메뉴 건너뛰기




Volumn 33, Issue , 2015, Pages 539-561

Early T cell activation: Integrating biochemical, structural, and biophysical cues

Author keywords

Mechanosensing; Mesoscale properties; Self awareness; Signal processing; Signal transduction; T cell antigen receptor

Indexed keywords

CD3 ANTIGEN; MULTIPROTEIN COMPLEX; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84927653551     PISSN: 07320582     EISSN: 15453278     Source Type: Book Series    
DOI: 10.1146/annurev-immunol-032414-112158     Document Type: Review
Times cited : (111)

References (142)
  • 1
    • 84901295133 scopus 로고    scopus 로고
    • Deconstructing the peptide-MHC specificity of T cell recognition
    • Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, et al. 2014. Deconstructing the peptide-MHC specificity of T cell recognition. Cell 157:1073-87
    • (2014) Cell , vol.157 , pp. 1073-1087
    • Birnbaum, M.E.1    Mendoza, J.L.2    Sethi, D.K.3    Dong, S.4    Glanville, J.5
  • 2
    • 34247346627 scopus 로고    scopus 로고
    • How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?
    • Mazza C, Auphan-Anezin N, Gregoire C, Guimezanes A, Kellenberger C, et al. 2007. How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides? EMBO J. 26:1972-83
    • (2007) EMBO J. , vol.26 , pp. 1972-1983
    • Mazza, C.1    Auphan-Anezin, N.2    Gregoire, C.3    Guimezanes, A.4    Kellenberger, C.5
  • 4
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran AE, Holzapfel KL, Xing Y, Cunningham NR, Maltzman JS, et al. 2011. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208:1279-89
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5
  • 5
    • 77950524377 scopus 로고    scopus 로고
    • Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen
    • Hochweller K, Wabnitz GH, Samstag Y, Suffner J, Hammerling GJ, Garbi N. 2010. Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen. PNAS 107:5931-36
    • (2010) PNAS , vol.107 , pp. 5931-5936
    • Hochweller, K.1    Wabnitz, G.H.2    Samstag, Y.3    Suffner, J.4    Hammerling, G.J.5    Garbi, N.6
  • 6
    • 84887615587 scopus 로고    scopus 로고
    • A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4+ T cells
    • Huang J, Brameshuber M, Zeng X, Xie J, Li QJ, et al. 2013. A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4+ T cells. Immunity 39:846-57
    • (2013) Immunity , vol.39 , pp. 846-857
    • Huang, J.1    Brameshuber, M.2    Zeng, X.3    Xie, J.4    Li, Q.J.5
  • 7
    • 79959328071 scopus 로고    scopus 로고
    • T-cell triggering thresholds aremodulated by the number of antigen within individual T-cell receptor clusters
    • Manz BN, Jackson BL, Petit RS, Dustin ML,Groves J. 2011. T-cell triggering thresholds aremodulated by the number of antigen within individual T-cell receptor clusters. PNAS 108:9089-94
    • (2011) PNAS , vol.108 , pp. 9089-9094
    • Manz, B.N.1    Jackson, B.L.2    Petit, R.S.3    Dustin, M.L.4    Groves, J.5
  • 8
    • 84880089372 scopus 로고    scopus 로고
    • Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells
    • O'Donoghue GP, Pielak RM, Smoligovets AA, Lin JJ, Groves JT. 2013. Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells. eLIFE 2:e00778
    • (2013) ELIFE , vol.2 , pp. e00778
    • O'donoghue, G.P.1    Pielak, R.M.2    Smoligovets, A.A.3    Lin, J.J.4    Groves, J.T.5
  • 9
    • 23444457121 scopus 로고    scopus 로고
    • Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways
    • Houtman JC, Houghtling RA, Barda-Saad M, Toda Y, Samelson LE. 2005. Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. J. Immunol. 175:2449-58
    • (2005) J. Immunol. , vol.175 , pp. 2449-2458
    • Houtman, J.C.1    Houghtling, R.A.2    Barda-Saad, M.3    Toda, Y.4    Samelson, L.E.5
  • 10
    • 34447647655 scopus 로고    scopus 로고
    • Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist
    • Huse M, Klein LO, Girvin AT, Faraj JM, Li QJ, et al. 2007. Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity 27:76-88
    • (2007) Immunity , vol.27 , pp. 76-88
    • Huse, M.1    Klein, L.O.2    Girvin, A.T.3    Faraj, J.M.4    Li, Q.J.5
  • 11
    • 84883417144 scopus 로고    scopus 로고
    • T lymphocytes sense antigens within seconds and make a decision within one minute
    • Brodovitch A, Bongrand P, Pierres A. 2013. T lymphocytes sense antigens within seconds and make a decision within one minute. J. Immunol. 191:2064-71
    • (2013) J. Immunol. , vol.191 , pp. 2064-2071
    • Brodovitch, A.1    Bongrand, P.2    Pierres, A.3
  • 13
    • 0037306046 scopus 로고    scopus 로고
    • An evolutionary and structural perspective on T cell antigen receptor function
    • Malissen B. 2003. An evolutionary and structural perspective on T cell antigen receptor function. Immunol. Rev. 191:7-27
    • (2003) Immunol. Rev. , vol.191 , pp. 7-27
    • Malissen, B.1
  • 14
    • 84900432315 scopus 로고    scopus 로고
    • Mechanism of activation of protein kinase JAK2 by the growth hormone receptor
    • Brooks AJ, DaiW, O'MaraML, AbankwaD, Chhabra Y, et al. 2014. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor. Science 344:1249783
    • (2014) Science , vol.344 , pp. 1249783
    • Brooks, A.J.1    Dai, W.2    O'mara, M.L.3    Abankwa, D.4    Chhabra, Y.5
  • 15
    • 79959542722 scopus 로고    scopus 로고
    • The CD3 subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse
    • DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, et al. 2011. The CD3 subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse. J. Immunol. 186:6839-47
    • (2011) J. Immunol. , vol.186 , pp. 6839-6847
    • Deford-Watts, L.M.1    Dougall, D.S.2    Belkaya, S.3    Johnson, B.A.4    Eitson, J.L.5
  • 16
    • 55449138409 scopus 로고    scopus 로고
    • Regulation of T cell receptor activation by dynamic membrane binding of the CD3ε cytoplasmic tyrosine-based motif
    • Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, et al. 2008. Regulation of T cell receptor activation by dynamic membrane binding of the CD3ε cytoplasmic tyrosine-based motif. Cell 135:702-13
    • (2008) Cell , vol.135 , pp. 702-713
    • Xu, C.1    Gagnon, E.2    Call, M.E.3    Schnell, J.R.4    Schwieters, C.D.5
  • 17
    • 84903639556 scopus 로고    scopus 로고
    • Membrane association of the CD3ε signaling domain is required for optimal T cell development and function
    • Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, et al. 2014. Membrane association of the CD3ε signaling domain is required for optimal T cell development and function. J. Immunol. 193:258-67
    • (2014) J. Immunol. , vol.193 , pp. 258-267
    • Bettini, M.L.1    Guy, C.2    Dash, P.3    Vignali, K.M.4    Hamm, D.E.5
  • 18
    • 0033762433 scopus 로고    scopus 로고
    • Phosphorylation of T cell receptor is regulated by a lipid dependent folding transition
    • Aivazian D, Stern LJ. 2000. Phosphorylation of T cell receptor is regulated by a lipid dependent folding transition. Nat. Struct. Biol. 7:1023-26
    • (2000) Nat. Struct. Biol. , vol.7 , pp. 1023-1026
    • Aivazian, D.1    Stern, L.J.2
  • 19
    • 0037188899 scopus 로고    scopus 로고
    • Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential forTcell receptor signaling and synapse formation
    • Gil D, Schamel WW, Montoya M, Sanchez-Madrid F, Alarcon B. 2002. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential forTcell receptor signaling and synapse formation. Cell 109:901-12
    • (2002) Cell , vol.109 , pp. 901-912
    • Gil, D.1    Schamel, W.W.2    Montoya, M.3    Sanchez-Madrid, F.4    Alarcon, B.5
  • 20
    • 21244489949 scopus 로고    scopus 로고
    • The CD3ε proline-rich sequence, and its interaction with Nck, is not required for T cell development and function
    • Szymczak AL, Workman CJ, Gil D, Dilioglou S, Vignali KM, et al. 2005. The CD3ε proline-rich sequence, and its interaction with Nck, is not required for T cell development and function. J. Immunol. 175:270-75
    • (2005) J. Immunol. , vol.175 , pp. 270-275
    • Szymczak, A.L.1    Workman, C.J.2    Gil, D.3    Dilioglou, S.4    Vignali, K.M.5
  • 21
    • 42449149487 scopus 로고    scopus 로고
    • The proline-rich sequence of CD3εcontrols T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes
    • Mingueneau M, SansoniA,Gregoire C, Roncagalli R, Aguado E, et al. 2008. The proline-rich sequence of CD3εcontrols T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes. Nat. Immunol. 9:522-32
    • (2008) Nat. Immunol. , vol.9 , pp. 522-532
    • Mingueneau, M.1    Sansoni, A.2    Gregoire, C.3    Roncagalli, R.4    Aguado, E.5
  • 22
    • 82755165363 scopus 로고    scopus 로고
    • Basic residues in the T-cell receptor cytoplasmic domain mediate membrane association and modulate signaling
    • Zhang H, Cordoba SP, Dushek O, van der Merwe PA. 2011. Basic residues in the T-cell receptor cytoplasmic domain mediate membrane association and modulate signaling. PNAS 108:19323-28
    • (2011) PNAS , vol.108 , pp. 19323-19328
    • Zhang, H.1    Cordoba, S.P.2    Dushek, O.3    Van Der Merwe, P.A.4
  • 24
    • 23744479535 scopus 로고    scopus 로고
    • How the T cell receptor sees antigen- A structural view
    • Garcia KC, Adams EJ. 2005. How the T cell receptor sees antigen- A structural view. Cell 122:333-36
    • (2005) Cell , vol.122 , pp. 333-336
    • Garcia, K.C.1    Adams, E.J.2
  • 25
    • 84877669593 scopus 로고    scopus 로고
    • The basic principles of chimeric antigen receptor design
    • Sadelain M, Brentjens R, Riviere I. 2013. The basic principles of chimeric antigen receptor design. Cancer Discov. 3:388-98
    • (2013) Cancer Discov. , vol.3 , pp. 388-398
    • Sadelain, M.1    Brentjens, R.2    Riviere, I.3
  • 26
    • 84864221004 scopus 로고    scopus 로고
    • A new era of GPCR structural and chemical biology
    • Granier S, Kobilka B. 2012. A new era of GPCR structural and chemical biology. Nat. Chem. Biol. 8:670-73
    • (2012) Nat. Chem. Biol. , vol.8 , pp. 670-673
    • Granier, S.1    Kobilka, B.2
  • 27
    • 1942540796 scopus 로고    scopus 로고
    • Supine orientation of a murine MHC class i molecule on the membrane bilayer
    • Mitra AK, Celia H, Ren G, Luz JG, Wilson IA, Teyton L. 2004. Supine orientation of a murine MHC class I molecule on the membrane bilayer. Curr. Biol. 14:718-24
    • (2004) Curr. Biol. , vol.14 , pp. 718-724
    • Mitra, A.K.1    Celia, H.2    Ren, G.3    Luz, J.G.4    Wilson, I.A.5    Teyton, L.6
  • 28
    • 84916613807 scopus 로고    scopus 로고
    • Molecular architecture of the αβT cell receptor-CD3 complex
    • Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-VazquezMA, et al. 2014. Molecular architecture of the αβT cell receptor-CD3 complex. PNAS 111:17576-81
    • (2014) PNAS , vol.111 , pp. 17576-17581
    • Birnbaum, M.E.1    Berry, R.2    Hsiao, Y.S.3    Chen, Z.4    Shingu-Vazquez, M.A.5
  • 29
    • 0025182959 scopus 로고
    • Adhesion receptors of the immune system
    • Springer TA. 1990. Adhesion receptors of the immune system. Nature 346:425-34
    • (1990) Nature , vol.346 , pp. 425-434
    • Springer, T.A.1
  • 30
    • 84859470532 scopus 로고    scopus 로고
    • Crystal structure of a complete ternary complex ofT-cell receptor, peptide-MHC, and CD4
    • Yin Y,Wang XX, Mariuzza RA. 2012. Crystal structure of a complete ternary complex ofT-cell receptor, peptide-MHC, and CD4. PNAS 109:5405-10
    • (2012) PNAS , vol.109 , pp. 5405-5410
    • Yin, Y.1    Wang, X.X.2    Mariuzza, R.A.3
  • 31
    • 0030581710 scopus 로고    scopus 로고
    • Immunology. Two faces are better than one
    • Malissen B. 1996. Immunology. Two faces are better than one. Nature 384:518-19
    • (1996) Nature , vol.384 , pp. 518-519
    • Malissen, B.1
  • 32
    • 77953911933 scopus 로고    scopus 로고
    • Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
    • Nika K, Soldani C, Salek M, Paster W, Gray A, et al. 2010. Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity 32:766-77
    • (2010) Immunity , vol.32 , pp. 766-777
    • Nika, K.1    Soldani, C.2    Salek, M.3    Paster, W.4    Gray, A.5
  • 33
    • 0032968708 scopus 로고    scopus 로고
    • The dynamics of T cell receptor signaling: Complex orchestration and the key roles of tempo and cooperation
    • Germain RN, Stefanova I. 1999. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu. Rev. Immunol. 17:467-522
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 467-522
    • Germain, R.N.1    Stefanova, I.2
  • 34
    • 84915754505 scopus 로고    scopus 로고
    • Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance
    • Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, et al. 2014. Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell 159:333-45
    • (2014) Cell , vol.159 , pp. 333-345
    • Stepanek, O.1    Prabhakar, A.S.2    Osswald, C.3    King, C.G.4    Bulek, A.5
  • 35
    • 0031028629 scopus 로고    scopus 로고
    • The single positive T cells found in CD3-ζ/η -/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex
    • Lin SY, Ardouin L, Gillet A, Malissen M, Malissen B. 1997. The single positive T cells found in CD3-ζ/η -/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex. J. Exp. Med. 185:707-15
    • (1997) J. Exp. Med. , vol.185 , pp. 707-715
    • Lin, S.Y.1    Ardouin, L.2    Gillet, A.3    Malissen, M.4    Malissen, B.5
  • 36
    • 0037077094 scopus 로고    scopus 로고
    • Induction of T helper type 2 immunity by a point mutation in the LAT adaptor
    • Aguado E, Richelme S, Nunez-Cruz S, Miazek A, Mura A-M, et al. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296:2036-40
    • (2002) Science , vol.296 , pp. 2036-2040
    • Aguado, E.1    Richelme, S.2    Nunez-Cruz, S.3    Miazek, A.4    Mura, A.-M.5
  • 37
    • 0028902752 scopus 로고
    • Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
    • Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN. 1995. Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science 267:515-18
    • (1995) Science , vol.267 , pp. 515-518
    • Madrenas, J.1    Wange, R.L.2    Wang, J.L.3    Isakov, N.4    Samelson, L.E.5    Germain, R.N.6
  • 38
    • 84878999914 scopus 로고    scopus 로고
    • Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker
    • Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, et al. 2013. Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker. Mol. Cell. Biol. 33:2188-201
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 2188-2201
    • Yan, Q.1    Barros, T.2    Visperas, P.R.3    Deindl, S.4    Kadlecek, T.A.5
  • 39
    • 84906241799 scopus 로고    scopus 로고
    • Insights into the initiation ofTCRsignaling
    • Chakraborty AK,Weiss A. 2014. Insights into the initiation ofTCRsignaling. Nat. Immunol. 15:798-807
    • (2014) Nat. Immunol. , vol.15 , pp. 798-807
    • Chakraborty, A.K.1    Weiss, A.2
  • 40
    • 0031229746 scopus 로고    scopus 로고
    • The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production
    • Lewis LA, Chung CD, Chen J, Parnes JR,Moran M, et al. 1997. The Lck SH2 phosphotyrosine binding site is critical for efficient TCR-induced processive tyrosine phosphorylation of the zeta-chain and IL-2 production. J. Immunol. 159:2292-300
    • (1997) J. Immunol. , vol.159 , pp. 2292-2300
    • Lewis, L.A.1    Chung, C.D.2    Chen, J.3    Parnes, J.R.4    Moran, M.5
  • 41
    • 84891836984 scopus 로고    scopus 로고
    • Locking the active conformation of c-SRC kinase through the phosphorylation of the activation loop
    • Meng Y, Roux B. 2014. Locking the active conformation of c-SRC kinase through the phosphorylation of the activation loop. J. Mol. Biol. 426:423-35
    • (2014) J. Mol. Biol. , vol.426 , pp. 423-435
    • Meng, Y.1    Roux, B.2
  • 42
    • 0032445491 scopus 로고    scopus 로고
    • CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
    • Azzam HS,Grinberg A, Lui K, ShenH, Shores EW, Love PE. 1998. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188:2301-11
    • (1998) J. Exp. Med. , vol.188 , pp. 2301-2311
    • Azzam, H.S.1    Grinberg, A.2    Lui, K.3    Shen, H.4    Shores, E.W.5    Love, P.E.6
  • 43
    • 84874244135 scopus 로고    scopus 로고
    • T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens
    • Mandl JN, Monteiro JP, Vrisekoop N, Germain RN. 2013. T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. Immunity 38:263-74
    • (2013) Immunity , vol.38 , pp. 263-274
    • Mandl, J.N.1    Monteiro, J.P.2    Vrisekoop, N.3    Germain, R.N.4
  • 44
    • 84924979971 scopus 로고    scopus 로고
    • The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8 T cells to respond to foreign antigens
    • Fulton RB, Hamilton SE, Xing Y, Best JA, Goldrath AW, et al. 2014. The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8 T cells to respond to foreign antigens. Nat. Immunol. 16:107-17
    • (2014) Nat. Immunol. , vol.16 , pp. 107-117
    • Fulton, R.B.1    Hamilton, S.E.2    Xing, Y.3    Best, J.A.4    Goldrath, A.W.5
  • 45
    • 84906243997 scopus 로고    scopus 로고
    • The self-obsession of T cells: How TCR signaling thresholds affect fate 'decisions' and effector function
    • Hogquist KA, Jameson SC. 2014. The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function. Nat. Immunol. 15:815-23
    • (2014) Nat. Immunol. , vol.15 , pp. 815-823
    • Hogquist, K.A.1    Jameson, S.C.2
  • 46
    • 84894447120 scopus 로고    scopus 로고
    • Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC
    • Persaud SP, Parker CR, Lo WL, Weber KS, Allen PM. 2014. Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat. Immunol. 15:266-74
    • (2014) Nat. Immunol. , vol.15 , pp. 266-274
    • Persaud, S.P.1    Parker, C.R.2    Lo, W.L.3    Weber, K.S.4    Allen, P.M.5
  • 47
    • 27844541328 scopus 로고    scopus 로고
    • Modeling T cell antigen discrimination based on feedback control of digital ERK responses
    • Altan-Bonnet G, Germain RN. 2005. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLOS Biol. 3:e356
    • (2005) PLOS Biol. , vol.3 , pp. e356
    • Altan-Bonnet, G.1    Germain, R.N.2
  • 48
    • 84857415635 scopus 로고    scopus 로고
    • Constitutive type i interferon modulates homeostatic balance through tonic signaling
    • Gough DJ, Messina NL, Clarke CJ, Johnstone RW, Levy DE. 2012. Constitutive type I interferon modulates homeostatic balance through tonic signaling. Immunity 36:166-74
    • (2012) Immunity , vol.36 , pp. 166-174
    • Gough, D.J.1    Messina, N.L.2    Clarke, C.J.3    Johnstone, R.W.4    Levy, D.E.5
  • 49
    • 62249131518 scopus 로고    scopus 로고
    • Complete but curtailed T-cell response to very low-affinity antigen
    • Zehn D, Lee SY, Bevan MJ. 2009. Complete but curtailed T-cell response to very low-affinity antigen. Nature 458:211-14
    • (2009) Nature , vol.458 , pp. 211-214
    • Zehn, D.1    Lee, S.Y.2    Bevan, M.J.3
  • 50
    • 84897458111 scopus 로고    scopus 로고
    • An induced rebinding model of antigen discrimination
    • Dushek O, van der Merwe PA. 2014. An induced rebinding model of antigen discrimination. Trends Immunol. 35:153-58
    • (2014) Trends Immunol. , vol.35 , pp. 153-158
    • Dushek, O.1    Van Der Merwe, P.A.2
  • 51
    • 34848898406 scopus 로고    scopus 로고
    • Quantitative challenges in understanding ligand discrimination by αβT cells
    • Feinerman O, Germain RN, Altan-Bonnet G. 2008. Quantitative challenges in understanding ligand discrimination by αβT cells. Mol. Immunol. 45:619-31
    • (2008) Mol. Immunol. , vol.45 , pp. 619-631
    • Feinerman, O.1    Germain, R.N.2    Altan-Bonnet, G.3
  • 52
  • 53
    • 38349177876 scopus 로고    scopus 로고
    • What is the biological relevance of the specific bond properties revealed by single-molecule studies?
    • Robert P, Benoliel AM, Pierres A, Bongrand P. 2007. What is the biological relevance of the specific bond properties revealed by single-molecule studies? J. Mol. Recognit. 20:432-47
    • (2007) J. Mol. Recognit. , vol.20 , pp. 432-447
    • Robert, P.1    Benoliel, A.M.2    Pierres, A.3    Bongrand, P.4
  • 54
    • 0035970109 scopus 로고    scopus 로고
    • Selectin receptor-ligand bonds: Formation limited by shear rate and dissociation governed by the Bell model
    • Chen S, Springer TA. 2001. Selectin receptor-ligand bonds: formation limited by shear rate and dissociation governed by the Bell model. PNAS 98:950-55
    • (2001) PNAS , vol.98 , pp. 950-955
    • Chen, S.1    Springer, T.A.2
  • 55
    • 84898644308 scopus 로고    scopus 로고
    • Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling
    • Liu B, Chen W, Evavold BD, Zhu C. 2014. Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling. Cell 157:357-68
    • (2014) Cell , vol.157 , pp. 357-368
    • Liu, B.1    Chen, W.2    Evavold, B.D.3    Zhu, C.4
  • 56
  • 57
    • 33847780609 scopus 로고    scopus 로고
    • A structure-based sliding-rebindingmechanism for catch bonds
    • Lou J, ZhuC. 2007. A structure-based sliding-rebindingmechanism for catch bonds. Biophys. J. 92:1471-85
    • (2007) Biophys. J. , vol.92 , pp. 1471-1485
    • Lou, J.1    Zhu, C.2
  • 58
    • 80054687448 scopus 로고    scopus 로고
    • The two-pathway model of the biological catch-bond as a limit of the allosteric model
    • Pereverzev YV, Prezhdo E, Sokurenko EV. 2011. The two-pathway model of the biological catch-bond as a limit of the allosteric model. Biophys. J. 101:2026-36
    • (2011) Biophys. J. , vol.101 , pp. 2026-2036
    • Pereverzev, Y.V.1    Prezhdo, E.2    Sokurenko, E.V.3
  • 60
    • 28444492383 scopus 로고    scopus 로고
    • The solution to the streptavidin-biotin paradox: The influence of history on the strength of single molecular bonds
    • Pincet F, Husson J. 2005. The solution to the streptavidin-biotin paradox: the influence of history on the strength of single molecular bonds. Biophys. J. 89:4374-81
    • (2005) Biophys. J. , vol.89 , pp. 4374-4381
    • Pincet, F.1    Husson, J.2
  • 62
    • 84866369099 scopus 로고    scopus 로고
    • Quantitative modeling assesses the contribution of bond strengthening, rebinding and force sharing to the avidity of biomolecule interactions
    • Lo Schiavo V, Robert P, Limozin L, Bongrand P. 2012. Quantitative modeling assesses the contribution of bond strengthening, rebinding and force sharing to the avidity of biomolecule interactions. PLOS ONE 7:e44070
    • (2012) PLOS ONE , vol.7 , pp. e44070
    • Lo Schiavo, V.1    Robert, P.2    Limozin, L.3    Bongrand, P.4
  • 63
    • 0029332175 scopus 로고
    • Influence of surface charges on cell adhesion: Difference between static and dynamic conditions
    • Sabri S, Pierres A, Benoliel AM, Bongrand P. 1995. Influence of surface charges on cell adhesion: difference between static and dynamic conditions. Biochem. Cell Biol. 73:411-20
    • (1995) Biochem. Cell Biol. , vol.73 , pp. 411-420
    • Sabri, S.1    Pierres, A.2    Benoliel, A.M.3    Bongrand, P.4
  • 64
    • 77249114784 scopus 로고    scopus 로고
    • TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity
    • Huppa JB, Axmann M, Mortelmaier MA, Lillemeier BF, Newell EW, et al. 2010. TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature 463:963-67
    • (2010) Nature , vol.463 , pp. 963-967
    • Huppa, J.B.1    Axmann, M.2    Mortelmaier, M.A.3    Lillemeier, B.F.4    Newell, E.W.5
  • 65
    • 77950809538 scopus 로고    scopus 로고
    • The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
    • Huang J, Zarnitsyna VI, Liu B, Edwards LJ, Jiang N, et al. 2010. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. Nature 464:932-36
    • (2010) Nature , vol.464 , pp. 932-936
    • Huang, J.1    Zarnitsyna, V.I.2    Liu, B.3    Edwards, L.J.4    Jiang, N.5
  • 66
    • 0000359208 scopus 로고
    • Kinetic proofreading: A new mechanism for reducing errors in biosynthetic processes requiring high specificity
    • Hopfield JJ. 1974. Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity. PNAS 71:4135-39
    • (1974) PNAS , vol.71 , pp. 4135-4139
    • Hopfield, J.J.1
  • 67
    • 0029063148 scopus 로고
    • Kinetic proofreading in T-cell receptor signal transduction
    • McKeithan TW. 1995. Kinetic proofreading in T-cell receptor signal transduction. PNAS 92:5042-46
    • (1995) PNAS , vol.92 , pp. 5042-5046
    • McKeithan, T.W.1
  • 68
    • 27744588266 scopus 로고    scopus 로고
    • Understanding specificity and sensitivity of T-cell recognition
    • George AJ, Stark J, Chan C. 2005. Understanding specificity and sensitivity of T-cell recognition. Trends Immunol. 26:653-59
    • (2005) Trends Immunol. , vol.26 , pp. 653-659
    • George, A.J.1    Stark, J.2    Chan, C.3
  • 69
    • 73449105773 scopus 로고    scopus 로고
    • A role for rebinding in rapid and reliableTcell responses to antigen
    • Dushek O, Das R,Coombs D. 2009. A role for rebinding in rapid and reliableTcell responses to antigen. PLOS Comput. Biol. 5:e1000578
    • (2009) PLOS Comput. Biol. , vol.5 , pp. e1000578
    • Dushek, O.1    Das, R.2    Coombs, D.3
  • 70
    • 84874137801 scopus 로고    scopus 로고
    • Membrane dynamics shape TCR-generated signaling
    • He HT, Bongrand P. 2012. Membrane dynamics shape TCR-generated signaling. Front. Immunol. 3:90
    • (2012) Front. Immunol. , vol.3 , pp. 90
    • He, H.T.1    Bongrand, P.2
  • 71
    • 84876376859 scopus 로고    scopus 로고
    • Improved ligand discrimination by force-induced unbinding of the T cell receptor from peptide-MHC
    • Klotzsch E, Schutz GJ. 2013. Improved ligand discrimination by force-induced unbinding of the T cell receptor from peptide-MHC. Biophys. J. 104:1670-75
    • (2013) Biophys. J. , vol.104 , pp. 1670-1675
    • Klotzsch, E.1    Schutz, G.J.2
  • 72
    • 0025202863 scopus 로고
    • Local mechanical oscillations of the cell surface within the range 0. 2-30 Hz
    • Krol A, Grinfeldt MG, Levin SV, Smilgavichus AD. 1990. Local mechanical oscillations of the cell surface within the range 0.2-30 Hz. Eur. Biophys. J. 19:93-99
    • (1990) Eur. Biophys. J. , vol.19 , pp. 93-99
    • Krol, A.1    Grinfeldt, M.G.2    Levin, S.V.3    Smilgavichus, A.D.4
  • 75
    • 33144457671 scopus 로고    scopus 로고
    • Brownian motion of nucleated cell envelopes impedes adhesion
    • Zidovska A, Sackmann E. 2006. Brownian motion of nucleated cell envelopes impedes adhesion. Phys. Rev. Lett. 96:048103
    • (2006) Phys. Rev. Lett. , vol.96 , pp. 048103
    • Zidovska, A.1    Sackmann, E.2
  • 76
    • 84925503759 scopus 로고    scopus 로고
    • Use of TIRF to monitor T-lymphocyte membrane dynamics with submicrometer and subsecond resolution
    • In press
    • Brodovitch A, Limozin L, Bongrand P, Pierres A. 2014. Use of TIRF to monitor T-lymphocyte membrane dynamics with submicrometer and subsecond resolution. Cell. Mol. Bioeng. In press. doi: 10.1007/s12195-014-0361-8
    • (2014) Cell. Mol. Bioeng.
    • Brodovitch, A.1    Limozin, L.2    Bongrand, P.3    Pierres, A.4
  • 77
    • 84893837202 scopus 로고    scopus 로고
    • CD28 and CD3 have complementary roles in T-cell traction forces
    • Bashour KT, Gondarenko A, Chen H, Shen K, Liu X, et al. 2014. CD28 and CD3 have complementary roles in T-cell traction forces. PNAS 111:2241-46
    • (2014) PNAS , vol.111 , pp. 2241-2246
    • Bashour, K.T.1    Gondarenko, A.2    Chen, H.3    Shen, K.4    Liu, X.5
  • 80
    • 77953473256 scopus 로고    scopus 로고
    • Cutting edge: Mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling
    • Li YC, Chen BM, Wu PC, Cheng TL, Kao LS, et al. 2010. Cutting edge: Mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling. J. Immunol. 184:5959-63
    • (2010) J. Immunol. , vol.184 , pp. 5959-5963
    • Li, Y.C.1    Chen, B.M.2    Wu, P.C.3    Cheng, T.L.4    Kao, L.S.5
  • 82
    • 42049101786 scopus 로고    scopus 로고
    • The receptor deformation model of TCR triggering
    • Ma Z, Janmey PA, Finkel TH. 2008. The receptor deformation model of TCR triggering. FASEB J. 22:1002-8
    • (2008) FASEB J. , vol.22 , pp. 1002-1008
    • Ma, Z.1    Janmey, P.A.2    Finkel, T.H.3
  • 83
    • 84862978540 scopus 로고    scopus 로고
    • TCR mechanobiology: Torques and tunable structures linked to early T cell signaling
    • Kim ST, Shin Y, Brazin K, Mallis RJ, Sun ZY, et al. 2012. TCR mechanobiology: torques and tunable structures linked to early T cell signaling. Front. Immunol. 3:76
    • (2012) Front. Immunol. , vol.3 , pp. 76
    • Kim, S.T.1    Shin, Y.2    Brazin, K.3    Mallis, R.J.4    Sun, Z.Y.5
  • 84
    • 0025655401 scopus 로고
    • Localization of calcium and microfilament changes in mechanically stressed cells
    • HoroyanM,BenolielAM,Capo C, Bongrand P. 1990. Localization of calcium and microfilament changes in mechanically stressed cells. Cell Biophys. 17:243-56. http://www.hal.inserm.fr/inserm-00401740/fr/
    • (1990) Cell Biophys. , vol.17 , pp. 243-256
    • Horoyan, M.1    Benoliel, A.M.2    Capo, C.3    Bongrand, P.4
  • 85
    • 77954486800 scopus 로고    scopus 로고
    • Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
    • Grashoff C, Hoffman BD, BrennerMD, Zhou R, ParsonsM, et al. 2010. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature 466:263-66
    • (2010) Nature , vol.466 , pp. 263-266
    • Grashoff, C.1    Hoffman, B.D.2    Brenner, M.D.3    Zhou, R.4    Parsons, M.5
  • 88
    • 79959397904 scopus 로고    scopus 로고
    • Mechanisms of membrane curvature sensing
    • Antonny B. 2011. Mechanisms of membrane curvature sensing. Annu. Rev. Biochem. 80:101-23
    • (2011) Annu. Rev. Biochem. , vol.80 , pp. 101-123
    • Antonny, B.1
  • 89
    • 84896349895 scopus 로고    scopus 로고
    • The interdependence of membrane shape and cellular signal processing
    • Schmick M, Bastiaens PI. 2014. The interdependence of membrane shape and cellular signal processing. Cell 156:1132-38
    • (2014) Cell , vol.156 , pp. 1132-1138
    • Schmick, M.1    Bastiaens, P.I.2
  • 90
    • 84864131658 scopus 로고    scopus 로고
    • Substrate rigidity regulates human T cell activation and proliferation
    • O'Connor RS, Hao X, Shen K, Bashour K, Akimova T, et al. 2012. Substrate rigidity regulates human T cell activation and proliferation. J. Immunol. 189:1330-39
    • (2012) J. Immunol. , vol.189 , pp. 1330-1339
    • O'connor, R.S.1    Hao, X.2    Shen, K.3    Bashour, K.4    Akimova, T.5
  • 91
    • 84862628815 scopus 로고    scopus 로고
    • Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC
    • Xie J, Huppa JB, Newell EW, Huang J, Ebert PJ, et al. 2012. Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC. Nat. Immunol. 13:674-80
    • (2012) Nat. Immunol. , vol.13 , pp. 674-680
    • Xie, J.1    Huppa, J.B.2    Newell, E.W.3    Huang, J.4    Ebert, P.J.5
  • 93
    • 84892719664 scopus 로고    scopus 로고
    • Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling
    • Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. 2014. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat. Immunol. 15:186-94
    • (2014) Nat. Immunol. , vol.15 , pp. 186-194
    • Tan, Y.X.1    Manz, B.N.2    Freedman, T.S.3    Zhang, C.4    Shokat, K.M.5    Weiss, A.6
  • 94
    • 84923264984 scopus 로고    scopus 로고
    • Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor
    • Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, et al. 2014. Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor. Nat. Commun. 5:5624
    • (2014) Nat. Commun. , vol.5 , pp. 5624
    • Casas, J.1    Brzostek, J.2    Zarnitsyna, V.I.3    Hong, J.S.4    Wei, Q.5
  • 95
    • 84884220136 scopus 로고    scopus 로고
    • Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC
    • Hoerter JA, Brzostek J, Artyomov MN, Abel SM, Casas J, et al. 2013. Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC. J. Exp.Med. 210:1807-21
    • (2013) J. Exp.Med. , vol.210 , pp. 1807-1821
    • Hoerter, J.A.1    Brzostek, J.2    Artyomov, M.N.3    Abel, S.M.4    Casas, J.5
  • 96
    • 15044358353 scopus 로고    scopus 로고
    • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
    • Krogsgaard M, Li QJ, Sumen C, Huppa JB, Huse M, Davis MM. 2005. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 434:238-43
    • (2005) Nature , vol.434 , pp. 238-243
    • Krogsgaard, M.1    Li, Q.J.2    Sumen, C.3    Huppa, J.B.4    Huse, M.5    Davis, M.M.6
  • 97
    • 0041695164 scopus 로고    scopus 로고
    • Continuous T cell receptor signaling required for synapse maintenance and full effector potential
    • Huppa JB, Gleimer M, Sumen C, Davis MM. 2003. Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immunol. 4:749-55
    • (2003) Nat. Immunol. , vol.4 , pp. 749-755
    • Huppa, J.B.1    Gleimer, M.2    Sumen, C.3    Davis, M.M.4
  • 98
    • 84888141725 scopus 로고    scopus 로고
    • Visualizing how T cells collect activation signals in vivo
    • Moreau HD, Bousso P. 2014. Visualizing how T cells collect activation signals in vivo. Curr. Opin. Immunol. 26:56-62
    • (2014) Curr. Opin. Immunol. , vol.26 , pp. 56-62
    • Moreau, H.D.1    Bousso, P.2
  • 99
    • 0026659406 scopus 로고
    • CD43 interferes with T-lymphocyte adhesion
    • Ardman B, Sikorski MA, Staunton DE. 1992. CD43 interferes with T-lymphocyte adhesion. PNAS 89:5001-5
    • (1992) PNAS , vol.89 , pp. 5001-5005
    • Ardman, B.1    Sikorski, M.A.2    Staunton, D.E.3
  • 100
    • 0023027034 scopus 로고
    • Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment
    • Bentley D, Toroian-Raymond A. 1986. Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment. Nature 323:712-15
    • (1986) Nature , vol.323 , pp. 712-715
    • Bentley, D.1    Toroian-Raymond, A.2
  • 102
    • 0034624809 scopus 로고    scopus 로고
    • Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes
    • Leupin O, Zaru R, Laroche T, Muller S, Valitutti S. 2000. Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes. Curr. Biol. 10:277-80
    • (2000) Curr. Biol. , vol.10 , pp. 277-280
    • Leupin, O.1    Zaru, R.2    Laroche, T.3    Muller, S.4    Valitutti, S.5
  • 103
    • 0030922973 scopus 로고    scopus 로고
    • Leukosialin (CD43) behavior during adhesion of human monocytic THP-1 cells to red blood cells
    • Soler M, Merant C, Servant C, Fraterno M, Allasia C, et al. 1997. Leukosialin (CD43) behavior during adhesion of human monocytic THP-1 cells to red blood cells. J. Leukocyte Biol. 61:609-18
    • (1997) J. Leukocyte Biol. , vol.61 , pp. 609-618
    • Soler, M.1    Merant, C.2    Servant, C.3    Fraterno, M.4    Allasia, C.5
  • 104
    • 84860333171 scopus 로고    scopus 로고
    • Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells
    • Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, et al. 2012. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J. Immunol. 188:3686-99
    • (2012) J. Immunol. , vol.188 , pp. 3686-3699
    • Sage, P.T.1    Varghese, L.M.2    Martinelli, R.3    Sciuto, T.E.4    Kamei, M.5
  • 105
    • 54949103906 scopus 로고    scopus 로고
    • Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C? Translocation
    • Yokosuka T, Kobayashi W, Sakata-Sogawa K, Takamatsu M, Hashimoto-Tane A, et al. 2008. Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C? translocation. Immunity 29:589-601
    • (2008) Immunity , vol.29 , pp. 589-601
    • Yokosuka, T.1    Kobayashi, W.2    Sakata-Sogawa, K.3    Takamatsu, M.4    Hashimoto-Tane, A.5
  • 106
    • 64049108784 scopus 로고    scopus 로고
    • The cellular context of T cell signaling
    • Dustin ML. 2009. The cellular context of T cell signaling. Immunity 30:482-92
    • (2009) Immunity , vol.30 , pp. 482-492
    • Dustin, M.L.1
  • 107
    • 77951688912 scopus 로고    scopus 로고
    • Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster
    • Vardhana S, Choudhuri K, Varma R, Dustin ML. 2010. Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity 32:531-40
    • (2010) Immunity , vol.32 , pp. 531-540
    • Vardhana, S.1    Choudhuri, K.2    Varma, R.3    Dustin, M.L.4
  • 108
    • 84895891752 scopus 로고    scopus 로고
    • Polarized release of T-cell-receptorenriched microvesicles at the immunological synapse
    • Choudhuri K, Llodra J, Roth EW, Tsai J, Gordo S, et al. 2014. Polarized release of T-cell-receptorenriched microvesicles at the immunological synapse. Nature 507:118-23
    • (2014) Nature , vol.507 , pp. 118-123
    • Choudhuri, K.1    Llodra, J.2    Roth, E.W.3    Tsai, J.4    Gordo, S.5
  • 110
    • 80054721880 scopus 로고    scopus 로고
    • CD4+ T-cell synapses involvemultiple distinct stages
    • Ueda H, MorphewMK, McIntosh JR,Davis MM. 2011. CD4+ T-cell synapses involvemultiple distinct stages. PNAS 108:17099-104
    • (2011) PNAS , vol.108 , pp. 17099-17104
    • Ueda, H.1    Morphew, M.K.2    McIntosh, J.R.3    Davis, M.M.4
  • 111
    • 84885347155 scopus 로고    scopus 로고
    • The actin-driven spatiotemporal organization of T-cell signaling at the system scale
    • Roybal KT, Sinai P, Verkade P, Murphy RF, Wulfing C. 2013. The actin-driven spatiotemporal organization of T-cell signaling at the system scale. Immunol. Rev. 256:133-47
    • (2013) Immunol. Rev. , vol.256 , pp. 133-147
    • Roybal, K.T.1    Sinai, P.2    Verkade, P.3    Murphy, R.F.4    Wulfing, C.5
  • 112
    • 0018420964 scopus 로고
    • Themechanism of T-cell mediated cytotoxicity. VI.T-cell projections and their role in target cell killing
    • SandersonCJ, Glauert AM. 1979. Themechanism of T-cell mediated cytotoxicity. VI.T-cell projections and their role in target cell killing. Immunology 36:119-29
    • (1979) Immunology , vol.36 , pp. 119-129
    • Sanderson, C.J.1    Glauert, A.M.2
  • 113
    • 84876775237 scopus 로고    scopus 로고
    • Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation
    • Pratama A, Ramiscal RR, Silva DG, Das SK, Athanasopoulos V, et al. 2013. Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. Immunity 38:669-80
    • (2013) Immunity , vol.38 , pp. 669-680
    • Pratama, A.1    Ramiscal, R.R.2    Silva, D.G.3    Das, S.K.4    Athanasopoulos, V.5
  • 114
    • 84880830434 scopus 로고    scopus 로고
    • The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells
    • Liang Y, Cucchetti M, Roncagalli R, Yokosuka T, Malzac A, et al. 2013. The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat. Immunol. 14:858-66
    • (2013) Nat. Immunol. , vol.14 , pp. 858-866
    • Liang, Y.1    Cucchetti, M.2    Roncagalli, R.3    Yokosuka, T.4    Malzac, A.5
  • 115
    • 84890561320 scopus 로고    scopus 로고
    • Themis sets the signal threshold for positive and negative selection in T-cell development
    • Fu G, Casas J, Rigaud S, Rybakin V, Lambolez F, et al. 2013. Themis sets the signal threshold for positive and negative selection in T-cell development. Nature 504:441-45
    • (2013) Nature , vol.504 , pp. 441-445
    • Fu, G.1    Casas, J.2    Rigaud, S.3    Rybakin, V.4    Lambolez, F.5
  • 116
    • 84897046940 scopus 로고    scopus 로고
    • Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
    • Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, et al. 2014. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat. Immunol. 15:384-92
    • (2014) Nat. Immunol. , vol.15 , pp. 384-392
    • Roncagalli, R.1    Hauri, S.2    Fiore, F.3    Liang, Y.4    Chen, Z.5
  • 118
    • 33748366578 scopus 로고    scopus 로고
    • Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1
    • Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, et al. 2006. Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. Nat. Struct. Mol. Biol. 13:798-805
    • (2006) Nat. Struct. Mol. Biol. , vol.13 , pp. 798-805
    • Houtman, J.C.1    Yamaguchi, H.2    Barda-Saad, M.3    Braiman, A.4    Bowden, B.5
  • 119
    • 81955164142 scopus 로고    scopus 로고
    • Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor
    • Sherman E, Barr V, Manley S, Patterson G, Balagopalan L, et al. 2011. Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor. Immunity 35:705-20
    • (2011) Immunity , vol.35 , pp. 705-720
    • Sherman, E.1    Barr, V.2    Manley, S.3    Patterson, G.4    Balagopalan, L.5
  • 120
    • 84888093616 scopus 로고    scopus 로고
    • The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo
    • Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, et al. 2013. The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo. Sci. Signal. 6:ra99
    • (2013) Sci. Signal. , vol.6 , pp. ra99
    • Kortum, R.L.1    Balagopalan, L.2    Alexander, C.P.3    Garcia, J.4    Pinski, J.M.5
  • 121
    • 80052211582 scopus 로고    scopus 로고
    • Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding
    • Kleiman LB, Maiwald T, Conzelmann H, Lauffenburger DA, Sorger PK. 2011. Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Mol. Cell 43:723-37
    • (2011) Mol. Cell , vol.43 , pp. 723-737
    • Kleiman, L.B.1    Maiwald, T.2    Conzelmann, H.3    Lauffenburger, D.A.4    Sorger, P.K.5
  • 123
    • 84923207688 scopus 로고    scopus 로고
    • Scientific method: Defend the integrity of physics
    • Ellis G, Silk J. 2014. Scientific method: Defend the integrity of physics. Nature 516:321-23
    • (2014) Nature , vol.516 , pp. 321-323
    • Ellis, G.1    Silk, J.2
  • 124
    • 84890506631 scopus 로고
    • Life at low Reynolds number
    • Purcell EM. 1977. Life at low Reynolds number. Am. J. Phys. 45:3-11
    • (1977) Am. J. Phys. , vol.45 , pp. 3-11
    • Purcell, E.M.1
  • 125
    • 34247127891 scopus 로고    scopus 로고
    • Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response
    • Kemp ML, Wille L, Lewis CL, Nicholson LB, Lauffenburger DA. 2007. Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response. J. Immunol. 178:4984-92
    • (2007) J. Immunol. , vol.178 , pp. 4984-4992
    • Kemp, M.L.1    Wille, L.2    Lewis, C.L.3    Nicholson, L.B.4    Lauffenburger, D.A.5
  • 126
    • 84904443484 scopus 로고    scopus 로고
    • Tcell receptor-dependent signal intensity dominantly controls CD4+ T cell polarization in vivo
    • van Panhuys N, Klauschen F,Germain RN. 2014.Tcell receptor-dependent signal intensity dominantly controls CD4+ T cell polarization in vivo. Immunity 41:63-74
    • (2014) Immunity , vol.41 , pp. 63-74
    • Van Panhuys, N.1    Klauschen, F.2    Germain, R.N.3
  • 127
    • 0016827251 scopus 로고
    • Migration and chemotaxis of anucleate cytoplasmic leukocyte fragments
    • Keller HU, Bessis M. 1975. Migration and chemotaxis of anucleate cytoplasmic leukocyte fragments. Nature 258:723-24
    • (1975) Nature , vol.258 , pp. 723-724
    • Keller, H.U.1    Bessis, M.2
  • 128
    • 0020449117 scopus 로고
    • The cytokineplast: Purified, stable, and functionalmotile machinery from human blood polymorphonuclear leukocytes
    • Malawista SE,De Boisfleury Chevance A. 1982. The cytokineplast: purified, stable, and functionalmotile machinery from human blood polymorphonuclear leukocytes. J. Cell Biol. 95:960-73
    • (1982) J. Cell Biol. , vol.95 , pp. 960-973
    • Malawista, S.E.1    De Boisfleury Chevance, A.2
  • 129
    • 84855479406 scopus 로고    scopus 로고
    • Actin disassembly clock determines shape and speed of lamellipodial fragments
    • Ofer N, Mogilner A, KerenK. 2011. Actin disassembly clock determines shape and speed of lamellipodial fragments. PNAS 108:20394-99
    • (2011) PNAS , vol.108 , pp. 20394-20399
    • Ofer, N.1    Mogilner, A.2    Keren, K.3
  • 130
    • 44349189707 scopus 로고    scopus 로고
    • Rapid signal transduction in living cells is a unique feature of mechanotransduction
    • Na S, Collin O, Chowdhury F, Tay B, Ouyang M, et al. 2008. Rapid signal transduction in living cells is a unique feature of mechanotransduction. PNAS 105:6626-31
    • (2008) PNAS , vol.105 , pp. 6626-6631
    • Na, S.1    Collin, O.2    Chowdhury, F.3    Tay, B.4    Ouyang, M.5
  • 131
    • 45249124996 scopus 로고    scopus 로고
    • A novel ZAP-70 dependent FRET based biosensor reveals kinase activity at both the immunological synapse and the antisynapse
    • Randriamampita C, Mouchacca P, Malissen B, Marguet D, Trautmann A, Lellouch AC. 2008. A novel ZAP-70 dependent FRET based biosensor reveals kinase activity at both the immunological synapse and the antisynapse. PLOS ONE 3:e1521
    • (2008) PLOS ONE , vol.3 , pp. e1521
    • Randriamampita, C.1    Mouchacca, P.2    Malissen, B.3    Marguet, D.4    Trautmann, A.5    Lellouch, A.C.6
  • 132
    • 0032864252 scopus 로고    scopus 로고
    • Spatial gradients of cellular phospho-proteins
    • Brown GC, Kholodenko BN. 1999. Spatial gradients of cellular phospho-proteins. FEBS Lett. 457:452-54
    • (1999) FEBS Lett. , vol.457 , pp. 452-454
    • Brown, G.C.1    Kholodenko, B.N.2
  • 133
    • 84866374306 scopus 로고    scopus 로고
    • A steep phosphoinositide bis-phosphate gradient forms during fungal filamentous growth
    • Vernay A, Schaub S, Guillas I, BassilanaM, Arkowitz RA. 2012. A steep phosphoinositide bis-phosphate gradient forms during fungal filamentous growth. J. Cell Biol. 198:711-30
    • (2012) J. Cell Biol. , vol.198 , pp. 711-730
    • Vernay, A.1    Schaub, S.2    Guillas, I.3    Bassilana, M.4    Arkowitz, R.A.5
  • 135
    • 0034698511 scopus 로고    scopus 로고
    • Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
    • Grabovsky V, Feigelson S, Chen C, Bleijs DA, Peled A, et al. 2000. Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions. J. Exp. Med. 192:495-506
    • (2000) J. Exp. Med. , vol.192 , pp. 495-506
    • Grabovsky, V.1    Feigelson, S.2    Chen, C.3    Bleijs, D.A.4    Peled, A.5
  • 137
    • 84874765320 scopus 로고    scopus 로고
    • Encoding and decoding cellular information through signaling dynamics
    • Purvis JE, Lahav G. 2013. Encoding and decoding cellular information through signaling dynamics. Cell 152:945-56
    • (2013) Cell , vol.152 , pp. 945-956
    • Purvis, J.E.1    Lahav, G.2
  • 138
    • 0037290768 scopus 로고    scopus 로고
    • Epitope dominance, competition andTcell affinitymaturation
    • Kedl RM,Kappler JW,Marrack P. 2003. Epitope dominance, competition andTcell affinitymaturation. Curr. Opin. Immunol. 15:120-27
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 120-127
    • Kedl, R.M.1    Kappler, J.W.2    Marrack, P.3
  • 139
    • 77953639786 scopus 로고    scopus 로고
    • Cutting edge: Lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production
    • Milner JD, Fazilleau N, McHeyzer-Williams M, Paul W. 2010. Cutting edge: lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production. J. Immunol. 184:6569-73
    • (2010) J. Immunol. , vol.184 , pp. 6569-6573
    • Milner, J.D.1    Fazilleau, N.2    McHeyzer-Williams, M.3    Paul, W.4
  • 140
    • 66449090934 scopus 로고    scopus 로고
    • Reprogramming cell fates: Reconciling rarity with robustness
    • Huang S. 2009. Reprogramming cell fates: reconciling rarity with robustness. BioEssays 31:546-60
    • (2009) BioEssays , vol.31 , pp. 546-560
    • Huang, S.1
  • 141
    • 78049424847 scopus 로고    scopus 로고
    • Diversity and plasticity of Th cell types predicted from regulatory network modelling
    • Naldi A, Carneiro J, Chaouiya C, Thieffry D. 2010. Diversity and plasticity of Th cell types predicted from regulatory network modelling. PLOS Comput. Biol. 6:e1000912
    • (2010) PLOS Comput. Biol. , vol.6 , pp. e1000912
    • Naldi, A.1    Carneiro, J.2    Chaouiya, C.3    Thieffry, D.4
  • 142
    • 0033555859 scopus 로고    scopus 로고
    • Emergent properties of networks of biological signaling pathways
    • Bhalla US, Iyengar R. 1999. Emergent properties of networks of biological signaling pathways. Science 283:381-87
    • (1999) Science , vol.283 , pp. 381-387
    • Bhalla, U.S.1    Iyengar, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.