-
1
-
-
34247847666
-
T cells as a self-referential, sensory organ
-
Davis, M.M. et al. T cells as a self-referential, sensory organ. Annu. Rev. Immunol. 25, 681-695 (2007).
-
(2007)
Annu. Rev. Immunol.
, vol.25
, pp. 681-695
-
-
Davis, M.M.1
-
2
-
-
0029743737
-
Phenotypic analysis of antigen-specific T lymphocytes
-
Altman, J.D. et al. Phenotypic analysis of antigen-specific T lymphocytes. Science 274, 94-96 (1996).
-
(1996)
Science
, vol.274
, pp. 94-96
-
-
Altman, J.D.1
-
3
-
-
79960835109
-
Interrogating the repertoire: Broadening the scope of peptide-MHC multimer analysis
-
Davis, M.M., Altman, J.D. & Newell, E.W. Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis. Nat. Rev. Immunol. 11, 551-558 (2011).
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 551-558
-
-
Davis, M.M.1
Altman, J.D.2
Newell, E.W.3
-
4
-
-
0029063148
-
Kinetic proofreading in T-cell receptor signal transduction
-
McKeithan, T.W. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA 92, 5042-5046 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 5042-5046
-
-
McKeithan, T.W.1
-
5
-
-
0029037210
-
Serial triggering of many T-cell receptors by a few peptide-MHC complexes
-
Valitutti, S., Muller, S., Cella, M., Padovan, E. & Lanzavecchia, A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148-151 (1995).
-
(1995)
Nature
, vol.375
, pp. 148-151
-
-
Valitutti, S.1
Muller, S.2
Cella, M.3
Padovan, E.4
Lanzavecchia, A.5
-
6
-
-
0035286588
-
Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex
-
Kalergis, A.M. et al. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat. Immunol. 2, 229-234 (2001).
-
(2001)
Nat. Immunol.
, vol.2
, pp. 229-234
-
-
Kalergis, A.M.1
-
7
-
-
0037331525
-
Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation
-
Holler, P.D. & Kranz, D.M. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity 18, 255-264 (2003).
-
(2003)
Immunity
, vol.18
, pp. 255-264
-
-
Holler, P.D.1
Kranz, D.M.2
-
8
-
-
77950809538
-
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
-
Huang, J. et al. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. Nature 464, 932-936 (2010).
-
(2010)
Nature
, vol.464
, pp. 932-936
-
-
Huang, J.1
-
9
-
-
77249114784
-
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity
-
Huppa, J.B. et al. TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature 463, 963-967 (2010).
-
(2010)
Nature
, vol.463
, pp. 963-967
-
-
Huppa, J.B.1
-
10
-
-
16344370564
-
T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell
-
González, P.A. et al. T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell. Proc. Natl. Acad. Sci. USA 102, 4824-4829 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 4824-4829
-
-
González, P.A.1
-
11
-
-
79960455299
-
Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen
-
Thomas, S. et al. Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen. Blood 118, 319-329 (2011).
-
(2011)
Blood
, vol.118
, pp. 319-329
-
-
Thomas, S.1
-
12
-
-
84862636672
-
Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness
-
published online, doi:10.1074/jbc.M112.357673 1 May
-
Irving, M. et al. Interplay between T cell receptor binding kinetics and the level of cognate peptide presented by major histocompatibility complexes governs CD8+ T cell responsiveness. J. Biol. Chem. published online, doi:10.1074/jbc.M112.357673 (1 May 2012).
-
(2012)
J. Biol. Chem.
-
-
Irving, M.1
-
13
-
-
0032480279
-
Three-dimensional segregation of supramolecular activation clusters in T cells
-
Monks, C.R., Freiberg, B.A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395, 82-86 (1998).
-
(1998)
Nature
, vol.395
, pp. 82-86
-
-
Monks, C.R.1
Freiberg, B.A.2
Kupfer, H.3
Sciaky, N.4
Kupfer, A.5
-
14
-
-
0032568580
-
Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels
-
Wülfing, C., Sjaastad, M.D. & Davis, M.M. Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. Proc. Natl. Acad. Sci. USA 95, 6302-6307 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6302-6307
-
-
Wülfing, C.1
Sjaastad, M.D.2
Davis, M.M.3
-
15
-
-
0033538574
-
The immunological synapse: A molecular machine controlling T cell activation
-
Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221-227 (1999).
-
(1999)
Science
, vol.285
, pp. 221-227
-
-
Grakoui, A.1
-
16
-
-
0028851581
-
Tyrosine-phosphorylated T cell receptor zeta chain associates with the actin cytoskeleton upon activation of mature T lymphocytes
-
Rozdzial, M.M., Malissen, B. & Finkel, T.H. Tyrosine-phosphorylated T cell receptor zeta chain associates with the actin cytoskeleton upon activation of mature T lymphocytes. Immunity 3, 623-633 (1995).
-
(1995)
Immunity
, vol.3
, pp. 623-633
-
-
Rozdzial, M.M.1
Malissen, B.2
Finkel, T.H.3
-
17
-
-
0028961573
-
Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton
-
Valitutti, S., Dessing, M., Aktories, K., Gallati, H. & Lanzavecchia, A. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J. Exp. Med. 181, 577-584 (1995).
-
(1995)
J. Exp. Med.
, vol.181
, pp. 577-584
-
-
Valitutti, S.1
Dessing, M.2
Aktories, K.3
Gallati, H.4
Lanzavecchia, A.5
-
18
-
-
27544441784
-
Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling
-
Campi, G., Varma, R. & Dustin, M.L. Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J. Exp. Med. 202, 1031-1036 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1031-1036
-
-
Campi, G.1
Varma, R.2
Dustin, M.L.3
-
19
-
-
33846626054
-
Regulation of T-cell activation by the cytoskeleton
-
Billadeau, D.D., Nolz, J.C. & Gomez, T.S. Regulation of T-cell activation by the cytoskeleton. Nat. Rev. Immunol. 7, 131-143 (2007).
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 131-143
-
-
Billadeau, D.D.1
Nolz, J.C.2
Gomez, T.S.3
-
20
-
-
42649127027
-
The actin cytoskeleton in T cell activation
-
Burkhardt, J.K., Carrizosa, E. & Shaffer, M.H. The actin cytoskeleton in T cell activation. Annu. Rev. Immunol. 26, 233-259 (2008).
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 233-259
-
-
Burkhardt, J.K.1
Carrizosa, E.2
Shaffer, M.H.3
-
21
-
-
67349114397
-
T cell antigen receptor signaling and immunological synapse stability require myosin IIA
-
Ilani, T., Vasiliver-Shamis, G., Vardhana, S., Bretscher, A. & Dustin, M.L. T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat. Immunol. 10, 531-539 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 531-539
-
-
Ilani, T.1
Vasiliver-Shamis, G.2
Vardhana, S.3
Bretscher, A.4
Dustin, M.L.5
-
22
-
-
79959332816
-
Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation
-
Hashimoto-Tane, A. et al. Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation. Immunity 34, 919-931 (2011).
-
(2011)
Immunity
, vol.34
, pp. 919-931
-
-
Hashimoto-Tane, A.1
-
23
-
-
0027378395
-
Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli
-
Altman, J.D., Reay, P.A. & Davis, M.M. Formation of functional peptide complexes of class II major histocompatibility complex proteins from subunits produced in Escherichia coli. Proc. Natl. Acad. Sci. USA 90, 10330-10334 (1993).
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10330-10334
-
-
Altman, J.D.1
Reay, P.A.2
Davis, M.M.3
-
24
-
-
32244442535
-
Design and use of conditional MHC class I ligands
-
Toebes, M. et al. Design and use of conditional MHC class I ligands. Nat. Med. 12, 246-251 (2006).
-
(2006)
Nat. Med.
, vol.12
, pp. 246-251
-
-
Toebes, M.1
-
25
-
-
34547128664
-
Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association
-
Grotenbreg, G.M. et al. Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. J. Biol. Chem. 282, 21425-21436 (2007).
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 21425-21436
-
-
Grotenbreg, G.M.1
-
26
-
-
84862626786
-
Distinct CD4+ helper T cells involved in primary and secondary responses to infection
-
in the press
-
Weber, K.S. et al. Distinct CD4+ helper T cells involved in primary and secondary responses to infection. Proc. Natl. Acad. Sci. USA (in the press).
-
Proc. Natl. Acad. Sci. USA
-
-
Weber, K.S.1
-
28
-
-
0024444304
-
+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
-
+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341, 746-749 (1989).
-
(1989)
Nature
, vol.341
, pp. 746-749
-
-
Kaye, J.1
-
29
-
-
33947189706
-
The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse
-
Cemerski, S. et al. The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse. Immunity 26, 345-355 (2007).
-
(2007)
Immunity
, vol.26
, pp. 345-355
-
-
Cemerski, S.1
-
31
-
-
0024583817
-
Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization
-
Carbone, F.R. & Bevan, M.J. Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization. J. Exp. Med. 169, 603-612 (1989).
-
(1989)
J. Exp. Med.
, vol.169
, pp. 603-612
-
-
Carbone, F.R.1
Bevan, M.J.2
-
32
-
-
0028987213
-
Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove
-
Fremont, D.H., Stura, E.A., Matsumura, M., Peterson, P.A. & Wilson, I.A. Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove. Proc. Natl. Acad. Sci. USA 92, 2479-2483 (1995).
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 2479-2483
-
-
Fremont, D.H.1
Stura, E.A.2
Matsumura, M.3
Peterson, P.A.4
Wilson, I.A.5
-
33
-
-
2442651482
-
T cell killing does not require the formation of a stable mature immunological synapse
-
Purbhoo, M.A., Irvine, D.J., Huppa, J.B. & Davis, M.M. T cell killing does not require the formation of a stable mature immunological synapse. Nat. Immunol. 5, 524-530 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 524-530
-
-
Purbhoo, M.A.1
Irvine, D.J.2
Huppa, J.B.3
Davis, M.M.4
-
34
-
-
77953506249
-
Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection
-
Juang, J. et al. Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection. J. Exp. Med. 207, 1223-1234 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1223-1234
-
-
Juang, J.1
-
35
-
-
0026585781
-
RAG-1-deficient mice have no mature B and T lymphocytes
-
Mombaerts, P. et al. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68, 869-877 (1992).
-
(1992)
Cell
, vol.68
, pp. 869-877
-
-
Mombaerts, P.1
-
36
-
-
0028178784
-
T cell receptor antagonist peptides induce positive selection
-
Hogquist, K.A. et al. T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27 (1994).
-
(1994)
Cell
, vol.76
, pp. 17-27
-
-
Hogquist, K.A.1
-
37
-
-
0032192469
-
Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands
-
Boniface, J.J. et al. Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands. Immunity 9, 459-466 (1998).
-
(1998)
Immunity
, vol.9
, pp. 459-466
-
-
Boniface, J.J.1
-
38
-
-
0033710093
-
The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
-
Cochran, J.R., Cameron, T.O. & Stern, L.J. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity 12, 241-250 (2000).
-
(2000)
Immunity
, vol.12
, pp. 241-250
-
-
Cochran, J.R.1
Cameron, T.O.2
Stern, L.J.3
-
39
-
-
21244497887
-
CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers
-
Cebecauer, M. et al. CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers. J. Biol. Chem. 280, 23820-23828 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23820-23828
-
-
Cebecauer, M.1
-
40
-
-
71449090489
-
The αβ T cell receptor is an anisotropic mechanosensor
-
Kim, S.T. et al. The αβ T cell receptor is an anisotropic mechanosensor. J. Biol. Chem. 284, 31028-31037 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 31028-31037
-
-
Kim, S.T.1
-
41
-
-
77953473256
-
Cutting Edge: Mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling
-
Li, Y.C. et al. Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling. J. Immunol. 184, 5959-5963 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 5959-5963
-
-
Li, Y.C.1
-
42
-
-
73149110138
-
T cell receptor triggering by force
-
Ma, Z. & Finkel, T.H. T cell receptor triggering by force. Trends Immunol. 31, 1-6 (2010).
-
(2010)
Trends Immunol.
, vol.31
, pp. 1-6
-
-
Ma, Z.1
Finkel, T.H.2
-
43
-
-
33645283107
-
A monovalent streptavidin with a single femtomolar biotin binding site
-
Howarth, M. et al. A monovalent streptavidin with a single femtomolar biotin binding site. Nat. Methods 3, 267-273 (2006).
-
(2006)
Nat. Methods
, vol.3
, pp. 267-273
-
-
Howarth, M.1
-
44
-
-
0027955977
-
Photoaffinity labeling of the T cell receptor on cloned cytotoxic T lymphocytes by covalent photoreactive ligand
-
Luescher, I.F., Cerottini, J.C. & Romero, P. Photoaffinity labeling of the T cell receptor on cloned cytotoxic T lymphocytes by covalent photoreactive ligand. J. Biol. Chem. 269, 5574-5582 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5574-5582
-
-
Luescher, I.F.1
Cerottini, J.C.2
Romero, P.3
-
45
-
-
0029048234
-
Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative
-
Luescher, I.F. et al. Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative. Immunity 3, 51-63 (1995).
-
(1995)
Immunity
, vol.3
, pp. 51-63
-
-
Luescher, I.F.1
-
46
-
-
35748983843
-
A constant affinity threshold for T cell tolerance
-
Naeher, D. et al. A constant affinity threshold for T cell tolerance. J. Exp. Med. 204, 2553-2559 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2553-2559
-
-
Naeher, D.1
-
47
-
-
0032528403
-
+ CTL clones is determined by the frequency of serial TCR engagement
-
+ CTL clones is determined by the frequency of serial TCR engagement. J. Immunol. 161, 553-562 (1998).
-
(1998)
J. Immunol.
, vol.161
, pp. 553-562
-
-
Hudrisier, D.1
-
48
-
-
33845375138
-
Photochemistry of phenyl azide - The role of singlet and triplet phenylnitrene as transient intermediates
-
Leyva, E., Platz, M.S., Persy, G. & Wirz, J. Photochemistry of phenyl azide - the role of singlet and triplet phenylnitrene as transient intermediates. J. Am. Chem. Soc. 108, 3783-3790 (1986).
-
(1986)
J. Am. Chem. Soc.
, vol.108
, pp. 3783-3790
-
-
Leyva, E.1
Platz, M.S.2
Persy, G.3
Wirz, J.4
-
49
-
-
33746011209
-
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
-
Varma, R., Campi, G., Yokosuka, T., Saito, T. & Dustin, M.L. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 25, 117-127 (2006).
-
(2006)
Immunity
, vol.25
, pp. 117-127
-
-
Varma, R.1
Campi, G.2
Yokosuka, T.3
Saito, T.4
Dustin, M.L.5
-
50
-
-
30044441433
-
Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
-
Yokosuka, T. et al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat. Immunol. 6, 1253-1262 (2005).
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1253-1262
-
-
Yokosuka, T.1
-
51
-
-
0242497659
-
The immunological synapse balances T cell receptor signaling and degradation
-
Lee, K.H. et al. The immunological synapse balances T cell receptor signaling and degradation. Science 302, 1218-1222 (2003).
-
(2003)
Science
, vol.302
, pp. 1218-1222
-
-
Lee, K.H.1
-
52
-
-
51349131307
-
The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality
-
Cemerski, S. et al. The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality. Immunity 29, 414-422 (2008).
-
(2008)
Immunity
, vol.29
, pp. 414-422
-
-
Cemerski, S.1
|