-
1
-
-
0028014460
-
Signal transduction by lymphocyte antigen receptors
-
Weiss, A. & Littman, D. R. Signal transduction by lymphocyte antigen receptors. Cell 76, 263-274 (1994).
-
(1994)
Cell
, vol.76
, pp. 263-274
-
-
Weiss, A.1
Littman, D.R.2
-
2
-
-
4043083712
-
-
ed. Paul, W. E. Lippincott Williams & Wilkins, Philadelphia
-
Weiss, A. & Samelson, L. E. in Fundamental Immunology (ed. Paul, W. E.) 321-364 (Lippincott Williams & Wilkins, Philadelphia, 2003).
-
(2003)
Fundamental Immunology
, pp. 321-364
-
-
Weiss, A.1
Samelson, L.E.2
-
3
-
-
0037188899
-
Recruitment of Nck by CD3ε reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation
-
Gil, D., Schamel, W. W., Montoya, M., Sanchez-Madrid, F. & Alarcon, B. Recruitment of Nck by CD3ε reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell 109, 901-912 (2002).
-
(2002)
Cell
, vol.109
, pp. 901-912
-
-
Gil, D.1
Schamel, W.W.2
Montoya, M.3
Sanchez-Madrid, F.4
Alarcon, B.5
-
4
-
-
14244262563
-
T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes
-
Gil, D., Schrum, A. G., Alarcon, B. & Palmer, E. T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes. J. Exp. Med. 201, 517-522 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 517-522
-
-
Gil, D.1
Schrum, A.G.2
Alarcon, B.3
Palmer, E.4
-
5
-
-
45849147745
-
T cell receptor engagement triggers its CD3ε and CD3ζ subunits to adopt a compact, locked conformation
-
Risueno, R. M., Schamel, W. W. & Alarcon, B. T cell receptor engagement triggers its CD3ε and CD3ζ subunits to adopt a compact, locked conformation. PLoS ONE 3, e1747 (2008).
-
(2008)
PLoS ONE
, vol.3
-
-
Risueno, R.M.1
Schamel, W.W.2
Alarcon, B.3
-
6
-
-
0033762433
-
Phosphorylation of T cell receptor ζ is regulated by a lipid dependent folding transition
-
Aivazian, D. & Stern, L. J. Phosphorylation of T cell receptor ζ is regulated by a lipid dependent folding transition. Nature Struct. Biol. 7, 1023-1026 (2000).
-
(2000)
Nature Struct. Biol.
, vol.7
, pp. 1023-1026
-
-
Aivazian, D.1
Stern, L.J.2
-
7
-
-
55449138409
-
Regulation of T cell receptor activation by dynamic membrane binding of the CD3ε cytoplasmic tyrosine-based motif
-
Xu, C. et al. Regulation of T cell receptor activation by dynamic membrane binding of the CD3ε cytoplasmic tyrosine-based motif. Cell 135, 702-713 (2008).
-
(2008)
Cell
, vol.135
, pp. 702-713
-
-
Xu, C.1
-
8
-
-
0030176270
-
Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
-
Sykulev, Y., Joo, M., Vturina, I., Tsomides, T. J. & Eisen, H. N. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 4, 565-571 (1996).
-
(1996)
Immunity
, vol.4
, pp. 565-571
-
-
Sykulev, Y.1
Joo, M.2
Vturina, I.3
Tsomides, T.J.4
Eisen, H.N.5
-
9
-
-
0037167816
-
Direct observation of ligand recognition by T cells
-
Irvine, D. J., Purbhoo, M. A., Krogsgaard, M. & Davis, M. M. Direct observation of ligand recognition by T cells. Nature 419, 845-849 (2002).
-
(2002)
Nature
, vol.419
, pp. 845-849
-
-
Irvine, D.J.1
Purbhoo, M.A.2
Krogsgaard, M.3
Davis, M.M.4
-
10
-
-
2442651482
-
T cell killing does not require the formation of a stable mature immunological synapse
-
Purbhoo, M. A., Irvine, D. J., Huppa, J. B. & Davis, M. M. T cell killing does not require the formation of a stable mature immunological synapse. Nature Immunol. 5, 524-530 (2004).
-
(2004)
Nature Immunol.
, vol.5
, pp. 524-530
-
-
Purbhoo, M.A.1
Irvine, D.J.2
Huppa, J.B.3
Davis, M.M.4
-
11
-
-
0033180491
-
The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
-
Ernst, B., Lee, D., Chang, J. M., Sprent, J. & Surh, C. D. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. Immunity 11, 173-181 (1999).
-
(1999)
Immunity
, vol.11
, pp. 173-181
-
-
Ernst, B.1
Lee, D.2
Chang, J.M.3
Sprent, J.4
Surh, C.D.5
-
13
-
-
0033136944
-
Designing and maintaining the mature TCR repertoire: The continuum of self-peptide:self-MHC complex recognition
-
Viret, C., Wong, F. S. & Janeway, C. A. Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition. Immunity 10, 559-568 (1999).
-
(1999)
Immunity
, vol.10
, pp. 559-568
-
-
Viret, C.1
Wong, F.S.2
Janeway, C.A.3
-
14
-
-
61349149901
-
Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper
-
Palmer, E. & Naeher, D. Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nature Rev. Immunol. 9, 207-213 (2009).
-
(2009)
Nature Rev. Immunol.
, vol.9
, pp. 207-213
-
-
Palmer, E.1
Naeher, D.2
-
15
-
-
34447647655
-
Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist
-
Huse, M. et al. Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity 27, 76-88 (2007).
-
(2007)
Immunity
, vol.27
, pp. 76-88
-
-
Huse, M.1
-
16
-
-
27844541328
-
Modeling T cell antigen discrimination based on feedback control of digital ERK responses
-
Altan-Bonnet, G. & Germain, R. N. Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol. 3, e356 (2005).
-
(2005)
PLoS Biol.
, vol.3
-
-
Altan-Bonnet, G.1
Germain, R.N.2
-
17
-
-
0035826696
-
Cooperative enhancement of specificity in a lattice of T cell receptors
-
Chan, C., George, A. J. & Stark, J. Cooperative enhancement of specificity in a lattice of T cell receptors. Proc. Natl Acad. Sci. USA 98, 5758-5763 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5758-5763
-
-
Chan, C.1
George, A.J.2
Stark, J.3
-
18
-
-
33645892299
-
A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex
-
Schamel, W. W., Risueno, R. M., Minguet, S., Ortiz, A. R. & Alarcon, B. A conformation- and avidity-based proofreading mechanism for the TCR-CD3 complex. Trends Immunol. 27, 176-182 (2006).
-
(2006)
Trends Immunol.
, vol.27
, pp. 176-182
-
-
Schamel, W.W.1
Risueno, R.M.2
Minguet, S.3
Ortiz, A.R.4
Alarcon, B.5
-
19
-
-
0032968708
-
The dynamics of T cell receptor signaling: Complex orchestration and the key roles of tempo and cooperation
-
Germain, R. N. & Stefanova, I. The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu. Rev. Immunol. 17, 467-522 (1999).
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 467-522
-
-
Germain, R.N.1
Stefanova, I.2
-
20
-
-
0037338890
-
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
-
Stefanova, I. et al. TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways. Nature Immunol. 4, 248-254 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 248-254
-
-
Stefanova, I.1
-
21
-
-
0042470456
-
Positive and negative selection of T cells
-
Starr, T. K., Jameson, S. C. & Hogquist, K. A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21, 139-176 (2003).
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 139-176
-
-
Starr, T.K.1
Jameson, S.C.2
Hogquist, K.A.3
-
22
-
-
58649114309
-
The molecular basis of TCR germline bias for MHC is surprisingly simple
-
Garcia, K. C., Adams, J. J., Feng, D. & Ely, L. K. The molecular basis of TCR germline bias for MHC is surprisingly simple. Nature Immunol. 10, 143-147 (2009).
-
(2009)
Nature Immunol.
, vol.10
, pp. 143-147
-
-
Garcia, K.C.1
Adams, J.J.2
Feng, D.3
Ely, L.K.4
-
23
-
-
42649112362
-
Evolutionarily conserved amino acids that control TCR-MHC interaction
-
Marrack, P., Scott-Browne, J. P., Dai, S., Gapin, L. & Kappler, J. W. Evolutionarily conserved amino acids that control TCR-MHC interaction. Annu. Rev. Immunol. 26, 171-203 (2008).
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 171-203
-
-
Marrack, P.1
Scott-Browne, J.P.2
Dai, S.3
Gapin, L.4
Kappler, J.W.5
-
24
-
-
33646181088
-
How TCRs bind MHCs, peptides, and coreceptors
-
Rudolph, M. G., Stanfield, R. L. & Wilson, I. A. How TCRs bind MHCs, peptides, and coreceptors. Annu. Rev. Immunol. 24, 419-466 (2006).
-
(2006)
Annu. Rev. Immunol.
, vol.24
, pp. 419-466
-
-
Rudolph, M.G.1
Stanfield, R.L.2
Wilson, I.A.3
-
25
-
-
27544446623
-
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide
-
Tynan, F. E. et al. T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nature Immunol. 6, 1114-1122 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 1114-1122
-
-
Tynan, F.E.1
-
26
-
-
77953742968
-
Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability
-
Burrows, S. R. et al. Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proc. Natl Acad. Sci. USA 107, 10608-10613 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 10608-10613
-
-
Burrows, S.R.1
-
27
-
-
34447286463
-
Molecular mechanisms involved in T cell receptor triggering
-
Choudhuri, K. & van der Merwe, P. A. Molecular mechanisms involved in T cell receptor triggering. Semin. Immunol. 19, 255-261 (2007).
-
(2007)
Semin. Immunol.
, vol.19
, pp. 255-261
-
-
Choudhuri, K.1
Van Der Merwe, P.A.2
-
28
-
-
0029037210
-
Serial triggering of many T-cell receptors by a few peptide-MHC complexes
-
Valitutti, S., Müller, S., Cella, M., Padovan, E. & Lanzavecchia, A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148-151 (1995).
-
(1995)
Nature
, vol.375
, pp. 148-151
-
-
Valitutti, S.1
Müller, S.2
Cella, M.3
Padovan, E.4
Lanzavecchia, A.5
-
29
-
-
0029063148
-
Kinetic proofreading in T-cell receptor signal transduction
-
McKeithan, T. W. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl Acad. Sci. USA 92, 5042-5046 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5042-5046
-
-
McKeithan, T.W.1
-
30
-
-
0029926145
-
Kinetic discrimination in T-cell activation
-
Rabinowitz, J. D., Beeson, C., Lyons, D. S., Davis, M. M. & McConnell, H. M. Kinetic discrimination in T-cell activation. Proc. Natl Acad. Sci. USA 93, 1401-1405 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 1401-1405
-
-
Rabinowitz, J.D.1
Beeson, C.2
Lyons, D.S.3
Davis, M.M.4
McConnell, H.M.5
-
31
-
-
44349161113
-
A mechanism for SRC kinase-dependent signaling by noncatalytic receptors
-
Cooper, J. A. & Qian, H. A mechanism for SRC kinase-dependent signaling by noncatalytic receptors. Biochemistry 47, 5681-5688 (2008).
-
(2008)
Biochemistry
, vol.47
, pp. 5681-5688
-
-
Cooper, J.A.1
Qian, H.2
-
32
-
-
0042266247
-
Initiation of TCR signalling revisited
-
Trautmann, A. & Randriamampita, C. Initiation of TCR signalling revisited. Trends Immunol. 24, 425-428 (2003).
-
(2003)
Trends Immunol.
, vol.24
, pp. 425-428
-
-
Trautmann, A.1
Randriamampita, C.2
-
33
-
-
0027488625
-
Helper T cells without CD4: Control of leishmaniasis in CD4-deficient mice
-
Locksley, R. M., Reiner, S. L., Hatam, F., Littman, D. R. & Killeen, N. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 261, 1448-1451 (1993).
-
(1993)
Science
, vol.261
, pp. 1448-1451
-
-
Locksley, R.M.1
Reiner, S.L.2
Hatam, F.3
Littman, D.R.4
Killeen, N.5
-
34
-
-
0027322465
-
Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8
-
Schilham, M. W. et al. Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8. Eur. J. Immunol. 23, 1299-1304 (1993).
-
(1993)
Eur. J. Immunol.
, vol.23
, pp. 1299-1304
-
-
Schilham, M.W.1
-
35
-
-
15044358353
-
Agonist/endogenous peptide- MHC heterodimers drive T cell activation and sensitivity
-
Krogsgaard, M. et al. Agonist/endogenous peptide- MHC heterodimers drive T cell activation and sensitivity. Nature 434, 238-243 (2005).
-
(2005)
Nature
, vol.434
, pp. 238-243
-
-
Krogsgaard, M.1
-
36
-
-
34447281286
-
A role for self in T-cell activation
-
Krogsgaard, M., Juang, J. & Davis, M. M. A role for "self" in T-cell activation. Semin. Immunol. 19, 236-244 (2007).
-
(2007)
Semin. Immunol.
, vol.19
, pp. 236-244
-
-
Krogsgaard, M.1
Juang, J.2
Davis, M.M.3
-
37
-
-
77953506249
-
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection
-
Juang, J. et al. Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J. Exp. Med. 207, 1223-1234 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1223-1234
-
-
Juang, J.1
-
38
-
-
0033082989
-
Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands
-
Alam, S. M. et al. Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity 10, 227-237 (1999).
-
(1999)
Immunity
, vol.10
, pp. 227-237
-
-
Alam, S.M.1
-
39
-
-
0030926137
-
Ligand-specific oligomerization of T-cell receptor molecules
-
Reich, Z. et al. Ligand-specific oligomerization of T-cell receptor molecules. Nature 387, 617-620 (1997).
-
(1997)
Nature
, vol.387
, pp. 617-620
-
-
Reich, Z.1
-
40
-
-
77950426522
-
Evidence for a functional sidedness to the αβTCR
-
Kuhns, M. S. et al. Evidence for a functional sidedness to the αβTCR. Proc. Natl Acad. Sci. USA 107, 5094-5099 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 5094-5099
-
-
Kuhns, M.S.1
-
41
-
-
74049157769
-
TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
-
Lillemeier, B. F. et al. TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation. Nature Immunol. 11, 90-96 (2010).
-
(2010)
Nature Immunol.
, vol.11
, pp. 90-96
-
-
Lillemeier, B.F.1
-
42
-
-
23944469458
-
Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response
-
Schamel, W. W. et al. Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response. J. Exp. Med. 202, 493-503 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 493-503
-
-
Schamel, W.W.1
-
43
-
-
33746011209
-
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
-
Varma, R., Campi, G., Yokosuka, T., Saito, T. & Dustin, M. L. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 25, 117-127 (2006).
-
(2006)
Immunity
, vol.25
, pp. 117-127
-
-
Varma, R.1
Campi, G.2
Yokosuka, T.3
Saito, T.4
Dustin, M.L.5
-
44
-
-
69349092619
-
DySCo: Quantitating associations of membrane proteins using two-color single-molecule tracking
-
Dunne, P. D. et al. DySCo: quantitating associations of membrane proteins using two-color single-molecule tracking. Biophys. J. 97, L5-L7 (2009).
-
(2009)
Biophys. J.
, vol.97
-
-
Dunne, P.D.1
-
45
-
-
36749064485
-
Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells
-
James, J. R. et al. Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells. Proc. Natl Acad. Sci. USA 104, 17662-17667 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 17662-17667
-
-
James, J.R.1
-
46
-
-
74049144148
-
Taking T cells beyond the diffraction limit
-
Van Der Merwe, P. A., Dunne, P. D., Klenerman, D. & Davis, S. J. Taking T cells beyond the diffraction limit. Nature Immunol. 11, 51-52 (2010).
-
(2010)
Nature Immunol.
, vol.11
, pp. 51-52
-
-
Van Der Merwe, P.A.1
Dunne, P.D.2
Klenerman, D.3
Davis, S.J.4
-
47
-
-
30044441433
-
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
-
Yokosuka, T. et al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nature Immunol. 6, 1253-1262 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 1253-1262
-
-
Yokosuka, T.1
-
48
-
-
27544441784
-
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
-
Campi, G., Varma, R. & Dustin, M. L. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J. Exp. Med. 202, 1031-1036 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1031-1036
-
-
Campi, G.1
Varma, R.2
Dustin, M.L.3
-
49
-
-
0037144842
-
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
-
Bunnell, S. C. et al. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J. Cell Biol. 158, 1263-1275 (2002).
-
(2002)
J. Cell Biol.
, vol.158
, pp. 1263-1275
-
-
Bunnell, S.C.1
-
50
-
-
0037240790
-
A structural basis for the selection of dominant a(3 T cell receptors in antiviral immunity
-
Kjer-Nielsen, L. et al. A structural basis for the selection of dominant a(3 T cell receptors in antiviral immunity. Immunity 18, 53-64 (2003).
-
(2003)
Immunity
, vol.18
, pp. 53-64
-
-
Kjer-Nielsen, L.1
-
51
-
-
67349283033
-
Antigen ligation triggers a conformational change within the constant domain of the a(3 T cell receptor
-
Beddoe, T. et al. Antigen ligation triggers a conformational change within the constant domain of the a(3 T cell receptor. Immunity 30, 777-788 (2009).
-
(2009)
Immunity
, vol.30
, pp. 777-788
-
-
Beddoe, T.1
-
52
-
-
10044292911
-
Solution structure of the CD3e5 ectodomain and comparison with CD3ey as a basis for modeling T cell receptor topology and signaling
-
Sun, Z.-Y. J. et al. Solution structure of the CD3e5 ectodomain and comparison with CD3ey as a basis for modeling T cell receptor topology and signaling. Proc. Natl Acad. Sci. USA 101, 16867-16872 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 16867-16872
-
-
Sun, Z.-Y.J.1
-
53
-
-
9244252501
-
Crystal structure of a human CD3-e/6 dimer in complex with a UCHT1 single-chain antibody fragment
-
Arnett, K. L, Harrison, S. C. & Wiley, D. C. Crystal structure of a human CD3-e/6 dimer in complex with a UCHT1 single-chain antibody fragment. Proc. Natl Acad. Sci. USA 101, 16268-16273 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 16268-16273
-
-
Arnett, K.L.1
Harrison, S.C.2
Wiley, D.C.3
-
54
-
-
0035967867
-
Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3ey heterodimer
-
Sun, Z.-Y. J., Kim, K. S., Wagner, G. & Reinherz, E. L. Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3ey heterodimer. Cell 105, 913-923 (2001).
-
(2001)
Cell
, vol.105
, pp. 913-923
-
-
Sun, Z.-Y.J.1
Kim, K.S.2
Wagner, G.3
Reinherz, E.L.4
-
55
-
-
2442667813
-
Crystal structure of the human T cell receptor CD3ey heterodimer complexed to the therapeutic mAb OKT3
-
Kjer-Nielsen, L. et al. Crystal structure of the human T cell receptor CD3ey heterodimer complexed to the therapeutic mAb OKT3. Proc. Natl Acad. Sci. USA 101, 7675-7680 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 7675-7680
-
-
Kjer-Nielsen, L.1
-
56
-
-
17644395663
-
W the T cell receptor: Critical role of the membrane environment in receptor assembly and function
-
Call, M. E. & Wucherpfennig, K. W The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu. Rev. Immunol. 23, 101-125 (2005).
-
(2005)
Annu. Rev. Immunol.
, vol.23
, pp. 101-125
-
-
Call, M.E.1
Wucherpfennig, K.2
-
57
-
-
32244435875
-
Deconstructing the form and function of the TCR/CD3 complex
-
Kuhns, M. S., Davis, M. M. & Garcia, K. C. Deconstructing the form and function of the TCR/CD3 complex. Immunity 24, 133-139 (2006).
-
(2006)
Immunity
, vol.24
, pp. 133-139
-
-
Kuhns, M.S.1
Davis, M.M.2
Garcia, K.C.3
-
58
-
-
78049391976
-
Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of a(3 T cell receptors
-
Kim, S. T. et al. Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of a(3 T cell receptors. J. Immunol. 185, 2951-2959 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 2951-2959
-
-
Kim, S.T.1
-
59
-
-
33947173844
-
Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling
-
Kuhns, M. S. & Davis, M. M. Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling. Immunity 26, 357-369 (2007).
-
(2007)
Immunity
, vol.26
, pp. 357-369
-
-
Kuhns, M.S.1
Davis, M.M.2
-
60
-
-
70449474683
-
Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3e
-
Martinez-Martin, N. et al. Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3e. Sci. Signal. 2, ra43 (2009).
-
(2009)
Sci. Signal.
, vol.2
-
-
Martinez-Martin, N.1
-
61
-
-
72949124550
-
A conserved CXXC motif in CD3e is critical for T cell development and TCR signaling
-
Wang, Y et al. A conserved CXXC motif in CD3e is critical for T cell development and TCR signaling. PLoS Biol. 7, e1000253 (2009).
-
(2009)
PLoS Biol.
, vol.7
-
-
Wang, Y.1
-
63
-
-
77950532705
-
Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development
-
Wang, H. et al. Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development. EMBO J. 29, 1285-1298 (2010).
-
(2010)
EMBO J.
, vol.29
, pp. 1285-1298
-
-
Wang, H.1
-
64
-
-
70249122432
-
The cytoplasmic tail of the T cell receptor CD3e subunit contains a phospholipid-binding motif that regulates T cell functions
-
Deford-Watts, L. M. et al. The cytoplasmic tail of the T cell receptor CD3e subunit contains a phospholipid-binding motif that regulates T cell functions. J. Immunol. 183, 1055-1064 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 1055-1064
-
-
Deford-Watts, L.M.1
-
65
-
-
55449093482
-
The safety on the TCR trigger
-
Kuhns, M. S. & Davis, M. M. The safety on the TCR trigger. Cell 135, 594-596 (2008).
-
(2008)
Cell
, vol.135
, pp. 594-596
-
-
Kuhns, M.S.1
Davis, M.M.2
-
66
-
-
0028140140
-
Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases
-
Imbert, V. et al. Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases. Biochem. J. 297, 163-173 (1994).
-
(1994)
Biochem. J.
, vol.297
, pp. 163-173
-
-
Imbert, V.1
-
67
-
-
0026475905
-
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation
-
O'Shea, J. J., McVicar, D. W, Bailey, T. L, Burns, C. & Smyth, M. J. Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc. Natl Acad. Sci. USA 89, 10306-10310 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 10306-10310
-
-
O'Shea, J.J.1
McVicar, D.W.2
Bailey, T.L.3
Burns, C.4
Smyth, M.J.5
-
68
-
-
0027417482
-
T Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events
-
Secrist, J. P., Burns, L. A., Karnitz, L, Koretzky, G. A. & Abraham, R. T Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J. Biol. Chem. 268, 5886-5893 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 5886-5893
-
-
Secrist, J.P.1
Burns, L.A.2
Karnitz, L.3
Koretzky, G.A.4
Abraham, R.5
-
69
-
-
77956167214
-
What controls T cell receptor phosphorylation?
-
Fernandes, R. A. et al. What controls T cell receptor phosphorylation? Cell 142, 668-669 (2010).
-
(2010)
Cell
, vol.142
, pp. 668-669
-
-
Fernandes, R.A.1
-
70
-
-
77956153437
-
Response multilayered control of T cell receptor phosphorylation
-
Gagnon, E. et al. Response multilayered control of T cell receptor phosphorylation. Cell 142, 669-671 (2010).
-
(2010)
Cell
, vol.142
, pp. 669-671
-
-
Gagnon, E.1
-
71
-
-
42049101786
-
The receptor deformation model of TCR triggering
-
Ma, Z., Janmey, P. A. & Finkel, T. H. The receptor deformation model of TCR triggering. FASEB J. 22, 1002-1008 (2008).
-
(2008)
FASEB J.
, vol.22
, pp. 1002-1008
-
-
Ma, Z.1
Janmey, P.A.2
Finkel, T.H.3
-
72
-
-
20144373553
-
Immunology: How do T cells recognize antigen?
-
Choudhuri, A., Kearney, A., Bakker, T. R. & van der Merwe, P. A. Immunology: how do T cells recognize antigen? Curr. Biol. 15, R382-R385 (2005).
-
(2005)
Curr. Biol.
, vol.15
-
-
Choudhuri, A.1
Kearney, A.2
Bakker, T.R.3
Van Der Merwe, P.A.4
-
73
-
-
77953473256
-
Cutting edge: Mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling
-
Li, Y C. et al. Cutting edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling. J. Immunol. 184, 5959-5963 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 5959-5963
-
-
Li, Y.C.1
-
74
-
-
0034948337
-
The TCR triggering puzzle
-
Van Der Merwe, P. The TCR triggering puzzle. Immunity 14, 665-668 (2001).
-
(2001)
Immunity
, vol.14
, pp. 665-668
-
-
Van Der Merwe, P.1
-
75
-
-
0032481906
-
One of the CD3e subunits within a T cell receptor complex lies in close proximity to the C(3 FG loop
-
Ghendler, Y, Smolyar, A., Chang, H. C. & Reinherz, E. L. One of the CD3e subunits within a T cell receptor complex lies in close proximity to the C(3 FG loop. J. Exp. Med. 187, 1529-1536 (1998).
-
(1998)
J. Exp. Med.
, vol.187
, pp. 1529-1536
-
-
Ghendler, Y.1
Smolyar, A.2
Chang, H.C.3
Reinherz, E.L.4
-
76
-
-
0023155358
-
Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3
-
Geppert, T. D. & Lipsky, P. E. Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3. J. Immunol. 138, 1660-1666 (1987).
-
(1987)
J. Immunol.
, vol.138
, pp. 1660-1666
-
-
Geppert, T.D.1
Lipsky, P.E.2
-
77
-
-
40149108609
-
Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
-
Ma, Z., Sharp, K. A., Janmey, P. A. & Finkel, T. H. Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity. PLoS Biol. 6, e43 (2008).
-
(2008)
PLoS Biol.
, vol.6
-
-
Ma, Z.1
Sharp, K.A.2
Janmey, P.A.3
Finkel, T.H.4
-
78
-
-
70350035998
-
Peptide-MHC dimensions control proximal kinase-phosphatase balance during T cell activation
-
Choudhuri, K. et al. Peptide-MHC dimensions control proximal kinase-phosphatase balance during T cell activation. J. Biol. Chem. 284, 26096-26105 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26096-26105
-
-
Choudhuri, K.1
-
79
-
-
23144455728
-
T cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand
-
Choudhuri, K., Wiseman, D., Brown, M. H., Gould, K. & van der Merwe, P. A. T cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. Nature 436, 578-582 (2005).
-
(2005)
Nature
, vol.436
, pp. 578-582
-
-
Choudhuri, K.1
Wiseman, D.2
Brown, M.H.3
Gould, K.4
Van Der Merwe, P.A.5
-
80
-
-
71449090489
-
The a(3 T cell receptor is an anisotropic mechanosensor
-
Kim, S. T et al. The a(3 T cell receptor is an anisotropic mechanosensor. J. Biol. Chem. 284, 31028-31037 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 31028-31037
-
-
Kim, S.T.1
-
81
-
-
0028961573
-
Sustained signalling leading to T cell activation results from prolonged T cell receptor occupancy. Role of the T cell actin cytoskeleton
-
Valitutti, S., Dessing, M., Aktories, K., Gallati, H. & Lanzavecchia, A. Sustained signalling leading to T cell activation results from prolonged T cell receptor occupancy. Role of the T cell actin cytoskeleton. J. Exp. Med. 181, 577-584 (1995).
-
(1995)
J. Exp. Med.
, vol.181
, pp. 577-584
-
-
Valitutti, S.1
Dessing, M.2
Aktories, K.3
Gallati, H.4
Lanzavecchia, A.5
-
82
-
-
0037047353
-
A new trigger for T cells
-
Davis, M. M. A new trigger for T cells. Cell 110, 285-287 (2002).
-
(2002)
Cell
, vol.110
, pp. 285-287
-
-
Davis, M.M.1
-
83
-
-
0037184955
-
W the organizing principle in the formation of the T cell receptor-CD3 complex
-
Call, M. E., Pyrdol, J., Wiedmann, M. & Wucherpfennig, K. W The organizing principle in the formation of the T cell receptor-CD3 complex. Cell 111, 967-979 (2002).
-
(2002)
Cell
, vol.111
, pp. 967-979
-
-
Call, M.E.1
Pyrdol, J.2
Wiedmann, M.3
Wucherpfennig, K.4
-
84
-
-
33750022623
-
The structure of the {,{, transmembrane dimer reveals features essential for its assembly with the T cell receptor
-
Call, M. E. et al. The structure of the {,{, transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell 127, 355-368 (2006).
-
(2006)
Cell
, vol.127
, pp. 355-368
-
-
Call, M.E.1
-
85
-
-
77950910326
-
A conformation-induced oligomerization model for B cell receptor microclustering and signaling
-
Tolar, P. & Pierce, S. K. A conformation-induced oligomerization model for B cell receptor microclustering and signaling. Curr. Top. Microbiol. Immunol. 340, 155-169 (2010).
-
(2010)
Curr. Top. Microbiol. Immunol.
, vol.340
, pp. 155-169
-
-
Tolar, P.1
Pierce, S.K.2
-
86
-
-
58149247765
-
The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens
-
Tolar, P., Hanna, J., Krueger, P. D. & Pierce, S. K. The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens. Immunity 30, 44-55 (2009).
-
(2009)
Immunity
, vol.30
, pp. 44-55
-
-
Tolar, P.1
Hanna, J.2
Krueger, P.D.3
Pierce, S.K.4
-
87
-
-
77953911933
-
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
-
Nika, K. et al. Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity 32, 766-777 (2010).
-
(2010)
Immunity
, vol.32
, pp. 766-777
-
-
Nika, K.1
-
88
-
-
0029930984
-
The structure and ligand interactions of CD2: Implications for T-cell function
-
Davis, S. J. & van der Merwe, P. A. The structure and ligand interactions of CD2: implications for T-cell function. Immunol. Today 17, 177-187 (1996).
-
(1996)
Immunol. Today
, vol.17
, pp. 177-187
-
-
Davis, S.J.1
Van Der Merwe, P.A.2
-
89
-
-
0034005120
-
Cytoskeletal polarization and redistribution of cell surface molecules during T cell antigen recognition
-
Van Der Merwe, P. A., Davis, S. J., Shaw, A. S. & Dustin, M. L. Cytoskeletal polarization and redistribution of cell surface molecules during T cell antigen recognition. Semin. Immunol. 12, 5-21 (2000).
-
(2000)
Semin. Immunol.
, vol.12
, pp. 5-21
-
-
Van Der Merwe, P.A.1
Davis, S.J.2
Shaw, A.S.3
Dustin, M.L.4
-
90
-
-
15244348270
-
Lipid rafts and their roles in T-cell activation
-
Horejsi, V. Lipid rafts and their roles in T-cell activation. Microbes Infect. 7, 310-316 (2005).
-
(2005)
Microbes Infect.
, vol.7
, pp. 310-316
-
-
Horejsi, V.1
-
91
-
-
33746114879
-
The kinetic-segregation model: TCR triggering and beyond
-
Davis, S. J. & van der Merwe, P. A. The kinetic-segregation model: TCR triggering and beyond. Nature Immunol. 7, 803-809 (2006).
-
(2006)
Nature Immunol.
, vol.7
, pp. 803-809
-
-
Davis, S.J.1
Van Der Merwe, P.A.2
-
92
-
-
0041976988
-
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
-
Lin, J. & Weiss, A. The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. J. Cell Biol. 162, 673-682 (2003).
-
(2003)
J. Cell Biol.
, vol.162
, pp. 673-682
-
-
Lin, J.1
Weiss, A.2
-
93
-
-
0037318863
-
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling
-
Irles, C. et al. CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Nature Immunol. 4, 189-197 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 189-197
-
-
Irles, C.1
-
94
-
-
77953228970
-
Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen
-
Bluemel, C. et al. Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen. Cancer Immunol. Immunother. 59, 1197-1209 (2010).
-
(2010)
Cancer Immunol. Immunother.
, vol.59
, pp. 1197-1209
-
-
Bluemel, C.1
-
95
-
-
45549093089
-
Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane
-
James, S. E. et al. Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane. J. Immunol. 180, 7028-7038 (2008).
-
(2008)
J. Immunol.
, vol.180
, pp. 7028-7038
-
-
James, S.E.1
-
96
-
-
0344585437
-
Lipid rafts: Elusive or illusive?
-
Munro, S. Lipid rafts: elusive or illusive? Cell 11 5, 377-388 (2003).
-
(2003)
Cell
, vol.115
, pp. 377-388
-
-
Munro, S.1
-
97
-
-
74849118341
-
Lipid rafts as a membrane-organizing principle
-
Lingwood, D. & Simons, K. Lipid rafts as a membrane-organizing principle. Science 327, 46-50 (2010).
-
(2010)
Science
, vol.327
, pp. 46-50
-
-
Lingwood, D.1
Simons, K.2
-
98
-
-
26444452661
-
Condensation of the plasma membrane at the site of T lymphocyte activation
-
Gaus, K., Chklovskaia, E., Fazekas de St. Groth, B., Jessup, W. & Harder, T. Condensation of the plasma membrane at the site of T lymphocyte activation. J. Cell Biol. 171, 121-131 (2005).
-
(2005)
J. Cell Biol.
, vol.171
, pp. 121-131
-
-
Gaus, K.1
Chklovskaia, E.2
De St, F.3
Groth, B.4
Jessup, W.5
Harder, T.6
-
99
-
-
62049084949
-
Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling
-
Zech, T. et al. Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling. EMBO J. 28, 466-476 (2009).
-
(2009)
EMBO J.
, vol.28
, pp. 466-476
-
-
Zech, T.1
-
100
-
-
77949888199
-
Plasma membrane rafts engaged in T cell signalling: New developments in an old concept
-
Harder, T. & Sangani, D. Plasma membrane rafts engaged in T cell signalling: new developments in an old concept. Cell Commun. Signal. 7, 21 (2009).
-
(2009)
Cell Commun. Signal.
, vol.7
, pp. 21
-
-
Harder, T.1
Sangani, D.2
-
101
-
-
1542399850
-
Lipid raft proteins have a random distribution during localized activation of the T-cell receptor
-
Glebov, O. O. & Nichols, B. J. Lipid raft proteins have a random distribution during localized activation of the T-cell receptor. Nature Cell Biol. 6, 238-243 (2004).
-
(2004)
Nature Cell Biol.
, vol.6
, pp. 238-243
-
-
Glebov, O.O.1
Nichols, B.J.2
-
102
-
-
77954380512
-
T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering
-
Hashimoto-Tane, A. et al. T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering. Mol. Cell. Biol. 30, 3421-3429 (2010).
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 3421-3429
-
-
Hashimoto-Tane, A.1
-
103
-
-
0036857767
-
Lipid rafts and T cell receptor signaling: A critical re-evaluation
-
Pizzo, P. et al. Lipid rafts and T cell receptor signaling: a critical re-evaluation. Eur. J. Immunol. 32, 3082-3091 (2002).
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 3082-3091
-
-
Pizzo, P.1
-
104
-
-
10844280748
-
Cutting edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development
-
Zhu, M., Shen, S., Liu, Y., Granillo, O. & Zhang, W. Cutting edge: localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development. J. Immunol. 174, 31-35 (2005).
-
(2005)
J. Immunol.
, vol.174
, pp. 31-35
-
-
Zhu, M.1
Shen, S.2
Liu, Y.3
Granillo, O.4
Zhang, W.5
-
105
-
-
77950809538
-
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
-
Huang, J. et al. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. Nature 464, 932-936 (2010).
-
(2010)
Nature
, vol.464
, pp. 932-936
-
-
Huang, J.1
-
106
-
-
77249114784
-
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity
-
Huppa, J. B. et al. TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature 463, 963-967 (2010).
-
(2010)
Nature
, vol.463
, pp. 963-967
-
-
Huppa, J.B.1
-
107
-
-
36749092326
-
Memory in receptor- ligand-mediated cell adhesion
-
Zarnitsyna, V. I. et al. Memory in receptor- ligand-mediated cell adhesion. Proc. Natl Acad. Sci. USA 104, 18037-18042 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 18037-18042
-
-
Zarnitsyna, V.I.1
|