receptor-linked activation of hypothalamic AMP-kinase Proc. Natl. Acad. Sci. U.S.A. 104 2007 3456 3459
35. K. Kokame, K.L. Agarwala, H. Kato, and T. Miyata Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress J. Biol. Chem. 275 2000 32846 32853
36. W.K. Kroeze, S.J. Hufeisen, B.A. Popadak, S.M. Renock, S. Steinberg, P. Ernsberger, K. Jayathilake, H.Y. Meltzer, and B.L. Roth H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs Neuropsychopharmacology 28 2003 519 526
37. E. Lai, G. Bikopoulos, M.B. Wheeler, M. Rozakis-Adcock, and A. Volchuk Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells Am. J. Physiol. Endocrinol. Metab. 294 2008 E540 E550
38. O. Larsson, M. Carlberg, and A. Zetterberg Selective killing induced by an inhibitor of N-linked glycosylation J. Cell Sci. 106 1993 299 307
39. E. Lauressergues, B. Staels, K. Valeille, Z. Majd, D.W. Hum, P. Duriez, and D. Cussac Antipsychotic drug action on SREBPs-related lipogenesis and cholesterogenesis in primary rat hepatocytes Naunyn Schmiedebergs Arch. Pharmacol. 381 2010 427 439
40. d.Y. Lee, K.S. Lee, H.J. Lee, d.H. Kim, Y.H. Noh, K. Yu, H.Y. Jung, S.H. Lee, J.Y. Lee, Y.C. Youn, Y. Jeong, D.K. Kim, W.B. Lee, and S.S. Kim Activation of PERK signaling attenuates Abeta-mediated ER stress PLoS One 5 2010 e10489
41. J.N. Lee, and J. Ye Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1 J. Biol. Chem. 279 2004 45257 45265
42. X. Lei, S. Zhang, S.E. Barbour, A. Bohrer, E.L. Ford, A. Koizumi, F.R. Papa, and S. Ramanadham Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1 J. Biol. Chem. 285 2010 6693 6705
43. R.C. Littell, G. Miliken, W.W. Stroup, and R.D. Wolfinger SAS System for Mixed Models 1996 SAS Institute Inc. Cary, North Carolina, USA
44. S. Luo, P. Baumeister, S. Yang, S.F. Abcouwer, and A.S. Lee Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements J. Biol. Chem. 278 2003 37375 37385
45. J.M. Meyer Effects of atypical antipsychotics on weight and serum lipid levels J. Clin. Psychiatry 62 Suppl. 27 2001 27 34
46. J.M. Meyer, and C.E. Koro The effects of antipsychotic therapy on serum lipids: a comprehensive review Schizophr. Res. 70 2004 1 17
47. J. Minet-Ringuet, P.C. Even, P. Valet, C. Carpene, V. Visentin, D. Prevot, D. Daviaud, A. Quignard-Boulange, D. Tome, and R. de Beaurepaire Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment Mol. Psychiatry 2007
48. Y. Minokoshi, T. Alquier, N. Furukawa, Y.B. Kim, A. Lee, B. Xue, J. Mu, F. Foufelle, P. Ferre, M.J. Birnbaum, B.J. Stuck, and B.B. Kahn AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature 428 2004 569 574
49. J.W. Newcomer Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review CNS Drugs 19 Suppl. 1 2005 1 93
50. 2C receptor gene Nat. Med. 4 1998 1152 1156
51. U. Osby, N. Correia, L. Brandt, A. Ekbom, and P. Sparen Mortality and causes of death in schizophrenia in Stockholm county, Sweden Schizophr. Res. 45 2000 21 28
52. S.L. Pelech, F. Jetha, and D.E. Vance Trifluoperazine and other anaesthetics inhibit rat liver CTP: phosphocholine cytidylyltransferase FEBS Lett. 158 1983 89 92
53. D. Perez-Sala, and F. Mollinedo Inhibition of N-linked glycosylation induces early apoptosis in human promyelocytic HL-60 cells J. Cell Physiol. 163 1995 523 531
54. M.B. Raeder, J. Ferno, M. Glambek, C. Stansberg, and V.M. Steen Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells Neurosci. Lett. 395 2006 185 190
55. M.B. Raeder, J. Ferno, A.O. Vik-Mo, and V.M. Steen SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects? Mol. Cell Biochem. 289 2006 167 173
56. R. Raghow, C. Yellaturu, X. Deng, E.A. Park, and M.B. Elam SREBPs: the crossroads of physiological and pathological lipid homeostasis Trends Endocrinol. Metab. 19 2008 65 73
57. 2C receptor gene polymorphism Lancet 359 2002 2086 2087
58. E. Richelson, and T. Souder Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds Life Sci. 68 2000 29 39
59. D. Ron, and P. Walter Signal integration in the endoplasmic reticulum unfolded protein response Nat. Rev. Mol. Cell Biol. 8 2007 519 529
60. C. Rummel-Kluge, K. Komossa, S. Schwarz, H. Hunger, F. Schmid, C.A. Lobos, W. Kissling, J.M. Davis, and S. Leucht Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis Schizophr. Res. 123 2010 225 233
61. D.T. Rutkowski, and R.J. Kaufman A trip to the ER: coping with stress Trends Cell Biol. 14 2004 20 28
62. D.T. Rutkowski, and R.J. Kaufman That which does not kill me makes me stronger: adapting to chronic ER stress Trends Biochem. Sci. 32 2007 469 476
63. D. Scheuner, B. Song, E. McEwen, C. Liu, R. Laybutt, P. Gillespie, T. Saunders, S. Bonner-Weir, and R.J. Kaufman Translational control is required for the unfolded protein response and in vivo glucose homeostasis Mol. Cell 7 2001 1165 1176
64. I.J. Schippers, H. Moshage, H. Roelofsen, M. Muller, H.S. Heymans, M. Ruiters, and F. Kuipers Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation Cell Biol. Toxicol. 13 1997 375 386
65. H. Shimano, N. Yahagi, M. Amemiya-Kudo, A.H. Hasty, J. Osuga, Y. Tamura, F. Shionoiri, Y. Iizuka, K. Ohashi, K. Harada, T. Gotoda, S. Ishibashi, and N. Yamada Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes J. Biol. Chem. 274 1999 35832 35839
66. J.S. Silvestre, and J. Prous Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes Methods Find. Exp. Clin. Pharmacol. 27 2005 289 304
67. 2c serotonin receptors Nature 374 1995 542 546
68. H.S. Vestri, L. Maianu, D.R. Moellering, and W.T. Garvey Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis Neuropsychopharmacology 32 2007 765 772
69. R.C. Wek, and D.R. Cavener Translational control and the unfolded protein response Antioxid. Redox Signal. 9 2007 2357 2371
70. G.H. Werstuck, S.R. Lentz, S. Dayal, G.S. Hossain, S.K. Sood, Y.Y. Shi, J. Zhou, N. Maeda, S.K. Krisans, M.R. Malinow, and R.C. Austin Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways J. Clin. Invest. 107 2001 1263 1273
71. D.A. Wirshing, J.A. Boyd, L.R. Meng, J.S. Ballon, S.R. Marder, and W.C. Wirshing The effects of novel antipsychotics on glucose and lipid levels J. Clin. Psychiatry 63 2002 856 865
72. J. Wu, D.T. Rutkowski, M. Dubois, J. Swathirajan, T. Saunders, J. Wang, B. Song, G.D. Yau, and R.J. Kaufman ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress Dev. Cell 13 2007 351 364
73. C. Xu, B. Bailly-Maitre, and J.C. Reed Endoplasmic reticulum stress: cell life and death decisions J. Clin. Invest. 115 2005 2656 2664
74. L.H. Yang, T.M. Chen, S.T. Yu, and Y.H. Chen Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells Pharmacol. Res. 56 2007 202 208
75. Z. Yang, J.Y. Yin, Z.C. Gong, Q. Huang, H. Chen, W. Zhang, H.H. Zhou, and Z.Q. Liu Evidence for an effect of clozapine on the regulation of fat-cell derived factors Clin. Chim. Acta 2009
76. H. Zinszner, M. Kuroda, X. Wang, N. Batchvarova, R.T. Lightfoot, H. Remotti, J.L. Stevens, and D. Ron CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum Genes Dev. 12 1998 982 995