CD4 + T-cell synapses involve multiple distinct stages

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 41, 2011, Pages 17099-17104

  Ueda, Hironori ^a,c   Morphew, Mary K ^b   McIntosh, J Richard ^b   Davis, Mark M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Centrosome; Microtubule organizing center

Indexed keywords

ANIMAL CELL; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL NUCLEUS MEMBRANE; CENTRIOLE; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; ELECTRON MICROSCOPY; GOLGI COMPLEX; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOPODIUM; SYNAPSE;

ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CENTRIOLES; DENDRITIC CELLS; ELECTRON MICROSCOPE TOMOGRAPHY; IMAGING, THREE-DIMENSIONAL; IMMUNOLOGICAL SYNAPSES; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULES; MODELS, IMMUNOLOGICAL; NUCLEAR PORE; PSEUDOPODIA; TIME FACTORS;

EID: 80054721880     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1113703108     Document Type: Article

References (45)

1. Grakoui A, et al. (1999) The immunological synapse: A molecular machine controlling T cell activation. Science 285:221-227. (Pubitemid 29329988)
2. Huppa JB, Davis MM (2003) T-cell-antigen recognition and the immunological synapse. Nat Rev Immunol 3:973-983. (Pubitemid 37521539)
3. Stinchcombe JC, Majorovits E, Bossi G, Fuller S, Griffiths GM (2006) Centrosome polarization delivers secretory granules to the immunological synapse. Nature 443: 462-465. (Pubitemid 44477283)
4. Dustin ML (2008) T-cell activation through immunological synapses and kinapses. Immunol Rev 221:77-89.
5. Richie LI, et al. (2002) Imaging synapse formation during thymocyte selection: Inability of CD3ζ to form a stable central accumulation during negative selection. Immunity 16: 595-606. (Pubitemid 34442583)
6. Maldonado RA, Irvine DJ, Schreiber R, Glimcher LH (2004) A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431:527-532. (Pubitemid 39336325)
7. Huse M, et al. (2007) Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity 27:76-88. (Pubitemid 47089024)
8. Krummel MF, Macara I (2006) Maintenance and modulation of T cell polarity. Nat Immunol 7:1143-1149. (Pubitemid 44594309)
9. Milstein O, et al. (2008) Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem 283:34414-34422.
10. Sims TN, et al. (2007) Opposing effects of PKCθ and WASp on symmetry breaking and relocation of the immunological synapse. Cell 129:773-785. (Pubitemid 46802378)
11. Huppa JB, Gleimer M, Sumen C, Davis MM (2003) Continuous T cell receptor signaling required for synapse maintenance and full effector potential. Nat Immunol 4: 749-755. (Pubitemid 36986758)
12. Williams GS, et al. (2007) Membranous structures transfer cell surface proteins across NK cell immune synapses. Traffic 8:1190-1204. (Pubitemid 47248473)
13. Singleton K, et al. (2006) A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse. J Immunol 177:4402-4413. (Pubitemid 44469769)
14. Sabatos CA, et al. (2008) A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction. Immunity 29:238-248.
15. Gomez TS, et al. (2007) Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity 26:177-190. (Pubitemid 46329435)
16. Brossard C, et al. (2005) Multifocal structure of the T cell - dendritic cell synapse. Eur J Immunol 35:1741-1753. (Pubitemid 40862322)
17. Kupfer A, Dennert G, Singer SJ (1983) Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets. Proc Natl Acad Sci USA 80:7224-7228. (Pubitemid 14208831)
18. Bornens M (2002) Centrosome composition and microtubule anchoring mechanisms. Curr Opin Cell Biol 14:25-34.
19. Job D, Valiron O, Oakley B (2003) Microtubule nucleation. Curr Opin Cell Biol 15: 111-117. (Pubitemid 36044723)
20. Rios RM, Bornens M (2003) The Golgi apparatus at the cell centre. Curr Opin Cell Biol 15:60-66. (Pubitemid 36044716)
21. Schwartz RH (1985) T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol 3:237-261.
22. Sanderson CJ, Glauert AM (1979) The mechanism of T-cell mediated cytotoxicity. VI. Tcell projections and their role in target cell killing. Immunology 36:119-129. (Pubitemid 9229583)
23. Rosen D, Fishelson Z, Berke G (1981) The role of cytotoxic T lymphocyte projections in target cell lysis. Transplant Proc 13:1073-1078. (Pubitemid 11159391)
24. Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM (2006) T cells use two directionally distinct pathways for cytokine secretion. Nat Immunol 7:247-255.
25. Kremer JR, Mastronarde DN, McIntosh JR (1996) Computer visualization of three-dimensional image data using IMOD. J Struct Biol 116:71-76. (Pubitemid 26093126)
26. Mastronarde DN (1997) Dual-axis tomography: An approach with alignment methods that preserve resolution. J Struct Biol 120:343-352.
27. O'Toole ET, Winey M, McIntosh JR (1999) High-voltage electron tomography of spindle pole bodies and early mitotic spindles in the yeast Saccharomyces cerevisiae. Mol Biol Cell 10:2017-2031. (Pubitemid 29272647)
28. D'Angelo MA, Hetzer MW (2008) Structure, dynamics and function of nuclear pore complexes. Trends Cell Biol 18:456-466.
29. Rizzuto R, Duchen MR, Pozzan T (2004) Flirting in little space: The ER/mitochondria Ca2+ liaison. Sci STKE 2004:re1.
30. Inaba K, et al. (1992) Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 176:1693-1702.
31. Wiedemann A, Depoil D, Faroudi M, Valitutti S (2006) Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses. Proc Natl Acad Sci USA 103:10985-10990. (Pubitemid 44148405)
32. Irvine DJ, Purbhoo MA, Krogsgaard M, Davis MM (2002) Direct observation of ligand recognition by T cells. Nature 419:845-849. (Pubitemid 35238571)
33. Purbhoo MA, Irvine DJ, Huppa JB, Davis MM (2004) T cell killing does not require the formation of a stable mature immunological synapse. Nat Immunol 5:524-530. (Pubitemid 38660465)
34. Kaizuka Y, Douglass AD, Varma R, Dustin ML, Vale RD (2007) Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci USA 104:20296-20301.
35. Huppa JB, et al. (2010) TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature 463:963-967.
36. Mitchison T, Kirschner M (1984) Dynamic instability of microtubule growth. Nature 312:237-242.
37. Wiese C, Zheng Y (2000) A new function for the γ-tubulin ring complex as a microtubule minus-end cap. Nat Cell Biol 2:358-364.
38. Janson ME, Setty TG, Paoletti A, Tran PT (2005) Efficient formation of bipolar microtubule bundles requires microtubule-bound γ-tubulin complexes. J Cell Biol 169: 297-308. (Pubitemid 40656567)
39. Zimmerman S, Chang F (2005) Effects of γ-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast. Mol Biol Cell 16:2719-2733. (Pubitemid 40741219)
40. Kupfer A, Dennert G (1984) Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells. J Immunol 133:2762-2766. (Pubitemid 15206939)
41. Quintana A, et al. (2007) T cell activation requires mitochondrial translocation to the immunological synapse. Proc Natl Acad Sci USA 104:14418-14423. (Pubitemid 350003276)
42. Li QJ, et al. (2007) miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129:147-161.
43. Marsh BJ, Mastronarde DN, Buttle KF, Howell KE, McIntosh JR (2001) Organellar relationships in the Golgi region of the pancreatic β cell line, HIT-T15, visualized by high resolution electron tomography. Proc Natl Acad Sci USA 98:2399-2406. (Pubitemid 32209494)
44. Ladinsky MS, Kremer JR, Furcinitti PS, McIntosh JR, Howell KE (1994) HVEM tomography of the trans-Golgi network: Structural insights and identification of a lace-like vesicle coat. J Cell Biol 127:29-38. (Pubitemid 24307654)
45. Ladinsky MS, Mastronarde DN, McIntosh JR, Howell KE, Staehelin LA (1999) Golgi structure in three dimensions: Functional insights from the normal rat kidney cell. J Cell Biol 144:1135-1149. (Pubitemid 29157294)