Themis sets the signal threshold for positive and negative selection in T-cell development

Nature

Volumn 504, Issue 7480, 2013, Pages 441-445

  Fu, Guo ^a   Casas, Javier ^a,b   Rigaud, Stephanie ^a   Rybakin, Vasily ^a,b   Lambolez, Florence ^c   Brzostek, Joanna ^a,b   Hoerter, John A H ^a   Paster, Wolfgang ^d   Acuto, Oreste ^d   Cheroutre, Hilde ^c   Sauer, Karsten ^a   Gascoigne, Nicholas R J ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN TYROSINE PHOSPHATASE SHP 1; T LYMPHOCYTE RECEPTOR; THEMIS PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN; CYTOLOGY; PEPTIDE; PHENOTYPE; SIGNAL;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8 ALPHA BETA T LYMPHOCYTE; CELL SELECTION; CONTROLLED STUDY; LYMPHOID ORGAN; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMOCYTE; THYMUS;

ANIMALS; APOPTOSIS; AUTOANTIGENS; CALCIUM SIGNALING; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LIGANDS; MICE; MICE, INBRED C57BL; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMOCYTES;

EID: 84890561320     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12718     Document Type: Article

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