The single positive T cells found in CD3-ζ/η(-/-) mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex

Journal of Experimental Medicine

Volumn 185, Issue 4, 1997, Pages 707-715

  Lin, Shih Yao ^a   Ardouin, Laurence ^a   Gillet, Anne ^a   Malissen, Marie ^a   Malissen, Bernard ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ADOLESCENT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HYBRIDOMA; LYMPH NODE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; SPLEEN; T LYMPHOCYTE; THYMOMA;

ANIMALS; ANTIGENS, CD3; HYBRIDOMAS; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 0031028629     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.4.707     Document Type: Article

References (43)

1. Kisielow, P., and H. von Boehmer. 1995. Development and selection of T cells: facts and puzzles. Adv. Immunol. 58:87-209.
2. Ashton-Rickardt, P.G., and S. Tonegawa. 1994. A differential-avidity model for T-cell selection. Immunol. Today. 15: 362-366.
3. Hogquist, K.A., and M.J. Bevan. 1996. The nature of the peptide/MHC ligand involved in positive selection. Semin. Immunol. 8:63-68.
4. Sloan-Lancaster, J., and P.M. Allen. 1996. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14:1-27.
5. Marrack, P., L. Ignatowicz, J.W. Kappler, J. Boymel, and J.H. Freed. 1993. Comparison of peptides bound to spleen and thymus class II. J. Exp. Med. 178:2173-2183.
6. Pircher, H., U.R. Hoffmann, D. Moskophidis, R.M. Zinkernagel, and H. Hengartner. 1991. Lower receptor avidity required for thymic clonal deletion than for effector T-cell function. Nature (Lond.). 351:482-485.
7. Malissen, B., and M. Malissen. 1996. Functions of TCR and pre-TCR subunits: lessons from gene ablation. Curr. Opin. Immunol. 8:383-393.
8. Malissen, M., A. Gillet, B. Rocha, J. Trucy, E. Vivier, C. Boyer, F. Köntgen, N. Brun, G. Mazza, E. Spanopoulou et al. 1993. T cell development in mice lacking the CD3-ζ/η gene. EMBO (Eur. Mol. Biol. Organ.) J. 12:4347-4355.
9. -/- mutant mice and identification of a novel T cell population in the intestine. EMBO (Eur. Mol. Biol. Organ.) J. 12:4863-4875.
10. Love, P.E., E.W. Shores, M.D. Johnson, M.L. Tremblay, E.J. Lee, A. Grinberg, S.P. Huang, A. Singer, and H. Westphal. 1993. T cell development in mice that lack the ζ chain of T cell antigen receptor complex. Science (Wash. DC). 261:918-921.
11. Irving, B.A., and A. Weiss. 1991. The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways. Cell. 64:891-901.
12. Romeo, C., M. Amiot, and B. Seed. 1992. Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor ζ chain. Cell. 68:889-897.
13. Wegener, A.-M.K., F. Letourneur, A. Hoeveler, T. Brocker, F. Luton, and B. Malissen. 1992. The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell. 68:83-95.
14. Samelson, L.E., M.D. Patel, A.M. Weissman, J.B. Harford, and R.D. Klausner. 1986. Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell. 46:1083-1090.
15. Hermans, M.H.A., and B. Malissen. 1993. The cytoplasmic tail of the T cell receptor ζ chain is dispensable for antigen-mediated T cell activation. Eur. J. Immunol. 23:2257-2262.
16. Speiser, D.E., U. Stübi, and R.M. Zinkernagel. 1992. Extrathymic positive selection of αβ T-cell precursors in nude mice. Nature (Lond.). 355:170-172.
17. Simpson, S., G. Holländer, J. She, C. Levelt, M. Huang, and C. Terhorst. 1995. Selection of peripheral and intestinal T lymphocytes lacking CD3 ζ. Int. Immunol. 7:287-293.
18. Vidal, K., B.L. Hsu, C.B. Williams, and P.M. Allen. 1996. Endogenous altered peptide ligands can affect peripheral T cell responses. J. Exp. Med. 183:1311-1321.
19. Brossart, P., and M.J. Bevan. 1996. Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self pepdde. J. Exp. Med. 183:2449-2458.
20. - cells. Eur. J. Immunol. 24:1903-1907.
21. Cosgrove, D., D. Gray, A. Dierich, J. Kaufman, M. Lemeur, C. Benoist, and D. Mathis. 1991. Mice lacking MHC class II molecules. Cell. 66:1051-1066.
22. + T cells. Science (Wash. DC). 248: 1227-1230.
23. White, J., M. Blackman, J. Bill, J. Kappler, P. Marrack, D. Gold, and W. Born. 1989. Two better cell lines for making hybridomas expressing specific T cell receptors. J. Immunol. 143:1822-1825.
24. Letourneur, F., and B. Malissen. 1989. Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α-mRNA of BW5147 origin. Eur. J. Immunol. 19:2269-2274.
25. Moingeon, P., J.L. Lucich, D.J. McConkey, F. Letourneur, B. Malissen, J. Kochan, H.-C. Chang, H.-R. Rodewald, and E.L. Reinherz. 1992. CD3ζ dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells. Proc. Natl. Acad. Sci. USA. 89:1492-1496.
26. Miltenyi, S., W. Müller, W. Weichet, and A. Radbruch. 1990. High gradient magnetic cell separation with MACS. Cytometry. 11:231-238.
27. Strober, W., and R.O. Ehrhardt. 1993. Chronic intestinal inflammation: an unexpected outcome in cytokine or T cell receptor mutant mice. Cell. 75:203-205.
28. Marrack, P., J. McCormack, and J. Kappler. 1989. Presentation of antigen, foreign major histocompatibility complex proteins and self by thymus cortical epithelium. Nature (Lond.). 338:503-505.
29. Ignatowicz, L., J. Kappler, and P. Marrack. 1996. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell. 84:521-529.
30. Ohno, H., S. Goto, S. Taki, T. Shirasawa, H. Nakano, S. Miyatake, T. Aoe, Y. Ishida, H. Maeda, T. Shirai et al. 1994. Targeted disruption of the CD3η locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand. EMBO (Eur. Mol. Biol. Organ.) J. 13:1157-1165.
31. Koyasu, S., R.E. Hussey, L.K. Clayton, A. Lerner, R. Pedersen, P. Delany-Heiken, F. Chau, and E.L. Reinherz. 1994. Targeted disruption within the CD3ζ/η/θ/Oct-1 locus in mouse. EMBO (Eur. Mol. Biol. Organ.) J. 13:784-797.
32. Carbone, A.M., P. Marrack, and J.W. Kappler. 1988. Remethylation at sites 5′ of the munne Lyt-2 gene in association with shutdown of Lyt-2 expression. J. Immunol. 141:1369-1375.
33. von Boehmer, H. 1996. CD4/CD8 lineage commitment: back to instruction? J. Exp. Med. 183:713-715.
34. Torres-Nagel, N., E. Kraus, M.H. Brown, G. Tiefenthaler, R. Mitnacht, A.F. Williams, and T. Hünig. 1992. Differential thymus dependence of rat CD8 isoform expression. Eur. J. Immunol. 22:2841-2848.
35. Rocha, B., P. Vassalli, and D. Guy-Grand. 1992. The extrathymic T-cell development pathway. Immunol. Today. 13: 449-454.
36. Guy-Grand, D., B. Rocha, P. Mintz, M. Malassis-Seris, F. Selz, B. Malissen, and P. Vassalli. 1994. Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation.J. Exp. Med. 180:673-679.
37. Lauter, T.M., J. DeKoning, J.S. Markowitz, D. Lo, and L.H. Glimcher. 1996. Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex. Nature (Lond.). 383:81-85.
38. Matzinger, P. 1993. Why positive selection? Immunol. Rev. 135:81-117.
39. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science (Wash. DC). 273:104-106.
40. + T cell repertoire in β2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I. J. Exp. Med. 179:661-672.
41. 2-microglobulin-deficient mice. J. Immunol. 154:47-57.
42. 2-microglobulin double mutant mice. Int. Immunol. 7:975-984.
43. Soudais, C., J.-P. de Villartay, F. Le Deist, A. Fischer, and B. Lisowska-Grospierre. 1993. Independent mutations of the human CD3-∈ gene resulting in a T cell receptor/CD3 complex immunodeficiency. Nat. Genet. 3:77-81.