Cutting edge: Lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production

Journal of Immunology

Volumn 184, Issue 12, 2010, Pages 6569-6573

  Milner, Joshua D ^a   Fazilleau, Nicolas ^b,c   McHeyzer Williams, Michael ^b   Paul, William ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CYTOCHROME C; INTERLEUKIN 4; PEPTIDE; TETRAMER; TRANSCRIPTION FACTOR GATA 3; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BETA CHAIN; CLONE; COMPETITION; CYTOKINE PRODUCTION; DRUG BINDING; LYMPHOCYTE DIFFERENTIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOTH; MOUSE; NONHUMAN; PHENOTYPE; PIGEON; PRIORITY JOURNAL; PROTEIN MOTIF; RECEPTOR AFFINITY; SEQUENCE ANALYSIS; T LYMPHOCYTE; TH2 CELL; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CELL SEPARATION; FLOW CYTOMETRY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; FLOW CYTOMETRY; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTE SUBSETS; TH2 CELLS;

EID: 77953639786     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000674     Document Type: Article

References (18)

1. + T cells. J. Exp. Med. 182: 1591-1596.
2. Pfeiffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181: 1569-1574.
3. + T cells to generate a Th2-inducing cytokine environment. J. Exp. Med. 202: 793-804.
4. Jun, J. E., L. E. Wilson, C. G. Vinuesa, S. Lesage, M. Blery, L. A. Miosge, M. C. Cook, E. M. Kucharska, H. Hara, J. M. Penninger, et al. 2003. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18: 751-762.
5. Siggs, O. M., L. A. Miosge, A. L. Yates, E. M. Kucharska, D. Sheahan, T. Brdicka, A. Weiss, A. Liston, and C. C. Goodnow. 2007. Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity 27: 912-926.
6. Jakob, T., G. V. Kollisch, M. Howaldt, M. Bewersdorff, B. Rathkolb, M. L. Muller, N. Sandholzer, L. Nitschke, M. Schiemann, M. Mempel, et al. 2008. Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis. J. Allergy Clin. Immunol. 121: 179-184.e7.
7. Sommers, C. L., C. S. Park, J. Lee, C. Feng, C. L. Fuller, A. Grinberg, J. A. Hildebrand, E. Lacaná, R. K. Menon, E. W. Shores, et al. 2002. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296: 2040-2043.
8. Steinfelder, S., J. F. Andersen, J. L. Cannons, C. G. Feng, M. Joshi, D. Dwyer, P. Caspar, P. L. Schwartzberg, A. Sher, and D. Jankovic. 2009. The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). J. Exp. Med. 206: 1681-1690.
9. Malherbe, L., C. Hausl, L. Teyton, and M. G. McHeyzer-Williams. 2004. Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties. Immunity 21: 669-679.
10. McHeyzer-Williams, L. J., J. F. Panus, J. A. Mikszta, and M. G. McHeyzer-Williams. 1999. Evolution of antigen-specific T cell receptors in vivo: preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs. J. Exp. Med. 189: 1823-1838.
11. Grakoui, A., D. L. Donermeyer, O. Kanagawa, K. M. Murphy, and P. M. Allen. 1999. TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization. J. Immunol. 162: 1923-1930.
12. Zehn, D., S. Y. Lee, and M. J. Bevan. 2009. Complete but curtailed T-cell response to very low-affinity antigen. Nature 458: 211-214.
13. Boyton, R. J., N. Zaccai, E. Y. Jones, and D. M. Altmann. 2002. CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3. J. Immunol. 168: 1018-1027.
14. Gomez-Rodriguez, J., N. Sahu, R. Handon, T. S. Davidson, S. M. Anderson, M. R. Kirby, A. August, and P. L. Schwartzberg. 2009. Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity 31: 587-597.
15. Chen, Z. M., J. H. Mao, L. Z. Du, and Y. M. Tang. 2002. Association of cytokine responses with disease severity in infants with respiratory syncytial virus infection. Acta Paediatr. 91: 914-922.
16. Bendelja, K., A. Gagro, A. Bace, R. Lokar-Kolbas, V. Krsulovic-Hresic, V. Drazenovic, G. Mlinaric-Galinovic, and S. Rabatic. 2000. Predominant type-2 response in infants with respiratory syncytial virus (RSV) infection demonstrated by cytokine flow cytometry. Clin. Exp. Immunol. 121: 332-338.
17. Milner, J. D., J. M. Ward, A. Keane-Myers, and W. E. Paul. 2007. Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease. Proc. Natl. Acad. Sci. USA 104: 576-581.
18. Ozcan, E., L. D. Notarangelo, and R. S. Geha. 2008. Primary immune deficiencies with aberrant IgE production. J. Allergy Clin. Immunol. 122: 1054-1062; quiz 1063-1064.