Locking the active conformation of c-Src kinase through the phosphorylation of the activation loop

Journal of Molecular Biology

Volumn 426, Issue 2, 2014, Pages 423-435

  Meng, Yilin ^a   Roux, Benoît ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

activation loop; c Src kinase; free energy landscapes; phosphorylation

Indexed keywords

PROTEIN TYROSINE KINASE; TYROSINE;

ARTICLE; CALCULATION; CATALYSIS; CONFORMATIONAL TRANSITION; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME STABILITY; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; STATIC ELECTRICITY;

ACTIVATION LOOP; C-SRC KINASE; FREE-ENERGY LANDSCAPES; MD; MFEP; MINIMUM FREE-ENERGY PATHWAY; MOLECULAR DYNAMICS; PHOSPHORYLATION; PMF; POTENTIAL OF MEAN FORCE; SFK; SH2; SH3; SRC FAMILY KINASE; SRC-HOMOLOGY 2; SRC-HOMOLOGY 3; UMBRELLA SAMPLING; US; WILD TYPE; WT;

AMINO ACID SEQUENCE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SRC-FAMILY KINASES; TYROSINE;

EID: 84891836984     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.10.001     Document Type: Article

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