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Volumn 189, Issue 3, 2012, Pages 1330-1339

Substrate rigidity regulates human T cell activation and proliferation

Author keywords

[No Author keywords available]

Indexed keywords

CD28 RECEPTOR; CD3 ANTIGEN; DIMETICONE; GAMMA INTERFERON; INTERLEUKIN 2; L SELECTIN; LYMPHOCYTE ANTIGEN RECEPTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 84864131658     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102757     Document Type: Article
Times cited : (238)

References (51)
  • 1
    • 34249868241 scopus 로고    scopus 로고
    • Adoptive T cell therapy for cancer in the clinic
    • DOI 10.1172/JCI32446
    • June, C. H. 2007. Adoptive T cell therapy for cancer in the clinic. J. Clin. Invest. 117: 1466-1476. (Pubitemid 46871329)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.6 , pp. 1466-1476
    • June, C.H.1
  • 2
    • 34248149835 scopus 로고    scopus 로고
    • Principles of adoptive T cell cancer therapy
    • DOI 10.1172/JCI31446
    • June, C. H. 2007. Principles of adoptive T cell cancer therapy. J. Clin. Invest. 117: 1204-1212. (Pubitemid 46718405)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.5 , pp. 1204-1212
    • June, C.H.1
  • 5
    • 0030994017 scopus 로고    scopus 로고
    • Extracellular matrix rigidity causes strengthening of integrin- cytoskeleton linkages
    • Choquet, D., D. P. Felsenfeld, and M. P. Sheetz. 1997. Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell 88: 39-48. (Pubitemid 27180329)
    • (1997) Cell , vol.88 , Issue.1 , pp. 39-48
    • Choquet, D.1    Felsenfeld, D.P.2    Sheetz, M.P.3
  • 6
    • 33747152561 scopus 로고    scopus 로고
    • Matrix Elasticity Directs Stem Cell Lineage Specification
    • DOI 10.1016/j.cell.2006.06.044, PII S0092867406009615
    • Engler, A. J., S. Sen, H. L. Sweeney, and D. E. Discher. 2006. Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689. (Pubitemid 44233625)
    • (2006) Cell , vol.126 , Issue.4 , pp. 677-689
    • Engler, A.J.1    Sen, S.2    Sweeney, H.L.3    Discher, D.E.4
  • 8
    • 0023155358 scopus 로고
    • Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3
    • Geppert, T. D., and P. E. Lipsky. 1987. Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3. J. Immunol. 138: 1660-1666. (Pubitemid 17040783)
    • (1987) Journal of Immunology , vol.138 , Issue.6 , pp. 1660-1666
    • Geppert, T.D.1    Lipsky, P.E.2
  • 10
    • 67349114397 scopus 로고    scopus 로고
    • T cell antigen receptor signaling and immunological synapse stability require myosin IIA
    • Ilani, T., G. Vasiliver-Shamis, S. Vardhana, A. Bretscher, and M. L. Dustin. 2009. T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat. Immunol. 10: 531-539.
    • (2009) Nat. Immunol. , vol.10 , pp. 531-539
    • Ilani, T.1    Vasiliver-Shamis, G.2    Vardhana, S.3    Bretscher, A.4    Dustin, M.L.5
  • 11
    • 0028961573 scopus 로고
    • Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy: Role of T cell actin cytoskeleton
    • Valitutti, S., M. Dessing, K. Aktories, H. Gallati, and A. Lanzavecchia. 1995. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy: role of T cell actin cytoskeleton. J. Exp. Med. 181: 577-584.
    • (1995) J. Exp. Med. , vol.181 , pp. 577-584
    • Valitutti, S.1    Dessing, M.2    Aktories, K.3    Gallati, H.4    Lanzavecchia, A.5
  • 12
    • 40149108609 scopus 로고    scopus 로고
    • Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    • Ma, Z., K. A. Sharp, P. A. Janmey, and T. H. Finkel. 2008. Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity. PLoS Biol. 6: e43.
    • (2008) PLoS Biol. , vol.6
    • Ma, Z.1    Sharp, K.A.2    Janmey, P.A.3    Finkel, T.H.4
  • 14
    • 77953473256 scopus 로고    scopus 로고
    • Cutting edge: Mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling
    • Li, Y. C., B. M. Chen, P. C. Wu, T. L. Cheng, L. S. Kao, M. H. Tao, A. Lieber, and S. R. Roffler. 2010. Cutting edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling. J. Immunol. 184: 5959-5963.
    • (2010) J. Immunol. , vol.184 , pp. 5959-5963
    • Li, Y.C.1    Chen, B.M.2    Wu, P.C.3    Cheng, T.L.4    Kao, L.S.5    Tao, M.H.6    Lieber, A.7    Roffler, S.R.8
  • 15
    • 55449138409 scopus 로고    scopus 로고
    • Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif
    • Xu, C., E. Gagnon, M. E. Call, J. R. Schnell, C. D. Schwieters, C. V. Carman, J. J. Chou, and K. W. Wucherpfennig. 2008. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell 135: 702-713.
    • (2008) Cell , vol.135 , pp. 702-713
    • Xu, C.1    Gagnon, E.2    Call, M.E.3    Schnell, J.R.4    Schwieters, C.D.5    Carman, C.V.6    Chou, J.J.7    Wucherpfennig, K.W.8
  • 16
    • 42649127027 scopus 로고    scopus 로고
    • The actin cytoskeleton in T cell activation
    • DOI 10.1146/annurev.immunol.26.021607.090347
    • Burkhardt, J. K., E. Carrizosa, and M. H. Shaffer. 2008. The actin cytoskeleton in T cell activation. Annu. Rev. Immunol. 26: 233-259. (Pubitemid 351600376)
    • (2008) Annual Review of Immunology , vol.26 , pp. 233-259
    • Burkhardt, J.K.1    Carrizosa, E.2    Shaffer, M.H.3
  • 17
    • 79953861194 scopus 로고    scopus 로고
    • Cell shape and substrate rigidity both regulate cell stiffness
    • Tee, S. Y., J. Fu, C. S. Chen, and P. A. Janmey. 2011. Cell shape and substrate rigidity both regulate cell stiffness. Biophys. J. 100: L25-L27.
    • (2011) Biophys. J. , vol.100
    • Tee, S.Y.1    Fu, J.2    Chen, C.S.3    Janmey, P.A.4
  • 19
    • 27544441784 scopus 로고    scopus 로고
    • Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
    • Campi, G., R. Varma, and M. L. Dustin. 2005. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J. Exp. Med. 202: 1031-1036.
    • (2005) J. Exp. Med. , vol.202 , pp. 1031-1036
    • Campi, G.1    Varma, R.2    Dustin, M.L.3
  • 20
    • 0011713787 scopus 로고
    • The relation between load and penetration in the axisymmetric Boussinesq problem for a punch of arbitrary profile
    • Sneddon, I. 1965. The relation between load and penetration in the axisymmetric Boussinesq problem for a punch of arbitrary profile. Int. J. Eng. Sci. 3: 47-57.
    • (1965) Int. J. Eng. Sci. , vol.3 , pp. 47-57
    • Sneddon, I.1
  • 21
    • 77953216589 scopus 로고    scopus 로고
    • Silicones in industrial applications
    • R. D. Jaeger, and M. Gleria, eds. Nova Science Publishers, New York
    • Androit, M., et al. 2007. Silicones in industrial applications. In Inorganic Polymers. R. D. Jaeger, and M. Gleria, eds. Nova Science Publishers, New York, p. 61-161.
    • (2007) Inorganic Polymers , pp. 61-161
    • Androit, M.1
  • 22
    • 0024506159 scopus 로고
    • Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway
    • Lindstein, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thompson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244: 339-343. (Pubitemid 19117870)
    • (1989) Science , vol.244 , Issue.4902 , pp. 339-343
    • Lindsten, T.1    June, C.H.2    Ledbetter, J.A.3    Stella, G.4    Thompson, C.B.5
  • 23
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone, N. A., and G. R. Crabtree. 1992. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357: 695-697.
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 25
    • 0035060814 scopus 로고    scopus 로고
    • On the adsorption of proteins on solid surfaces, a common but very complicated phenomenon
    • DOI 10.1016/S1389-1723(01)80127-4
    • Nakanishi, K., T. Sakiyama, and K. Imamura. 2001. On the adsorption of proteins on solid surfaces, a common but very complicated phenomenon. J. Biosci. Bioeng. 91: 233-244. (Pubitemid 32324614)
    • (2001) Journal of Bioscience and Bioengineering , vol.91 , Issue.3 , pp. 233-244
    • Nakanishi, K.1    Sakiyama, T.2    Imamura, K.3
  • 26
    • 33645238778 scopus 로고    scopus 로고
    • Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems
    • Mata, A., A. J. Fleischman, and S. Roy. 2005. Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems. Biomed. Microdevices 7: 281-293.
    • (2005) Biomed. Microdevices , vol.7 , pp. 281-293
    • Mata, A.1    Fleischman, A.J.2    Roy, S.3
  • 27
    • 0344306445 scopus 로고    scopus 로고
    • Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus
    • Gray, D. S., J. Tien, and C. S. Chen. 2003. Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus. J. Biomed. Mater. Res. A 66: 605-614. (Pubitemid 37517206)
    • (2003) Journal of Biomedical Materials Research - Part A , vol.66 , Issue.3 , pp. 605-614
    • Gray, D.S.1    Tien, J.2    Chen, C.S.3
  • 28
    • 10644246059 scopus 로고    scopus 로고
    • Evaluation of polydimethylsiloxane scaffolds with physiologically- relevant elastic moduli: Interplay of substrate mechanics and surface chemistry effects on vascular smooth muscle cell response
    • DOI 10.1016/j.biomaterials.2004.08.009, PII S0142961204007586
    • Brown, X. Q., K. Ookawa, and J. Y. Wong. 2005. Evaluation of polydimethylsiloxane scaffolds with physiologically-relevant elastic moduli: interplay of substrate mechanics and surface chemistry effects on vascular smooth muscle cell response. Biomaterials 26: 3123-3129. (Pubitemid 39647247)
    • (2005) Biomaterials , vol.26 , Issue.16 , pp. 3123-3129
    • Brown, X.Q.1    Ookawa, K.2    Wong, J.Y.3
  • 29
    • 0842325726 scopus 로고    scopus 로고
    • Actin Cytoskeleton Regulates Calcium Dynamics and NFAT Nuclear Duration
    • DOI 10.1128/MCB.24.4.1628-1639.2004
    • Rivas, F. V., J. P. O'Keefe, M. L. Alegre, and T. F. Gajewski. 2004. Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration. Mol. Cell. Biol. 24: 1628-1639. (Pubitemid 38167084)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.4 , pp. 1628-1639
    • Rivas, F.V.1    O'Keefe, J.P.2    Alegre, M.-L.3    Gajewski, T.F.4
  • 30
    • 0035075507 scopus 로고    scopus 로고
    • Dynamic actin polymerization drives T cell receptor-induced spreading: A role for the signal transduction adaptor LAT
    • DOI 10.1016/S1074-7613(01)00112-1
    • Bunnell, S. C., V. Kapoor, R. P. Trible, W. Zhang, and L. E. Samelson. 2001. Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity 14: 315-329. (Pubitemid 32289295)
    • (2001) Immunity , vol.14 , Issue.3 , pp. 315-329
    • Bunnell, S.C.1    Kapoor, V.2    Trible, R.P.3    Zhang, W.4    Samelson, L.E.5
  • 31
    • 0034979287 scopus 로고    scopus 로고
    • Probing the relation between force - Lifetime - And chemistry in single molecular bonds
    • DOI 10.1146/annurev.biophys.30.1.105
    • Evans, E. 2001. Probing the relation between force - lifetime - and chemistry in single molecular bonds. Annu. Rev. Biophys. Biomol. Struct. 30: 105-128. (Pubitemid 32566158)
    • (2001) Annual Review of Biophysics and Biomolecular Structure , vol.30 , pp. 105-128
    • Evans, E.1
  • 32
    • 0033531109 scopus 로고    scopus 로고
    • Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy
    • DOI 10.1038/16219
    • Merkel, R., P. Nassoy, A. Leung, K. Ritchie, and E. Evans. 1999. Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy. Nature 397: 50-53. (Pubitemid 29038244)
    • (1999) Nature , vol.397 , Issue.6714 , pp. 50-53
    • Merkel, R.1    Nassoy, P.2    Leung, A.3    Ritchie, K.4    Evans, E.5
  • 33
    • 0035844869 scopus 로고    scopus 로고
    • Focal contacts as mechanosensors: Externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism
    • Riveline, D., E. Zamir, N. Q. Balaban, U. S. Schwarz, T. Ishizaki, S. Narumiya, Z. Kam, B. Geiger, and A. D. Bershadsky. 2001. Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J. Cell Biol. 153: 1175-1186.
    • (2001) J. Cell Biol. , vol.153 , pp. 1175-1186
    • Riveline, D.1    Zamir, E.2    Balaban, N.Q.3    Schwarz, U.S.4    Ishizaki, T.5    Narumiya, S.6    Kam, Z.7    Geiger, B.8    Bershadsky, A.D.9
  • 34
    • 79955538660 scopus 로고    scopus 로고
    • Actomyosin-generated tension controls the molecular kinetics of focal adhesions
    • Wolfenson, H., A. Bershadsky, Y. I. Henis, and B. Geiger. 2011. Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J. Cell Sci. 124: 1425-1432.
    • (2011) J. Cell Sci. , vol.124 , pp. 1425-1432
    • Wolfenson, H.1    Bershadsky, A.2    Henis, Y.I.3    Geiger, B.4
  • 35
    • 0031571195 scopus 로고    scopus 로고
    • T Cell Receptor Engagement Induces Tyrosine Phosphorylation of FAK and Pyk2 and their Association with Lck
    • Berg, N. N., and H. L. Ostergaard. 1997. T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck. J. Immunol. 159: 1753-1757. (Pubitemid 127484161)
    • (1997) Journal of Immunology , vol.159 , Issue.4 , pp. 1753-1757
    • Berg, N.N.1    Ostergaard, H.L.2
  • 37
    • 77952321910 scopus 로고    scopus 로고
    • T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells
    • Collins, M., R. R. Bartelt, and J. C. Houtman. 2010. T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells. Mol. Immunol. 47: 1665-1674.
    • (2010) Mol. Immunol. , vol.47 , pp. 1665-1674
    • Collins, M.1    Bartelt, R.R.2    Houtman, J.C.3
  • 38
    • 29144503720 scopus 로고    scopus 로고
    • A role for phosphatidylinositol 3-kinase in TCR-stimulated ERK activation leading to paxillin phosphorylation and CTL degranulation
    • Robertson, L. K., L. R. Mireau, and H. L. Ostergaard. 2005. A role for phosphatidylinositol 3-kinase in TCR-stimulated ERK activation leading to paxillin phosphorylation and CTL degranulation. J. Immunol. 175: 8138-8145. (Pubitemid 41798377)
    • (2005) Journal of Immunology , vol.175 , Issue.12 , pp. 8138-8145
    • Robertson, L.K.1    Mireau, L.R.2    Ostergaard, H.L.3
  • 39
    • 34548259213 scopus 로고    scopus 로고
    • WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse
    • DOI 10.1128/MCB.00136-07
    • Nolz, J. C., R. B. Medeiros, J. S. Mitchell, P. Zhu, B. D. Freedman, Y. Shimizu, and D. D. Billadeau. 2007. WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Mol. Cell. Biol. 27: 5986-6000. (Pubitemid 47326689)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.17 , pp. 5986-6000
    • Nolz, J.C.1    Medeiros, R.B.2    Mitchell, J.S.3    Zhu, P.4    Freedman, B.D.5    Shimizu, Y.6    Billadeau, D.D.7
  • 41
    • 4143132014 scopus 로고    scopus 로고
    • Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming
    • DOI 10.1126/science.1099159
    • Benvenuti, F., S. Hugues, M. Walmsley, S. Ruf, L. Fetler, M. Popoff, V. L. Tybulewicz, and S. Amigorena. 2004. Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science 305: 1150-1153. (Pubitemid 39100327)
    • (2004) Science , vol.305 , Issue.5687 , pp. 1150-1153
    • Benvenuti, F.1    Hugues, S.2    Walmsley, M.3    Ruf, S.4    Fetler, L.5    Popoff, M.6    Tybulewicz, V.L.J.7    Amigorena, S.8
  • 42
    • 0142242134 scopus 로고    scopus 로고
    • Cutting Edge: Dendritic Cell Actin Cytoskeletal Polarization during Immunological Synapse Formation Is Highly Antigen-Dependent
    • Al-Alwan, M. M., R. S. Liwski, S. M. Haeryfar, W. H. Baldridge, D. W. Hoskin, G. Rowden, and K. A. West. 2003. Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent. J. Immunol. 171: 4479-4483. (Pubitemid 37310562)
    • (2003) Journal of Immunology , vol.171 , Issue.9 , pp. 4479-4483
    • Al-Alwan, M.M.1    Liwski, R.S.2    Haeryfar, S.M.M.3    Baldridge, W.H.4    Hoskin, D.W.5    Rowden, G.6    West, K.A.7
  • 43
    • 0035253596 scopus 로고    scopus 로고
    • Cutting edge: The dendritic cell cytoskeleton is critical for the formation of the immunological synapse
    • Al-Alwan, M. M., G. Rowden, T. D. Lee, and K. A. West. 2001. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J. Immunol. 166: 1452-1456. (Pubitemid 32114622)
    • (2001) Journal of Immunology , vol.166 , Issue.3 , pp. 1452-1456
    • Al-Alwan, M.M.1    Rowden, G.2    Lee, T.D.G.3    West, K.A.4
  • 44
    • 0030587897 scopus 로고    scopus 로고
    • Subcellular Localization of CD80 Receptors Is Dependent on an Intact Cytoplasmic Tail and Is Required for CD28-Dependent T Cell Costimulation
    • Doty, R. T., and E. A. Clark. 1996. Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation. J. Immunol. 157: 3270-3279. (Pubitemid 126449136)
    • (1996) Journal of Immunology , vol.157 , Issue.8 , pp. 3270-3279
    • Doty, R.T.1    Clark, E.A.2
  • 45
    • 29144467684 scopus 로고    scopus 로고
    • CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse
    • Tseng, S. Y., M. Liu, and M. L. Dustin. 2005. CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse. J. Immunol. 175: 7829-7836. (Pubitemid 41798343)
    • (2005) Journal of Immunology , vol.175 , Issue.12 , pp. 7829-7836
    • Tseng, S.-Y.1    Liu, M.2    Dustin, M.L.3
  • 46
    • 0028799945 scopus 로고
    • Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells
    • Constant, S., C. Pfeiffer, A. Woodard, T. Pasqualini, and K. Bottomly. 1995. Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J. Exp. Med. 182: 1591-1596.
    • (1995) J. Exp. Med. , vol.182 , pp. 1591-1596
    • Constant, S.1    Pfeiffer, C.2    Woodard, A.3    Pasqualini, T.4    Bottomly, K.5
  • 47
    • 0028874351 scopus 로고
    • The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model
    • Hosken, N. A., K. Shibuya, A. W. Heath, K. M. Murphy, and A. O'Garra. 1995. The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J. Exp. Med. 182: 1579-1584.
    • (1995) J. Exp. Med. , vol.182 , pp. 1579-1584
    • Hosken, N.A.1    Shibuya, K.2    Heath, A.W.3    Murphy, K.M.4    O'Garra, A.5
  • 48
    • 0032532650 scopus 로고    scopus 로고
    • High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines
    • Rogers, P. R., G. Huston, and S. L. Swain. 1998. High antigen density and IL-2 are required for generation of CD4 effectors secreting Th1 rather than Th0 cytokines. J. Immunol. 161: 3844-3852. (Pubitemid 28468957)
    • (1998) Journal of Immunology , vol.161 , Issue.8 , pp. 3844-3852
    • Rogers, P.R.1    Huston, G.2    Swain, S.L.3
  • 49
    • 0033179403 scopus 로고    scopus 로고
    • Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance
    • Rogers, P. R., and M. Croft. 1999. Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance. J. Immunol. 163: 1205-1213. (Pubitemid 29352735)
    • (1999) Journal of Immunology , vol.163 , Issue.3 , pp. 1205-1213
    • Rogers, P.R.1    Croft, M.2


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